Allosteric modulation of metabotropic glutamate receptors by chloride ions

FASEB Journal

Volumn 29, Issue 10, 2015, Pages 4174-4188

  Tora, Amélie S ^a,b   Rovira, Xavier ^a,b   Dione, Ibrahima ^c   Bertrand, Hugues Olivier ^d   Brabet, Isabelle ^a,b   De Koninck, Yves ^c   Doyon, Nicolas ^c   Pin, Jean Philippe ^a,b   Acher, Francine ^e   Goudet, Cyril ^a,b  

^a UNIV MONTPELLIER   (France)

^b INSTITUT DE GÉNOMIQUE FONCTIONNELLE   (France)

^c CENTRE DE RECHERCHE DE L INSTITUT UNIVERSITAIRE EN SANTÉ MENTALE DE QUÉBEC   (Canada)

^d DASSAULT SYSTÈMES   (France)

^e UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Allostery; Anion; GABA; GPCR; PAM

Indexed keywords

ALANINE; ASPARTIC ACID; CHLORIDE ION; GLUTAMIC ACID; GLYCOSYL PHOSPHATIDYLINOSITOL; METABOTROPIC RECEPTOR 2; METABOTROPIC RECEPTOR 4; PHOSPHATIDYLINOSITOL; SERINE; UNCLASSIFIED DRUG; CHLORIDE; METABOTROPIC RECEPTOR; PROTEIN BINDING;

ALLOSTERISM; ARTICLE; BINDING SITE; CELL MEMBRANE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; EMBRYO; EXTRACELLULAR SPACE; HUMAN; HUMAN CELL; HYDROGEN BOND; LIGAND BINDING; MOLECULAR MODEL; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; SECOND MESSENGER; SEQUENCE ALIGNMENT; SITE DIRECTED MUTAGENESIS; SYNAPSE; AMINO ACID SEQUENCE; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; GENETICS; HEK293 CELL LINE; METABOLISM; MUTATION; PROTEIN TERTIARY STRUCTURE; RAT; SEQUENCE HOMOLOGY;

ALLOSTERIC REGULATION; ALLOSTERIC SITE; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CHLORIDES; EXTRACELLULAR SPACE; HEK293 CELLS; HUMANS; MODELS, MOLECULAR; MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 84946944477     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.14-269746     Document Type: Article

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