Novel p75 neurotrophin receptor ligand stabilizes neuronal calcium, preserves mitochondrial movement and protects against HIV associated neuropathogenesis

Experimental Neurology

Volumn 275, Issue , 2016, Pages 182-198

  Meeker, Rick B ^a   Poulton, Winona ^a,c   Clary, Gillian ^a,d   Schriver, Michael ^a   Longo, Frank M ^b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Durham County Health Department   (United States)

^d CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Dementia; Encephalitis; Inflammation; LM11A 31; Nerve growth factor; Viral infection

Indexed keywords

CALCIUM; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLYCOPROTEIN GP 120; LM 11A 31; MICROTUBULE ASSOCIATED PROTEIN 2; NEUROTROPHIC FACTOR; NEUROTROPHIN RECEPTOR P75; PROTEIN KINASE B; UNCLASSIFIED DRUG; ISOLEUCINE; LM11A-31; MORPHOLINE DERIVATIVE; NERVE GROWTH FACTOR RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN INFECTION; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CELL MOTION; CONTROLLED STUDY; CYTOSKELETAL DAMAGE; DENDRITIC SWELLING; DRUG EFFECT; DRUG MECHANISM; ENZYME PHOSPHORYLATION; FEMALE; FETUS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INTRACELLULAR SIGNALING; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL MOVEMENT; NERVE CELL LESION; NERVE DEGENERATION; NEUROPATHOLOGY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; ANALOGS AND DERIVATIVES; ANIMAL; BRAIN; CELL CULTURE; CELL DEATH; DRUG EFFECTS; LONG EVANS RAT; MACROPHAGE; METABOLISM; MICROGLIA; MITOCHONDRION; MONONUCLEAR CELL; NERVE CELL; PATHOLOGY;

ANIMALS; BRAIN; CALCIUM; CELL DEATH; CELLS, CULTURED; HIV ENVELOPE PROTEIN GP120; HIV INFECTIONS; HUMANS; ISOLEUCINE; LEUKOCYTES, MONONUCLEAR; MACROPHAGES; MICROGLIA; MITOCHONDRIA; MORPHOLINES; NEURONS; RATS; RATS, LONG-EVANS; RECEPTOR, NERVE GROWTH FACTOR;

EID: 84946887711     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2015.09.012     Document Type: Article

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