메뉴 건너뛰기




Volumn 5, Issue , 2015, Pages

Improving chemotherapeutic efficiency in acute myeloid leukemia treatments by chemically synthesized peptide interfering with CXCR4/CXCL12 axis

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CHEMOKINE RECEPTOR CXCR4; CXCL12 PROTEIN, HUMAN; CXCR4 PROTEIN, HUMAN; CYCLOPHOSPHAMIDE; STROMAL CELL DERIVED FACTOR 1; VINCRISTINE;

EID: 84946592745     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep16228     Document Type: Article
Times cited : (40)

References (56)
  • 2
    • 77956620024 scopus 로고    scopus 로고
    • Can inhibition of the SDF-1/CXCR4 axis eradicate acute leukemia
    • Tavor, S. & Petit, I. Can inhibition of the SDF-1/CXCR4 axis eradicate acute leukemia. Semin Cancer Biol. 20, 178-185 (2010).
    • (2010) Semin Cancer Biol. , vol.20 , pp. 178-185
    • Tavor, S.1    Petit, I.2
  • 3
    • 33750631842 scopus 로고    scopus 로고
    • Tumor microenvironment and drug resistance in hematologic malignancies
    • Li, Z. W. & Dalton, W. S. Tumor microenvironment and drug resistance in hematologic malignancies. Blood Rev. 20, 333-342 (2006).
    • (2006) Blood Rev. , vol.20 , pp. 333-342
    • Li, Z.W.1    Dalton, W.S.2
  • 4
    • 35948984135 scopus 로고    scopus 로고
    • Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region
    • Ishikawa, F. et al. Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region. Nat Biotechnol. 25, 1315-1321 (2007).
    • (2007) Nat Biotechnol. , vol.25 , pp. 1315-1321
    • Ishikawa, F.1
  • 5
    • 34447537778 scopus 로고    scopus 로고
    • Targeting the leukemia microenvironment
    • Konopleva, M. & Andreeff, M. Targeting the leukemia microenvironment. Curr Drug Targets. 8, 685-701 (2007).
    • (2007) Curr Drug Targets. , vol.8 , pp. 685-701
    • Konopleva, M.1    Andreeff, M.2
  • 6
    • 52049103847 scopus 로고    scopus 로고
    • The bone marrow microenvironment as a tumor sanctuary and contributor to drug resistance
    • Meads, M. B., Hazlehurst, L. A. & Dalton, W. S. The bone marrow microenvironment as a tumor sanctuary and contributor to drug resistance. Clin Cancer Res. 14, 2519-2526 (2008).
    • (2008) Clin Cancer Res. , vol.14 , pp. 2519-2526
    • Meads, M.B.1    Hazlehurst, L.A.2    Dalton, W.S.3
  • 7
    • 84871412842 scopus 로고    scopus 로고
    • A review on CXCR4/CXCL12 axis in oncology: No place to hide
    • Domanska, U. M. et al. A review on CXCR4/CXCL12 axis in oncology: no place to hide. Eur J Cancer. 49, 219-230 (2013).
    • (2013) Eur J Cancer. , vol.49 , pp. 219-230
    • Domanska, U.M.1
  • 8
    • 34247481994 scopus 로고    scopus 로고
    • The CXCR4 chemokine receptor in acute and chronic leukaemia: A marrow homing receptor and potential therapeutic target
    • Burger, J. A. & Bürkle, A. The CXCR4 chemokine receptor in acute and chronic leukaemia: a marrow homing receptor and potential therapeutic target. Br J Haematol. 137, 288-296 (2007).
    • (2007) Br J Haematol. , vol.137 , pp. 288-296
    • Burger, J.A.1    Bürkle, A.2
  • 9
    • 0036738149 scopus 로고    scopus 로고
    • Stromal cells prevent apoptosis of AML cells by up-regulation of anti-apoptotic proteins
    • Konopleva, M. et al. Stromal cells prevent apoptosis of AML cells by up-regulation of anti-apoptotic proteins. Leukemia 16, 1713-1724 (2002).
