Recent progress in understanding coxsackievirus replication, dissemination, and pathogsenesis

Virology

Volumn 484, Issue , 2015, Pages 288-304

  Sin, Jon ^a   Mangale, Vrushali ^b   Thienphrapa, Wdee ^b   Gottlieb, Roberta A ^a   Feuer, Ralph ^b  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b SAN DIEGO STATE UNIVERSITY   (United States)

Author keywords

Autophagy; Cardiac progenitor cells; Coxsackievirus; Enterovirus; Meningoencephalitis; Microvesicles; Myocarditis; Neural progenitor cells; Picornavirus; Virus dissemination

Indexed keywords

ANTIVIRUS AGENT; COXSACKIEVIRUS VACCINE; PROTEINASE; UNCLASSIFIED DRUG; VIRUS VACCINE;

ADAPTIVE IMMUNITY; AUTOPHAGOSOME; AUTOPHAGY; CARDIAC STEM CELL; CELL MEMBRANE; CHRONIC DISEASE; COXSACKIE VIRUS INFECTION; ENTEROVIRUS; HUMAN; IMMUNE RESPONSE; INNATE IMMUNITY; MICROBIAL ACTIVITY; MOLECULAR BIOLOGY; NEURAL STEM CELL; NONHUMAN; PATHOGENESIS; PERSISTENT VIRUS INFECTION; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; REVIEW; TARGET CELL; TIGHT JUNCTION; VIRAL TROPISM; VIRUS CELL INTERACTION; VIRUS ENTRY; VIRUS MYOCARDITIS; VIRUS RECOMBINANT; VIRUS REPLICATION; VIRUS TRANSMISSION; IMMUNE EVASION; PATHOGENICITY; PHYSIOLOGY; VIROLOGY; VIRUS RELEASE;

AUTOPHAGY; COXSACKIEVIRUS INFECTIONS; ENTEROVIRUS; HUMANS; IMMUNE EVASION; VIRAL TROPISM; VIRUS INTERNALIZATION; VIRUS RELEASE; VIRUS REPLICATION;

EID: 84947245785     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2015.06.006     Document Type: Review

References (225)

1. Abzug M.J. Presentation, diagnosis, and management of enterovirus infections in neonates. Paediatr. Drugs 2004, 6:1-10.
2. Ahn J., Jee Y., Seo I., Yoon S.Y., Kim D., Kim Y.K., Lee H. Primary neurons become less susceptible to coxsackievirus B5 following maturation: the correlation with the decreased level of CAR expression on cell surface. J. Med. Virol. 2008, 80(3):434-440.
3. Alderman C.P., Moritz C.K., Ben-Tovim D.I. Abnormal platelet aggregation associated with fluoxetine therapy. Ann. Pharmacother. 1992, 26:1517-1519.
4. Alidjinou E.K., Sane F., Bertin A., Caloone D., Hober D. Persistent infection of human pancreatic cells with Coxsackievirus B4 is cured by fluoxetine. Antivir. Res. 2015, 10.
5. Alirezaei M., Flynn C.T., Whitton J.L. Interactions between enteroviruses and autophagy in vivo. Autophagy 2012, 8:973-975.
6. Alirezaei M., Flynn C.T., Wood M.R., Whitton J.L. Pancreatic acinar cell-specific autophagy disruption reduces coxsackievirus replication and pathogenesis in vivo. Cell Host. Microbe 2012, 11:298-305.
7. Alirezaei M., Kemball C.C., Flynn C.T., Wood M.R., Whitton J.L., Kiosses W.B. Short-term fasting induces profound neuronal autophagy. Autophagy 2010, 6(6):702-710.
8. Aliyari R., Ding S.W. RNA-based viral immunity initiated by the Dicer family of host immune receptors. Immunol. Rev. 2009, 227:176-188.
9. Althof N., Harkins S., Kemball C.C., Flynn C.T., Alirezaei M., Whitton J.L. In vivo ablation of type I interferon receptor from cardiomyocytes delays coxsackieviral clearance and accelerates myocardial disease. J. Virol. 2014, 88:5087-5099.
10. Althof N., Whitton J.L. Coxsackievirus B3 infects the bone marrow and diminishes the restorative capacity of erythroid and lymphoid progenitors. J. Virol. 2012, 87:2823-2834.
11. Arnesjo B., Eden T., Ihse I., Nordenfelt E., Ursing B. Enterovirus infections in acute pancreatitis - a possible etiological connection. Scand. J. Gastroenterol. 1976, 11:645-649.
12. Badorff C., Berkely N., Mehrotra S., Talhouk J.W., Rhoads R.E., Knowlton K.U. Enteroviral protease 2A directly cleaves dystrophin and is inhibited by a dystrophin-based substrate analogue. J. Biol. Chem. 2000, 275:11191-11197.
13. Badorff C., Lee G.H., Lamphear B.J., Martone M.E., Campbell K.P., Rhoads R.E., Knowlton K.U. Enteroviral protease 2A cleaves dystrophin: evidence of cytoskeletal disruption in an acquired cardiomyopathy. Nat. Med. 1999, 5:320-326.
14. Belov G.A., Altan-Bonnet N., Kovtunovych G., Jackson C.L., Lippincott-Schwartz J., Ehrenfeld E. Hijacking components of the cellular secretory pathway for replication of poliovirus RNA. J. Virol. 2007, 81:558-567.
15. Belov G.A., van Kuppeveld F.J. (+)RNA viruses rewire cellular pathways to build replication organelles. Curr. Opin. Virol. 2012, 2:740-747.
16. Bergelson J.M. Intercellular junctional proteins as receptors and barriers to virus infection and spread. Cell Host Microbe 2009, 5:517-521.
17. Bergelson J.M., Chan M., Solomon K.R., John N.F., Lin H., Finberg R.W. Decay-accelerating factor (CD55), a glycosylphosphatidylinositol-anchored complement regulatory protein, is a receptor for several echoviruses. Proc. Natl. Acad. Sci. USA 1994, 91:6245-6248.
18. Bergelson J.M., Cunningham J.A., Droguett G., Kurt-Jones E.A., Krithivas A., Hong J.S., Horwitz M.S., Crowell R.L., Finberg R.W. Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5. Science 1997, 275:1320-1323.
19. Bird S.W., Maynard N.D., Covert M.W., Kirkegaard K. Nonlytic viral spread enhanced sby autophagy components. Proc. Natl. Acad. Sci. USA 2014, 111:13081-13086.
20. Bozym R.A., Delorme-Axford E., Harris K., Morosky S., Ikizler M., Dermody T.S., Sarkar S.N., Coyne C.B. Focal adhesion kinase is a component of antiviral RIG-I-like receptor signaling. Cell Host Microbe 2012, 11:153-166.
21. Campanella M., de Jong A.S., Lanke K.W., Melchers W.J., Willems P.H., Pinton P., Rizzuto R., van Kuppeveld F.J. The coxsackievirus 2B protein suppresses apoptotic host cell responses by manipulating intracellular Ca2+ homeostasis. J. Biol. Chem. 2004, 279:18440-18450.
22. Chamberlain R.N., Christie P.N., Holt K.S., Huntley R.M., Pollard R., Roche M.C. A study of school children who had identified virus infections of the central nervous system during infancy. Child Care Health Dev. 1983, 9:29-47.
23. Chang L.Y., Huang L.M., Gau S.S., Wu Y.Y., Hsia S.H., Fan T.Y., Lin K.L., Huang Y.C., Lu C.Y., Lin T.Y. Neurodevelopment and cognition in children after enterovirus 71 infection. N. Engl. J. Med. 2007, 356:1226-1234.
24. Chapman N.M., Kim K.S. Persistent coxsackievirus infection: enterovirus persistence in chronic myocarditis and dilated cardiomyopathy. Curr. Top. Microbiol. Immunol. 2008, 323(275-92):275-292.
