Endotoxin-induced myocardial tumor necrosis factor-α synthesis depresses contractility of isolated rat hearts: Evidence for a role of sphingosine and cyclooxygenase-2-derived thromboxane production

Circulation

Volumn 102, Issue 22, 2000, Pages 2758-2764

  Grandel, U ^a   Fink, L ^a   Blum, A ^a   Heep, M ^a   Buerke, M ^a   Kraemer, H J ^a   Mayer, K ^a   Bohle, R M ^a   Seeger, W ^a   Grimminger, F ^a   Sibelius, U ^a  

^a Department of Internal Medicine ^*  (Germany)

Author keywords

Contractility; Heart failure; Nitric oxide; Nitric oxide synthase; Perfusion; Shock

Indexed keywords

CYCLOOXYGENASE 2; DALTROBAN; ENDOTOXIN; ETHANOLAMINE DERIVATIVE; INDOMETACIN; LIPOPOLYSACCHARIDE; MESSENGER RNA; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROSTACYCLIN; PROSTANOID; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOSINE; THROMBOXANE; THROMBOXANE A2; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA ANTIBODY;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME ACTIVATION; ENZYME INHIBITION; GENE CONTROL; HEART FAILURE; HEART MUSCLE CONTRACTILITY; HEART PERFUSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

EID: 0034727713     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.102.22.2758     Document Type: Article

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