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Volumn 130, Issue 2, 2010, Pages 481-491

The role of mitogen-activated protein kinase-activated protein kinase 2 in the p38/TNF-α pathway of systemic and cutaneous inflammation

Author keywords

[No Author keywords available]

Indexed keywords

1 FLUORO 2,4 DINITROBENZENE; 2 O TETRADECANOYLPHORBOL 13 ACETATE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ENDOTOXIN; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE P38; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 75549090082     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2009.218     Document Type: Article
Times cited : (34)

References (33)
  • 1
    • 0027082806 scopus 로고
    • Temporal infiltration of leukocyte subsets into mouse skin inflamed with phorbol ester
    • Alford JG, Stanley PL, Todderud G, Tramposch KM (1992) Temporal infiltration of leukocyte subsets into mouse skin inflamed with phorbol ester. Agents Actions 37:260-267
    • (1992) Agents Actions , vol.37 , pp. 260-267
    • Alford, J.G.1    Stanley, P.L.2    Todderud, G.3    Tramposch, K.M.4
  • 2
    • 0034610981 scopus 로고    scopus 로고
    • Deficiency of the stress kinase p38alpha results in embryonic lethality: Characterization of the kinase dependence of stress responses of enzyme-deficient embryonic stem cells
    • Allen M, Svensson L, Roach M, Hambor J, McNeish J, Gabel CA (2000) Deficiency of the stress kinase p38alpha results in embryonic lethality: characterization of the kinase dependence of stress responses of enzyme-deficient embryonic stem cells. J Exp Med 191:859-870
    • (2000) J Exp Med , vol.191 , pp. 859-870
    • Allen, M.1    Svensson, L.2    Roach, M.3    Hambor, J.4    McNeish, J.5    Gabel, C.A.6
  • 3
    • 34250181285 scopus 로고    scopus 로고
    • Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)
    • Anderson DR, Meyers MJ, Vernier WF, Mahoney MW, Kurumbail RG, Caspers N et al. (2007) Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). J Med Chem 50:2647-2654
    • (2007) J Med Chem , vol.50 , pp. 2647-2654
    • Anderson, D.R.1    Meyers, M.J.2    Vernier, W.F.3    Mahoney, M.W.4    Kurumbail, R.G.5    Caspers, N.6
  • 4
    • 0030426902 scopus 로고    scopus 로고
    • Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function
    • Badger AM, Bradbeer JN, Votta B, Lee JC, Adams JL, Griswold DE (1996) Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function. J Pharmacol Exp Ther 279:1453-1461
    • (1996) J Pharmacol Exp Ther , vol.279 , pp. 1453-1461
    • Badger, A.M.1    Bradbeer, J.N.2    Votta, B.3    Lee, J.C.4    Adams, J.L.5    Griswold, D.E.6
  • 5
    • 27744522930 scopus 로고    scopus 로고
    • Potential adverse effects associated with inhibition of p38alpha/beta MAP kinases
    • Dambach DM (2005) Potential adverse effects associated with inhibition of p38alpha/beta MAP kinases. Curr Top Med Chem 5:929-939
    • (2005) Curr Top Med Chem , vol.5 , pp. 929-939
    • Dambach, D.M.1
  • 8
    • 33244471768 scopus 로고    scopus 로고
    • MAPKAP kinases-MKs-two's company, three's a crowd
    • Gaestel M (2006) MAPKAP kinases-MKs-two's company, three's a crowd. Nat Rev Mol Cell Biol 7:120-130
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 120-130
    • Gaestel, M.1
  • 9
    • 35348907987 scopus 로고    scopus 로고
    • Protein kinases as small molecule inhibitor targets in inflammation
    • Gaestel M, Mengel A, Bothe U, Asadullah K (2007) Protein kinases as small molecule inhibitor targets in inflammation. Curr Med Chem 14:2214-2234
    • (2007) Curr Med Chem , vol.14 , pp. 2214-2234
    • Gaestel, M.1    Mengel, A.2    Bothe, U.3    Asadullah, K.4
  • 10
    • 66749134594 scopus 로고    scopus 로고
    • Targeting innate immunity protein kinase signaling in inflammtion
    • Gaestel M, Kotlyarov A, Kracht M (2009) Targeting innate immunity protein kinase signaling in inflammtion. Nat Rev Drug Discov 8:480-499
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 480-499
    • Gaestel, M.1    Kotlyarov, A.2    Kracht, M.3
  • 11
    • 34447258367 scopus 로고    scopus 로고
