Anti-hepatitis C virus activity and toxicity of type III phosphatidylinositol-4-kinase beta inhibitors

Antimicrobial Agents and Chemotherapy

Volumn 56, Issue 10, 2012, Pages 5149-5156

  LaMarche, M J ^a   Borawski, J ^a   Bose, A ^a   Capacci Daniel, C ^a   Colvin, R ^a   Dennehy, M ^a   Ding, J ^a   Dobler, M ^b   Drumm, J ^c   Gaither, L A ^a   Gao, J ^a   Jiang, X ^a   Lin, K ^a   McKeever, U ^b   Puyang, X ^a   Raman, P ^d   Thohan, S ^a   Tommasi, R ^d   Wagner, K ^b   Xiong, X ^a   Zabawa, T ^a   Zhu, S ^a   Wiedmann, B ^c   more..

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

^c Novartis Diagnostics and Vaccines Inc   (United States)

^d ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; INSULIN; ION CHANNEL; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; TYPE III PHOSPHATIDYLINOSITOL 4 KINASE BETA INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ANTIVIRAL ACTIVITY; ARTICLE; B LYMPHOCYTE ACTIVATION; BLOOD SAMPLING; BONE MARROW CELL; CELL VIABILITY; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; FEMALE; GASTROCNEMIUS MUSCLE; GENOTYPE; HEPATITIS C; HEPATITIS C VIRUS; IN VITRO STUDY; INSULIN RELEASE; LYMPHOCYTE PROLIFERATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION; RADIOACTIVITY; RAT; REGULATORY MECHANISM; REPLICON; SIGNAL TRANSDUCTION; TARGET CELL DESTRUCTION; VIRUS REPLICATION;

1-PHOSPHATIDYLINOSITOL 4-KINASE; ANIMALS; ANTIVIRAL AGENTS; BONE MARROW CELLS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; HEPACIVIRUS; HUMANS; MALE; MICE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84866335624     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00946-12     Document Type: Article

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