25. Chapman N.M., Kim K.S., Drescher K.M., Oka K., Tracy S. 5' terminal deletions in the genome of a coxsackievirus B2 strain occurred naturally in human heart. Virology 2008, 375:480-491.
26. Chen T.C., Weng K.F., Chang S.C., Lin J.Y., Huang P.N., Shih S.R. Development of antiviral agents for enteroviruses. J. Antimicrob. Chemother. 2008, 62:1169-1173.
27. Chen Y.H., Du W., Hagemeijer M.C., Takvorian P.M., Pau C., Cali A., Brantner C.A., Stempinski E.S., Connelly P.S., Ma H.C., Jiang P., Wimmer E., Altan-Bonnet G., Altan-Bonnet N. Phosphatidylserine vesicles enable efficient en bloc transmission of enteroviruses. Cell 2015, 160:619-630.
28. Cheng M.F., Chen B.C., Huang T.S., Hsieh K.S., Chen S.N., Liu Y.C. Clinical application of reverse-transcription polymerase chain reaction and intravenous immunoglobulin for enterovirus encephalitis. Jpn. J. Infect. Dis. 2008, 61:18-24.
29. Cheng T.O. Viral myocarditis is a frequent cause of idiopathic dilated cardiomyopathy. Int. J. Cardiol. 2006, 109:270.
30. Chiriboga-Klein S., Oberfield S.E., Casullo A.M., Holahan N., Fedun B., Cooper L.Z., Levine L.S. Growth in congenital rubella syndrome and correlation with clinical manifestations. J. Pediatr. 1989, 115:251-255.
31. Christen U., Bender C., von Herrath M.G. Infection as a cause of type 1 diabetes?. Curr. Opin. Rheumatol. 2012, 24:417-423.
32. Cornell C.T., Kiosses W.B., Harkins S., Whitton J.L. Inhibition of protein trafficking by coxsackievirus b3: multiple viral proteins target a single organelle. J. Virol. 2006, 80:6637-6647.
33. Cornell C.T., Kiosses W.B., Harkins S., Whitton J.L. Coxsackievirus B3 proteins directionally complement each other to downregulate surface major histocompatibility complex class I. J. Virol. 2007, 81:6785-6797.
34. Coyne C.B., Bergelson J.M. Virus-induced Abl and Fyn kinase signals permit coxsackievirus entry through epithelial tight junctions. Cell 2006, 124(1):119-131.
35. Coyne C.B., Shen L., Turner J.R., Bergelson J.M. Coxsackievirus entry across epithelial tight junctions requires occludin and the small GTPases Rab34 and Rab5. Cell Host. Microbe 2007, 2:181-192.
36. Cree B.C., Bernardini G.L., Hays A.P., Lowe G. A fatal case of coxsackievirus B4 meningoencephalitis. Arch. Neurol. 2003, 60:107-112.
37. Crotty S., Andino R. Implications of high RNA virus mutation rates: lethal mutagenesis and the antiviral drug ribavirin. Microbes Infect. 2002, 4:1301-1307.
38. Crotty S., Cameron C.E., Andino R. RNA virus error catastrophe: direct molecular test by using ribavirin. Proc. Natl. Acad. Sci. USA 2001, 98:6895-6900.
39. Crotty S., Maag D., Arnold J.J., Zhong W., Lau J.Y., Hong Z., Andino R., Cameron C.E. The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen. Nat. Med. 2000, 6:1375-1379.
40. Dan M., Chantler J.K. A genetically engineered attenuated coxsackievirus B3 strain protects mice against lethal infection. J. Virol. 2005, 79(14):9285-9295.
41. David P., Baleriaux D., Bank W.O., Amrom D., De T.D., Babusiaux C., Matos C., Van S.C., Lloret-Pastor C., Szliwowski H.B. MRI of acute disseminated encephalomyelitis after coxsackie B infection. J. Neuroradiol. 1993, 20:258-265.
42. de Jong A.S., Visch H.J., de M.F., van Dommelen M.M., Swarts H.G., Luyten T., Callewaert G., Melchers W.J., Willems P.H., van Kuppeveld F.J The coxsackievirus 2B protein increases efflux of ions from the endoplasmic reticulum and Golgi, thereby inhibiting protein trafficking through the Golgi. J. Biol. Chem. 2006, 281:14144-14150.
43. Delorme-Axford E., Coyne C.B. The actin cytoskeleton as a barrier to virus infection of polarized epithelial cells. Viruses 2011, 3:2462-2477.
44. Delorme-Axford E., Donker R.B., Mouillet J.F., Chu T., Bayer A., Ouyang Y., Wang T., Stolz D.B., Sarkar S.N., Morelli A.E., Sadovsky Y., Coyne C.B. Human placental trophoblasts confer viral resistance to recipient cells. Proc. Natl. Acad. Sci. USA 2013, 110:12048-12053.
45. Delorme-Axford E., Morosky S., Bomberger J., Stolz D.B., Jackson W.T., Coyne C.B. BPIFB3 regulates autophagy and coxsackievirus B replication through a noncanonical pathway independent of the core initiation machinery. MBio 2014, 5:e02147-14.
46. Dickson P.W., Aldred A.R., Marley P.D., Bannister D., Schreiber G. Rat choroid plexus specializes in the synthesis and the secretion of transthyretin (prealbumin). Regulation of transthyretin synthesis in choroid plexus is independent from that in liver. J. Biol. Chem. 1986, 261:3475-3478.
47. Doceul V., Hollinshead M., van der Linden L., Smith G.L. Repulsion of superinfecting virions: a mechanism for rapid virus spread. Science 2010, 327:873-876.
48. Dougherty J.D., White J.P., Lloyd R.E. Poliovirus-mediated disruption of cytoplasmic processing bodies. J. Virol. 2011, 85:64-75.
49. Drescher K.M., Kono K., Bopegamage S., Carson S.D., Tracy S. Coxsackievirus B3 infection and type 1 diabetes development in NOD mice: insulitis determines susceptibility of pancreatic islets to virus infection. Virology 2004, 329:381-394.
50. Dreux M., Garaigorta U., Boyd B., Decembre E., Chung J., Whitten-Bauer C., Wieland S., Chisari F.V. Short-range exosomal transfer of viral RNA from infected cells to plasmacytoid dendritic cells triggers innate immunity. Cell Host Microbe 2012, 12:558-570.
51. Emerich D.F., Skinner S.J., Borlongan C.V., Vasconcellos A.V., Thanos C.G. The choroid plexus in the rise, fall and repair of the brain. Bioessays 2005, 27:262-274.
52. Eriksson C., Bjorklund A., Wictorin K. Neuronal differentiation following transplantation of expanded mouse neurosphere cultures derived from different embryonic forebrain regions. Exp. Neurol. 2003, 184:615-635.
53. Esfandiarei M., Luo H., Yanagawa B., Suarez A., Dabiri D., Zhang J., McManus B.M. Protein kinase B/Akt regulates coxsackievirus B3 replication through a mechanism which is not caspase dependent. J. Virol. 2004, 78:4289-4298.
54. Esfandiarei M., McManus B.M. Molecular biology and pathogenesis of viral myocarditis. Annu. Rev. Pathol 2008, 3(127-55):127-155.
55. Etchison D., Milburn S.C., Edery I., Sonenberg N., Hershey J.W. Inhibition of HeLa cell protein synthesis following poliovirus infection correlates with the proteolysis of a 220,000-dalton polypeptide associated with eucaryotic initiation factor 3 and a cap binding protein complex. J. Biol. Chem. 1982, 257(24):14806-14810.
56. Euscher E., Davis J., Holzman I., Nuovo G.J. Coxsackie virus infection of the placenta associated with neurodevelopmental delays in the newborn. Obstet. Gynecol. 2001, 98:1019-1026.
