Increased Arginine Vasopressin mRNA Expression in the Human Hypothalamus in Depression: A Preliminary Report

Biological Psychiatry

Volumn 60, Issue 8, 2006, Pages 892-895

  Meynen, Gerben ^a,b   Unmehopa, Unga A ^a   van Heerikhuize, Joop J ^a   Hofman, Michel A ^a   Swaab, Dick F ^a   Hoogendijk, Witte J G ^b  

^a NETHERLANDS INSTITUTE FOR NEUROSCIENCE   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Depression; hypothalamic pituitary adrenal axis; hypothalamus; melancholic type; postmortem; vasopressin

Indexed keywords

ARGIPRESSIN; MESSENGER RNA;

ADULT; AGED; ARTICLE; AUTOPSY; BLOOD LEVEL; BRAIN TISSUE; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DEPRESSION; FEMALE; GENE EXPRESSION; HUMAN; HYPOTHALAMUS; IN SITU HYBRIDIZATION; MALE; PRIORITY JOURNAL; SUPRACHIASMATIC NUCLEUS; SUPRAOPTIC NUCLEUS; THALAMUS MIDLINE NUCLEUS;

AGED; AGED, 80 AND OVER; ARGININE VASOPRESSIN; DEPRESSIVE DISORDER; FEMALE; HUMANS; HYPOTHALAMUS; IN SITU HYBRIDIZATION; MALE; MIDDLE AGED; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; PSYCHIATRIC STATUS RATING SCALES; RNA, MESSENGER; SUICIDE; SUPRAOPTIC NUCLEUS;

EID: 33749515446     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2005.12.010     Document Type: Article

References (25)

