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Volumn 25, Issue 8, 2011, Pages 1314-1323

Combination of drug therapy in acute lymphoblastic leukemia with a CXCR4 antagonist

Author keywords

AMD11070; AMD3100; leukemia cell mobilization; Ph ALL; SDF 1 ; stromal co culture

Indexed keywords

8 [(4 AMINOBUTYL)(2 BENZIMIDAZOLYLMETHYL)AMINO] 1,2,3,4 TETRAHYDROQUINOLINE; CD19 ANTIBODY; CHEMOKINE RECEPTOR CXCR4 ANTAGONIST; NILOTINIB; PLERIXAFOR; STROMAL CELL DERIVED FACTOR 1; VINCRISTINE;

EID: 80051787355     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2011.76     Document Type: Article
Times cited : (63)

References (50)
  • 3
    • 0027497571 scopus 로고
    • Treatment of late bone marrow relapse in children with acute lymphoblastic leukemia: A Pediatric Oncology Group study
    • Sadowitz PD, Smith SD, Shuster J, Wharam MD, Buchanan GR, Rivera GK. Treatment of late bone marrow relapse in children with acute lymphoblastic leukemia: a Pediatric Oncology Group study. Blood 1993;81:602-609. (Pubitemid 23040849)
    • (1993) Blood , vol.81 , Issue.3 , pp. 602-609
    • Sadowitz, P.D.1    Smith, S.D.2    Shuster, J.3    Wharam, M.D.4    Buchanan, G.R.5    Rivera, G.K.6
  • 4
    • 30444437486 scopus 로고    scopus 로고
    • Treatment of acute lymphoblastic leukemia
    • DOI 10.1056/NEJMra052603
    • Pui CH, Evans WE. Treatment of acute lymphoblastic leukemia. N Engl J Med 2006;354:166-178. (Pubitemid 43076714)
    • (2006) New England Journal of Medicine , vol.354 , Issue.2 , pp. 166-178
    • Pui, C.-H.1    Evans, W.E.2
  • 5
    • 33644798329 scopus 로고    scopus 로고
    • Childhood acute lymphoblastic leukaemia and relapse
    • DOI 10.1111/j.1365-2141.2005.05773.x
    • Gaynon PS. Childhood acute lymphoblastic leukaemia and relapse. Br J Haematol 2005;131:579-587. (Pubitemid 43903802)
    • (2005) British Journal of Haematology , vol.131 , Issue.5 , pp. 579-587
    • Gaynon, P.S.1
  • 7
    • 0035810142 scopus 로고    scopus 로고
    • Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome
    • DOI 10.1056/NEJM200104053441402
    • Druker BJ, Sawyers CL, Kantarjian H, Resta DJ, Reese SF, Ford JM et al. Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N Engl J Med 2001;344:1038-1042. (Pubitemid 32267973)
    • (2001) New England Journal of Medicine , vol.344 , Issue.14 , pp. 1038-1042
    • Druker, B.J.1    Sawyers, C.L.2    Kantarjian, H.3    Resta, D.J.4    Reese, S.F.5    Ford, J.M.6    Capdeville, R.7    Talpaz, M.8
  • 8
    • 33644845081 scopus 로고    scopus 로고
    • Microenvironmental niches in the bone marrow required for B-cell development
    • DOI 10.1038/nri1780, PII N1780
    • Nagasawa T. Microenvironmental niches in the bone marrow required for B-cell development. Nat Rev 2006;2:107-116. (Pubitemid 43361586)
    • (2006) Nature Reviews Immunology , vol.6 , Issue.2 , pp. 107-116
    • Nagasawa, T.1
  • 9
    • 0029948610 scopus 로고    scopus 로고
    • Long-term survival and proliferation of precursor-B acute lymphoblastic leukemia cells on human bone marrow stroma
    • Bradstock K, Bianchi A, Makrynikola V, Filshie R, Gottlieb D. Long-term survival and proliferation of precursor-B acute lymphoblastic leukemia cells on human bone marrow stroma. Leukemia 1996;10:813-820. (Pubitemid 26168398)
    • (1996) Leukemia , vol.10 , Issue.5 , pp. 813-820
    • Bradstock, K.1    Bianchi, A.2    Makrynikola, V.3    Filshie, R.4    Gottlieb, D.5
  • 10
    • 0034093830 scopus 로고    scopus 로고
    • Effects of the chemokine stromal cell-derived factor-1 on the migration and localization of precursor-B acute lymphoblastic leukemia cells within bone marrow stromal layers