57. Falk A., Frisen J. Amphiregulin is a mitogen for adult neural stem cells. J. Neurosci. Res. 2002, 69:757-762.
58. Feng Q., Langereis M.A., Lork M., Nguyen M., Hato S.V., Lanke K., Emdad L., Bhoopathi P., Fisher P.B., Lloyd R.E., van Kuppeveld F.J. Enterovirus 2Apro targets MDA5 and MAVS in infected cells. J. Virol. 2014, 88:3369-3378.
59. Feng Q., Langereis M.A., van Kuppeveld F.J. Induction and suppression of innate antiviral responses by picornaviruses. Cytokine Growth Factor Rev. 2014, 25:577-585.
60. Feng Z., Hensley L., McKnight K.L., Hu F., Madden V., Ping L., Jeong S.H., Walker C., Lanford R.E., Lemon S.M. A pathogenic picornavirus acquires an envelope by hijacking cellular membranes. Nature 2013, 10.
61. Feng Z., Lemon S.M. Peek-a-boo: membrane hijacking and the pathogenesis of viral hepatitis. Trends Microbiol. 2014, 22:59-64. (%19. (piiS0966-842X), 10).
62. Feuer R., Mena I., Pagarigan R., Slifka M.K., Whitton J.L. Cell cycle status affects coxsackievirus replication, persistence, and reactivation in vitro. J. Virol. 2002, 76:4430-4440.
63. Feuer R., Mena I., Pagarigan R.R., Harkins S., Hassett D.E., Whitton J.L. Coxsackievirus B3 and the neonatal CNS: the roles of stem cells, developing neurons, and apoptosis in infection, viral dissemination, and disease. Am. J. Pathol. 2003, 163:1379-1393.
64. Feuer R., Mena I., Pagarigan R.R., Hassett D.E., Whitton J.L. Coxsackievirus replication and the cell cycle: a potential regulatory mechanism for viral persistence/latency. Med. Microbiol. Immunol. 2004, 193:83-90.
65. Feuer R., Pagarigan R.R., Harkins S., Liu F., Hunziker I.P., Whitton J.L. Coxsackievirus targets proliferating neuronal progenitor cells in the neonatal CNS. J. Neurosci. 2005, 25:2434-2444.
66. Feuer R., Ruller C.M., Tabor-Godwin N., Rhoades J.M., Maciejewski R.E., Pagarigan S., Cornell R.R., Crocker C.T., Kiosses S.J., Pham-Mitchell W.B., Campbell N., Whitton, J.L.I.L. Viral persistence and chronic immunopathology in the adult central nervous system following Coxsackievirus infection during the neonatal period. J. Virol. 2009, 83:9356-9369.
67. Feuer R., Whitton J.L. Preferential coxsackievirus replication in proliferating/activated cells: implications for virus tropism, persistence, and pathogenesis. Curr. Top. Microbiol. Immunol. 2008, 323:149-173.
68. Ford Siltz L.A., Viktorova E.G., Zhang B., Kouiavskaia D., Dragunsky E., Chumakov K., Isaacs L., Belov G.A. New small-molecule inhibitors effectively blocking picornavirus replication. J. Virol. 2014, 88:11091-11107.
69. Fujita K., Krishnakumar S.S., Franco D., Paul A.V., London E., Wimmer E. Membrane topography of the hydrophobic anchor sequence of poliovirus 3A and 3AB proteins and the functional effect of 3A/3AB membrane association upon RNA replication. Biochemistry. 2007, 46(17):5185-5199.
70. Galama J.M., Vogels M.T., Jansen G.H., Gielen M., Heessen F.W. Antibodies against enteroviruses in intravenous Ig preparations: great variation in titres and poor correlation with the incidence of circulating serotypes. J. Med. Virol. 1997, 53:273-276.
71. Gallo A., Tandon M., Alevizos I., Illei G.G. The majority of microRNAs detectable in serum and saliva is concentrated in exosomes. PLoS One 2012, 7:e30679.
72. Gamarnik A.V., Andino R. Switch from translation to RNA replication in a positive-stranded RNA virus. Genes Dev. 1998, 12(15):2293-2304.
73. Gitlin L., Andino R. Nucleic acid-based immune system: the antiviral potential of mammalian RNA silencing. J. Virol. 2003, 77:7159-7165.
74. Guan J.L., Simon A.K., Prescott M., Menendez J.A., Liu F., Wang F., Wang C., Wolvetang E., Vazquez-Martin A., Zhang J. Autophagy in stem cells. Autophagy 2013, 9.
75. Gustafsson A.B., Gottlieb R.A. Recycle or die: the role of autophagy in cardioprotection. J. Mol. Cell. Cardiol. 2008, 44:654-661.
76. Hamasaki M., Furuta N., Matsuda A., Nezu A., Yamamoto A., Fujita N., Oomori H., Noda T., Haraguchi T., Hiraoka Y., Amano A., Yoshimori T. Autophagosomes form at ER-mitochondria contact sites. Nature 2013, 495:389-393.
77. Harris K.G., Coyne C.B. Enter at your own risk: how enteroviruses navigate the dangerous world of pattern recognition receptor signaling. Cytokine 2013, 63:230-236.
78. Harris K.G., Coyne C.B. Death waits for no man - does it wait for a virus? How enteroviruses induce and control cell death. Cytokine Growth Factor Rev. 2014, 25:587-596.
79. Henke A., Zell R., Ehrlich G., Stelzner A. Expression of immunoregulatory cytokines by recombinant coxsackievirus B3 variants confers protection against virus-caused myocarditis. J. Virol. 2001, 75:8187-8194.
80. Herold J., Andino R. Poliovirus RNA replication requires genome circularization through a protein-protein bridge. Mol. Cell 2001, 7(3):581-591.
81. Honda T., Saitoh H., Masuko M., Katagiri-Abe T., Tominaga K., Kozakai I., Kobayashi K., Kumanishi T., Watanabe Y.G., Odani S., Kuwano R. The coxsackievirus-adenovirus receptor protein as a cell adhesion molecule in the developing mouse brain. Brain Res. Mol. Brain Res. 2000, 77:19-28.
82. Horwitz M.S., Bradley L.M., Harbertson J., Krahl T., Lee J., Sarvetnick N. Diabetes induced by Coxsackie virus: initiation by bystander damage and not molecular mimicry. Nat. Med. 1998, 4:781-785.
83. Hotta Y., Honda T., Naito M., Kuwano R. Developmental distribution of coxsackie virus and adenovirus receptor localized in the nervous system. Brain Res. Dev. Brain Res. 2003, 143:1-13.
84. Hsu N.Y., Ilnytska O., Belov G., Santiana M., Chen Y.H., Takvorian P.M., Pau C., van der Schaar H., Kaushik-Basu N., Balla T., Cameron C.E., Ehrenfeld E., van Kuppeveld F.J., Altan-Bonnet N. Viral reorganization of the secretory pathway generates distinct organelles for RNA replication. Cell 2010, 141:799-811.
85. Huang C., Zhang X., Ramil J.M., Rikka S., Kim L., Lee Y., Gude N.A., Thistlethwaite P.A., Sussman M.A., Gottlieb R.A., Gustafsson A.B. Juvenile exposure to anthracyclines impairs cardiac progenitor cell function and vascularization resulting in greater susceptibility to stress-induced myocardial injury in adult mice. Circulation 2010, 121:675-683.
86. Huang S.C., Chang C.L., Wang P.S., Tsai Y., Liu H.S. Enterovirus 71-induced autophagy detected in vitro and in vivo promotes viral replication. J. Med. Virol. 2009, 81(7):1241-1252.
87. Hunziker I.P., Harkins S., Feuer R., Cornell C.T., Whitton J.L. Generation and analysis of an RNA vaccine that protects against coxsackievirus B3 challenge. Virology 2004, 330:196-208.
88. Hyypia T., Kallajoki M., Maaronen M., Stanway G., Kandolf R., Auvinen P., Kalimo H. Pathogenetic differences between coxsackie A and B virus infections in newborn mice. Virus Res. 1993, 27:71-78.