    • MK2 controls the level of negative feedback in the NF-kappaB pathway and is essential for vascular permeability and airway inflammation
    • Gorska MM, Liang Q, Stafford SJ, Goplen N, Dharajiya N, Guo L et al. (2007) MK2 controls the level of negative feedback in the NF-kappaB pathway and is essential for vascular permeability and airway inflammation. J Exp Med 204:1637-1652
    • (2007) J Exp Med , vol.204 , pp. 1637-1652
    • Gorska, M.M.1    Liang, Q.2    Stafford, S.J.3    Goplen, N.4    Dharajiya, N.5    Guo, L.6
  • 12
    • 34548757393 scopus 로고    scopus 로고
    • Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B
    • Grimbaldeston MA, Nakae S, Kalesnikoff J, Tsai M, Galli SJ (2007) Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B. Natu Immunol 8:1095-1104
    • (2007) Natu Immunol , vol.8 , pp. 1095-1104
    • Grimbaldeston, M.A.1    Nakae, S.2    Kalesnikoff, J.3    Tsai, M.4    Galli, S.J.5
  • 13
  • 14
    • 0031934170 scopus 로고    scopus 로고
    • Pharmacological effects of SB 220025, a selective inhibitor of P38 mitogen-activated protein kinase, in angiogenesis and chronic inflammatory disease models
    • Jackson JR, Bolognese B, Hillegass L, Kassis S, Adams J, Griswold DE et al. (1998) Pharmacological effects of SB 220025, a selective inhibitor of P38 mitogen-activated protein kinase, in angiogenesis and chronic inflammatory disease models. J Pharmacol Exp Ther 284:687-692
    • (1998) J Pharmacol Exp Ther , vol.284 , pp. 687-692
    • Jackson, J.R.1    Bolognese, B.2    Hillegass, L.3    Kassis, S.4    Adams, J.5    Griswold, D.E.6
  • 15
    • 31144468296 scopus 로고    scopus 로고
    • Protein expression of TNF-alpha in psoriatic skin is regulated at a posttranscriptional level by MAPK-activated protein kinase 2
    • Johansen C, Funding AT, Otkjaer K, Kragballe K, Jensen UB, Madsen M et al. (2006) Protein expression of TNF-alpha in psoriatic skin is regulated at a posttranscriptional level by MAPK-activated protein kinase 2. J Immunol 176:1431-1438
    • (2006) J Immunol , vol.176 , pp. 1431-1438
    • Johansen, C.1    Funding, A.T.2    Otkjaer, K.3    Kragballe, K.4    Jensen, U.B.5    Madsen, M.6
  • 17
    • 0037121941 scopus 로고    scopus 로고
    • Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's like inflammatory bowel disease
    • Kontoyiannis D, Boulougouris G, Manoloukos M, Armaka M, Apostoloki M, Pizarro T et al. (2002) Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's like inflammatory bowel disease. J Exp Med 196:1563-1574
    • (2002) J Exp Med , vol.196 , pp. 1563-1574
    • Kontoyiannis, D.1    Boulougouris, G.2    Manoloukos, M.3    Armaka, M.4    Apostoloki, M.5    Pizarro, T.6
  • 19
    • 0028605318 scopus 로고
    • A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
    • Lee JC, Laydon JT, McDonnell PC, Gallagher TF, Kumar S, Green D et al. (1994) A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 372:739-746
    • (1994) Nature , vol.372 , pp. 739-746
    • Lee, J.C.1    Laydon, J.T.2    McDonnell, P.C.3    Gallagher, T.F.4    Kumar, S.5    Green, D.6
  • 20
    • 0033118982 scopus 로고    scopus 로고
    • Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice
    • Lu HT, Yang DD, Wysk M, Gatti E, Mellman I, Davis RJ et al. (1999) Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice. EMBO J 18:1845-1857
    • (1999) EMBO J , vol.18 , pp. 1845-1857
    • Lu, H.T.1    Yang, D.D.2    Wysk, M.3    Gatti, E.4    Mellman, I.5    Davis, R.J.6
  • 21
    • 0033407594 scopus 로고    scopus 로고
    • Simple chemicals can induce maturation and apoptosis of dendritic cells
    • DOI 10.1046/j.1365-2567.1999.00916.x
    • Manome H, Aiba S, Tagami H (1999) Simple chemicals can induce maturation and apoptosis of dendritic cells. Immunology 98:481-490 (Pubitemid 30005327)
    • (1999) Immunology , vol.98 , Issue.4 , pp. 481-490
    • Manome, H.1    Aiba, S.2    Tagami, H.3
  • 22
    • 0036479125 scopus 로고    scopus 로고
    • MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels
    • Neininger A, Kontoyiannis D, Kotlyarov A, Winzen R, Eckert R, Volk HD et al. (2002) MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels. J Biol Chem 277:3065-3068
