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Volumn 90, Issue , 2015, Pages 56-66

Anti-inflammatory effects of noradrenaline on LPS-treated microglial cells: Suppression of NFκB nuclear translocation and subsequent STAT1 phosphorylation

Author keywords

Adrenergic receptor; cAMP; IRF; JAK; Phenylephrine; TLR4

Indexed keywords

ADRENERGIC RECEPTOR STIMULATING AGENT; BUTOXAMINE; CYCLIC AMP; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 1; INTERLEUKIN 6; JANUS KINASE; KT 5720; LIPOPOLYSACCHARIDE; MESSENGER RNA; NITRIC OXIDE; NORADRENALIN; SMALL INTERFERING RNA; STAT1 PROTEIN; TERAZOCINE; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG; YOHIMBINE; ANTIINFLAMMATORY AGENT; STAT1 PROTEIN, RAT;

EID: 84947036917     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2015.07.010     Document Type: Article
Times cited : (42)

References (44)
  • 1
    • 0024307175 scopus 로고
    • Partial injury to central noradrenergic neurons: Reduction of tissue norepinephrine content is greater than reduction of extracellular norepinephrine measured by microdialysis
    • E.D. Abercrombie, and M.J. Zigmond Partial injury to central noradrenergic neurons: reduction of tissue norepinephrine content is greater than reduction of extracellular norepinephrine measured by microdialysis J. Neurosci. 9 1989 4062 4067
    • (1989) J. Neurosci. , vol.9 , pp. 4062-4067
    • Abercrombie, E.D.1    Zigmond, M.J.2
  • 2
    • 0016821937 scopus 로고
    • Identification of cardiac beta-adrenergic receptors by (minus) [3H]alprenolol binding
    • R.W. Alexander, L.T. Williams, and R.J. Lefkowitz Identification of cardiac beta-adrenergic receptors by (minus) [3H]alprenolol binding Proc. Natl. Acad. Sci. U. S. A. 72 1975 1564 1568
    • (1975) Proc. Natl. Acad. Sci. U. S. A. , vol.72 , pp. 1564-1568
    • Alexander, R.W.1    Williams, L.T.2    Lefkowitz, R.J.3
  • 3
    • 0033847081 scopus 로고    scopus 로고
    • Catecholamines inhibit microglial nitric oxide production
    • J.Y. Chang, and L.Z. Liu Catecholamines inhibit microglial nitric oxide production Brain Res. Bull. 52 2000 525 530
    • (2000) Brain Res. Bull. , vol.52 , pp. 525-530
    • Chang, J.Y.1    Liu, L.Z.2
  • 4
    • 84864280408 scopus 로고    scopus 로고
    • A cytokine mixture of GM-CSF and IL-3 that induces a neuroprotective phenotype of microglia leading to amelioration of (6-OHDA)-induced Parkinsonism of rats
    • M.E. Choudhury, K. Sugimoto, M. Kubo, M. Nagai, M. Nomoto, H. Takahashi, H. Yano, and J. Tanaka A cytokine mixture of GM-CSF and IL-3 that induces a neuroprotective phenotype of microglia leading to amelioration of (6-OHDA)-induced Parkinsonism of rats Brain Behav. 1 2011 26 43
    • (2011) Brain Behav. , vol.1 , pp. 26-43
    • Choudhury, M.E.1    Sugimoto, K.2    Kubo, M.3    Nagai, M.4    Nomoto, M.5    Takahashi, H.6    Yano, H.7    Tanaka, J.8
  • 5
    • 4344605751 scopus 로고    scopus 로고
    • Inhibition of microglial inflammatory responses by norepinephrine: Effects on nitric oxide and interleukin-1beta production
    • C. Dello Russo, A.I. Boullerne, V. Gavrilyuk, and D.L. Feinstein Inhibition of microglial inflammatory responses by norepinephrine: effects on nitric oxide and interleukin-1beta production J. Neuroinflammation 1 2004 9
    • (2004) J. Neuroinflammation , vol.1 , pp. 9