    • (2002) Leukemia , vol.16 , pp. 1713-1724
    • Konopleva, M.1
  • 10
    • 0026630954 scopus 로고
    • Bone marrow-derived stromal cells prevent apoptotic cell death in B-lineage acute lymphoblastic leukemia
    • Manabe, A., Coustan-Smith, E., Behm, F. G., Raimondi, S. C. & Campana, D. Bone marrow-derived stromal cells prevent apoptotic cell death in B-lineage acute lymphoblastic leukemia. Blood 79, 2370-2377 (1992).
    • (1992) Blood , vol.79 , pp. 2370-2377
    • Manabe, A.1    Coustan-Smith, E.2    Behm, F.G.3    Raimondi, S.C.4    Campana, D.5
  • 11
    • 0030048565 scopus 로고    scopus 로고
    • Human bone marrow stromal cells prevent apoptosis and support the survival of chronic lymphocytic leukaemia cells in vitro
    • Panayiotidis, P., Jones, D., Ganeshaguru, K., Foroni, L. & Hoffbrand, A. V. Human bone marrow stromal cells prevent apoptosis and support the survival of chronic lymphocytic leukaemia cells in vitro. Br J Haematol. 92, 97-103 (1996).
    • (1996) Br J Haematol. , vol.92 , pp. 97-103
    • Panayiotidis, P.1    Jones, D.2    Ganeshaguru, K.3    Foroni, L.4    Hoffbrand, A.V.5
  • 12
    • 79955801053 scopus 로고    scopus 로고
    • Leukemic stromal hematopoietic microenvironment negatively regulates the normal hematopoiesis in mouse model of leukemia
    • Basak, P. et al. Leukemic stromal hematopoietic microenvironment negatively regulates the normal hematopoiesis in mouse model of leukemia. Chin J Cancer. 29, 969-979 (2010).
    • (2010) Chin J Cancer. , vol.29 , pp. 969-979
    • Basak, P.1
  • 13
    • 0034667624 scopus 로고    scopus 로고
    • Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor-1
    • Burger, J. A. et al. J. Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor-1. Blood 96, 2655-2663 (2000).
    • (2000) Blood , vol.96 , pp. 2655-2663
    • Burger, J.A.1
  • 14
    • 33344464945 scopus 로고    scopus 로고
    • CXCR4: A key receptor in the crosstalk between tumor cells and their microenvironment
    • Burger, J. A. & Kipps, T. J. CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment. Blood 107, 1761-1767 (2006).
    • (2006) Blood , vol.107 , pp. 1761-1767
    • Burger, J.A.1    Kipps, T.J.2
  • 15
    • 58249100053 scopus 로고    scopus 로고
    • CXCR4 antagonists: Targeting the microenvironment in leukemia and other cancers
    • Burger, J. A. & Peled, A. CXCR4 antagonists: targeting the microenvironment in leukemia and other cancers. Leukemia 23, 43-52 (2009).
    • (2009) Leukemia , vol.23 , pp. 43-52
    • Burger, J.A.1    Peled, A.2
  • 16
    • 0038103869 scopus 로고    scopus 로고
    • Effects of inhibitors of the chemokine receptor CXCR4 on acute lymphoblastic leukemia cells in vitro
    • Juarez, J., Bradstock, K. F., Gottlieb, D. J. & Bendall, L. J. Effects of inhibitors of the chemokine receptor CXCR4 on acute lymphoblastic leukemia cells in vitro. Leukemia 17, 1294-300 (2003).
    • (2003) Leukemia , vol.17 , pp. 1294-1300
    • Juarez, J.1    Bradstock, K.F.2    Gottlieb, D.J.3    Bendall, L.J.4
  • 17
    • 67650410440 scopus 로고    scopus 로고
    • Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100
    • Nervi, B. et al. Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100. Blood 113, 6206-6214 (2009).
    • (2009) Blood , vol.113 , pp. 6206-6214
    • Nervi, B.1
  • 18
    • 84860349448 scopus 로고    scopus 로고
    • A phase 1/2 study of chemosensitization with the CXCR4 antagonist plerixafor in relapsed or refractory acute myeloid leukemia
    • Uy, G. L. et al. A phase 1/2 study of chemosensitization with the CXCR4 antagonist plerixafor in relapsed or refractory acute myeloid leukemia. Blood 119, 3917-3924 (2012).
    • (2012) Blood , vol.119 , pp. 3917-3924
    • Uy, G.L.1
  • 19
    • 67650367598 scopus 로고    scopus 로고
    • Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML
    • Zeng, Z. et al. Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML. Blood 113, 6215-6224 (2009).