89. Ilnytska O., Santiana M., Hsu N.Y., Du W.L., Chen Y.H., Viktorova E.G., Belov G., Brinker A., Storch J., Moore C., Dixon J.L., Altan-Bonnet N. Enteroviruses harness the cellular endocytic machinery to remodel the host cell cholesterol landscape for effective viral replication. Cell Host Microbe 2013, 14:281-293.
90. Inal J.M., Jorfi S. Coxsackievirus B transmission and possible new roles for extracellular vesicles. Biochem. Soc. Trans. 2013, 41:299-302.
91. Iwakawa H.O., Mizumoto H., Nagano H., Imoto Y., Takigawa K., Sarawaneeyaruk S., Kaido M., Mise K., Okuno T. A viral noncoding RNA generated by cis-element-mediated protection against 5'->3' RNA decay represses both cap-independent and cap-dependent translation. J. Virol. 2008, 82:10162-10174.
92. Jackson W.T. Poliovirus-induced changes in cellular membranes throughout infection. Curr. Opin. Virol. 2014, 9:67-73. (Epub@2014 Oct 11., 67-73). 10.1016/j.coviro.2014.09.007.
93. Jackson W.T., Giddings T.H., Taylor M.P., Mulinyawe S., Rabinovitch M., Kopito R.R., Kirkegaard K. Subversion of cellular autophagosomal machinery by RNA viruses. PLoS Biol. 2005, 3(5):e156.
94. Jackson W.T., Giddings T.H., Taylor M.P., Mulinyawe S., Rabinovitch M., Kopito R.R., Kirkegaard K. Subversion of cellular autophagosomal machinery by RNA viruses. PLoS Biol. 2005, 3(5):e156.
95. Jaidane H., Hober D. Role of coxsackievirus B4 in the pathogenesis of type 1 diabetes. Diabetes Metab. 2008, 34:537-548.
96. Jensen K.J., Garmaroudi F.S., Zhang J., Lin J., Boroomand S., Zhang M., Luo Z., Yang D., Luo H., McManus B.M., Janes K.A. An ERK-p38 subnetwork coordinates host cell apoptosis and necrosis during coxsackievirus B3 infection. Cell Host Microbe 2013, 13:67-76.
97. Jiang P., Liu Y., Ma H.C., Paul A.V., Wimmer E. Picornavirus morphogenesis. Microbiol. Mol. Biol. Rev. 2014, 78:418-437.
98. Kallewaard N.L., Zhang L., Chen J.W., Guttenberg M., Sanchez M.D., Bergelson J.M. Tissue-specific deletion of the coxsackievirus and adenovirus receptor protects mice from virus-induced pancreatitis and myocarditis. Cell Host Microbe 2009, 6:91-98.
99. Kanno T., Kim K., Kono K., Drescher K.M., Chapman N.M., Tracy S. Group B coxsackievirus diabetogenic phenotype correlates with replication efficiency. J. Virol. 2006, 80:5637-5643.
100. Kearney M.T., Cotton J.M., Richardson P.J., Shah A.M. Viral myocarditis and dilated cardiomyopathy: mechanisms, manifestations, and management. Postgrad. Med. J. 2001, 77:4-10.
101. Kemball C.C., Alirezaei M., Flynn C.T., Wood M.R., Harkins S., Kiosses W.B., Whitton J.L. Coxsackievirus infection induces autophagy-like vesicles and megaphagosomes in pancreatic acinar cells in vivo. J. Virol. 2010, 84:12110-12124.
102. Kemball C.C., Alirezaei M., Whitton J.L. Type B coxsackieviruses and their interactions with the innate and adaptive immune systems. Future Microbiol. 2010, 5:1329-1347.
103. Kemball C.C., Flynn C.T., Hosking M.P., Botten J., Whitton J.L. Wild-type coxsackievirus infection dramatically alters the abundance, heterogeneity, and immunostimulatory capacity of conventional dendritic cells in vivo. Virology 2012, 429:74-90.
104. Kemball C.C., Harkins S., Whitmire J.K., Flynn C.T., Feuer R., Whitton J.L. Coxsackievirus B3 inhibits antigen presentation in vivo, exerting a profound and selective effect on the MHC class I pathway. PLoS Pathog. 2009, 5:e1000618.
105. Kiani-Alikhan S., Skoulidis F., Barroso A., Nuovo G., Ushiro-Lumb I., Breuer J., Lister A., Mattes F. Enterovirus infection of neuronal cells post-Rituximab. Br. J. Haematol. 2009, 146:333-335.
106. Kim D.S., Kim H., Shim S.H., Kim C., Song M., Kim Y.H., Jung Y.W., Nam J.H. Coxsackievirus B3 used as a gene therapy vector to express functional FGF2. Gene Ther. 2012, 19:1159-1165.
107. Kim K.S., Tracy S., Tapprich W., Bailey J., Lee C.K., Kim K., Barry W.H., Chapman N.M. 5'-Terminal deletions occur in coxsackievirus B3 during replication in murine hearts and cardiac myocyte cultures and correlate with encapsidation of negative-strand viral RNA. J. Virol. 2005, 79:7024-7041.
108. Kirkegaard K. Subversion of the cellular autophagy pathway by viruses. Curr. Top. Microbiol. Immunol. 2009, 335(323-33):323-333.
109. Kitamura N., Semler B.L., Rothberg P.G., Larsen G.R., Adler C.J., Dorner A.J., Emini E.A., Hanecak R., Lee J.J., van der Werf S., Anderson C.W., Wimmer E. Primary structure, gene organization and polypeptide expression of poliovirus RNA. Nature 1981, 291(5816):547-553.