    • Bradstock KF, Makrynikola V, Bianchi A, Shen W, Hewson J, Gottlieb DJ. Effects of the chemokine stromal cell-derived factor-1 on the migration and localization of precursor-B acute lymphoblastic leukemia cells within bone marrow stromal layers. Leukemia 2000;14:882-888. (Pubitemid 30235067)
    • (2000) Leukemia , vol.14 , Issue.5 , pp. 882-888
    • Bradstock, K.F.1    Makrynikola, V.2    Bianchi, A.3    Shen, W.4    Hewson, J.5    Gottlieb, D.J.6
  • 11
    • 33744913814 scopus 로고    scopus 로고
    • Resistance to imatinib of Bcr/Abl P190 lymphoblastic leukemia cells
    • DOI 10.1158/0008-5472.CAN-05-3058
    • Mishra S, Zhang B, Cunnick JM, Heisterkamp N, Groffen J. Resistance to imatinib of bcr/abl p190 lymphoblastic leukemia cells. Cancer Res 2006;66:5387-5393. (Pubitemid 43844965)
    • (2006) Cancer Research , vol.66 , Issue.10 , pp. 5387-5393
    • Mishra, S.1    Zhang, B.2    Cunnick, J.M.3    Heisterkamp, N.4    Groffen, J.5
  • 12
    • 0034667624 scopus 로고    scopus 로고
    • Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor-1
    • Burger JA, Tsukada N, Burger M, Zvaifler NJ, Dell'Aquila M, Kipps TJ. Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor-1. Blood 2000;96:2655-2663.
    • (2000) Blood , vol.96 , pp. 2655-2663
    • Burger, J.A.1    Tsukada, N.2    Burger, M.3    Zvaifler, N.J.4    Dell'Aquila, M.5    Kipps, T.J.6
  • 13
    • 0027954624 scopus 로고
    • Adhesion-dependent survival of normal and leukemic human B lymphoblasts on bone marrow stromal cells
    • Manabe A, Murti KG, Coustan-Smith E, Kumagai M, Behm FG, Raimondi SC et al. Adhesion-dependent survival of normal and leukemic human B lymphoblasts on bone marrow stromal cells. Blood 1994;83:758-766. (Pubitemid 24043737)
    • (1994) Blood , vol.83 , Issue.3 , pp. 758-766
    • Manabe, A.1    Murti, K.G.2    Coustan-Smith, E.3    Kumagai, M.-A.4    Behm, F.G.5    Raimondi, S.C.6    Campana, D.7
  • 14
    • 0033647496 scopus 로고    scopus 로고
    • Induction of the chemokine stromal-derived factor-1 following DNA damage improves human stem cell function
    • Ponomaryov T, Peled A, Petit I, Taichman RS, Habler L, Sandbank J et al. Induction of the chemokine stromal-derived factor-1 following DNA damage improves human stem cell function. J Clin Invest 2000;106:1331-1339.
    • (2000) J Clin Invest , vol.106 , pp. 1331-1339
    • Ponomaryov, T.1    Peled, A.2    Petit, I.3    Taichman, R.S.4    Habler, L.5    Sandbank, J.6
  • 18
    • 0242668752 scopus 로고    scopus 로고
    • A role of CXC chemokine ligand 12/stromal cell-derived factor-1/pre-B cell growth stimulating factor and its receptor CXCR4 in fetal and adult T cell development in vivo
    • Ara T, Itoi M, Kawabata K, Egawa T, Tokoyoda K, Sugiyama T et al. A role of CXC chemokine ligand 12/stromal cell-derived factor-1/pre-B cell growth stimulating factor and its receptor CXCR4 in fetal and adult T cell development in vivo. J Immunol 2003;170:4649-4655. (Pubitemid 36519971)
    • (2003) Journal of Immunology , vol.170 , Issue.9 , pp. 4649-4655
    • Ara, T.1    Itoi, M.2    Kawabata, K.3    Egawa, T.4    Tokoyoda, K.5    Sugiyama, T.6    Fujii, N.7    Amagai, T.8    Nagasawa, T.9
  • 19
    • 65349111856 scopus 로고    scopus 로고
    • CXCR4 mediates the homing of B cell progenitor acute lymphoblastic leukaemia cells to the bone marrow via activation of p38MAPK
    • Juarez JG, Thien M, Dela Pena A, Baraz R, Bradstock KF, Bendall LJ. CXCR4 mediates the homing of B cell progenitor acute lymphoblastic leukaemia cells to the bone marrow via activation of p38MAPK. Br J Haematol 2009;145:491-499.
