Childhood maltreatment is associated with distinct genomic and epigenetic profiles in posttraumatic stress disorder

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 20, 2013, Pages 8302-8307

  Mehta, Divya ^a   Klengel, Torsten ^a   Conneely, Karen N ^b   Smith, Alicia K ^b   Altmann, André ^a   Pace, Thaddeus W ^b,c   Rex Haffner, Monika ^a   Loeschner, Anne ^a   Gonik, Mariya ^a   Mercer, Kristina B ^a   Bradley, Bekh ^b,e   Müller Myhsok, Bertram ^a   Ressler, Kerry J ^b,c,d   Binder, Elisabeth B ^a,b  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c EMORY UNIVERSITY   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^e VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Biomarkers; Development; Epigenome; Psychiatry

Indexed keywords

ADULT; ARTICLE; CELL ADHESION; CELL MATURATION; CELL MIGRATION; CELL SURVIVAL; CHILD ABUSE; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; EPIGENETICS; FEMALE; GENE EXPRESSION; GENE LOCUS; GENOMICS; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; PERSONALIZED MEDICINE; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TRANSCRIPTION INITIATION SITE;

BIOMARKERS; DEVELOPMENT; EPIGENOME; PSYCHIATRY;

ADULT; BIOLOGICAL MARKERS; CHILD; CHILD ABUSE; DNA METHYLATION; EPIGENESIS, GENETIC; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENOME, HUMAN; GENOMICS; HUMANS; MALE; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RNA, MESSENGER; SEVERITY OF ILLNESS INDEX; STRESS DISORDERS, POST-TRAUMATIC; WOUNDS AND INJURIES;

EID: 84877850278     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1217750110     Document Type: Article

References (45)

