The activation of EGFR promotes myocardial tumor necrosis factor-a production and cardiac failure in endotoxemia

Oncotarget

Volumn 6, Issue 34, 2015, Pages 35478-35495

  Sun, Xuegang ^a   Liang, Jiani ^a   Yao, Xueqing ^b   Lu, Chunhua ^a   Zhong, Tianyu ^c   Hong, Xiaoyang ^d   Wang, Xiaofei ^a   Xu, Wenjuan ^a   Gu, Miaoning ^a   Tang, Jing ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b GUANGDONG PROVINCIAL PEOPLE'S HOSPITAL   (China)

^c The Department of Laboratory Medicine   (China)

^d CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

Cardiac failure; EGFR; Pathology section; Sepsis; Tumor necrosis factor alpha

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; N [4 (3 BROMOANILINO) 6 QUINAZOLINYL]ACRYLAMIDE; NEUTRALIZING ANTIBODY; TRANSFORMING GROWTH FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME INHIBITOR; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME INHIBITOR 1; UNCLASSIFIED DRUG; EGFR PROTEIN, MOUSE; PD168393; QUINAZOLINE DERIVATIVE; TUMOR NECROSIS FACTOR;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG BLOOD LEVEL; DRUG EFFICACY; ENZYME PHOSPHORYLATION; GENE SILENCING; HEART FAILURE; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE CELL; IN VITRO STUDY; IN VIVO STUDY; LIPOPOLYSACCHARIDE-INDUCED ENDOTOXEMIA; MALE; MOUSE; NEWBORN; NONHUMAN; SEPSIS; SURVIVAL RATE; TRANSACTIVATION; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CARDIAC MUSCLE CELL; ENDOTOXEMIA; METABOLISM; PATHOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; ENDOTOXEMIA; ERLOTINIB HYDROCHLORIDE; HEART FAILURE; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED C57BL; MYOCYTES, CARDIAC; PHOSPHORYLATION; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84946865862     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.6071     Document Type: Article

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