    • (2009) Blood , vol.113 , pp. 6215-6224
    • Zeng, Z.1
  • 20
    • 33846254013 scopus 로고    scopus 로고
    • Inhibition of CXCR4 with the novel RCP168 peptide overcomes stroma-mediated chemoresistance in chronic and acute leukemias
    • Zeng, Z. et al. Inhibition of CXCR4 with the novel RCP168 peptide overcomes stroma-mediated chemoresistance in chronic and acute leukemias. Mol Cancer Ther. 5, 3113-3121 (2006).
    • (2006) Mol Cancer Ther. , vol.5 , pp. 3113-3121
    • Zeng, Z.1
  • 21
    • 80051787355 scopus 로고    scopus 로고
    • Combination of drug therapy in acute lymphoblastic leukemia with a CXCR4 antagonist
    • Parameswaran, R., Yu, M., Lim, M., Groffen, J. & Heisterkamp, N. Combination of drug therapy in acute lymphoblastic leukemia with a CXCR4 antagonist. Leukemia 25, 1314-1323 (2011).
    • (2011) Leukemia , vol.25 , pp. 1314-1323
    • Parameswaran, R.1    Yu, M.2    Lim, M.3    Groffen, J.4    Heisterkamp, N.5
  • 22
    • 23944488816 scopus 로고    scopus 로고
    • Small peptide inhibitors of the CXCR4 chemokine receptor (CD184) antagonize the activation, migration, and antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells
    • Burger, M. et al. Small peptide inhibitors of the CXCR4 chemokine receptor (CD184) antagonize the activation, migration, and antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells. Blood 106, 1824-1830 (2005).
    • (2005) Blood , vol.106 , pp. 1824-1830
    • Burger, M.1
  • 23
    • 34249692617 scopus 로고    scopus 로고
    • CXCR4 antagonists mobilize childhood acute lymphoblastic leukemia cells into the peripheral blood and inhibit engraftment
    • Juarez, J. et al. CXCR4 antagonists mobilize childhood acute lymphoblastic leukemia cells into the peripheral blood and inhibit engraftment. Leukemia 21, 1249-1257 (2007).
    • (2007) Leukemia , vol.21 , pp. 1249-1257
    • Juarez, J.1
  • 24
    • 84930368054 scopus 로고    scopus 로고
    • A designed peptide targeting CXCR4 displays anti-acute myelocytic leukemia activity in vitro and in vivo
    • Li, X. et al. A designed peptide targeting CXCR4 displays anti-acute myelocytic leukemia activity in vitro and in vivo. Sci Rep. 4, 6610 (2014).
    • (2014) Sci Rep. , vol.4 , pp. 6610
    • Li, X.1
  • 26
    • 33846241600 scopus 로고    scopus 로고
    • CXCR4 is a prognostic marker in acute myelogenous leukemia
    • Spoo, A. C., Lübbert, M., Wierda, W. G. & Burger, J. A. CXCR4 is a prognostic marker in acute myelogenous leukemia. Blood 109, 786-791 (2007).
    • (2007) Blood , vol.109 , pp. 786-791
    • Spoo, A.C.1    Lübbert, M.2    Wierda, W.G.3    Burger, J.A.4
  • 27
    • 84883194655 scopus 로고    scopus 로고
    • Role of CXCR4 in the pathogenesis of acute myeloid leukemia
    • Peled, A. & Tavor, S. Role of CXCR4 in the pathogenesis of acute myeloid leukemia. Theranostics 3, 34-39 (2013).
    • (2013) Theranostics , vol.3 , pp. 34-39
    • Peled, A.1    Tavor, S.2
  • 29
    • 0032845864 scopus 로고    scopus 로고
    • Selective secretion of chemoattractants for haemopoietic progenitor cells by bone marrow endothelial cells: A possible role in homing of haemopoietic progenitor cells to bone marrow
    • Imai, K. et al. Selective secretion of chemoattractants for haemopoietic progenitor cells by bone marrow endothelial cells: a possible role in homing of haemopoietic progenitor cells to bone marrow. Br J Haematol. 106, 905-911 (1999).