    • Dello Russo, C.1    Boullerne, A.I.2    Gavrilyuk, V.3    Feinstein, D.L.4
  • 6
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • S.M. Elbashir, J. Harborth, W. Lendeckel, A. Yalcin, K. Weber, and T. Tuschl Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells Nature 411 2001 494 498
    • (2001) Nature , vol.411 , pp. 494-498
    • Elbashir, S.M.1    Harborth, J.2    Lendeckel, W.3    Yalcin, A.4    Weber, K.5    Tuschl, T.6
  • 7
    • 0033712736 scopus 로고    scopus 로고
    • Beta-adrenergic agonists exert their "anti-inflammatory" effects in monocytic cells through the IkappaB/NF-kappaB pathway
    • P. Farmer, and J. Pugin Beta-adrenergic agonists exert their "anti-inflammatory" effects in monocytic cells through the IkappaB/NF-kappaB pathway Am. J. Physiol. Lung Cell Mol. Physiol. 279 2000 L675 L682
    • (2000) Am. J. Physiol. Lung Cell Mol. Physiol. , vol.279 , pp. L675-L682
    • Farmer, P.1    Pugin, J.2
  • 8
    • 0032488930 scopus 로고    scopus 로고
    • Adrenergic agonists suppress the proliferation of microglia through beta 2-adrenergic receptor
    • H. Fujita, J. Tanaka, N. Maeda, and M. Sakanaka Adrenergic agonists suppress the proliferation of microglia through beta 2-adrenergic receptor Neurosci. Lett. 242 1998 37 40
    • (1998) Neurosci. Lett. , vol.242 , pp. 37-40
    • Fujita, H.1    Tanaka, J.2    Maeda, N.3    Sakanaka, M.4
  • 9
    • 0030459070 scopus 로고    scopus 로고
    • Effects of GM-CSF and ordinary supplements on the ramification of microglia in culture: A morphometrical study
    • H. Fujita, J. Tanaka, K. Toku, N. Tateishi, Y. Suzuki, S. Matsuda, M. Sakanaka, and N. Maeda Effects of GM-CSF and ordinary supplements on the ramification of microglia in culture: a morphometrical study Glia 18 1996 269 281
    • (1996) Glia , vol.18 , pp. 269-281
    • Fujita, H.1    Tanaka, J.2    Toku, K.3    Tateishi, N.4    Suzuki, Y.5    Matsuda, S.6    Sakanaka, M.7    Maeda, N.8
  • 10
    • 84880089425 scopus 로고    scopus 로고
    • Microglial physiopathology: How to explain the dual role of microglia after acute neural disorders?
    • W. Gomes-Leal Microglial physiopathology: how to explain the dual role of microglia after acute neural disorders? Brain Behav. 2 2012 345 356
    • (2012) Brain Behav. , vol.2 , pp. 345-356
    • Gomes-Leal, W.1
  • 11
    • 0029009409 scopus 로고
    • Local influence of endogenous norepinephrine on extracellular dopamine in rat medial prefrontal cortex
    • P.J. Gresch, A.F. Sved, M.J. Zigmond, and J.M. Finlay Local influence of endogenous norepinephrine on extracellular dopamine in rat medial prefrontal cortex J. Neurochem. 65 1995 111 116
    • (1995) J. Neurochem. , vol.65 , pp. 111-116
    • Gresch, P.J.1    Sved, A.F.2    Zigmond, M.J.3    Finlay, J.M.4
  • 13
    • 0032168152 scopus 로고    scopus 로고
    • Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
    • P.C. Heinrich, I. Behrmann, G. Muller-Newen, F. Schaper, and L. Graeve Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway Biochem. J. 334 Pt 2 1998 297 314
    • (1998) Biochem. J. , vol.334 , pp. 297-314
    • Heinrich, P.C.1    Behrmann, I.2    Muller-Newen, G.3    Schaper, F.4    Graeve, L.5
  • 15
    • 7044235774 scopus 로고    scopus 로고
    • IFN-gamma/STAT1 acts as a proinflammatory signal in T cell-mediated hepatitis via induction of multiple chemokines and adhesion molecules: A critical role of IRF-1
