The microtubule-associated molecular pathways may be genetically disrupted in patients with Bipolar Disorder. Insights from the molecular cascades

Journal of Affective Disorders

Volumn 190, Issue , 2016, Pages 429-438

  Drago, Antonio ^a   Crisafulli, Concetta ^b   Sidoti, Antonina ^b   Calabrò, Marco ^b   Serretti, Alessandro ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF MESSINA   (Italy)

Author keywords

Aurora; Integrin; Microtubule related process; Pathway analysis; Reelin

Indexed keywords

AURORA B KINASE; AURORA KINASE; CYTOPLASMIC POLYADENYLATION ELEMENT BINDING PROTEIN 1; DIAPHANOUS RELATED FORMIN 1; GEN LIKE DOMAIN 2 LIM AND SENESCENT CELL ANTIGEN DOMAINS 2; GLUTAMATE RECEPTOR IONO TROPIC N METHYL DEXTRO ASPARTATE 2B; HEAT SHOCK PROTEIN 90 ALPHA CLASS A MEMBER 1; INTEGRIN; LITHIUM; NCK ADAPTER PROTEIN 2; PARVIN BETA; PARVIN GAMMA; PHOSPHATIDYLINOSITOL; PHOSPHOINOSITIDE 3 KINASE REGULATORY SUBUNIT 1 ALPHA; PROTEIN; PROTEIN PHOSPHATASE 2 REGULATORY SUBUNIT B' DELTA; REELIN; RUVB LIKE AAA ATPASE 2; SNAIL FAMILY ZINC FINGER 1; TPX2 PROTEIN; TRANSFORMING ACIDIC COILED COIL CONTAINING PROTEIN 3; TUDOR DOMAIN CONTAINING 7; UNCLASSIFIED DRUG; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR; CPEB1 PROTEIN, HUMAN; NERVE CELL ADHESION MOLECULE; NERVE PROTEIN; REELIN PROTEIN; SCLEROPROTEIN; SERINE PROTEINASE; TRANSCRIPTION FACTOR;

ARTICLE; BIPOLAR DISORDER; CONTROLLED STUDY; GENE INTERACTION; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; HUMAN; MAJOR CLINICAL STUDY; MICROTUBULE; MOLECULAR MECHANICS; MOLECULAR PATHOLOGY; PHOSPHORYLATION; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; ADULT; CASE CONTROL STUDY; DRUG DATABASE; DRUG EFFECTS; FEMALE; GENETIC DATABASE; GENETIC VARIATION; GENETICS; MALE; SIGNAL TRANSDUCTION;

ADULT; BIPOLAR DISORDER; CASE-CONTROL STUDIES; CELL ADHESION MOLECULES, NEURONAL; DATABASES, GENETIC; DATABASES, PHARMACEUTICAL; EXTRACELLULAR MATRIX PROTEINS; FEMALE; GENETIC VARIATION; HUMANS; INTEGRINS; LITHIUM; MALE; MICROTUBULES; MRNA CLEAVAGE AND POLYADENYLATION FACTORS; NERVE TISSUE PROTEINS; SERINE ENDOPEPTIDASES; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 84946545906     PISSN: 01650327     EISSN: 15732517     Source Type: Journal    
DOI: 10.1016/j.jad.2015.10.016     Document Type: Article

References (75)

