A critical pocket close to the glutamate binding site of mGlu receptors opens new possibilities for agonist design

Neuropharmacology

Volumn 60, Issue 1, 2011, Pages 102-107

  Acher, Francine C ^a   Selvam, Chelliah ^a   Pin, Jean Philippe ^b,c   Goudet, Cyril ^b,c   Bertrand, Hugues Olivier ^d  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b UNIV MONTPELLIER   (France)

^c INSTITUT DE GÉNOMIQUE FONCTIONNELLE   (France)

^d ACCELRYS INC   (United States)

Author keywords

Allosteric modulation; Chloride binding site; Class C GPCR; LIVBP; Metabotropic glutamate receptors; Orthosteric ligand

Indexed keywords

ATRIAL NATRIURETIC FACTOR RECEPTOR; BINDING PROTEIN; CHLORIDE ION; G PROTEIN COUPLED RECEPTOR; GLUTAMIC ACID; ISOLEUCINE; LEUCINE; LSP 12093; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR 4; METABOTROPIC RECEPTOR AGONIST; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG; VALINE;

ALLOSTERISM; ARTICLE; BINDING SITE; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; HUMAN; HUMAN CELL; MOLECULAR DOCKING; NEUROMODULATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN STRUCTURE; RECEPTOR BINDING;

ALLOSTERIC REGULATION; ALLOSTERIC SITE; DRUG DESIGN; GLUTAMIC ACID; HEK293 CELLS; HUMANS; MODELS, MOLECULAR; PROTEIN CONFORMATION; RECEPTORS, METABOTROPIC GLUTAMATE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78149499652     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2010.07.002     Document Type: Article

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