    • B. Jaruga, F. Hong, W.H. Kim, and B. Gao IFN-gamma/STAT1 acts as a proinflammatory signal in T cell-mediated hepatitis via induction of multiple chemokines and adhesion molecules: a critical role of IRF-1 Am. J. Physiol. Gastrointest. Liver Physiol. 287 2004 G1044 G1052
    • (2004) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.287 , pp. G1044-G1052
    • Jaruga, B.1    Hong, F.2    Kim, W.H.3    Gao, B.4
  • 16
    • 84927961442 scopus 로고    scopus 로고
    • A novel role of microglial NADPH oxidase in mediating extra-synaptic function of norepinephrine in regulating brain immune homeostasis
    • L. Jiang, S.H. Chen, C.H. Chu, S.J. Wang, E. Oyarzabal, B. Wilson, V. Sanders, K. Xie, Q. Wang, and J.S. Hong A novel role of microglial NADPH oxidase in mediating extra-synaptic function of norepinephrine in regulating brain immune homeostasis Glia 63 2015 1057 1072
    • (2015) Glia , vol.63 , pp. 1057-1072
    • Jiang, L.1    Chen, S.H.2    Chu, C.H.3    Wang, S.J.4    Oyarzabal, E.5    Wilson, B.6    Sanders, V.7    Xie, K.8    Wang, Q.9    Hong, J.S.10
  • 17
    • 77956238695 scopus 로고    scopus 로고
    • Norepinephrine promotes microglia to uptake and degrade amyloid beta peptide through upregulation of mouse formyl peptide receptor 2 and induction of insulin-degrading enzyme
    • Y. Kong, L. Ruan, L. Qian, X. Liu, and Y. Le Norepinephrine promotes microglia to uptake and degrade amyloid beta peptide through upregulation of mouse formyl peptide receptor 2 and induction of insulin-degrading enzyme J. Neurosci. 30 2010 11848 11857
    • (2010) J. Neurosci. , vol.30 , pp. 11848-11857
    • Kong, Y.1    Ruan, L.2    Qian, L.3    Liu, X.4    Le, Y.5
  • 18
    • 0027405703 scopus 로고
    • Identification of a functional silencer element involved in neuron-specific expression of the synapsin i gene
    • L. Li, T. Suzuki, N. Mori, and P. Greengard Identification of a functional silencer element involved in neuron-specific expression of the synapsin I gene Proc. Natl. Acad. Sci. U. S. A. 90 1993 1460 1464
    • (1993) Proc. Natl. Acad. Sci. U. S. A. , vol.90 , pp. 1460-1464
    • Li, L.1    Suzuki, T.2    Mori, N.3    Greengard, P.4
  • 21
    • 25444432765 scopus 로고    scopus 로고
    • Norepinephrine protects cortical neurons against microglial-induced cell death
    • J.L. Madrigal, D.L. Feinstein, and C. Dello Russo Norepinephrine protects cortical neurons against microglial-induced cell death J. Neurosci. Res. 81 2005 390 396
    • (2005) J. Neurosci. Res. , vol.81 , pp. 390-396
    • Madrigal, J.L.1    Feinstein, D.L.2    Dello Russo, C.3
  • 22
    • 78650296101 scopus 로고    scopus 로고
    • Beta-Adrenoceptor activation depresses brain inflammation and is neuroprotective in lipopolysaccharide-induced sensitization to oxygen-glucose deprivation in organotypic hippocampal slices
    • T. Markus, S.R. Hansson, T. Cronberg, C. Cilio, T. Wieloch, and D. Ley Beta-Adrenoceptor activation depresses brain inflammation and is neuroprotective in lipopolysaccharide-induced sensitization to oxygen-glucose deprivation in organotypic hippocampal slices J. Neuroinflammation 7 2010 94
    • (2010) J. Neuroinflammation , vol.7 , pp. 94
    • Markus, T.1    Hansson, S.R.2    Cronberg, T.3    Cilio, C.4    Wieloch, T.5    Ley, D.6
  • 23