    • (2009) Br J Haematol , vol.145 , pp. 491-499
    • Juarez, J.G.1    Thien, M.2    Pena, A.D.3    Baraz, R.4    Bradstock, K.F.5    Bendall, L.J.6
  • 20
    • 17144384436 scopus 로고    scopus 로고
    • Defective p38 mitogen-activated protein kinase signaling impairs chemotaxic but not proliferative responses to stromal-derived factor-1α in acute lymphoblastic leukemia
    • Bendall LJ, Baraz R, Juarez J, Shen W, Bradstock KF. Defective p38 mitogen-activated protein kinase signaling impairs chemotaxic but not proliferative responses to stromal-derived factor-1alpha in acute lymphoblastic leukemia. Cancer Res 2005;65:3290-3298. (Pubitemid 40524613)
    • (2005) Cancer Research , vol.65 , Issue.8 , pp. 3290-3298
    • Bendall, L.J.1    Baraz, R.2    Juarez, J.3    Shen, W.4    Bradstock, K.F.5
  • 21
    • 1842579596 scopus 로고    scopus 로고
    • Unique SDF-1-induced activation of human precursor-B ALL cells as a result of altered CXCR4 expression and signaling
    • DOI 10.1182/blood-2003-06-1891
    • Spiegel A, Kollet O, Peled A, Abel L, Nagler A, Bielorai B et al. Unique SDF-1-induced activation of human precursor-B ALL cells as a result of altered CXCR4 expression and signaling. Blood 2004;103:2900-2907. (Pubitemid 38451658)
    • (2004) Blood , vol.103 , Issue.8 , pp. 2900-2907
    • Spiegel, A.1    Kollet, O.2    Peled, A.3    Abel, L.4    Nagler, A.5    Bielorai, B.6    Rechavi, G.7    Vormoor, J.8    Lapidot, T.9
  • 22
    • 0038103869 scopus 로고    scopus 로고
    • Effects of inhibitors of the chemokine receptor CXCR4 on acute lymphoblastic leukemia cells in vitro
    • DOI 10.1038/sj.leu.2402998
    • Juarez J, Bradstock KF, Gottlieb DJ, Bendall LJ. Effects of inhibitors of the chemokine receptor CXCR4 on acute lymphoblastic leukemia cells in vitro. Leukemia 2003;17:1294-1300. (Pubitemid 36857336)
    • (2003) Leukemia , vol.17 , Issue.7 , pp. 1294-1300
    • Juarez, J.1    Bradstock, K.F.2    Gottlieb, D.J.3    Bendall, L.J.4
  • 23
    • 70449466602 scopus 로고    scopus 로고
    • Inhibition of the SDF-1alpha-CXCR4 axis by the CXCR4 antagonist AMD3100 suppresses the migration of cultured cells from ATL patients and murine lymphoblastoid cells from HTLV-I Tax transgenic mice
    • Kawaguchi A, Orba Y, Kimura T, Iha H, Ogata M, Tsuji T et al. Inhibition of the SDF-1alpha-CXCR4 axis by the CXCR4 antagonist AMD3100 suppresses the migration of cultured cells from ATL patients and murine lymphoblastoid cells from HTLV-I Tax transgenic mice. Blood 2009;114:2961-2968.
    • (2009) Blood , vol.114 , pp. 2961-2968
    • Kawaguchi, A.1    Orba, Y.2    Kimura, T.3    Iha, H.4    Ogata, M.5    Tsuji, T.6
  • 24
    • 67650410440 scopus 로고    scopus 로고
    • Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100
    • Nervi B, Ramirez P, Rettig MP, Uy GL, Holt MS, Ritchey JK et al. Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100. Blood 2009;113:6206-6214.