    • (2002) J Biol Chem , vol.277 , pp. 3065-3068
    • Neininger, A.1    Kontoyiannis, D.2    Kotlyarov, A.3    Winzen, R.4    Eckert, R.5    Volk, H.D.6
  • 23
    • 33645989497 scopus 로고    scopus 로고
    • T cell-and B cell-independent adaptive immunity mediated by natural killer cells
    • O'Leary JG, Goodarzi M, Drayton DL, von Andrian UH (2006) T cell-and B cell-independent adaptive immunity mediated by natural killer cells. Nat Immunol 7:507-516
    • (2006) Nat Immunol , vol.7 , pp. 507-516
    • O'Leary, J.G.1    Goodarzi, M.2    Drayton, D.L.3    Von Andrian, U.H.4
  • 25
    • 33845807361 scopus 로고    scopus 로고
    • The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK
    • Ronkina N, Kotlyarov A, Dittrich-Breiholz O, Kracht M, Hitti E, Milarski K et al. (2007) The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK. Mol Cell Biol 27:170-181
    • (2007) Mol Cell Biol , vol.27 , pp. 170-181
    • Ronkina, N.1    Kotlyarov, A.2    Dittrich-Breiholz, O.3    Kracht, M.4    Hitti, E.5    Milarski, K.6
  • 27
    • 0037114166 scopus 로고    scopus 로고
    • An aspirin-triggered lipoxin A4 stable analog displays a unique topical anti-inflammatory profile
    • Schottelius AJ, Giesen C, Asadullah K, Fierro IM, Colgan SP, Bauman J et al. (2002) An aspirin-triggered lipoxin A4 stable analog displays a unique topical anti-inflammatory profile. J Immunol 169:7063-7070
    • (2002) J Immunol , vol.169 , pp. 7063-7070
    • Schottelius, A.J.1    Giesen, C.2    Asadullah, K.3    Fierro, I.M.4    Colgan, S.P.5    Bauman, J.6
  • 29
    • 0037020247 scopus 로고    scopus 로고
    • Essential role of p38 mitogen-activated protein kinase in contact hypersensitivity
    • Takanami-Ohnishi Y, Amano S, Kimura S, Asada S, Utani A, Maruyama M et al. (2002) Essential role of p38 mitogen-activated protein kinase in contact hypersensitivity. J Biol Chem 277:37896-37903
    • (2002) J Biol Chem , vol.277 , pp. 37896-37903
    • Takanami-Ohnishi, Y.1    Amano, S.2    Kimura, S.3    Asada, S.4    Utani, A.5    Maruyama, M.6
  • 30
    • 0037113928 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 deficiency protects brain from ischemic injury in mice
    • Wang X, Xu L, Wang H, Young PR, Gaestel M, Feuerstein GZ (2002) Mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 deficiency protects brain from ischemic injury in mice. J Biol Chem 277:43968-43972
    • (2002) J Biol Chem , vol.277 , pp. 43968-43972
    • Wang, X.1    Xu, L.2    Wang, H.3    Young, P.R.4    Gaestel, M.5    Feuerstein, G.Z.6
  • 31
    • 0033616588 scopus 로고    scopus 로고
    • Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression
    • Wysk M, Yang DD, Lu HT, Flavell RA, Davis RJ (1999) Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression. Proc Natl Acad Sci USA 96:3763-3768
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 3763-3768
    • Wysk, M.1    Yang, D.D.2    Lu, H.T.3    Flavell, R.A.4    Davis, R.J.5
  • 32
    • 75549089512 scopus 로고    scopus 로고
    • Acute and chronic models of allergic contact dermatitis: Advantages and limitations
    • (Zollner T, Renz H, Asadullah K, eds). Springer Berlin, Heidelberg, New York, ISBN: 3-540-21067-9
    • Zollner T, Igney FH, Asadullah K (2004) Acute and chronic models of allergic contact dermatitis: advantages and limitations. In: Animal Models of T Cell-Mediated Skin Diseases. (Zollner T, Renz H, Asadullah K, eds). Springer Berlin, Heidelberg, New York, ISBN: 3-540-21067-9, 255-275
    • (2004) Animal Models of T Cell-Mediated Skin Diseases , pp. 255-275
    • Zollner, T.1    Igney, F.H.2    Asadullah, K.3
  • 33
    • 0036886377 scopus 로고    scopus 로고
    • A novel immunosup-pressive 1alpha,25-dihydroxyvitamin D3 analog with reduced hypercal-cemic activity
    • Zugel U, Steinmeyer A, Giesen C, Asadullah K (2002) A novel immunosup-pressive 1alpha,25-dihydroxyvitamin D3 analog with reduced hypercal-cemic activity. J Invest Dermatol 119:1434-1442
    • (2002) J Invest Dermatol , vol.119 , pp. 1434-1442
    • Zugel, U.1    Steinmeyer, A.2    Giesen, C.3    Asadullah, K.4


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