    • 77953285381 scopus 로고    scopus 로고
    • Noradrenaline acting at beta-adrenoceptors induces expression of IL-1beta and its negative regulators IL-1ra and IL-1RII, and drives an overall anti-inflammatory phenotype in rat cortex
    • E.N. McNamee, E.W. Griffin, K.M. Ryan, K.J. Ryan, S. Heffernan, A. Harkin, and T.J. Connor Noradrenaline acting at beta-adrenoceptors induces expression of IL-1beta and its negative regulators IL-1ra and IL-1RII, and drives an overall anti-inflammatory phenotype in rat cortex Neuropharmacology 59 2010 37 48
    • (2010) Neuropharmacology , vol.59 , pp. 37-48
    • McNamee, E.N.1    Griffin, E.W.2    Ryan, K.M.3    Ryan, K.J.4    Heffernan, S.5    Harkin, A.6    Connor, T.J.7
  • 24
    • 0021068580 scopus 로고
    • Binding properties of alpha-1 adrenergic receptors in rat cerebral cortex: Similarity to smooth muscle
    • K.P. Minneman Binding properties of alpha-1 adrenergic receptors in rat cerebral cortex: similarity to smooth muscle J. Pharmacol. Exp. Ther. 227 1983 605 612
    • (1983) J. Pharmacol. Exp. Ther. , vol.227 , pp. 605-612
    • Minneman, K.P.1
  • 25
    • 0036849157 scopus 로고    scopus 로고
    • Effects of norepinephrine on rat cultured microglial cells that express alpha1, alpha2, beta1 and beta2 adrenergic receptors
    • K. Mori, E. Ozaki, B. Zhang, L. Yang, A. Yokoyama, I. Takeda, N. Maeda, M. Sakanaka, and J. Tanaka Effects of norepinephrine on rat cultured microglial cells that express alpha1, alpha2, beta1 and beta2 adrenergic receptors Neuropharmacology 43 2002 1026 1034
    • (2002) Neuropharmacology , vol.43 , pp. 1026-1034
    • Mori, K.1    Ozaki, E.2    Zhang, B.3    Yang, L.4    Yokoyama, A.5    Takeda, I.6    Maeda, N.7    Sakanaka, M.8    Tanaka, J.9
  • 26
    • 67349143648 scopus 로고    scopus 로고
    • Noradrenaline reduces the ATP-stimulated phosphorylation of p38 MAP kinase via beta-adrenergic receptors-cAMP-protein kinase A-dependent mechanism in cultured rat spinal microglia
    • N. Morioka, H. Tanabe, A. Inoue, T. Dohi, and Y. Nakata Noradrenaline reduces the ATP-stimulated phosphorylation of p38 MAP kinase via beta-adrenergic receptors-cAMP-protein kinase A-dependent mechanism in cultured rat spinal microglia Neurochem. Int. 55 2009 226 234
    • (2009) Neurochem. Int. , vol.55 , pp. 226-234
    • Morioka, N.1    Tanabe, H.2    Inoue, A.3    Dohi, T.4    Nakata, Y.5
  • 27
    • 0035067108 scopus 로고    scopus 로고
    • Requirement for STAT1 in LPS-induced gene expression in macrophages
    • Y. Ohmori, and T.A. Hamilton Requirement for STAT1 in LPS-induced gene expression in macrophages J. Leukoc. Biol. 69 2001 598 604
    • (2001) J. Leukoc. Biol. , vol.69 , pp. 598-604
    • Ohmori, Y.1    Hamilton, T.A.2
  • 28
    • 0022544543 scopus 로고
    • Characteristics of the beta-adrenergic receptor in the rat ventral prostate using [125I]cyanopindolol
    • P. Poyet, B. Gagne, M. Lavoie, and F. Labrie Characteristics of the beta-adrenergic receptor in the rat ventral prostate using [125I]cyanopindolol Mol. Cell Endocrinol. 48 1986 59 67
    • (1986) Mol. Cell Endocrinol. , vol.48 , pp. 59-67
    • Poyet, P.1    Gagne, B.2    Lavoie, M.3    Labrie, F.4
  • 29
    • 70449633057 scopus 로고    scopus 로고
    • Beta2 Adrenergic receptor activation induces microglial NADPH oxidase activation and dopaminergic neurotoxicity through an ERK-dependent/protein kinase A-independent pathway
