Activation of signal transducers and activators of transcription by α(1A)-adrenergic receptor stimulation in PC12 cells

Molecular Pharmacology

Volumn 57, Issue 5, 2000, Pages 961-967

  Zhong, Hongying ^a   Murphy, T J ^a   Minneman, Kenneth P ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; 4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ALPHA 1A ADRENERGIC RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; GAMMA INTERFERON; GFX 203290; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; NORADRENALIN; PRAZOSIN; PROTEIN KINASE C INHIBITOR; RECEPTOR BLOCKING AGENT; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; VIRUS VECTOR;

ADRENERGIC SYSTEM; ANIMAL CELL; ARTICLE; ENZYME ACTIVITY; ENZYME INHIBITION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR DENSITY; RETROVIRUS; SECOND MESSENGER; SIGNAL TRANSDUCTION;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GENES, REPORTER; GROWTH SUBSTANCES; INTERLEUKIN-6; LUCIFERASES; MITOGEN-ACTIVATED PROTEIN KINASES; NOREPINEPHRINE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PC12 CELLS; PHOSPHORYLATION; RATS; RECEPTORS, ADRENERGIC, ALPHA-1; SIGNAL TRANSDUCTION; TRANS-ACTIVATION (GENETICS); TRANSFECTION; TYROSINE;