    • (2009) Blood , vol.113 , pp. 6206-6214
    • Nervi, B.1    Ramirez, P.2    Rettig, M.P.3    Uy, G.L.4    Holt, M.S.5    Ritchey, J.K.6
  • 25
    • 1842509856 scopus 로고    scopus 로고
    • Rapid mobilization of CD34+ cells following administration of the CXCR4 antagonist AMD3100 to patients with multiple myeloma and non-Hodgkin's lymphoma
    • DOI 10.1200/JCO.2004.07.131
    • Devine SM, Flomenberg N, Vesole DH, Liesveld J, Weisdorf D, Badel K et al. Rapid mobilization of CD34+ cells following administration of the CXCR4 antagonist AMD3100 to patients with multiple myeloma and non-Hodgkin's lymphoma. J Clin Oncol 2004;22:1095-1102. (Pubitemid 41095043)
    • (2004) Journal of Clinical Oncology , vol.22 , Issue.6 , pp. 1095-1102
    • Devine, S.M.1    Flomenberg, N.2    Vesole, D.H.3    Liesveld, J.4    Weisdorf, D.5    Badel, K.6    Calandra, G.7    DiPersio, J.F.8
  • 26
    • 67650367598 scopus 로고    scopus 로고
    • Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML
    • Zeng Z, Shi YX, Samudio IJ, Wang RY, Ling X, Frolova O et al. Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML. Blood 2009;113:6215-6224.
    • (2009) Blood , vol.113 , pp. 6215-6224
    • Zeng, Z.1    Shi, Y.X.2    Samudio, I.J.3    Wang, R.Y.4    Ling, X.5    Frolova, O.6
  • 27
    • 57849163583 scopus 로고    scopus 로고
    • The CXCR4 antagonist AMD3100 impairs survival of human AML cells and induces their differentiation
    • Tavor S, Eisenbach M, Jacob-Hirsch J, Golan T, Petit I, Benzion K et al. The CXCR4 antagonist AMD3100 impairs survival of human AML cells and induces their differentiation. Leukemia 2008;22:2151-2158.
    • (2008) Leukemia , vol.22 , pp. 2151-2158
    • Tavor, S.1    Eisenbach, M.2    Jacob-Hirsch, J.3    Golan, T.4    Petit, I.5    Benzion, K.6
  • 29
    • 67650367598 scopus 로고    scopus 로고
    • Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML
    • Zeng Z, Shi YX, Samudio IJ, Wang RY, Ling X, Frolova O et al. Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML. Blood 2009;113:6215-6224.
    • (2009) Blood , vol.113 , pp. 6215-6224
    • Zeng, Z.1    Shi, Y.X.2    Samudio, I.J.3    Wang, R.Y.4    Ling, X.5    Frolova, O.6
  • 30
    • 0344645722 scopus 로고    scopus 로고
    • BCR/ABL gene structure and BCR stl
    • Carella AM, Daley GQ, Eaves CJ, Goldman JM, Hehlman R eds, Martin Dunitz Ltd: London, UK
    • Heisterkamp N, Groffen J. BCR/ABL gene structure and BCR stl. In: Carella AM, Daley GQ, Eaves CJ, Goldman JM, Hehlman R (eds). Chronic Myeloid Leukemia: Biology and Treatment. Martin Dunitz Ltd: London, UK, 2001, pp 3-17.
    • (2001) Chronic Myeloid Leukemia: Biology and Treatment , pp. 3-17
    • Heisterkamp, N.1    Groffen, J.2
  • 31
    • 70350755790 scopus 로고    scopus 로고
    • Plerixafor inhibits chemotaxis toward SDF-1 and CXCR4-mediated stroma contact in a dose-dependent manner resulting in increased susceptibility of BCR-ABL+ cell to Imatinib and Nilotinib
    • Dillmann F, Veldwijk MR, Laufs S, Sperandio M, Calandra G, Wenz F et al. Plerixafor inhibits chemotaxis toward SDF-1 and CXCR4-mediated stroma contact in a dose-dependent manner resulting in increased susceptibility of BCR-ABL+ cell to Imatinib and Nilotinib. Leuk Lymphoma 2009;50:1676-1686.
    • (2009) Leuk Lymphoma , vol.50 , pp. 1676-1686
    • Dillmann, F.1    Veldwijk, M.R.2    Laufs, S.3    Sperandio, M.4    Calandra, G.5    Wenz, F.6
  • 32
    • 77954215485 scopus 로고    scopus 로고
    • Bone marrow mesenchymal stromal cells non-selectively protect chronic myeloid leukemia cells from imatinib-induced apoptosis via the CXCR4/CXCL12 axis
    • Vianello F, Villanova F, Tisato V, Lymperi S, Ho KK, Gomes AR et al. Bone marrow mesenchymal stromal cells non-selectively protect chronic myeloid leukemia cells from imatinib-induced apoptosis via the CXCR4/CXCL12 axis. Haematologica 2010;95:1081-1089.
