DNA methyltransferase inhibitors coordinately induce expression of the human reelin and glutamic acid decarboxylase 67 genes

Molecular Pharmacology

Volumn 71, Issue 3, 2007, Pages 644-653

  Kundakovic, Marija ^a   Chen, Ying ^a   Costa, Erminio ^a   Grayson, Dennis R ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE INHIBITOR; DOXORUBICIN; GLUTAMATE DECARBOXYLASE 67; HISTONE H3; METHYL CPG BINDING PROTEIN 2; REELIN; ZEBULARINE;

ACETYLATION; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DISSOCIATION; DNA METHYLATION; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVITY; GENE ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; NERVE CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEM CELL; WESTERN BLOTTING;

ACETYLATION; AZACITIDINE; CELL ADHESION MOLECULES, NEURONAL; CELLS, CULTURED; CYTIDINE; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; ENZYME INHIBITORS; EXTRACELLULAR MATRIX PROTEINS; GENE EXPRESSION REGULATION; GLUTAMATE DECARBOXYLASE; HISTONES; HUMANS; ISOENZYMES; METHYL-CPG-BINDING PROTEIN 2; NERVE TISSUE PROTEINS; RNA, MESSENGER; SERINE ENDOPEPTIDASES;

EID: 33847111254     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.106.030635     Document Type: Article

References (37)