110. Klionsky D.J., Abdalla F.C., Abeliovich H., Abraham R.T., Acevedo-Arozena A., Adeli K., Agholme L., Agnello M., Agostinis P., Aguirre-Ghiso J.A., Ahn H.J., Ait-Mohamed O., Ait-Si-Ali S., Akematsu T., Akira S., Al-Younes H.M., Al-Zeer M.A., Albert M.L., Albin R.L., Alegre-Abarrategui J., Aleo M.F., Alirezaei M., Almasan A., Almonte-Becerril M., Amano A., Amaravadi R., Amarnath S., Amer A.O., Andrieu-Abadie N., Anantharam V., Ann D.K., Anoopkumar-Dukie S., Aoki H., Apostolova N., Auberger P., Baba M., Backues S.K., Baehrecke E.H., Bahr B.A., Bai X.Y., Bailly Y., Baiocchi R., Baldini G., Balduini W., Ballabio A., Bamber B.A., Bampton E.T., Banhegyi G., Bartholomew C.R., Bassham D.C., Bast R.C., Batoko H., Bay B.H., Beau I., Bechet D.M., Begley T.J., Behl C., Behrends C., Bekri S., Bellaire B., Bendall L.J., Benetti L., Berliocchi L., Bernardi H., Bernassola F., Besteiro S., Bhatia-Kissova I., Bi X., Biard-Piechaczyk M., Blum J.S., Boise L.H., Bonaldo P., Boone D.L., Bornhauser B.C., Bortoluci K.R., Bossis I., Bost F., Bourquin J.P., Boya P., Boyer-Guittaut M., Bozhkov P.V., Brady N.R., Brancolini C., Brech A., Brenman J.E., Brennand A., Bresnick E.H., Brest P., Bridges D., Bristol M.L., Brookes P.S., Brown E.J., Brumell J.H., Brunetti-Pierri N., Brunk U.T., Bulman D.E., Bultman S.J., Bultynck G., Burbulla L.F., Bursch W., Butchar J.P., Buzgariu W., Bydlowski S.P., Cadwell K., Cahova M., Cai D., Cai J., Cai Q., Calabretta B., Calvo-Garrido J., Camougrand N., Campanella M., Campos-Salinas J., Candi E., Cao L., Caplan A.B., Carding S.R., Cardoso S.M., Carew J.S., Carlin C.R., Carmignac V., Carneiro L.A., Carra S., Caruso R.A., Casari G., Casas C., Castino R., Cebollero E., Cecconi F., Celli J., Chaachouay H., Chae H.J., Chai C.Y., Chan D.C., Chan E.Y., Chang R.C., Che C.M., Chen C.C., Chen G.C., Chen G.Q., Chen M., Chen Q., Chen S.S., Chen W., Chen X., Chen X., Chen X., Chen Y.G., Chen Y., Chen Y., Chen Y.J., Chen Z., Cheng A., Cheng C.H., Cheng Y., Cheong H., Cheong J.H., Cherry S., Chess-Williams R., Cheung Z.H., Chevet E., Chiang H.L., Chiarelli R., Chiba T., Chin L.S., Chiou S.H., Chisari F.V., Cho C.H., Cho D.H., Choi A.M., Choi D., Choi K.S., Choi M.E., Chouaib S., Choubey D., Choubey V., Chu C.T., Chuang T.H., Chueh S.H., Chun T., Chwae Y.J., Chye M.L., Ciarcia R., Ciriolo M.R., Clague M.J., Clark R.S., Clarke P.G., Clarke R., Codogno P., Coller H.A., Colombo M.I., Comincini S., Condello M., Condorelli F., Cookson M.R., Coombs G.H., Coppens I., Corbalan R., Cossart P., Costelli P., Costes S., Coto-Montes A., Couve E., Coxon F.P., Cregg J.M., Crespo J.L., Cronje M.J., Cuervo A.M., Cullen J.J., Czaja M.J., D'Amelio M., Darfeuille-Michaud A., Davids L.M., Davies F.E., De F.M., de Groot J.F., de Haan C.A., De M.L., De M.A., De T., V, Debnath J., Degterev A., Dehay B., Delbridge L.M., Demarchi F., Deng Y.Z., Dengjel J., Dent P., Denton D., Deretic V., Desai S.D., Devenish R.J., Di G.M., Di P.G., Di P.C., Diaz-Araya G., Diaz-Laviada I., Diaz-Meco M.T., Diaz-Nido J., Dikic I., Dinesh-Kumar S.P., Ding W.X., Distelhorst C.W., Diwan A., Djavaheri-Mergny M., Dokudovskaya S., Dong Z., Dorsey F.C., Dosenko V., Dowling J.J., Doxsey S., Dreux M., Drew M.E., Duan Q., Duchosal M.A Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012, 8:445-544.
111. Kuss S.K., Etheredge C.A., Pfeiffer J.K. Multiple host barriers restrict poliovirus trafficking in mice. PLoS.Pathog. 2008, 4(6):e1000082.
112. Laitinen O.H., Honkanen H., Pakkanen O., Oikarinen S., Hankaniemi M.M., Huhtala H., Ruokoranta T., Lecouturier V., Andre P., Harju R., Virtanen S.M., Lehtonen J., Almond J.W., Simell T., Simell O., Ilonen J., Veijola R., Knip M., Hyoty H. Coxsackievirus B1 is associated with induction of beta-cell autoimmunity that portends type 1 diabetes. Diabetes 2014, 63:446-455.
113. Lamarche M.J., Borawski J., Bose A., Capacci-Daniel C., Colvin R., Dennehy M., Ding J., Dobler M., Drumm J., Gaither L.A., Gao J., Jiang X., Lin K., McKeever U., Puyang X., Raman P., Thohan S., Tommasi R., Wagner K., Xiong X., Zabawa T., Zhu S., Wiedmann B. Anti-hepatitis C virus activity and toxicity of type III phosphatidylinositol-4-kinase beta inhibitors. Antimicrob. Agents Chemother. 2012, 56:5149-5156.
114. Lanke K.H., van der Schaar H.M., Belov G.A., Feng Q., Duijsings D., Jackson C.L., Ehrenfeld E., van Kuppeveld F.J. GBF1, a guanine nucleotide exchange factor for Arf, is crucial for coxsackievirus B3 RNA replication. J. Virol. 2009, 83:11940-11949.
115. Law G.L., Korth M.J., Benecke A.G., Katze M.G. Systems virology: host-directed approaches to viral pathogenesis and drug targeting. Nat. Rev. Microbiol. 2013, 11:455-466.
116. Lee C.K., Kono K., Haas E., Kim K.S., Drescher K.M., Chapman N.M., Tracy S. Characterization of an infectious cDNA copy of the genome of a naturally occurring, avirulent coxsackievirus B3 clinical isolate. J. Gen. Virol. 2005, 86:197-210.
117. Leeper N.J., Hunter A.L., Cooke J.P. Stem cell therapy for vascular regeneration: adult, embryonic, and induced pluripotent stem cells. Circulation 2010, 122:517-526.
118. Lim B., Yun S., Ju E., Kim B., Lee Y., Yoo D., Kim Y., Jeon E. Soluble Coxsackievirus B3 3C protease inhibitor prevents cardiomyopathy in an experimental chronic myocarditis murine model. Virus Res. 2014, 10.
119. Lim B.K., Choi J.H., Nam J.H., Gil C.O., Shin J.O., Yun S.H., Kim D.K., Jeon E.S. Virus receptor trap neutralizes coxsackievirus in experimental murine viral myocarditis. Cardiovasc. Res. 2006, 71:517-526.
120. Lim B.K., Peter A.K., Xiong D., Narezkina A., Yung A., Dalton N.D., Hwang K.K., Yajima T., Chen J., Knowlton K.U. Inhibition of Coxsackievirus-associated dystrophin cleavage prevents cardiomyopathy. J. Clin. Investig. 2013, 123:5146-5151.
121. Lloyd R.E. How do viruses interact with stress-associated RNA granules?. PLoS Pathog. 2012, 8:e1002741.
122. Lloyd R.E. Regulation of stress granules and P-bodies during RNA virus infection. Wiley Interdiscip. Rev. RNA 2013, 4:317-331.
123. Loria R.M., Shadoff N., Kibrick S., Broitman S. Maturation of intestinal defenses against peroral infection with group B coxsackievirus in mice. Infect. Immun. 1976, 13:1397-1401.
124. Lu J., Pompili V.J., Das H. Neovascularization and hematopoietic stem cells. Cell Biochem. Biophys. 2013, 67:235-245.
125. Marchant D.J., Bellac C.L., Moraes T.J., Wadsworth S.J., Dufour A., Butler G.S., Bilawchuk L.M., Hendry R.G., Robertson A.G., Cheung C.T., Ng J., Ang L., Luo Z., Heilbron K., Norris M.J., Duan W., Bucyk T., Karpov A., Devel L., Georgiadis D., Hegele R.G., Luo H., Granville D.J., Dive V., McManus B.M., Overall C.M. A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity. Nat. Med. 2014, 20:493-502.
126. Masciopinto F., Giovani C., Campagnoli S., Galli-Stampino L., Colombatto P., Brunetto M., Yen T.S., Houghton M., Pileri P., Abrignani S. Association of hepatitis C virus envelope proteins with exosomes. Eur. J. Immunol. 2004, 34:2834-2842.
127. Mason J.W. Viral latency: a link between myocarditis and dilated cardiomyopathy?. J. Mol. Cell. Cardiol. 2002, 34:695-698.
128. Mavrouli M.D., Spanakis N., Levidiotou S., Politi C., Alexiou S., Tseliou P., Hatzitaki M., Foundouli K., Tsakris A., Legakis N.J., Routsias J.G. Serologic prevalence of coxsackievirus group B in Greece. Viral Immunol. 2007, 20:11-18.
129. Meckes D.G., Raab-Traub N. Microvesicles and viral infection. J. Virol. 2011, 85:12844-12854.
130. Mena I., Perry C.M., Harkins S., Rodriguez F., Gebhard J., Whitton J.L. The role of B lymphocytes in coxsackievirus B3 infection. Am. J. Pathol. 1999, 155:1205-1215.