    • (1999) Br J Haematol. , vol.106 , pp. 905-911
    • Imai, K.1
  • 30
    • 1842483293 scopus 로고    scopus 로고
    • Chemokines and their receptors as therapeutic targets: The role of the SDF-1/CXCR4 axis
    • Juarez, J., Bendall, L. & Bradstock, K. Chemokines and their receptors as therapeutic targets: the role of the SDF-1/CXCR4 axis. Curr Pharm Des. 10, 1245-1259 (2004).
    • (2004) Curr Pharm Des. , vol.10 , pp. 1245-1259
    • Juarez, J.1    Bendall, L.2    Bradstock, K.3
  • 31
    • 0033395790 scopus 로고    scopus 로고
    • The World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues. Report of the Clinical Advisory Committee meeting, Airlie House, Virginia, November, 1997
    • Harris, N. L. et al. The World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues. Report of the Clinical Advisory Committee meeting, Airlie House, Virginia, November, 1997. Ann Oncol. 10, 1419-1432 (1999).
    • (1999) Ann Oncol. , vol.10 , pp. 1419-1432
    • Harris, N.L.1
  • 32
    • 84860767803 scopus 로고    scopus 로고
    • Inhibition of CXCR4 in CML cells disrupts their interaction with the bone marrow microenvironment and sensitizes them to nilotinib
    • Weisberg, E. et al. Inhibition of CXCR4 in CML cells disrupts their interaction with the bone marrow microenvironment and sensitizes them to nilotinib. Leukemia 26, 985-990 (2012).
    • (2012) Leukemia , vol.26 , pp. 985-990
    • Weisberg, E.1
  • 33
    • 13744255245 scopus 로고    scopus 로고
    • CXCR4 regulates migration and development of human acute myelogenous leukemia stem cells in transplanted NOD/SCID mice
    • Tavor, S. et al. CXCR4 regulates migration and development of human acute myelogenous leukemia stem cells in transplanted NOD/SCID mice. Cancer Res. 64, 2817-2824 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 2817-2824
    • Tavor, S.1
  • 34
    • 70449466602 scopus 로고    scopus 로고
    • Inhibition of the SDF-1alpha-CXCR4 axis by the CXCR4 antagonist AMD3100 suppresses the migration of cultured cells from ATL patients and murine lymphoblastoid cells from HTLV-I Tax transgenic mice
    • Kawaguchi, A. et al. Inhibition of the SDF-1alpha-CXCR4 axis by the CXCR4 antagonist AMD3100 suppresses the migration of cultured cells from ATL patients and murine lymphoblastoid cells from HTLV-I Tax transgenic mice. Blood 114, 2961-2968 (2009).
    • (2009) Blood , vol.114 , pp. 2961-2968
    • Kawaguchi, A.1
  • 35
    • 0344012474 scopus 로고    scopus 로고
    • Lipid bilayer simulations of CXCR4 with inverse agonists and weak partial agonists
    • Trent, J. O. et al. Lipid bilayer simulations of CXCR4 with inverse agonists and weak partial agonists. J Biol Chem. 278, 47136-47144 (2003).
    • (2003) J Biol Chem. , vol.278 , pp. 47136-47144
    • Trent, J.O.1
  • 36
    • 0037025357 scopus 로고    scopus 로고
    • A point mutation that confers constitutive activity to CXCR4 reveals that T140 is an inverse agonist and that AMD3100 and ALX40-4C are weak partial agonists
    • Zhang, W. B. et al. A point mutation that confers constitutive activity to CXCR4 reveals that T140 is an inverse agonist and that AMD3100 and ALX40-4C are weak partial agonists. J Biol Chem. 277, 24515-24521 (2002).
    • (2002) J Biol Chem. , vol.277 , pp. 24515-24521
    • Zhang, W.B.1
  • 37
    • 62449253981 scopus 로고    scopus 로고
    • Proof of activity with AMD11070, an orally bioavailable inhibitor of CXCR4-tropic HIV type 1
    • Moyle, G. et al. Proof of activity with AMD11070, an orally bioavailable inhibitor of CXCR4-tropic HIV type 1. Clin Infect Dis. 48, 798-805 (2009).