    • (2010) Haematologica , vol.95 , pp. 1081-1089
    • Vianello, F.1    Villanova, F.2    Tisato, V.3    Lymperi, S.4    Ho, K.K.5    Gomes, A.R.6
  • 34
    • 62449253981 scopus 로고    scopus 로고
    • Proof of activity with AMD11070, an orally bioavailable inhibitor of CXCR4-tropic HIV type 1
    • Moyle G, DeJesus E, Boffito M, Wong RS, Gibney C, Badel K et al. Proof of activity with AMD11070, an orally bioavailable inhibitor of CXCR4-tropic HIV type 1. Clin Infect Dis 2009;48:798-805.
    • (2009) Clin Infect Dis , vol.48 , pp. 798-805
    • Moyle, G.1    DeJesus, E.2    Boffito, M.3    Wong, R.S.4    Gibney, C.5    Badel, K.6
  • 37
    • 77953173862 scopus 로고    scopus 로고
    • A functional receptor for B-cell activating factor is expressed on human acute lymphoblastic leukemias
    • Parameswaran R, Müschen M, Kim YM, Groffen J, Heisterkamp N. A functional receptor for B-cell activating factor is expressed on human acute lymphoblastic leukemias. Cancer Res 2010;70:4346-4356.
    • (2010) Cancer Res , vol.70 , pp. 4346-4356
    • Parameswaran, R.1    Müschen, M.2    Kim, Y.M.3    Groffen, J.4    Heisterkamp, N.5
  • 38
    • 77952122462 scopus 로고    scopus 로고
    • Activity of the Aurora kinase inhibitor VX-680 against Bcr/Abl-positive acute lymphoblastic leukemias
    • Fei F, Stoddart S, Groffen J, Heisterkamp N. Activity of the Aurora kinase inhibitor VX-680 against Bcr/Abl-positive acute lymphoblastic leukemias. Mol Cancer Ther 2010;9:1318-1327.
    • (2010) Mol Cancer Ther , vol.9 , pp. 1318-1327
    • Fei, F.1    Stoddart, S.2    Groffen, J.3    Heisterkamp, N.4
  • 40
    • 0034062515 scopus 로고    scopus 로고
    • Inhibition of HIV infection by bicyclams, highly potent and specific CXCR4 antagonists
    • De Clercq E. Inhibition of HIV infection by bicyclams, highly potent and specific CXCR4 antagonists. Mol Pharmacol 2000;57:833-839. (Pubitemid 30253364)
    • (2000) Molecular Pharmacology , vol.57 , Issue.5 , pp. 833-839
    • De Clercq, E.1
  • 41
    • 0035676386 scopus 로고    scopus 로고
    • High expression of the chemokine receptor CXCR4 predicts extramedullary organ infiltration in childhood acute lymphoblastic leukaemia
    • DOI 10.1046/j.1365-2141.2001.03164.x
    • Crazzolara R, Kreczy A, Mann G, Heitger A, Eibl G, Fink FM et al. High expression of the chemokine receptor CXCR4 predicts extramedullary organ infiltration in childhood acute lymphoblastic leukaemia. Br J Haematol 2001;115:545-553. (Pubitemid 34015643)
    • (2001) British Journal of Haematology , vol.115 , Issue.3 , pp. 545-553
    • Crazzolara, R.1    Kreczy, A.2    Mann, G.3    Heitger, A.4    Eibl, G.5    Fink, F.-M.6    Mohle, R.7    Meister, B.8
  • 42
    • 57349105727 scopus 로고    scopus 로고
    • Comparison of the potential multiple binding modes of bicyclam, monocylam, and noncyclam small-molecule CXC chemokine receptor 4 inhibitors
    • Wong RS, Bodart V, Metz M, Labrecque J, Bridger G, Fricker SP. Comparison of the potential multiple binding modes of bicyclam, monocylam, and noncyclam small-molecule CXC chemokine receptor 4 inhibitors. Mol Pharmacol 2008;74:1485-1495.
    • (2008) Mol Pharmacol , vol.74 , pp. 1485-1495
    • Wong, R.S.1    Bodart, V.2    Metz, M.3    Labrecque, J.4    Bridger, G.5    Fricker, S.P.6
  • 43
    • 67349105601 scopus 로고    scopus 로고
    • A pilot study of continuous imatinib vs pulsed imatinib with or without G-CSF in CML patients who have achieved a complete cytogenetic response
    • Drummond MW, Heaney N, Kaeda J, Nicolini FE, Clark RE, Wilson G et al. A pilot study of continuous imatinib vs pulsed imatinib with or without G-CSF in CML patients who have achieved a complete cytogenetic response. Leukemia 2009;23:1199-1201.
