High fat diet enhances β-site cleavage of amyloid precursor protein (APP) via promoting β-site APP cleaving enzyme 1/adaptor protein 2/clathrin complex formation

PLoS ONE

Volumn 10, Issue 9, 2015, Pages

  Maesako, Masato ^a,f   Uemura, Maiko ^a   Tashiro, Yoshitaka ^a   Sasaki, Kazuki ^a   Watanabe, Kiwamu ^a   Noda, Yasuha ^a   Ueda, Karin ^a   Asada Utsugi, Megumi ^a   Kubota, Masakazu ^a   Okawa, Katsuya ^b   Ihara, Masafumi ^c   Shimohama, Shun ^d   Uemura, Kengo ^a,e   Kinoshita, Ayae ^a  

^a KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KYOWA HAKKO KOGYO CO LTD   (Japan)

^c NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^d SAPPORO MEDICAL UNIVERSITY   (Japan)

^e Ishiki Hospital   (Japan)

^f MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE 1; CELL SURFACE PROTEIN; CLATHRIN; APP PROTEIN, HUMAN; ASPARTIC PROTEINASE; BACE1 PROTEIN, MOUSE; FAT INTAKE; SECRETASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; BIOTINYLATION; CELL MIGRATION; CELL SURFACE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HETEROZYGOSITY; IMMUNOPRECIPITATION; INTERNALIZATION; LIPID DIET; MOUSE; NONHUMAN; OLFACTORY SYSTEM; PLASMID; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; TRANSGENIC MOUSE; ADVERSE EFFECTS; ALZHEIMER DISEASE; AMINO ACID SUBSTITUTION; ANIMAL; CHO CELL LINE; CRICETULUS; DRUG EFFECTS; FAT INTAKE; GENETICS; HAMSTER; HUMAN; METABOLISM; MISSENSE MUTATION; OBESITY; PATHOLOGY; PHARMACOLOGY; PROTEIN DEGRADATION; PROTEIN TRANSPORT;

ADAPTOR PROTEIN COMPLEX 2; ALZHEIMER DISEASE; AMINO ACID SUBSTITUTION; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; CHO CELLS; CRICETINAE; CRICETULUS; DIETARY FATS; HUMANS; MICE; MICE, TRANSGENIC; MUTATION, MISSENSE; OBESITY; PROTEIN TRANSPORT; PROTEOLYSIS;

EID: 84946904993     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0131199     Document Type: Article

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