    • (2009) Clin Infect Dis. , vol.48 , pp. 798-805
    • Moyle, G.1
  • 38
    • 34447286192 scopus 로고    scopus 로고
    • Multiple-dose escalation study of the safety, pharmacokinetics, and biologic activity of oral AMD070, a selective CXCR4 receptor inhibitor, in human subjects
    • Stone, N. D. et al. Multiple-dose escalation study of the safety, pharmacokinetics, and biologic activity of oral AMD070, a selective CXCR4 receptor inhibitor, in human subjects. Antimicrob Agents Chemother. 51, 2351-2358 (2007).
    • (2007) Antimicrob Agents Chemother. , vol.51 , pp. 2351-2358
    • Stone, N.D.1
  • 39
    • 84923369983 scopus 로고    scopus 로고
    • Identification of LY2510924, a novel cyclic peptide CXCR4 antagonist that exhibits antitumor activities in solid tumor and breast cancer metastatic models
    • Peng, S. B. et al. Identification of LY2510924, a novel cyclic peptide CXCR4 antagonist that exhibits antitumor activities in solid tumor and breast cancer metastatic models. Mol Cancer Ther. 14, 480-490 (2015).
    • (2015) Mol Cancer Ther. , vol.14 , pp. 480-490
    • Peng, S.B.1
  • 40
    • 0037080459 scopus 로고    scopus 로고
    • Neuropsychologic impact of standard-dose systemic chemotherapy in long-term survivors of breast cancer and lymphoma
    • Ahles, T. A. et al. Neuropsychologic impact of standard-dose systemic chemotherapy in long-term survivors of breast cancer and lymphoma. J Clin Oncol. 20, 485-493 (2002).
    • (2002) J Clin Oncol. , vol.20 , pp. 485-493
    • Ahles, T.A.1
  • 41
    • 0035752985 scopus 로고    scopus 로고
    • Side effects of chemotherapy and combined chemohormonal therapy in women with early-stage breast cancer
    • Partridge, A. H., Burstein, H. J. & Winer, E. P. Side effects of chemotherapy and combined chemohormonal therapy in women with early-stage breast cancer. J Natl Cancer Inst Monogr. 30, 135-142 (2001).
    • (2001) J Natl Cancer Inst Monogr. , vol.30 , pp. 135-142
    • Partridge, A.H.1    Burstein, H.J.2    Winer, E.P.3
  • 42
    • 0032997716 scopus 로고    scopus 로고
    • Long-term survivors of childhood cancer: The late effects of therapy
    • Schwartz, C. L. Long-term survivors of childhood cancer: the late effects of therapy. Oncologist 4, 45-54 (1999).
    • (1999) Oncologist , vol.4 , pp. 45-54
    • Schwartz, C.L.1
  • 44
    • 80051758831 scopus 로고    scopus 로고
    • Agonists for the chemokine receptor CXCR4
    • Lefrançois, M. et al. Agonists for the Chemokine Receptor CXCR4. ACS Med Chem Lett. 2, 597-602 (2011).
    • (2011) ACS Med Chem Lett. , vol.2 , pp. 597-602
    • Lefrançois, M.1
  • 45
    • 0142096799 scopus 로고    scopus 로고
    • Synthesis of potent CXCR4 inhibitors possessing low cytotoxicity and improved biostability based on T140 derivatives
    • Tamamura, H. et al. Synthesis of potent CXCR4 inhibitors possessing low cytotoxicity and improved biostability based on T140 derivatives. Org Biomol Chem. 1, 3656-3662 (2003).
    • (2003) Org Biomol Chem. , vol.1 , pp. 3656-3662
    • Tamamura, H.1
  • 46
    • 0037457802 scopus 로고    scopus 로고
    • Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: An overview
    • Schinkel, A. H. & Jonker, J. W. Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview. Adv Drug Deliv Rev. 55, 3-29 (2003).
    • (2003) Adv Drug Deliv Rev. , vol.55 , pp. 3-29
    • Schinkel, A.H.1    Jonker, J.W.2
  • 47
    • 17544368685 scopus 로고    scopus 로고
    • Multidrug resistance proteins: Role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense
    • Leslie, E. M., Deeley, R. G. & Cole, S. P. Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense. Toxicol Appl Pharmacol. 204, 216-237 (2005).