    • L. Qian, X. Hu, D. Zhang, A. Snyder, H.M. Wu, Y. Li, B. Wilson, R.B. Lu, J.S. Hong, and P.M. Flood Beta2 Adrenergic receptor activation induces microglial NADPH oxidase activation and dopaminergic neurotoxicity through an ERK-dependent/protein kinase A-independent pathway Glia 57 2009 1600 1609
    • (2009) Glia , vol.57 , pp. 1600-1609
    • Qian, L.1    Hu, X.2    Zhang, D.3    Snyder, A.4    Wu, H.M.5    Li, Y.6    Wilson, B.7    Lu, R.B.8    Hong, J.S.9    Flood, P.M.10
  • 30
    • 79955000817 scopus 로고    scopus 로고
    • Beta2-adrenergic receptor activation prevents rodent dopaminergic neurotoxicity by inhibiting microglia via a novel signaling pathway
    • L. Qian, H.M. Wu, S.H. Chen, D. Zhang, S.F. Ali, L. Peterson, B. Wilson, R.B. Lu, J.S. Hong, and P.M. Flood Beta2-adrenergic receptor activation prevents rodent dopaminergic neurotoxicity by inhibiting microglia via a novel signaling pathway J. Immunol. 186 2011 4443 4454
    • (2011) J. Immunol. , vol.186 , pp. 4443-4454
    • Qian, L.1    Wu, H.M.2    Chen, S.H.3    Zhang, D.4    Ali, S.F.5    Peterson, L.6    Wilson, B.7    Lu, R.B.8    Hong, J.S.9    Flood, P.M.10
  • 32
    • 0034607040 scopus 로고    scopus 로고
    • Linkage between alpha(1) adrenergic receptor and the Jak/STAT signaling pathway in vascular smooth muscle cells
    • T. Sasaguri, H. Teruya, A. Ishida, T. Abumiya, and J. Ogata Linkage between alpha(1) adrenergic receptor and the Jak/STAT signaling pathway in vascular smooth muscle cells Biochem. Biophys. Res. Commun. 268 2000 25 30
    • (2000) Biochem. Biophys. Res. Commun. , vol.268 , pp. 25-30
    • Sasaguri, T.1    Teruya, H.2    Ishida, A.3    Abumiya, T.4    Ogata, J.5
  • 33
    • 0030062098 scopus 로고    scopus 로고
    • Neuron-specific gene expression of synapsin I. Major role of a negative regulatory mechanism
    • S. Schoch, G. Cibelli, and G. Thiel Neuron-specific gene expression of synapsin I. Major role of a negative regulatory mechanism J. Biol. Chem. 271 1996 3317 3323
    • (1996) J. Biol. Chem. , vol.271 , pp. 3317-3323
    • Schoch, S.1    Cibelli, G.2    Thiel, G.3
  • 34
    • 84890152999 scopus 로고    scopus 로고
    • Activated microglia in a rat stroke model express NG2 proteoglycan in peri-infarct tissue through the involvement of TGF-beta1
    • K. Sugimoto, R. Nishioka, A. Ikeda, A. Mise, H. Takahashi, H. Yano, Y. Kumon, T. Ohnishi, and J. Tanaka Activated microglia in a rat stroke model express NG2 proteoglycan in peri-infarct tissue through the involvement of TGF-beta1 Glia 62 2014 185 198
    • (2014) Glia , vol.62 , pp. 185-198
    • Sugimoto, K.1    Nishioka, R.2    Ikeda, A.3    Mise, A.4    Takahashi, H.5    Yano, H.6    Kumon, Y.7    Ohnishi, T.8    Tanaka, J.9
  • 36
    • 0032189990 scopus 로고    scopus 로고
    • Induction of resting microglia in culture medium devoid of glycine and serine
    • J. Tanaka, K. Toku, S. Matsuda, S. Sudo, H. Fujita, M. Sakanaka, and N. Maeda Induction of resting microglia in culture medium devoid of glycine and serine Glia 24 1998 198 215
    • (1998) Glia , vol.24 , pp. 198-215
    • Tanaka, J.1    Toku, K.2    Matsuda, S.3    Sudo, S.4    Fujita, H.5    Sakanaka, M.6    Maeda, N.7
  • 37
    • 0033230119 scopus 로고    scopus 로고
