A cytokine mixture of GM-CSF and IL-3 that induces a neuroprotective phenotype of microglia leading to amelioration of (6-OHDA)-induced Parkinsonism of rats

Brain and Behavior

Volumn 1, Issue 1, 2011, Pages 26-43

  Choudhury, Mohammed Emamussalehin ^a   Sugimoto, Kana ^a,b   Kubo, Madoka ^a   Nagai, Masahiro ^a   Nomoto, Masahiro ^a   Takahashi, Hisaaki ^a,b   Yano, Hajime ^a,b   Tanaka, Junya ^a,b  

^a EHIME UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b EHIME UNIVERSITY   (Japan)

Author keywords

6 hydroxydopamine; Astrocyte; Dopamine; HGF; Neuroinflammation; NG2 glia

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CD123 ANTIGEN; CELL PROTEIN; COPPER ZINC SUPEROXIDE DISMUTASE; CYTOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR RECEPTOR; INTERLEUKIN 1BETA; METALLOTHIONEIN II; NG2 PROTEOGLYCAN; OXIDOPAMINE; PROTEIN BCL XL; PROTEIN IBA1; PROTEOGLYCAN; RECOMBINANT GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; RECOMBINANT INTERLEUKIN 3; SCATTER FACTOR; SOMATOMEDIN C; TUMOR NECROSIS FACTOR ALPHA; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL ACTIVATION; CELL CONTACT; CELL CULTURE; CELL DENSITY; CELL FUNCTION; CELL INTERACTION; CELL SURVIVAL; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINE BRAIN LEVEL; DOPAMINERGIC NERVE CELL; DRUG ACTIVITY; INFLAMMATORY CELL; MALE; MICROGLIA; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; PARKINSONISM; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SUBSTANTIA NIGRA PARS COMPACTA;

EID: 84864280408     PISSN: 21623279     EISSN: 21579032     Source Type: Journal    
DOI: 10.1002/brb3.11     Document Type: Article

References (47)