1. Szyf M (2011) The early life social environment and DNA methylation: DNA methylation mediating the long-term impact of social environments early in life. Epigenetics 6(8):971-978.
2. Danese A, et al. (2011) Biological embedding of stress through inflammation processes in childhood. Mol Psychiatry 16(3):244-246.
3. Danese A, et al. (2009) Adverse childhood experiences and adult risk factors for agerelated disease: Depression, inflammation, and clustering of metabolic risk markers. Arch Pediatr Adolesc Med 163(12):1135-1143.
4. Danese A, et al. (2008) Elevated inflammation levels in depressed adults with a history of childhood maltreatment. Arch Gen Psychiatry 65(4):409-415.
5. Danese A, Pariante CM, Caspi A, Taylor A, Poulton R (2007) Childhood maltreatment predicts adult inflammation in a life-course study. Proc Natl Acad Sci USA 104(4):1319-1324. (Pubitemid 46184002)
6. Pradhan AD, Manson JE, Rifai N, Buring JE, Ridker PM (2001) C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA 286(3):327-334. (Pubitemid 32656163)
7. Ridker PM, Cushman M, Stampfer MJ, Tracy RP, Hennekens CH (1997) Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med 336(14):973-979. (Pubitemid 27152782)
8. Sin DD, Man SF (2003) Why are patients with chronic obstructive pulmonary disease at increased risk of cardiovascular diseases? The potential role of systemic inflammation in chronic obstructive pulmonary disease. Circulation 107(11):1514-1519. (Pubitemid 36378490)
9. Widom CS, DuMont K, Czaja SJ (2007) A prospective investigation of major depressive disorder and comorbidity in abused and neglected children grown up. Arch Gen Psychiatry 64(1):49-56. (Pubitemid 46041738)
10. McGowan PO, et al. (2009) Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat Neurosci 12(3):342-348.
11. Drury SS, et al. (2012) Telomere length and early severe social deprivation: Linking early adversity and cellular aging. Mol Psychiatry 17(7):719-727.
12. Oberlander TF, et al. (2008) Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses. Epigenetics 3(2):97-106.
13. Ressler KJ, et al. (2011) Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor. Nature 470(7335):492-497.
14. Bremner JD, Southwick SM, Johnson DR, Yehuda R, Charney DS (1993) Childhood physical abuse and combat-related posttraumatic stress disorder in Vietnam veterans. Am J Psychiatry 150(2):235-239. (Pubitemid 23046508)
15. Breslau N, Chilcoat HD, Kessler RC, Davis GC (1999) Previous exposure to trauma and PTSD effects of subsequent trauma: Results from the Detroit Area Survey of Trauma. Am J Psychiatry 156(6):902-907. (Pubitemid 29260346)
16. Cougle JR, Timpano KR, Sachs-Ericsson N, Keough ME, Riccardi CJ (2010) Examining the unique relationships between anxiety disorders and childhood physical and sexual abuse in the National Comorbidity Survey-Replication. Psychiatry Res 177(1-2):150-155.
17. Brewin CR, Andrews B, Valentine JD (2000) Meta-analysis of risk factors for posttraumatic stress disorder in trauma-exposed adults. J Consult Clin Psychol 68(5):748-766.
18. Widom CS (1999) Posttraumatic stress disorder in abused and neglected children grown up. Am J Psychiatry 156(8):1223-1229. (Pubitemid 29374883)
19. Andersen SL, Teicher MH (2008) Stress, sensitive periods and maturational events in adolescent depression. Trends Neurosci 31(4):183-191.
20. Heim C, Newport DJ, Mletzko T, Miller AH, Nemeroff CB (2008) The link between childhood trauma and depression: Insights from HPA axis studies in humans. Psychoneuroendocrinology 33(6):693-710.
21. Lupien SJ, McEwen BS, Gunnar MR, Heim C (2009) Effects of stress throughout the lifespan on the brain, behaviour and cognition. Nat Rev Neurosci 10(6):434-445.
22. Klengel T, et al. (2013) Allele-specific FKBP5 DNA demethylation mediates genechildhood trauma interactions. Nat Neurosci 16(1):33-41.
23. Brenet F, et al. (2011) DNA methylation of the first exon is tightly linked to transcriptional silencing. PLoS ONE 6(1):e14524.
24. Chuang TJ, Chen FC, Chen YZ (2012) Position-dependent correlations between DNA methylation and the evolutionary rates of mammalian coding exons. Proc Natl Acad Sci USA 109(39):15841-15846.
25. Davies MN, et al. (2012) Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood. Genome Biol 13(6):R43.
26. Gunnar M, Quevedo K (2007) The neurobiology of stress and development. Annu Rev Psychol 58:145-173.
27. Sommershof A, et al. (2009) Substantial reduction of naïve and regulatory T cells following traumatic stress. Brain Behav Immun 23(8):1117-1124.
28. Provençal N, et al. (2012) The signature of maternal rearing in the methylome in rhesus macaque prefrontal cortex and T cells. J Neurosci 32(44):15626-15642.
29. Labonté B, et al. (2012) Genome-wide epigenetic regulation by early-life trauma. Arch Gen Psychiatry 69(7):722-731.
30. SmithAK, et al. (2011) Differentialimmune systemDNAmethylation and cytokine regulation in post-traumatic stress disorder.AmJMedGenet B NeuropsychiatrGenet 156B(6):700-708.
31. Uddin M, et al. (2010) Epigenetic and immune function profiles associated with posttraumatic stress disorder. Proc Natl Acad Sci USA 107(20):9470-9475.
32. Lee RS, et al. (2011) A measure of glucocorticoid load provided by DNA methylation of Fkbp5 in mice. Psychopharmacology (Berl) 218(1):303-312.
33. Gillespie CF, et al. (2009) Trauma exposure and stress-related disorders in inner city primary care patients. Gen Hosp Psychiatry 31(6):505-514.
34. Mehta D, et al. (2011) Using polymorphisms in FKBP5 to define biologically distinct subtypes of posttraumatic stress disorder: Evidence from endocrine and gene expression studies. Arch Gen Psychiatry 68(9):901-910.
35. Foa EB, Tolin DF (2000) Comparison of the PTSD symptom scale-interview version and the clinician-administered PTSD scale. J Trauma Stress 13(2):181-191. (Pubitemid 30333790)
36. Jovanovic T, et al. (2010) Impaired fear inhibition is a biomarker of PTSD but not depression. Depress Anxiety 27(3):244-251.
37. Blake DD, et al. (1990) A clinician rating scale for assessing current and lifetime PTSD: The CAPS-1. Behav Therapist 13:187-188.
38. Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J (1961) An inventory for measuring depression. Arch Gen Psychiatry 4:561-571.
39. Bernstein DP, et al. (2003) Development and validation of a brief screening version of the Childhood Trauma Questionnaire. Child Abuse Negl 27(2):169-190. (Pubitemid 36293325)
40. Bradley RG, et al. (2008) Influence of child abuse on adult depression: Moderation by the corticotropin-releasing hormone receptor gene. Arch Gen Psychiatry 65(2):190-200. (Pubitemid 351214318)
41. Hovens JE, Bramsen I, van der Ploeg HM, Reuling IE (2000) Test-retest reliability of the trauma and life events self-report inventory. Psychol Rep 87(3 Pt 1):750-752.
42. Huber W, von Heydebreck A, Sültmann H, Poustka A, Vingron M (2002) Variance stabilization applied to microarray data calibration and to the quantification of differential expression. Bioinformatics 18(Suppl 1):S96-S104. (Pubitemid 41185642)
43. Johnson WE, Li C, Rabinovic A (2007) Adjusting batch effects in microarray expression data using empirical Bayes methods. Biostatistics 8(1):118-127. (Pubitemid 44906106)
44. Dedeurwaerder S, et al. (2011) Evaluation of the Infinium Methylation 450K technology. Epigenomics 3(6):771-784.
45. Wang D, et al. (2012) IMA: An R package for high-throughput analysis of Illumina's 450K Infinium methylation data. Bioinformatics 28(5):729-730.