Immunohistochemical analysis of the relationship between islet cell proliferation and the production of the enteroviral capsid protein, VP1, in the islets of patients with recent-onset type 1 diabetes

Diabetologia

Volumn 54, Issue 9, 2011, Pages 2417-2420

  Willcox, A ^a   Richardson, S J ^b   Bone, A J ^c   Foulis, A K ^d   Morgan, N G ^a  

^a UNIVERSITY OF EXETER   (United Kingdom)

^b UNIVERSITY OF PLYMOUTH   (United Kingdom)

^c UNIVERSITY OF BRIGHTON   (United Kingdom)

^d GLASGOW ROYAL INFIRMARY   (United Kingdom)

Author keywords

Beta cell; Enterovirus; Ki67; Proliferation; Type 1 diabetes; VP1

Indexed keywords

INSULIN; KI 67 ANTIGEN; PROTEIN VP1;

ADOLESCENT; ADULT; ANTIGEN EXPRESSION; ARTICLE; CELL PROLIFERATION; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETIC PATIENT; ENTEROVIRUS; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; IMMUNOPEROXIDASE STAINING; INSULIN DEPENDENT DIABETES MELLITUS; MALE; PANCREAS ISLET CELL; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; SCHOOL CHILD; VIRUS REPLICATION;

ADOLESCENT; ADULT; CAPSID PROTEINS; CELL PROLIFERATION; CHILD; DIABETES MELLITUS, TYPE 1; ENTEROVIRUS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INFANT; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; KI-67 ANTIGEN; MALE; RETROSPECTIVE STUDIES; VIRUS REPLICATION; YOUNG ADULT;

EID: 80054684267     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-011-2192-7     Document Type: Article

References (14)

1. Hober D, Sauter P (2010) Pathogenesis of type 1 diabetes mellitus: interplay between enterovirus and host. Nat Rev Endocrinol 6:279-289
2. Tauriainen S, Oikarinen S, Oikarinen M, Hyöty H (2011) Enteroviruses in the pathogenesis of type 1 diabetes. Semin Immunopathol 33:45-55
3. Richardson SJ, Willcox A, Bone AJ, Morgan NG, Foulis AK (2011) Immunopathology of the human pancreas in type-I diabetes. Semin Immunopathol 33:9-21
4. Richardson SJ, Willcox A, Bone AJ, Foulis AK, Morgan NG (2009) The prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes. Diabetologia 52:1143-1151
5. Feuer R, Mena I, Pagarigan R, Slifka MK, Whitton JL (2002) Cell cycle status affects coxsackievirus replication, persistence, and reactivation in vitro. J Virol 76:4430-4440 (Pubitemid 34309580)
6. Meier JJ, Butler AE, Saisho Y et al (2008) Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans. Diabetes 57:1584-1594
7. Cnop M, Hughes SJ, Igoillo-Esteve M et al (2009) The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation. Diabetologia 53:321-330
8. Willcox A, Richardson SJ, Bone AJ, Foulis AK, Morgan NG (2010) Evidence of increased islet cell proliferation in patients with recent-onset type 1 diabetes. Diabetologia 53:2020-2028
9. Moya-Suri V, Schlosser M, Zimmermann K, Rjasanowski I, Gurtler L, Mentel R (2005) Enterovirus RNA sequences in sera of schoolchildren in the general population and their association with type 1-diabetes-associated autoantibodies. J Med Microbiol 54:879-883 (Pubitemid 41216286)
10. Stene LC, Oikarinen S, Hyoty H et al (2010) Enterovirus infection and progression from islet autoimmunity to type 1 diabetes: the Diabetes and Autoimmunity Study in the Young (DAISY). Diabetes 59:3174-3180
11. Feuer R, Ruller CM, An N et al (2009) Viral persistence and chronic immunopathology in the adult central nervous system following Coxsackievirus infection during the neonatal period. J Virol 83:9356-9369
12. Feuer R, Whitton JL (2008) Preferential coxsackievirus replication in proliferating/activated cells: implications for virus tropism, persistence, and pathogenesis. Curr Top Microbiol Immunol 323:149-173
13. Meier JJ, Lin JC, Butler AE, Galasso R, Martinez DS, Butler PC (2006) Direct evidence of attempted beta cell regeneration in an 89-year-old patient with recent-onset type 1 diabetes. Diabetologia 49:1838-1844 (Pubitemid 44025038)
14. Maedler K, Schumann DM, Sauter N et al (2006) Low concentration of interleukin-1beta induces FLICE-inhibitory protein-mediated beta-cell proliferation in human pancreatic islets. Diabetes 55:2713-2722 (Pubitemid 44923669)