Computational modeling of three-dimensional electrodiffusion in biological systems: Application to the node of Ranvier

Biophysical Journal

Volumn 95, Issue 6, 2008, Pages 2624-2635

  Lopreore, Courtney L ^a,b   Bartol, Thomas M ^b,c   Coggan, Jay S ^a,b   Keller, Daniel X ^b,c,d   Sosinsky, Gina E ^e   Ellisman, Mark H ^e   Sejnowski, Terrence J ^a,b,c,d  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

POTASSIUM CHANNEL; SODIUM CHANNEL;

ACTION POTENTIAL; ARTICLE; BIOLOGICAL MODEL; CELL MEMBRANE; CHANNEL GATING; COMPUTER SIMULATION; DIFFUSION; ELECTRICITY; METABOLISM; RANVIER NODE; REPRODUCIBILITY;

ACTION POTENTIALS; CELL MEMBRANE; COMPUTER SIMULATION; DIFFUSION; ELECTRICITY; ION CHANNEL GATING; MODELS, BIOLOGICAL; POTASSIUM CHANNELS; RANVIER'S NODES; REPRODUCIBILITY OF RESULTS; SODIUM CHANNELS;

EID: 55549124558     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1529/biophysj.108.132167     Document Type: Article

References (19)

1. Hines, M. L., and N. T. Carnevale. 1997. The NEURON simulation environment. Neural Comput. 9:1179-1209.
2. Hines, M. L., and N. T. Carnevale. 2001. NEURON: a tool for neuroscientists. Neuroscientist. 7:123-135.
3. Bhalla, U. S. 1998. The Network within: Signalling Pathways. In The Book of GENESIS: Exploring Realistic Neural Models with the GEneral NEural SImulation System, 2nd ed. J. M. Bower and D. Beeman, editors. Springer-Verlag, New York.
4. Rall, W. 1969. Time constants and electrotonic length constants of membrane cylinders and neurons. Biophys. J. 9:1483-1508.
5. Rall, W. 1977. Core conductor theory and cable properties of neurons. Handb. Physiol. 1:39-97.
6. Hille, B. 2001. Ion Channels of Excitable Membranes. Sinauer Associates, Sunderland, MA.
7. Qian, N., and T. J. Sejnowski. 1989. An electro-diffusion model for computing membrane potentials and ionic concentrations in branching dendrites, spines, and axons. Biol. Cybern. 62:1-15.
8. van Egeraat, J. M., and J. P. Wikswo. 1993. A model for axonal propagation incorporating both radial and axial ionic transport. Biophys. J. 64:1287-1298.
9. Jack, J. J. B., D. Noble, and R. W. Tsien. 1975. Electric Current Flow in Excitable Cells. Oxford University Press, Oxford.
10. Sosinsky, G. E., T. J. Deerinck, R. Greco, C. H. Buitenhuys, T. M. Bartol, and M. H. Ellisman. 2005. Development of a model for microphysiological simulations. Neuroinformatics. 3:133-162.
11. Press, W. H., S. A. Teukolsky, W. T. Vetterling, and B. P. Flannery. 1992. Numerical Recipes in Fortran 77: The Art of Scientific Computing. Cambridge University Press, New York.
12. Hodgkin, A. L., and A. F. Huxley. 1952. A quantitative description of membrane current and its application to conduction and excitation in nerve. J. Physiol. 117:500-544.
13. Destexhe, A., Z. F. Mainen, and T. J. Sejnowski. 1994. Synthesis of models for excitable membranes, synaptic transmission and neuromodulation using a common kinetic formalism. J. Comput. Neurosci. 1:195-230.
14. Frankenhaeuser, B., and A. F. Huxley. 1964. The action potential in the myelinated nerve fibre of Xenopus laevis, as computed on the basis of voltage clamp data. J. Physiol. 171:302-315.
15. Ellisman, M. H. 1979. Molecular specialization of the axon membrane at nodes of Ranvier are not dependent upon myelination. J. Neurocytol. 8:719-735.
16. Ellisman, M. H., and S. R. Levinson. 1982. Immunocytochemical localization of sodium channel distributions in the excitable membranes of Electrophorus electricus. Proc. Natl. Acad. Sci. USA. 79:6707-6711.
17. Gustafsson, M. G. L., D. A. Agard, and J. W. Sedat. 1999. I5M: 3D widefield light microscopy with better than 100 nm axial resolution. J. Microsc. 195:10-16.
18. Gugel, H., J. Bewersdorf, S. Jakobs, J. Engelhardt, R. Storz, and S. W. Hell. 2004. Cooperative 4Pi excitation and detection yields sevenfold sharper optical sections in live cell microscopy. Biophys. J. 87:4146-4152.
19. Baker, B. J., H. Lee, V. A. Pieribone, L. B. Cohen, E. Y. Isacoff, T. Knopfel, and E. K. Kosmidis. 2007. Three fluorescent protein voltage sensors exhibit low plasma membrane expression in mammalian cells. J. Neurosci. Methods. 161:32-38.