1. Antoni F.A. Vasopressinergic control of pituitary adrenocorticotropin secretion comes of age. Front Neuroendocrinol 14 (1993) 76-122
2. Brunner J., Keck M.E., Landgraf R., Uhr M., Namendorf C., and Bronisch T. Vasopressin in CSF and plasma in depressed suicide attempters: Preliminary results. Eur Neuropsychopharmacol 12 (2002) 489-494
3. De Winter R.F., van Hemert A.M., DeRijk R.H., Zwinderman K.H., Frankhuijzen-Sierevogel A.C., Wiegant V.M., et al. Anxious-retarded depression: Relation with plasma vasopressin and cortisol. Neuropsychopharmacology 28 (2003) 140-147
4. Erkut Z.A., Pool C., and Swaab D.F. Glucocorticoids suppress corticotropin-releasing hormone and vasopressin expression in human hypothalamic neurons. J Clin Endocrinol Metab 83 (1998) 2066-2073
5. Gispen-de Wied C.C., Westenberg H.G., Koppeschaar H.P., Thijssen J.H., and van Ree J.M. Stimulation of the pituitary-adrenal axis with a low dose [Arg8]-vasopressin in depressed patients and healthy subjects. Eur Neuropsychopharmacol 2 (1992) 411-419
6. Harding A.J., Halliday G.M., Ng J.L., Harper C.G., and Kril J.J. Loss of vasopressin-immunoreactive neurons in alcoholics is dose-related and time-dependent. Neuroscience 72 (1996) 699-708
7. Holsboer F. Stress, hypercortisolism and corticosteroid receptors in depression: Implications for therapy. J Affect Disord 62 (2001) 77-91
8. Inder W.J., Donald R.A., Prickett T.C., Frampton C.M., Sullivan P.F., Mulder R.T., et al. Arginine vasopressin is associated with hypercortisolemia and suicide attempts in depression. Biol Psychiatry 42 (1997) 744-747
9. Keck M.E., Welt T., Muller M.B., Uhr M., Ohl F., Wigger A., et al. Reduction of hypothalamic vasopressinergic hyperdrive contributes to clinically relevant behavioral and neuroendocrine effects of chronic paroxetine treatment in a psychopathological rat model. Neuropsychopharmacology 28 (2003) 235-243
10. Kim J.K., Summer S.N., Wood W.M., and Schrier R.W. Role of glucocorticoid hormones in arginine vasopressin gene regulation. Biochem Biophys Res Commun 289 (2001) 1252-1256
11. Liu R.Y., Zhou J.N., Hoogendijk W.J., van Heerikhuize J., Kamphorst W., Unmehopa U.A., et al. Decreased vasopressin gene expression in the biological clock of Alzheimer disease patients with and without depression. J Neuropathol Exp Neurol 59 (2000) 314-322
12. Lucassen P.J., Goudsmit E., Pool C.W., Mengod G., Palacios J.M., Raadsheer F.C., et al. In situ hybridization for vasopressin mRNA in the human supraoptic and paraventricular nucleus: Quantitative aspects of formalin-fixed paraffin-embedded tissue sections as compared to cryostat sections. J Neurosci Methods 57 (1995) 221-230
13. Marar I.E., and Amico J.A. Vasopressin, oxytocin, corticotrophin-releasing factor, and sodium responses during fluoxetine administration in the rat. Endocrine 8 (1998) 13-18
14. Morimoto M., Morita N., Ozawa H., Yokoyama K., and Kawata M. Distribution of glucocorticoid receptor immunoreactivity and mRNA in the rat brain: An immunohistochemical and in situ hybridization study. Neurosci Res 26 (1996) 235-269
15. Nakase S., Kitayama I., Soya H., Hamanaka K., and Nomura J. Increased expression of magnocellular arginine vasopressin mRNA in paraventricular nucleus of stress-induced depression-model rats. Life Sci 63 (1998) 23-31
16. Purba J.S., Hoogendijk W.J., Hofman M.A., and Swaab D.F. Increased number of vasopressin- and oxytocin-expressing neurons in the paraventricular nucleus of the hypothalamus in depression. Arch Gen Psychiatry 53 (1996) 137-143
17. Raadsheer F.C., Hoogendijk W.J., Stam F.C., Tilders F.J., and Swaab D.F. Increased numbers of corticotropin-releasing hormone expressing neurons in the hypothalamic paraventricular nucleus of depressed patients. Neuroendocrinology 60 (1994) 436-444
18. Sanchez M.M., Young L.J., Plotsky P.M., and Insel T.R. Distribution of corticosteroid receptors in the rhesus brain: Relative absence of glucocorticoid receptors in the hippocampal formation. J Neurosci 20 (2000) 4657-4668
19. Scott L.V., and Dinan T.G. Vasopressin as a target for antidepressant development: An assessment of the available evidence. J Affect Disord 72 (2002) 113-124
20. Spigset O., and Hedenmalm K. Hyponatraemia and the syndrome of inappropriate antidiuretic hormone secretion (SIADH) induced by psychotropic drugs. Drug Saf 12 (1995) 209-225
21. Swaab D.F. The Human Hypothalamus. Basic and Clinical Aspects. Part I: Nuclei of the Hypothalamus. Handbook of Clinical Neurology (2003), Elsevier, Amsterdam
22. Swaab D.F., Fliers E., Hoogendijk W.J., Veltman D.J., and Zhou J.N. Interaction of prefrontal cortical and hypothalamic systems in the pathogenesis of depression. Prog Brain Res 126 (2000) 369-396
23. Van Londen L. Vasopressin in Major Depression (2003), Universitair Facilitair Bedrijf, Grafische Dienstverlening, Leiden
24. Van Londen L., Goekoop J.G., van Kempen G.M., Frankhuijzen-Sierevogel A.C., Wiegant V.M., van der Velde E.A., et al. Plasma levels of arginine vasopressin elevated in patients with major depression. Neuropsychopharmacology 17 (1997) 284-292
25. Wotjak C.T., Kubota M., Kohl G., and Landgraf R. Release of vasopressin from supraoptic neurons within the median eminence in vivo. A combined microdialysis and push-pull perfusion study in the rat. Brain Res 726 (1996) 237-241