131. Merl S., Michaelis C., Jaschke B., Vorpahl M., Seidl S., Wessely R. Targeting 2A protease by RNA interference attenuates coxsackieviral cytopathogenicity and promotes survival in highly susceptible mice. Circulation 2005, 111:1583-1592.
132. Merl S., Wessely R. Anti-coxsackieviral efficacy of RNA interference is highly dependent on genomic target selection and emergence of escape mutants. Oligonucleotides 2007, 17:44-53.
133. Miller J.P., Geng Y., Ng H.L., Yang O.O., Krogstad P. Packaging limits and stability of HIV-1 sequences in a coxsackievirus B vector. Vaccine 2009, 27:3992-4000.
134. Misbah S.A., Spickett G.P., Ryba P.C., Hockaday J.M., Kroll J.S., Sherwood C., Kurtz J.B., Moxon E.R., Chapel H.M. Chronic enteroviral meningoencephalitis in agammaglobulinemia: case report and literature review. J. Clin. Immunol. 1992, 12:266-270.
135. Miyanishi M., Tada K., Koike M., Uchiyama Y., Kitamura T., Nagata S. Identification of Tim4 as a phosphatidylserine receptor. Nature 2007, 450:435-439.
136. Moore B.B., Murray L., Das A., Wilke C.A., Herrygers A.B., Toews G.B. The role of CCL12 in the recruitment of fibrocytes and lung fibrosis. Am. J. Respir. Cell Mol. Biol. 2006, 35:175-181.
137. Muir P., van Loon A.M. Enterovirus infections of the central nervous system. Intervirology 1997, 40:153-166.
138. Mukherjee A., Morosky S.A., Delorme-Axford E., Dybdahl-Sissoko N., Oberste M.S., Wang T., Coyne C.B. The coxsackievirus B 3C protease cleaves MAVS and TRIF to attenuate host type I interferon and apoptotic signaling. PLoS Pathog. 2011, 7:e1001311.
139. Nejmeddine M., Bangham C.R. The HTLV-1 Virological Synapse. Viruses 2010, 2:1427-1447.
140. Noda S., Aguirre S.A., Bitmansour A., Brown J.M., Sparer T.E., Huang J., Mocarski E.S. Cytomegalovirus MCK-2 controls mobilization and recruitment of myeloid progenitor cells to facilitate dissemination. Blood 2006, 107:30-38.
141. Novak J.E., Kirkegaard K. Improved method for detecting poliovirus negative strands used to demonstrate specificity of positive-strand encapsidation and the ratio of positive to negative strands in infected cells. J. Virol. 1991, 65(6):3384-3387.
142. Oberste M.S., Maher K., Pallansch M.A. Molecular phylogeny and proposed classification of the simian picornaviruses. J. Virol. 2002, 76:1244-1251.
143. Ohka S., Igarashi H., Nagata N., Sakai M., Koike S., Nochi T., Kiyono H., Nomoto A. Establishment of a poliovirus oral infection system in human poliovirus receptor-expressing transgenic mice that are deficient in alpha/beta interferon receptor. J. Virol. 2007, 81(15):7902-7912.
144. Oldstone M.B. Molecular mimicry and immune-mediated diseases. FASEB J. 1998, 12:1255-1265.
145. Onomoto K., Yoneyama M., Fung G., Kato H., Fujita T. Antiviral innate immunity and stress granule responses. Trends Immunol. 2014, 35:420-428.
146. Ooi M.H., Wong S.C., Lewthwaite P., Cardosa M.J., Solomon T. Clinical features, diagnosis, and management of enterovirus 71. Lancet Neurol. 2010, 9:1097-1105.
147. Ornoy A., Tenenbaum A. Pregnancy outcome following infections by coxsackie, echo, measles, mumps, hepatitis, polio and encephalitis viruses. Reprod. Toxicol. 2006, 21:446-457.
148. Pan J., Zhang L., Odenwald M.A., Shen L., Turner J.R., Bergelson J.M. Expression of human decay-accelerating factor on intestinal epithelium of transgenic mice does not facilitate infection by the enteral route. J. Virol 2015, 8:4311-4318. (JVI-14).
149. Park J.H., Kim D.S., Cho Y.J., Kim Y.J., Jeong S.Y., Lee S.M., Cho S.J., Yun C.W., Jo I., Nam J.H. Attenuation of coxsackievirus B3 by VP2 mutation and its application as a vaccine against virus-induced myocarditis and pancreatitis. Vaccine 2009, 27:1974-1983.
150. Patel K.P., Coyne C.B., Bergelson J.M. Dynamin- and lipid raft-dependent entry of decay-accelerating factor (DAF)-binding and non-DAF-binding coxsackieviruses into nonpolarized cells. J. Virol. 2009, 83(21):11064-11077.
151. Payment P Antibody levels to selected enteric viruses in a normal randomly selected Canadian population. Immunol. Infect. Dis. 1991, 1:317-322.
152. Pelletier J., Sonenberg N. Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA. Nature 1988, 334(6180):320-325.
153. Petitjean J., Kopecka H., Freymuth F., Langlard J.M., Scanu P., Galateau F., Bouhour J.B., Ferriere M., Charbonneau P., Komajda M. Detection of enteroviruses in endomyocardial biopsy by molecular approach. J. Med. Virol. 1992, 37:76-82.
154. Pevear D.C., Tull T.M., Seipel M.E., Groarke J.M. Activity of pleconaril against enteroviruses. Antimicrob. Agents Chemother. 1999, 43:2109-2115.
155. Pinkert S., Klingel K., Lindig V., Dorner A., Zeichhardt H., Spiller O.B., Fechner H. Virus-host coevolution in a persistently coxsackievirus B3-infected cardiomyocyte cell line. J. Virol. 2011, 85:13409-13419.
156. Puccini J.M., Ruller C.M., Robinson S.M., Knopp K.A., Buchmeier M.J., Doran K.S., Feuer R. Distinct neural stem cell tropism, early immune activation, and choroid plexus pathology following coxsackievirus infection in the neonatal central nervous system. Lab Investig. 2014, 94:161-181.
157. Ransohoff R.M., Kivisakk P., Kidd G. Three or more routes for leukocyte migration into the central nervous system. Nat. Rev. Immunol. 2003, 3:569-581.
158. Rantakallio P., Jones P., Moring J., Von W.L. Association between central nervous system infections during childhood and adult onset schizophrenia and other psychoses: a 28-year follow-up. Int. J. Epidemiol. 1997, 26:837-843.
159. Reineke L.C., Lloyd R.E. The stress granule protein G3BP1 Recruits protein kinase R to promote multiple innate immune antiviral responses. J. Virol. 2015, 89:2575-2589.
160. Rhoades R.E., Tabor-Godwin J.M., Tsueng G., Feuer R. Enterovirus infections of the central nervous system. Virology 2011, 411:288-305.
161. Richards A.L., Jackson W.T. Intracellular vesicle acidification promotes maturation of infectious poliovirus particles. PLoS Pathog. 2012, 8:e1003046.
162. Richards A.L., Jackson W.T. How positive-strand RNA viruses benefit from autophagosome maturation. J. Virol. 2013, 87:9966-9972.
163. Robinson S.M., Tsueng G., Sin J., Mangale V., Rahawi S., McIntyre L.L., Williams W., Kha N., Cruz C., Hancock B.M., Nguyen D.P., Sayen M.R., Hilton B.J., Doran K.S., Segall A.M., Wolkowicz R., Cornell C.T., Whitton J.L., Gottlieb R.A., Feuer R. Coxsackievirus B exits the host cell in shed microvesicles displaying autophagosomal markers. PLoS Pathog. 2014, 10:e1004045.
164. Rolls A., Shechter R., London A., Ziv Y., Ronen A., Levy R., Schwartz M. Toll-like receptors modulate adult hippocampal neurogenesis. Nat. Cell Biol. 2007, 9:1081-1088.