    • (2005) Toxicol Appl Pharmacol. , vol.204 , pp. 216-237
    • Leslie, E.M.1    Deeley, R.G.2    Cole, S.P.3
  • 48
    • 61449258247 scopus 로고    scopus 로고
    • Naringenin enhances the anti-tumor effect of doxorubicin through selectively inhibiting the activity of multidrug resistance-associated proteins but not P-glycoprotein
    • Zhang, F. Y. et al. Naringenin enhances the anti-tumor effect of doxorubicin through selectively inhibiting the activity of multidrug resistance-associated proteins but not P-glycoprotein. Pharm Res. 26, 914-925 (2009).
    • (2009) Pharm Res. , vol.26 , pp. 914-925
    • Zhang, F.Y.1
  • 49
    • 79954616058 scopus 로고    scopus 로고
    • Pegylated phosphotidylethanolamine inhibiting P-glycoprotein expression and enhancing retention of doxorubicin in MCF7/ADR cells
    • Wang, J. et al. Pegylated phosphotidylethanolamine inhibiting P-glycoprotein expression and enhancing retention of doxorubicin in MCF7/ADR cells. J Pharm Sci. 100, 2267-2277 (2011).
    • (2011) J Pharm Sci. , vol.100 , pp. 2267-2277
    • Wang, J.1
  • 50
    • 78049281857 scopus 로고    scopus 로고
    • Apatinib (YN968D1) reverses multidrug resistance by inhibiting the efflux function of multiple ATP-binding cassette transporters
    • Mi, Y. J. et al. Apatinib (YN968D1) reverses multidrug resistance by inhibiting the efflux function of multiple ATP-binding cassette transporters. Cancer Res. 70, 7981-7991 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 7981-7991
    • Mi, Y.J.1
  • 51
    • 0035282432 scopus 로고    scopus 로고
    • Involvement of chemokine receptors in breast cancer metastasis
    • Müller, A. et al. Involvement of chemokine receptors in breast cancer metastasis. Nature 410, 50-56 (2001).
    • (2001) Nature , vol.410 , pp. 50-56
    • Müller, A.1
  • 52
    • 0345687920 scopus 로고    scopus 로고
    • Functional expression of CXCR4 (CD184) on small-cell lung cancer cells mediates migration, integrin activation, and adhesion to stromal cells
    • Burger, M. et al. Functional expression of CXCR4 (CD184) on small-cell lung cancer cells mediates migration, integrin activation, and adhesion to stromal cells. Oncogene 22, 8093-8101 (2003).
    • (2003) Oncogene , vol.22 , pp. 8093-8101
    • Burger, M.1
  • 53
    • 0036830045 scopus 로고    scopus 로고
    • Regulation of cellular proliferation, cytoskeletal function, and signal transduction through CXCR4 and c-kit in small cell lung cancer cells
    • Kijima, T. et al. Regulation of cellular proliferation, cytoskeletal function, and signal transduction through CXCR4 and c-Kit in small cell lung cancer cells. Cancer Res. 62, 6304-6311 (2002).
    • (2002) Cancer Res. , vol.62 , pp. 6304-6311
    • Kijima, T.1
  • 54
    • 20144389833 scopus 로고    scopus 로고
    • Expression of CXCR4 predicts poor prognosis in patients with malignant melanoma
    • Scala, S. et al. Expression of CXCR4 predicts poor prognosis in patients with malignant melanoma. Clin Cancer Res. 11, 1835-1841 (2005).
    • (2005) Clin Cancer Res. , vol.11 , pp. 1835-1841
    • Scala, S.1
  • 55
    • 24344436325 scopus 로고    scopus 로고
    • Diverse signaling pathways through the SDF-1/CXCR4 chemokine axis in prostate cancer cell lines leads to altered patterns of cytokine secretion and angiogenesis
    • Wang, J. et al. Diverse signaling pathways through the SDF-1/CXCR4 chemokine axis in prostate cancer cell lines leads to altered patterns of cytokine secretion and angiogenesis. Cell Signal. 17, 1578-1592 (2005).
    • (2005) Cell Signal. , vol.17 , pp. 1578-1592
    • Wang, J.1
  • 56
    • 0037108923 scopus 로고    scopus 로고
    • Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer
    • Scotton, C. J. et al. Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer. Cancer Res. 62, 5930-5938 (2002).
    • (2002) Cancer Res. , vol.62 , pp. 5930-5938
    • Scotton, C.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.