1. Asanuma, M., I. Miyazaki, F. J. Diaz-Corrales, N. Kimoto, Y. Kikkawa, M. Takeshima, K. Miyoshi, and M. Murata. 2010. Neuroprotective effects of zonisamide target astrocyte. Ann. Neurol. 67:239-249.
2. Bastion, Y., L. Campos, N. Roubi, J. Bienvenu, P. Felman, C. Dumontet, and B. Coiffier. 1995. IL-3 increases marrow and peripheral erythroid precursors in chronic pure red cell aplasia presenting in childhood. Br. J. Haematol. 89:413-416.
3. Block, M. L., L. Zecca, and J. S. Hong. 2007. Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nature Rev. Neurosci. 8:57-69.
4. Butt, A. M., N. Hamilton, P. Hubbard, M. Pugh, and M. Ibrahim. 2005. Synantocytes: the fifth element. J. Anat. 207:695-706.
5. Choudhury, M. E., T. Moritoyo, M. Kubo, W. T. Kyaw, H. Yabe, N. Nishikawa, M. Nagai, S. Matsuda, and M. Nomoto. 2011. Zonisamide-induced long-lasting recovery of dopaminergic neurons from MPTP-toxicity. Brain Res. 1384: 170-178.
6. Clarkson, E. D., W.M. Zawada, K. P. Bell, J. E. Esplen, P. K. Choi, K. A. Heidenreich, and C. R. Freed. 2001. IGF-I and bFGF improve dopamine neuron survival and behavioral outcome in parkinsonian rats receiving cultured human fetal tissue strands. Exp. Neurol. 168:183-191.
7. Cullheim, S., and S. Thams. 2007. The microglial networks of the brain and their role in neuronal network plasticity after lesion. Brain Res. Rev. 55:89-96.
8. De Lella Ezcurra, A. L., M. Chertoff, C. Ferrari, M. Graciarena, and F. Pitossi. 2010. Chronic expression of low levels of tumor necrosis factor-alpha in the substantia nigra elicits progressive neurodegeneration, delayed motor symptoms and microglia/macrophage activation. Neurobiol. Dis. 37:630-640.
9. Dekundy, A., M. Lundblad, W. Danysz, and M. A. Cenci. 2007. Modulation of L-DOPA-induced abnormal involuntary movements by clinically tested compounds: further validation of the rat dyskinesia model. Behav. Brain Res. 179:76-89.
10. Dreyfus, C. F., X. Dai, L. D. Lercher, B. R. Racey, W. J. Friedman, and I. B. Black. 1999. Expression of neurotrophins in the adult spinal cord in vivo. J. Neurosci. Res. 56:1-7.
11. Ebert, A. D., A. J. Beres, A. E. Barber, and C. N. Svendsen. 2008. Human neural progenitor cells over-expressing IGF-1 protect dopamine neurons and restore function in a rat model of Parkinson's disease. Exp. Neurol. 209:213-223.
12. Fujita, H., J. Tanaka, K. Toku, N. Tateishi, Y. Suzuki, S. Matsuda, M. Sakanaka, and N. Maeda. 1996. Effects of GM-CSF and ordinary supplements on the ramification of microglia in culture: a morphometrical study. Glia 18:269-281.
13. Glinka, Y., M. Gassen, and M. B. Youdim. 1997. Mechanism of 6-hydroxydopamine neurotoxicity. J. Neural Transm. Suppl. 50:55-66.
14. Guan, J., R. Krishnamurthi, H. J.Waldvogel, R. L. Faull, R. Clark, and P. Gluckman. 2000. N-terminal tripeptide of IGF-1 (GPE) prevents the loss of TH positive neurons after 6-OHDA induced nigral lesion in rats. Brain Res. 859:286-292.
15. Henry, V., V. Paille, F. Lelan, P. Brachet, and P. Damier. 2009. Kinetics of microglial activation and degeneration of dopamine-containing neurons in a rat model of Parkinson disease induced by 6-hydroxydopamine. J. Neuropathol. Exp. Neurol. 68:1092-1102.
16. Hocker, P., K. Geissler, M. Kurz, A.Wagner, and K. Gerhartl. 1993. Potentiation of GM-CSF or G-CSF induced mobilization of circulating progenitor cells by pretreatment with IL-3 and harvest by apheresis. Int. J. Artif. Organs 16(Suppl 5):25-29.
17. Huang, X., J. K. Choi, S. R. Park, Y. Ha, H. Park, S. H. Yoon, H. C. Park, J. O. Park, and B. H. Choi. 2007. GM-CSF inhibits apoptosis of neural cells via regulating the expression of apoptosis-related proteins. Neurosci. Res. 58:50-57.
18. Kitamura, Y., M. Inden, H. Minamino, M. Abe, K. Takata, and T. Taniguchi. 2010. The 6-hydroxydopamine-induced nigrostriatal neurodegeneration produces microglia-like NG2 glial cells in the rat substantia nigra. Glia 58:1686-1700.
19. Koike, H., A. Ishida, M. Shimamura, S. Mizuno, T. Nakamura, T. Ogihara, Y. Kaneda, and R. Morishita. 2006. Prevention of onset of Parkinson's disease by in vivo gene transfer of human hepatocyte growth factor in rodent model: a model of gene therapy for Parkinson's disease. Gene Ther. 13:1639-1644.
20. Kreutzberg, G.W. 1996. Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 19:312-318.
21. Levesque, S., B.Wilson, V. Gregoria, L. B. Thorpe, S. Dallas, V. S. Polikov, J. S. Hong, and M. L. Block. 2010. Reactive microgliosis: extracellular micro-calpain and microglia-mediated dopaminergic neurotoxicity. Brain 133:808-821.
22. Liberatore, G. T., V. Jackson-Lewis, S. Vukosavic, A. S. Mandir, M. Vila, W. G. McAuliffe, V. L. Dawson, T.M.Dawson, and S. Przedborski. 1999. Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease. Nature Med. 5:1403-1409.
