Mechanistic involvement of the calpain-calpastatin system in Alzheimer neuropathology

FASEB Journal

Volumn 26, Issue 3, 2012, Pages 1204-1217

  Higuchi, Makoto ^a,b   Iwata, Nobuhisa ^a   Matsuba, Yukio ^a   Takano, Jiro ^a   Suemoto, Takahiro ^a   Maeda, Jun ^b   Ji, Bin ^b   Ono, Maiko ^c   Staufenbiel, Matthias ^c   Suhara, Tetsuya ^b   Saido, Takaomi C ^a  

^a RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^b NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^c NOVARTIS PHARMA AG   (Switzerland)

Author keywords

A ; Amyloid peptide; Amyloid precursor protein; APP; Humans; Mice

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CALPAIN; CALPASTATIN; SPECTRIN; TAU PROTEIN;

ADULT; AGED; ALZHEIMER DISEASE; AMYLOID PLAQUE; AMYLOIDOSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN DISEASE; CEREBROSPINAL FLUID; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE OVEREXPRESSION; GLIOSIS; HUMAN; MALE; MICROGLIA; MICROGLIOSIS; MOUSE; NEUROPATHOLOGY; NONHUMAN; POSTSYNAPTIC POTENTIAL; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN PHOSPHORYLATION; SOMATODENDRITIC DYSTROPHY; TRANSGENIC ANIMAL;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BRAIN; CALCIUM-BINDING PROTEINS; CALPAIN; CASPASES; ENZYME ACTIVATION; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IMMUNOBLOTTING; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MIDDLE AGED; NEURODEGENERATIVE DISEASES; PHOSPHORYLATION; PLAQUE, AMYLOID; SURVIVAL ANALYSIS; TAU PROTEINS;

MUS; MUS MUSCULUS;

EID: 84857754220     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.11-187740     Document Type: Article

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