    • Astrocytes prevent neuronal death induced by reactive oxygen and nitrogen species
    • J. Tanaka, K. Toku, B. Zhang, K. Ishihara, M. Sakanaka, and N. Maeda Astrocytes prevent neuronal death induced by reactive oxygen and nitrogen species Glia 28 1999 85 96
    • (1999) Glia , vol.28 , pp. 85-96
    • Tanaka, J.1    Toku, K.2    Zhang, B.3    Ishihara, K.4    Sakanaka, M.5    Maeda, N.6
  • 38
    • 0037107345 scopus 로고    scopus 로고
    • Existence of functional beta1- and beta2-adrenergic receptors on microglia
    • K.F. Tanaka, H. Kashima, H. Suzuki, K. Ono, and M. Sawada Existence of functional beta1- and beta2-adrenergic receptors on microglia J. Neurosci. Res. 70 2002 232 237
    • (2002) J. Neurosci. Res. , vol.70 , pp. 232-237
    • Tanaka, K.F.1    Kashima, H.2    Suzuki, H.3    Ono, K.4    Sawada, M.5
  • 40
    • 0442276437 scopus 로고    scopus 로고
    • Differential regulation of inducible nitric oxide synthase and cytokine gene expression by forskolin and dibutyryl-cAMP in lipopolysaccharide-stimulated murine BV2 microglial cells
    • M.S. Woo, S.H. Jung, J.W. Hyun, and H.S. Kim Differential regulation of inducible nitric oxide synthase and cytokine gene expression by forskolin and dibutyryl-cAMP in lipopolysaccharide-stimulated murine BV2 microglial cells Neurosci. Lett. 356 2004 187 190
    • (2004) Neurosci. Lett. , vol.356 , pp. 187-190
    • Woo, M.S.1    Jung, S.H.2    Hyun, J.W.3    Kim, H.S.4
  • 41
    • 0346655312 scopus 로고    scopus 로고
    • Microglia, a potential source of neurons, astrocytes, and oligodendrocytes
    • A. Yokoyama, L. Yang, S. Itoh, K. Mori, and J. Tanaka Microglia, a potential source of neurons, astrocytes, and oligodendrocytes Glia 45 2004 96 104
    • (2004) Glia , vol.45 , pp. 96-104
    • Yokoyama, A.1    Yang, L.2    Itoh, S.3    Mori, K.4    Tanaka, J.5
  • 42
    • 0037337815 scopus 로고    scopus 로고
    • Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson diseases
    • C. Zarow, S.A. Lyness, J.A. Mortimer, and H.C. Chui Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson diseases Arch. Neurol. 60 2003 337 341
    • (2003) Arch. Neurol. , vol.60 , pp. 337-341
    • Zarow, C.1    Lyness, S.A.2    Mortimer, J.A.3    Chui, H.C.4
  • 43
    • 0036172694 scopus 로고    scopus 로고
    • Suppressive effects of phosphodiesterase type IV inhibitors on rat cultured microglial cells: Comparison with other types of cAMP-elevating agents
    • B. Zhang, L. Yang, Y. Konishi, N. Maeda, M. Sakanaka, and J. Tanaka Suppressive effects of phosphodiesterase type IV inhibitors on rat cultured microglial cells: comparison with other types of cAMP-elevating agents Neuropharmacology 42 2002 262 269
    • (2002) Neuropharmacology , vol.42 , pp. 262-269
    • Zhang, B.1    Yang, L.2    Konishi, Y.3    Maeda, N.4    Sakanaka, M.5    Tanaka, J.6
  • 44
    • 0034014855 scopus 로고    scopus 로고
    • Activation of signal transducers and activators of transcription by alpha(1A)-adrenergic receptor stimulation in PC12 cells
    • H. Zhong, T.J. Murphy, and K.P. Minneman Activation of signal transducers and activators of transcription by alpha(1A)-adrenergic receptor stimulation in PC12 cells Mol. Pharmacol. 57 2000 961 967
    • (2000) Mol. Pharmacol. , vol.57 , pp. 961-967
    • Zhong, H.1    Murphy, T.J.2    Minneman, K.P.3


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