165. Romero J.R. Pediatric group B coxsackievirus infections. Curr. Top. Microbiol. Immunol. 2008, 323:223-239.
166. Ruller C.M., Tabor-Godwin J.M., Van Deren D.A.J., Robinson S.M., Maciejewski S., Gluhm S., Gilbert P.E., Gude N., Sussman N.A., Whitton M.A., Feuer, R.J.L. Neural stem cell depletion and CNS developmental defects after enteroviral infection. Am. J. Pathol. 2012, 180:1107-1120.
167. Sampey G.C., Meyering S.S., Asad Z.M., Saifuddin M., Hakami R.M., Kashanchi F. Exosomes and their role in CNS viral infections. J. Neurovirol. 2014, 20:199-208.
168. Sane F., Moumna I., Hober D. Group B coxsackieviruses and autoimmunity: focus on Type 1 diabetes. Expert Rev. Clin. Immunol. 2011, 7:357-366.
169. Sarafi M.N., Garcia-Zepeda E.A., MacLean J.A., Charo I.F., Luster Murine monocyte chemoattractant protein (MCP)-5: a novel CC chemokine that is a structural and functional homologue of human MCP-1. J. Exp. Med. 1997, 185:99-109.
170. Satoh M., Tamura G., Segawa I. Enteroviral RNA in endomyocardial biopsy tissues of myocarditis and dilated cardiomyopathy. Pathol. Int. 1994, 44:345-351.
171. Sawyer M.H. Enterovirus infections: diagnosis and treatment. Semin. Pediatr. Infect. Dis. 2002, 13:40-47.
172. Schilthuizen C., Berenschot H.W., Levin M.D. Enteroviral encephalitis in a patient with a marginal zone lymphomatreated with rituximab. Neth. J. Med. 2010, 68:221-223.
173. Schmidtke M., Hammerschmidt E., Schuler S., Zell R., Birch-Hirschfeld E., Makarov V.A., Riabova O.B., Wutzler P. Susceptibility of coxsackievirus B3 laboratory strains and clinical isolates to the capsid function inhibitor pleconaril: antiviral studies with virus chimeras demonstrate the crucial role of amino acid 1092 in treatment. J. Antimicrob. Chemother. 2005, 56:648-656.
174. Servais S., Caers J., Warling O., Frusch N., Baron F., De P.B., Beguin Y. Enteroviral meningoencephalitis as complication of Rituximab therapy in a patient treated for diffuse large B-cell lymphoma. Br. J. Haematol. 2010, 150:379-381.
175. Sharma A., Marceau C., Hamaguchi R., Burridge P.W., Rajarajan K., Churko J.M., Wu H., Sallam K.I., Matsa E., Sturzu A.C., Che Y., Ebert A., Diecke S., Liang P., Red-Horse K., Carette J.E., Wu S.M., Wu J.C. Human induced pluripotent stem cell-derived cardiomyocytes as an in vitro model for coxsackievirus B3-induced myocarditis and antiviral drug screening platform. Circ. Res. 2014, 115:556-566.
176. Shi J., Wong J., Piesik P., Fung G., Zhang J., Jagdeo J., Li X., Jan E., Luo H. Cleavage of sequestosome 1/p62 by an enteroviral protease results in disrupted selective autophagy and impaired NFKB signaling. Autophagy 2013, 9:1591-1603.
177. Shi Y., Chen C., Lisewski U., Wrackmeyer U., Radke M., Westermann D., Sauter M., Tschope C., Poller W., Klingel K., Gotthardt M. Cardiac deletion of the Coxsackievirus-adenovirus receptor abolishes Coxsackievirus B3 infection and prevents myocarditis in vivo. J. Am. Coll. Cardiol. 2009, 53:1219-1226.
178. Shih S.R., Stollar V., Li M.L. Host factors in enterovirus 71 replication. J. Virol. 2011, 85:9658-9666.
179. Shingo T., Gregg C., Enwere E., Fujikawa H., Hassam R., Geary C., Cross J.C., Weiss S. Pregnancy-stimulated neurogenesis in the adult female forebrain mediated by prolactin. Science 2003, 299:117-120.
180. Simonsen A., Cumming R.C., Brech A., Isakson P., Schubert D.R., Finley K.D. Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila. Autophagy 2008, 4(2):176-184.
181. Sin J., Puccini J.M., Huang C., Konstandin M.H., Gilbert P.E., Sussman M.A., Gottlieb R.A., Feuer R. The impact of juvenile coxsackievirus infection on cardiac progenitor cells and postnatal heart development. PLoS Pathog. 2014, 10:e1004249.
182. Slifka M.K., Pagarigan R., Mena I., Feuer R., Whitton J.L. Using recombinant coxsackievirus B3 to evaluate the induction and protective efficacy of CD8+ T cells during picornavirus infection. J. Virol. 2001, 75:2377-2387.
183. Steil B.P., Barton D.J. Cis-active RNA elements (CREs) and picornavirus RNA replication. Virus Res. 2009, 139(2):240-252.
184. Strating J.R., van der Linden L., Albulescu L., Bigay J., Arita M., Delang L., Leyssen P., van der Schaar H.M., Lanke K.H., Thibaut H.J., Ulferts R., Drin G., Schlinck N., Wubbolts R.W., Sever N., Head S.A., Liu J.O., Beachy P.A., De Matteis M.A., Shair M.D., Olkkonen V.M., Neyts J., van Kuppeveld F.J. Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding protein. Cell Rep. 2015, 10.
185. Suhy D.A., Giddings T.H., Kirkegaard K. Remodeling the endoplasmic reticulum by poliovirus infection and by individual viral proteins: an autophagy-like origin for virus-induced vesicles. J. Virol. 2000, 74(19):8953-8965.
186. Tabor-Godwin J.M., Ruller C.M., Bagalso N., Pagarigan N., Harkins R.R., Gilbert S., Kiosses P.E., Gude W.B., Cornell N.A., Doran C.T., Sussman K.S., Whitton M.A., Feuer, R.J.L. A novel population of myeloid cells responding to coxsackievirus infection assists in the dissemination of virus within the neonatal CNS. J. Neurosci. 2010, 30:8676-8691.
187. Tabor-Godwin J.M., Tsueng G., Sayen M.R., Gottlieb R.A., Feuer R. The role of autophagy during coxsackievirus infection of neural progenitor and stem cells. Autophagy 2012, 8:938-953.
188. Tam P.E., Fontana D.R., Messner R.P. Coxsackievirus B1-induced chronic inflammatory myopathy: differences in induction of autoantibodies to muscle and nuclear antigens by cloned myopathic and amyopathic viruses. J. Lab Clin. Med. 2003, 142:196-204.
189. Tam P.E., Messner R.P. Molecular mechanisms of coxsackievirus persistence in chronic inflammatory myopathy: viral RNA persists through formation of a double-stranded complex without associated genomic mutations or evolution. J. Virol. 1999, 73:10113-10121.
190. Tan E.L., Wong A.P., Poh C.L. Development of potential antiviral strategy against coxsackievirus B4. Virus Res. 2010, 150:85-92.
191. Tao Z., Li B., Xu A., Liu Y., Song L., Wang S., Xiong P., Lin X., Song Y. Seroprevalence of coxsackievirus B3 in Yantai, China. Jpn. J. Infect. Dis. 2013, 66:537-538.
192. Taylor M.P., Burgon T.B., Kirkegaard K., Jackson W.T. Role of microtubules in extracellular release of poliovirus. J. Virol. 2009, 83:6599-6609.
193. Taylor M.P., Kirkegaard K. Potential subversion of autophagosomal pathway by picornaviruses. Autophagy 2008, 4:286-289.