EID: 0034014855     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. κB by Gαq-coupled and cytokine receptors. J Mol Cell Cardiol 32:391-403.
2. Ali MS, Sayeski PP, Dirksen LB, Hayzer DJ, Marrero MB and Bernstein KE (1997) Dependence on the motif YIPP for the physical association of Jak2 kinase with the intracellular carboxyl tail of the angiotensin II AT1 receptor. J Biol Chem 272: 23382-23388.
3. 1A-adrenergic receptors expressed in PC12 cells. Mol Pharmacol 55:296-303.
4. Bhat GJ, Abraham ST, Singer HA and Baker KM (1997) Alpha-thrombin stimulates sis-inducing factor-A DNA binding activity in rat aortic smooth muscle cells. Hypertension 29:356-360.
5. Bhat GJ, Thekkumkara TJ, Thomas WG, Conrad KM and Baker KM (1994) Angiotensin II stimulates sis-inducing factor-like DNA binding activity. Evidence that the AT1A receptor activates transcription factor-Stat91 and/or a related protein. J Biol Chem 269:31443-31449.
6. Bhat GJ, Thekkumkara TJ, Thomas WG, Conrad KM and Baker KM (1995) Activation of the STAT pathway by angiotensin II in T3CHO/AT1A cells. Cross-talk between angiotensin II and interleukin-6 nuclear signaling. J Biol Chem 270: 19059-19065.
7. Boss V, Abbott KL, Wang XF, Pavlath GK and Murphy TJ (1998) The cyclosporin A-sensitive nuclear factor of activated T cells (NFAT) proteins are expressed in vascular smooth muscle cells. Differential localization of NFAT isoforms and induction of NFAT-mediated transcription by phospholipase C-coupled cell surface receptors. J Biol Chem 273:19664-19671.
8. Chung J, Uchida E, Grammer TC and Blenis J (1997) STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation. Mol Cell Biol 17:6508-6516.
9. Cuenda A, Rouse J, Doza YN, Meier R, Cohen P, Gallagher TF, Young PR and Lee JC (1995) SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett 364:229-233.
10. Darnell JE (1997) State and gene regulation. Science (Wash DC) 277:1630-1635.
11. de Groot RP, Coffer PJ and Koenderman L (1998) Regulation of proliferation, differentiation and survival by the IL-3/IL-5/GM-CSF receptor family. Cell Signal 10:619-628.
12. Ihle JN (1996) STATs: Signal transducers and activators of transcription. Cell 84:331-334.
13. 1A/D-adrenergic receptor and inducible expression of three human subtypes in SKNMC cells. Mol Pharmacol 47:977-985.
14. Gazit A, Osherov N, Posner I, Yaish P, Poradosu E, Gilon C and Levitzki A (1991) Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases. J Med Chem 34:1896-1907.
15. 2A receptor coupled to the Jak/STAT pathway. J Biol Chem 272:14825-14829.
16. Hanke JH, Gardner JP, Dow RL, Changelian PS, Brissette WH, Weringer EJ, Pollok BA and Connelly PA 119961 Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation. J Biol Chem 271:695-701.
17. Hirasawa A, Horie K, Tanaka T, Takagaki K, Murai M, Yano J and Tsujimoto G (1993) Cloning, functional expression and tissue distribution of human cDNA for the alpha 1C-adrenergic receptor. Biochem Biophys Res Commun 195:902-909.
18. Hu ZW, Shi XY, Lin RZ and Hoffman BB (1996) Alphal adrenergic receptors activate phosphatidylinositol 3-kinase in human vascular smooth muscle cells. Role in mitogenesis. J Biol Chem 271:8977-8982.
19. Leaman DW, Leung S, Li X and Stark GR (1996) Regulation of Stat-dependent pathways by growth factors and cytokines. FASEB J 10:1578-1588.
20. Levitzki A and Gazit A (1995) Tyrosine kinase inhibition: an approach to drug development. Science (Wash DC) 267:1782-1788.
21. Marrero MB, Schieffer B, Li B, Sun J, Harp JB and Ling BN (1997) Role of Janus kinase/signal transducer and activator of transcription and mitogen-activated protein kinase cascades in angiotensin II- and platelet-derived growth factor-induced vascular smooth muscle cell proliferation. J Biol Chem 272:24684-24690.
22. Marrero MB, Schieffer B, Paxton WG, Heerdt L, Berk BC, Delafontaine P and Bernstein KE (1995) Direct stimulation of Jak/Stat pathway by the angiotensin II ATI receptor. Nature (Lond) 375:247-250.
23. McWhinney CD, Hunt RA, Conrad KM, Dostal DE and Baker KM (1997) The type I angiotensin II receptor couples to Stat1 and Stat3 activation through Jak2 kinase in neonatal rat cardiac myocytes. J Mol Cell Cardiol 29:2513-2524.
24. Meydan N, Grunberger T, Dadi H, Shahar M, Arpaia E, Lapidot Z, Leeder JS, Freedman M, Cohen A, Gazit A, Levitzki A and Roifman CM (1996) Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor. Nature (Lond) 379:645-648.
25. Pang L, Sawada T, Decker SJ and Saltiel AR (1995) Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor. J Biol Chem 270:13585-13588.
26. Peeler TC, Conrad KM and Baker KM (1996) Endothelin stimulates sis-inducing factor-like DNA binding activity in CHO-K1 cells expressing ETA receptors. Biochem Biophys Res Commun 221:62-66.
27. Sengupta TK, Talbot ES, Scherle PA and Ivashkiv LB (1998) Rapid inhibition of interleukin-6 signaling and Stat3 activation mediated by mitogen-activated protein kinases. Proc Natl Acad Sci USA 95:11107-11112.
28. Silvennoinen O, Schindler C, Schlessinger J and Levy DE (1993) Ras-independent growth factor signaling by transcription factor tyrosine phosphorylation. Science (Wash DC) 261:1736-1739.
29. Sims SH, Cha Y, Romine MF, Gao PQ, Gottlieb K and Deisseroth AB (1993) A novel interferon-inducible domain: Structural and functional analysis of the human interferon regulatory factor 1 gene promoter. Mol Cell Biol 13:690-702.
30. Soltoff SP, Avraham H, Avraham S and Cantley LC 11998) Activation of P2Y2 receptors by UTP and ATP stimulates mitogen-activated kinase activity through a pathway that involves related adhesion focal tyrosine kinase and protein kinase C. J Biol Chem 273:2653-2660.
31. Toullec D, Pianetti P, Coste H, Bellevergue P, Grand-Perret T, Ajakane M, Baudet V, Boissin P, Boursier E, Loriolle F, et al. (1991) The bisindolyhnaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J Biol Chem 266:15771-15781.
32. Vlahos CJ, Matter WF, Hui KY and Brown RF (1994) A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J Biol Chem 269:5241-5248.
33. 2-, and β-adrenergic receptors to MAP kinase pathways and differentiation in transfected PC12 cells. J Biol Chem 273:24624-24632.
34. Zauberman A, Zipori D, Krupsky M and Ben-Levy R (1999) Stress activated protein kinase p38 is involved in IL-6 induced transcriptional activation of STAT3. Oncogene 18:3886-3893
35. 1-Adrenoceptor subtypes. Eur J Pharmacol 375:261-276.
36. 1-adrenergic receptor subtypes. J Neurochem 72:2388-2396.
37. 1A-adrenergic and growth factor receptors in transfected PC12 cells. Biochem J 344:889-894.