    • (2009) Leukemia , vol.23 , pp. 1199-1201
    • Drummond, M.W.1    Heaney, N.2    Kaeda, J.3    Nicolini, F.E.4    Clark, R.E.5    Wilson, G.6
  • 44
    • 18844428327 scopus 로고    scopus 로고
    • Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
    • DOI 10.1016/j.cell.2005.02.034, PII S0092867405002370
    • Orimo A, Gupta PB, Sgroi DC, Arenzana-Seisdedos F, Delaunay T, Naeem R et al. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 2005;121:335-348. (Pubitemid 40692295)
    • (2005) Cell , vol.121 , Issue.3 , pp. 335-348
    • Orimo, A.1    Gupta, P.B.2    Sgroi, D.C.3    Arenzana-Seisdedos, F.4    Delaunay, T.5    Naeem, R.6    Carey, V.J.7    Richardson, A.L.8    Weinberg, R.A.9
  • 45
    • 0035887626 scopus 로고    scopus 로고
    • A possible role for CXCR4 and its ligand, the CXC chemokine stromal cell-derived factor-1, in the development of bone marrow metastases in neuroblastoma
    • Geminder H, Sagi-Assif O, Goldberg L, Meshel T, Rechavi G, Witz IP et al. A possible role for CXCR4 and its ligand, the CXC chemokine stromal cell-derived factor-1, in the development of bone marrow metastases in neuroblastoma. J Immunol 2001;167:4747-4757. (Pubitemid 32954357)
    • (2001) Journal of Immunology , vol.167 , Issue.8 , pp. 4747-4757
    • Geminder, H.1    Sagi-Assif, O.2    Goldberg, L.3    Meshel, T.4    Rechavi, G.5    Witz, I.P.6    Ben-Baruch, A.7
  • 46
    • 58249100053 scopus 로고    scopus 로고
    • CXCR4 antagonists: Targeting the microenvironment in leukemia and other cancers
    • Burger JA, Peled A. CXCR4 antagonists: targeting the microenvironment in leukemia and other cancers. Leukemia 2009;23:43-52.
    • (2009) Leukemia , vol.23 , pp. 43-52
    • Burger, J.A.1    Peled, A.2
  • 48
    • 0038079014 scopus 로고    scopus 로고
    • The chemokine receptor CXCR4 is required for outgrowth of colon carcinoma micrometastases
    • Zeelenberg IS, Ruuls-Van Stalle L, Roos E. The chemokine receptor CXCR4 is required for outgrowth of colon carcinoma micrometastases. Cancer Res 2003;63:3833-3839. (Pubitemid 36793074)
    • (2003) Cancer Research , vol.63 , Issue.13 , pp. 3833-3839
    • Zeelenberg, I.S.1    Ruuls-Van Stalle, L.2    Roos, E.3
  • 49
    • 33344464945 scopus 로고    scopus 로고
    • CXCR4: A key receptor in the crosstalk between tumor cells and their microenvironment
    • DOI 10.1182/blood-2005-08-3182
    • Burger JA, Kipps TJ. CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment. Blood 2006;107:1761-1767. (Pubitemid 43289351)
    • (2006) Blood , vol.107 , Issue.5 , pp. 1761-1767
    • Burger, J.A.1    Kipps, T.J.2
  • 50
    • 24344436325 scopus 로고    scopus 로고
    • Diverse signaling pathways through the SDF-1/CXCR4 chemokine axis in prostate cancer cell lines leads to altered patterns of cytokine secretion and angiogenesis
    • DOI 10.1016/j.cellsig.2005.03.022, PII S0898656805000677
    • Wang J, Wang J, Sun Y, Song W, Nor JE, Wang CY et al. Diverse signaling pathways through the SDF-1/CXCR4 chemokine axis in prostate cancer cell lines leads to altered patterns of cytokine secretion and angiogenesis. Cell Signal 2005;17:1578-1592. (Pubitemid 41253997)
    • (2005) Cellular Signalling , vol.17 , Issue.12 , pp. 1578-1592
    • Wang, J.1    Wang, J.2    Sun, Y.3    Song, W.4    Nor, J.E.5    Wang, C.Y.6    Taichman, R.S.7


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