194. Tebruegge M., Curtis N. Enterovirus infections in neonates. Semin. Fetal Neonatal Med. 2009, 14:222-227.
195. Terskikh A., Fradkov A., Ermakova G., Zaraisky A., Tan P., Kajava A.V., Zhao X., Lukyanov S., Matz M., Kim S., Weissman I., Siebert P. "Fluorescent timer": protein that changes color with time. Science 2000, 290:1585-1588.
196. Thibaut H.J., van der Linden L., Jiang P., Thys B., Canela M.D., Aguado L., Rombaut B., Wimmer E., Paul A., Perez-Perez M.J., van Kuppeveld F.J., Neyts J. Binding of glutathione to enterovirus capsids is essential for virion morphogenesis. PLoS Pathog. 2014, 10:e1004039.
197. Tracy S., Drescher K.M., Chapman N.M. Enteroviruses and type 1 diabetes. Diabetes Metab. Res. Rev. 2011, 27:820-823.
198. Tracy S., Smithee S., Alhazmi A., Chapman N. Coxsackievirus can persist in murine pancreas by deletion of 5' terminal genomic sequences. J. Med. Virol. 2015, 87:240-247.
199. Tsueng, G., Rhoades, R. E., Nguyen D.P., Deline, S., Zamudio Montes de Oca, A. V., Gurney, M., Gottlieb, R. A., Feuer R, 2015. Lasting alterations in autophagic flux and increased coxsackievirus virulence during the establishment of a carrier-state infection in neural progenitor cells. Manuscript in preparation.
200. Tsueng G., Tabor-Godwin J.M., Gopal A., Ruller C.M., Deline S., Frausto N., Milner R.F., Crocker R., Whitton S.J., Feuer, R.J.L. Coxsackievirus preferentially replicates and induces cytopathic effects in undifferentiated neural progenitor cells. J. Virol. 2011, 85:5718-5732.
201. van der Schaar H.M., Leyssen P., Thibaut H.J., de P.A., van der Linden L., Lanke K.H., Lacroix C., Verbeken E., Conrath K., Macleod A.M., Mitchell D.R., Palmer N.J., van de Poel H., Andrews M., Neyts J., van Kuppeveld F.J. A novel, broad-spectrum inhibitor of enterovirus replication that targets host cell factor phosphatidylinositol 4-kinase IIIbeta. Antimicrob. Agents Chemother. 2013, 57:4971-4981.
202. van der Schaar H.M., van der Linden L., Lanke K.H., Strating J.R., Purstinger G., de V.E., de Haan C.A., Neyts J., van Kuppeveld F.J. Coxsackievirus mutants that can bypass host factor PI4KIIIbeta and the need for high levels of PI4P lipids for replication. Cell Res. 2012, 22:1576-1592.
203. Venkatraman G., Behrens M., Pyrski M., Margolis F.L. Expression of Coxsackie-Adenovirus receptor (CAR) in the developing mouse olfactory system. J. Neurocytol. 2005, 34:295-305.
204. Vessoni A.T., Muotri A.R., Okamoto O.K. Autophagy in stem cell maintenance and differentiation. Stem Cells Dev. 2012, 21:513-520.
205. Victoria J.G., Kapoor A., Li L., Blinkova O., Slikas B., Wang C., Naeem A., Zaidi S., Delwart E. Metagenomic analyses of viruses in stool samples from children with acute flaccid paralysis. J. Virol. 2009, 83:4642-4651.
206. Vignuzzi M., Stone J.K., Arnold J.J., Cameron C.E., Andino R. Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population. Nature 2006, 439:344-348.
207. Vogt D.A., Andino R. An RNA element at the 5'-end of the poliovirus genome functions as a general promoter for RNA synthesis. PLoS Pathog. 2010, 6(6):e1000936.
208. Weller A.H., Simpson K., Herzum M., Van H.N., Huber S.A. Coxsackievirus-B3-induced myocarditis: virus receptor antibodies modulate myocarditis. J. Immunol. 1989, 143:1843-1850.
209. Werk D., Schubert S., Lindig V., Grunert H.P., Zeichhardt H., Erdmann V.A., Kurreck J. Developing an effective RNA interference strategy against a plus-strand RNA virus: silencing of coxsackievirus B3 and its cognate coxsackievirus-adenovirus receptor. Biol. Chem. 2005, 386:857-863.
210. Wessels E., Duijsings D., Lanke K.H., Melchers W.J., Jackson C.L., van Kuppeveld F.J. Molecular determinants of the interaction between coxsackievirus protein 3A and guanine nucleotide exchange factor GBF1. J. Virol. 2007, 81:5238-5245.
211. Wessely R., Klingel K., Knowlton K.U., Kandolf R. Cardioselective infection with coxsackievirus B3 requires intact type I interferon signaling: implications for mortality and early viral replication. Circulation 2001, 103:756-761.
212. Wessely R., Klingel K., Santana L.F., Dalton N., Hongo M., Jonathan L.W., Kandolf R., Knowlton K.U. Transgenic expression of replication-restricted enteroviral genomes in heart muscle induces defective excitation-contraction coupling and dilated cardiomyopathy. J. Clin. Investig. 1998, 102:1444-1453.
213. Whitton J.L., Cornell C.T., Feuer R. Host and virus determinants of picornavirus pathogenesis and tropism. Nat. Rev. Microbiol. 2005, 3:765-776.
214. Whitton J.L., Feuer R. Myocarditis, microbes and autoimmunity. Autoimmunity 2004, 37:375-386.
215. Wileman T. Aggresomes and autophagy generate sites for virus replication. Science 2006, 312:875-878.
216. Willcox A., Richardson S.J., Bone A.J., Foulis A.K., Morgan N.G. Immunohistochemical analysis of the relationship between islet cell proliferation and the production of the enteroviral capsid protein, VP1, in the islets of patients with recent-onset type 1 diabetes. Diabetologia 2011, 54:2417-2420.
217. Wong J., Zhang J., Si X., Gao G., Mao I., McManus B.M., Luo H. Autophagosome supports coxsackievirus B3 replication in host cells. J. Virol. 2008, 82(18):9143-9153.
218. Wong J., Zhang J., Si X., Gao G., Mao I., McManus B.M., Luo H. Autophagosome supports coxsackievirus B3 replication in host cells. J. Virol. 2008, 82(18):9143-9153.
219. Woodall C.J., Graham D.I. Evidence for neuronal localisation of enteroviral sequences in motor neurone disease/amyotrophic lateral sclerosis by in situ hybridization. Eur. J. Histochem. 2004, 48:129-134.
220. Woodall C.J., Riding M.H., Graham D.I., Clements G.B. Sequences specific for enterovirus detected in spinal cord from patients with motor neurone disease. BMJ 1994, 308:1541-1543.
221. Yoon S.Y., Ha Y.E., Choi J.E., Ahn J., Lee H., Kim D.H. Autophagy in coxsackievirus-infected neurons. Autophagy 2009, 5(3):388-389.
222. Yoon S.Y., Ha Y.E., Choi J.E., Ahn J., Lee H., Kweon H.S., Lee J.Y., Kim D.H. Coxsackievirus B4 uses autophagy for replication after calpain activation in rat primary neurons. J. Virol. 2008, 82(23):11976-11978.
223. Yuan J., Cheung P.K., Zhang H.M., Chau D., Yang D. Inhibition of coxsackievirus B3 replication by small interfering RNAs requires perfect sequence match in the central region of the viral positive strand. J. Virol. 2005, 79:2151-2159.
224. Zeng J., Chen X., Dai J., Zhao X., Xin G., Su Y., Wang G., Li R., Yan Y., Su J., Deng Y., Li K. An attenuated coxsackievirus b3 vector: a potential tool for viral tracking study and gene delivery. PLoS One 2013, 8:e83753.
225. Zuo J., Quinn K.K., Kye S., Cooper P., Damoiseaux R., Krogstad P. Fluoxetine is a potent inhibitor of coxsackievirus replication. Antimicrob. Agents Chemother. 2012, 56:4838-4844.