1. Abdolmaleky HM, Cheng K, Russo A, Smith CL, Faraone SV, Wilcox M, Shafa R, Glatt SJ, Nguyen G, Ponte JF, et al. (2005) Hypermethylation of the reelin (RELN) promoter in the brain of schizophrenic patients: a preliminary report. Am J Med Genet B Neuropsychiatr Genet 134:60-66.
2. Auta J, Chen Y, Ruzicka WB, and Grayson DR (2006) Nucleic acid quantitation using the competitive polymerase chain reaction, in Handbook of Neurochemistry and Molecular Neurobiology: Practical Neurochemistry Methods, 3rd ed (Lajtha A, Baker GB, Dunn SMJ, and Holt A eds) pp 341-361, Kluwer Academic Publishers, New York.
3. Burgers WA, Fuks F, and Kouzarides T (2002) DNA methyltransferases get connected to chromatin. Trends Genet 18:275-277.
4. Chen Y, Sharma RP, Costa RH, Costa E, and Grayson DR (2002) On the epigenetic regulation of the human reelin promoter. Nucleic Acids Res 30:2930-2939.
5. Cheng JC, Weisenberger DJ, Gonzales FA, Liang G, Xu G, Hu Y, Marquez VE, and Jones PA (2004) Continuous zebularine treatment effectively sustains demethylation in human bladder cancer cells. Mol Cell Biol 24:1270-1278.
6. Costa E, Davis JM, Dong E, Grayson DR, Guidotti A, Tremolizzo L, and Veldic M (2004) A GABAergic cortical deficit dominates schizophrenia pathophysiology. Crit Rev Neurobiol 16:1-23.
7. 67 promoter remodeling in an epigenetic methionine-induced mouse model of schizophrenia. Proc Natl Acad Sci USA 102:12578-12583.
8. Eastwood SL and Harrison PJ (2003) Interstitial white matter neurons express less reelin and are abnormally distributed in schizophrenia: towards an integration of molecular and morphologic aspects of the neurodevelopmental hypothesis. Mol Psychiatry 769:821-831.
9. Easwaran HP, Schermelleh L, Leonhardt H, and Cardoso MC (2004) Replication-independent chromatin loading of Dnmt1 during G2 and M phases. EMBO Rep 5:1181-1186.
10. Egger G, Liang G, Aparacio A, and Jones PA (2004) Epigenetics in human disease and prospects for epigenetic therapy. Nature (Lond) 429:457-463.
11. Esteve P, Chin HG, and Pradhan S (2005) Human maintenance DNA (cytosine-5)-methyltransferase and p53 modulate expression of p53-repressed promoters. Proc Natl Acad Sci USA 102:1000-1005.
12. Fan G, Beard C, Chen RZ, Csankovszki G, Sun Y, Siniaia M, Biniszkiewicz D, Bates B, Lee PP, Kuhn R, et al. (2001) DNA hypomethylation perturbs the function and survival of CNS neurons in postnatal animals. J Neurosci 21:788-797.
13. Fatemi SH, Earle JA, and McMenomy T (2000) Reduction in reelin immunoreactivity in hippocampus of subjects with schizophrenia, bipolar disorder and major depression. Mol Psychiatry 5:654-663.
14. Fuks F, Burgers WA, Brehm A, Hughes-Davies L, and Kouzarides T (2000) DNA methyltransferase Dnmt1 associates with histone deacetylase activity. Nat Genet 24:88-91.
15. Ghoshal K, Datta J, Majumder S, Bai S, Kutay H, Motiwala T, and Jacob ST (2005) 5-aza-deoxycytidine induces selective degradation of DNA methyltransferase 1 by a proteasomal pathway that requires the KEN box, bromo-adjacent homology domain, and nuclear localization signal. Mol Cell Biol 25:4727-4741.
16. Grayson DR, Chen Y, Costa E, Dong E, Guidotti A, Kundakovic M, and Sharma RP (2006) The human reelin gene: transcription factors (+), repressors (-) and the methylation switch (±) in schizophrenia. Pharmacol Ther 111:272-286.
17. Grayson DR and Ikonomovic S (1999) Competitive RT-PCR to quantitate steady-state mRNA levels, in In Vitro Neurochemical Methods (Boulton AA, Baker GB, Bateson AN, eds), Neuromethods, Vol 34, pp 127-151, Humana Press, New Jersey.
18. Grayson DR, Jia X, Chen Y, Sharma RP, Mitchell CP, Guidotti A, and Costa E (2005) Reelin promoter hypermethylation in schizophrenia. Proc Natl Acad Sci USA 102:9341-9346.
19. 67) expression in schizophrenia and bipolar disorder. Arch Gen Psychiatry 57:1061-1069.
20. Guidotti A, Auta J, Davis JM, Dong E, Grayson DR, Veldic M, Zhang X, and Costa E (2005) GABAergic dysfunction in schizophrenia: new treatment strategies on the horizon. Psychopharmacology (Berl) 180:191-205.
21. Jiang Y, Bressler J, and Beaudet (2004) Epigenetics and human disease. Ann Rev Genomics Hum Genet 5:479-510.
22. Kimura H and Shiota K (2003) Methyl-CpG-binding protein, MeCP2, is a target molecule for maintenance DNA methyltransferase, Dnmt1. J Biol Chem 278:4806-4812.
23. Levenson JM, Roth TL, Lubin FD, Miller CA, Huang I, Desai P, Malone LM, and Sweatt JD (2006) Evidence that DNA (cytosine-5) methyltransferase regulates synaptic plasticity in the hippocampus. J Biol Chem 281:15763- 15773.
24. Levenson JM and Sweatt JD (2005) Epigenetic mechanisms in memory formation. Nat Rev Neurosci 6:108-118.
25. Majumder S, Kutay H, Datta J, Summers D, Jacob ST, and Ghoshal K (2006) Epigenetic regulation of metallothionein-I gene expression: differential regulation of methylated and unmethylated promoters by DNA methyltransferases and methyl CpG binding proteins. J Cell Biochem 97:1300-1316.
26. Martinowich K, Hattori D, Wu H, Fouse S, He F, Hu Y, Fan G, and Sun YE (2003) DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation Science (Wash DC) 302:890-893.
27. Mitchell CP, Chen Y, Kundakovic M, Costa E, and Grayson DR (2005) Histone deacetylase inhibitors decrease reelin promoter methylation in vitro. J Neurochem 93:483-492.
28. Noh JS, Sharma RP, Veldic M, Salvacion AA, Jia X, Chen Y, Costa E, Guidotti A, and Grayson DR (2005) DNA methyltransferase 1 regulates reelin mRNA expression in mouse primary cortical cultures. Proc Natl Acad Sci USA 102:1749-1754.
29. Qiu S, Korwek KM, and Weeber EJ (2006) A fresh look at an ancient receptor family: emerging roles for low density lipoprotein receptors in synaptic plasticity and memory formation. Neurobiol Learn Mem 85:16-29.
30. Ramchandani S, Bigey P, and Szyf M (1998) Genomic structure of the human DNA methyltransferase gene. Biol Chem 379:535-540.
31. Szyf M, Bozovic V, and Tanigawa G (1991) Growth regulation of mouse DNA methyltransferase gene expression. J Biol Chem 266:10027-10030.
32. Torrey EF, Barci BM, Webster MJ, Bartko JJ, Meador-Woodruff JH, and Knable MB (2005) Neurochemical markers for schizophrenia, bipolar disorder, and major depression in postmortem brains. Biol Psychiatry 57:252-260.
33. Tremolizzo L, Carboni G, Ruzicka WB, Mitchell CP, Sugaya I, Tueting P, Sharma R, Grayson DR, Costa E, and Guidotti A (2002) An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability. Proc Natl Acad Sci USA 99:17095-17100.
34. Tucker KL (2001) Methylated cytosine and the brain: a new base for neuroscience. Neuron 30:649-652.
35. Veldic M, Caruncho HJ, Liu S, Davis J, Satta R, Grayson DR, Guidotti A, and Costa E (2004) DNA-methyltransferase 1 mRNA is selectively overexpressed in telencephalic GABAergic interneurons of schizophrenia brains. Proc Natl Acad Sci USA 101:348-353.
36. Weaving LS, Ellaway CJ, Gecz J, and Christodoulou J (2005) Rett syndrome: clinical review and genetic update. J Med Genet 42:1-7.
37. Yokochi T and Robertson KD (2004) Doxorubicin inhibits DNMT1, resulting in conditional apoptosis. Mol Pharmacol 66:1415-1420.