23. Long-Smith, C. M., A. M. Sullivan, Y. M. Nolan. 2009. The influence of microglia on the pathogenesis of Parkinson's disease. Prog. Neurobiol. 89:277-287.
24. Lue, L. F., Y. M. Kuo, T. Beach, and D. G.Walker. 2010. Microglia activation and anti-inflammatory regulation in Alzheimer's disease. Mol. Neurobiol. 41:115-128.
25. Marinova-Mutafchieva, L., M. Sadeghian, L. Broom, J. B. Davis, A. D. Medhurst, D. T. Dexter. 2009. Relationship between microglial activation and dopaminergic neuronal loss in the substantia nigra: a time course study in a 6-hydroxydopamine model of Parkinson's disease. J. Neurochem. 110:966-975.
26. McGeer, P. L., and E. G. McGeer. 2008. Glial reactions in Parkinson's disease. Mov. Disord. 23:474-483.
27. Miyazaki, I., M. Asanuma, Y. Kikkawa, M. Takeshima, S. Murakami, K. Miyoshi, N. Sogawa, and T. Kita. 2011.Astrocyte-derived metallothionein protects dopaminergic neurons from dopamine quinone toxicity. Glia 59:435-451.
28. Mosley, R. L., E. J. Benner, I. Kadiu, M. Thomas, M. D. Boska, K. Hasan, C. Laurie, and H. E. Gendelman. 2006. Neuroinflammation, Oxidative Stress and the Pathogenesis of Parkinson's Disease. Clin. Neurosci. Res. 6:261-281.
29. Nishihara, T., M. Ochi, K. Sugimoto, H. Takahashi, H. Yano, Y. Kumon, T. Ohnishi, and J. Tanaka. 2011. Subcutaneous injection containing IL-3 and GM-CSF ameliorates stab wound-induced brain injury in rats. Exp. Neurol. 229:507-516.
30. Ohya, W., H. Funakoshi, T. Kurosawa, and T. Nakamura. 2007. Hepatocyte growth factor (HGF) promotes oligodendrocyte progenitor cell proliferation and inhibits its differentiation during postnatal development in the rat. Brain Res. 1147:51-65.
31. Schaar, D. G., B. A. Sieber, C. F. Dreyfus, and I. B. Black. 1993. Regional and cell-specific expression of GDNF in rat brain. Exp. Neurol. 124:368-371.
32. Schabitz, W. R., C. Kruger, C. Pitzer, D.Weber, R. Laage, N. Gassler, J. Aronowski, W. Mier, F. Kirsch, T. Dittgen, et al. 2008. A neuroprotective function for the hematopoietic protein granulocyte-macrophage colony stimulating factor (GM-CSF). J. Cereb. Blood Flow Metab.: 28:29-43.
33. Staugaitis, S. M., and B. D. Trapp. 2009. NG2-positive glia in the human central nervous system. Neuron Glia Biol. 5:35-44.
34. Streit, W. J., S. A.Walter, and N. A. Pennell. 1999. Reactive microgliosis. Prog. Neurobiol. 57:563-581.
35. Sudo, S., J. Tanaka, K. Toku, J. Desaki, S. Matsuda, T. Arai, M. Sakanaka, and N. Maeda. 1998. Neurons induce the activation of microglial cells in vitro. Exp. Neurol. 154:499-510.
36. Sundberg, M., H. Skottman, R. Suuronen, and S. Narkilahti. 2010. Production and isolation of NG2+ oligodendrocyte precursors from human embryonic stem cells in defined serum-free medium. Stem Cell Res. 5:91-103.
37. Takahashi, H., H. Matsumoto, A. Smirkin, T. Itai, Y. Nishimura, and J. Tanaka. 2008. Involvement of heparanase in migration of microglial cells. Biochim. Biophys. Acta 1780:709-715.
38. Tanaka, J., K. Toku, S. Matsuda, S. Sudo, H. Fujita, M. Sakanaka, and N. Maeda. 1998. Induction of resting microglia in culture medium devoid of glycine and serine. Glia 24:198-215.
39. Tanaka, J., K. Toku, B. Zhang, K. Ishihara, M. Sakanaka, and N. Maeda. 1999. Astrocytes prevent neuronal death induced by reactive oxygen and nitrogen species. Glia 28:85-96.
40. Tansey, M. G., and M. S. Goldberg. 2010. Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention. Neurobiol. Dis. 37:510-518.
41. Trapp, B. D., J. R.Wujek, G. A. Criste, W. Jalabi, X. Yin, G. J. Kidd, S. Stohlman, and R. Ransohoff. 2007. Evidence for synaptic stripping by cortical microglia. Glia 55:360-368.
42. Trotter, J., K. Karram, and A. Nishiyama. 2010. NG2 cells: Properties, progeny and origin. Brain Res. Rev. 63:72-82.
43. Wen, T. C., J. Tanaka, H. Peng, J. Desaki, S. Matsuda, N. Maeda, H. Fujita, K. Sato, and M. Sakanaka. 1998. Interleukin 3 prevents delayed neuronal death in the hippocampal CA1 field. J. Exp. Med. 188:635-649.
44. Yabe, H., M. E. Choudhury, M. Kubo, N. Nishikawa, M. Nagai, and M. Nomoto. 2009. Zonisamide increases dopamine turnover in the striatum of mice and common marmosets treated with MPTP. J. Pharm. Sci. 110:64-68.
45. Yacoubian, T. A., and D. G. Standaert. 2009. Targets for neuroprotection in Parkinson's disease. Biochim. Biophys. Acta 1792:676-687.
46. Yokoyama, A., A. Sakamoto, K. Kameda, Y. Imai, J. Tanaka. 2006. NG2 proteoglycan-expressing microglia as multipotent neural progenitors in normal and pathologic brains. Glia 53:754-768.
47. Zhu, L., J. Lu, S. S. Tay, H. Jiang, and B. P. He. 2010. Induced NG2 expressing microglia in the facial motor nucleus after facial nerve axotomy. Neuroscience 166:842-851.