1. American Psychiatric Association, 2000. Diagnostic and statistical manual of mental disorders: DSM-IV-TR, Revised 4th ed.
2. American Psychiatric Association Practice guideline for the treatment of patients with bipolar disorder Am. J. Psychiatry 159 Suppl. 4 2002 1 50 Revision
3. J. Angst, and R. Sellaro Historical perspectives and natural history of bipolar disorder Biol. Psychiatry 48 6 2000 445 457
4. A.H. Assadi, G. Zhang, U. Beffert, R.S. McNeil, A.L. Renfro, S. Niu, C.C. Quattrocchi, B.A. Antalffy, M. Sheldon, D.D. Armstrong, A. Wynshaw-Boris, J. Herz, G. D'Arcangelo, and G.D. Clark Interaction of reelin signaling and Lis1 in brain development Nat. Genet. 35 3 2003 270 276 10.1038/ng1257
5. M. Berk, F. Kapczinski, A.C. Andreazza, O.M. Dean, F. Giorlando, M. Maes, M. Yucel, C.S. Gama, S. Dodd, B. Dean, P.V. Magalhaes, P. Amminger, P. McGorry, and G.S. Malhi Pathways underlying neuroprogression in bipolar disorder: focus on inflammation, oxidative stress and neurotrophic factors Neurosci. Biobehav. Rev. 35 3 2011 804 817 10.1016/j.neubiorev.2010.10.001
6. R.J. Baldessarini, and L. Tondo Does lithium treatment still work? Evidence of stable responses over three decades Arch. Gen. Psychiatry 57 2 2000 187 190
7. H.H. Bock, and J. Herz Reelin activates SRC family tyrosine kinases in neurons Curr. Biol. 13 1 2003 18 26
8. U. Beffert, G. Morfini, H.H. Bock, H. Reyna, S.T. Brady, and J. Herz Reelin-mediated signaling locally regulates protein kinase B/Akt and glycogen synthase kinase 3beta J. Biol. Chem. 277 51 2002 49958 49964 10.1074/jbc.M209205200
9. U. Beffert, E.J. Weeber, A. Durudas, S. Qiu, I. Masiulis, J.D. Sweatt, W.P. Li, G. Adelmann, M. Frotscher, R.E. Hammer, and J. Herz Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2 Neuron 47 4 2005 567 579 10.1016/j.neuron.2005.07.007
10. Core Team, R., 2014. R: A Language and Environment for Statistical Computing.
11. C. Chen, C. Zhang, L. Cheng, J.L. Reilly, J.R. Bishop, J.A. Sweeney, H.Y. Chen, E.S. Gershon, and C. Liu Correlation between DNA methylation and gene expression in the brains of patients with bipolar disorder and schizophrenia Bipolar Disord. 16 8 2014 790 799 10.1111/bdi.12255
12. T. Curran, and G. D'Arcangelo Role of reelin in the control of brain development Brain Res. Rev. 26 2-3 1998 285 294
13. Y. Chen, U. Beffert, M. Ertunc, T.S. Tang, E.T. Kavalali, I. Bezprozvanny, and J. Herz Reelin modulates NMDA receptor activity in cortical neurons J. Neurosci.: Off. J. Soc. Neurosci. 25 36 2005 8209 8216 10.1523/JNEUROSCI.1951-05.2005
14. Cytoscape-Consortium, 2001. Cytoscape. (http://cytoscape.org). (accessed 07.04.11).
15. L.W. Cheung, B.T. Hennessy, J. Li, S. Yu, A.P. Myers, B. Djordjevic, Y. Lu, K. Stemke-Hale, M.D. Dyer, F. Zhang, Z. Ju, L.C. Cantley, S.E. Scherer, H. Liang, K.H. Lu, R.R. Broaddus, and G.B. Mills High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability Cancer Discov. 1 2 2011 170 185 10.1158/2159-8290.CD-11-0039
16. A. Drago, C. Crisafulli, and A. Serretti The genetics of antipsychotic induced tremors: a genome-wide pathway analysis on the STEP-BD SCP sample Am. J. Med. Genet. B: Neuropsychiatr. Genet.: Off. Publ. Int. Soc. Psychiatr. Genet. 156B 8 2011 975 986 10.1002/ajmg.b.31245
17. J.A. Del Rio, B. Heimrich, V. Borrell, E. Forster, A. Drakew, S. Alcantara, K. Nakajima, T. Miyata, M. Ogawa, K. Mikoshiba, P. Derer, M. Frotscher, and E. Soriano A role for Cajal-Retzius cells and reelin in the development of hippocampal connections Nature 385 6611 1997 70 74 10.1038/385070a0
18. G. D'Arcangelo, R. Homayouni, L. Keshvara, D.S. Rice, M. Sheldon, and T. Curran Reelin is a ligand for lipoprotein receptors Neuron 24 2 1999 471 479
19. A. Dunaevsky, A. Tashiro, A. Majewska, C. Mason, and R. Yuste Developmental regulation of spine motility in the mammalian central nervous system Proc. Natl. Acad. Sci. U.S.A. 96 23 1999 13438 13443
20. S. Dedhar, B. Williams, and G. Hannigan Integrin-linked kinase (ILK): a regulator of integrin and growth-factor signalling Trends Cell. Biol. 9 8 1999 319 323
21. M. Delcommenne, C. Tan, V. Gray, L. Rue, J. Woodgett, and S. Dedhar Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase Proc. Natl. Acad. Sci. U.S.A. 95 19 1998 11211 11216
22. A.G. Ercan-Sencicek, S. Jambi, D. Franjic, S. Nishimura, M. Li, P. El-Fishawy, T.M. Morgan, S.J. Sanders, K. Bilguvar, M. Suri, M.H. Johnson, A.R. Gupta, Z. Yuksel, S. Mane, E. Grigorenko, M. Picciotto, A.S. Alberts, M. Gunel, N. Sestan, and M.W. State Homozygous loss of DIAPH1 is a novel cause of microcephaly in humans Eur. J. Hum. Genet. 23 2 2015 165 172 10.1038/ejhg.2014.82
23. M. Frotscher Cajal-Retzius cells, Reelin, and the formation of layers Curr. Opin. Neurobiol. 8 5 1998 570 575
24. T.D. Folsom, and S.H. Fatemi The involvement of Reelin in neurodevelopmental disorders Neuropharmacology 68 2013 122 135 10.1016/j.neuropharm.2012.08.015
25. A. Falnikar, S. Tole, M. Liu, J.S. Liu, and P.W. Baas Polarity in migrating neurons is related to a mechanism analogous to cytokinesis Curr. Biol. 23 13 2013 1215 1220 10.1016/j.cub.2013.05.027
26. M.M. Fraser, I.T. Bayazitov, S.S. Zakharenko, and S.J. Baker Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities Neuroscience 151 2 2008 476 488 10.1016/j.neuroscience.2007.10.048
27. L. Groc, D. Choquet, F.A. Stephenson, D. Verrier, O.J. Manzoni, and P. Chavis NMDA receptor surface trafficking and synaptic subunit composition are developmentally regulated by the extracellular matrix protein Reelin J. Neurosci.: Off. J. Soc. Neurosci. 27 38 2007 10165 10175 10.1523/JNEUROSCI.1772-07.2007
28. L.A. Glantz, and D.A. Lewis Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia Arch. Gen. Psychiatry 57 1 2000 65 73
29. L.J. Garey, W.Y. Ong, T.S. Patel, M. Kanani, A. Davis, A.M. Mortimer, T.R. Barnes, and S.R. Hirsch Reduced dendritic spine density on cerebral cortical pyramidal neurons in schizophrenia J. Neurol. Neurosurg. Psychiatry 65 4 1998 446 453
30. D.M. Glover, M.H. Leibowitz, D.A. McLean, and H. Parry Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles Cell 81 1 1995 95 105
31. P. Holmans Statistical methods for pathway analysis of genome-wide data for association with complex genetic traits Adv. Genet. 72 2010 141 179 10.1016/B978-0-12-380862-2.00007-2
32. Y.S. Huang, J.H. Carson, E. Barbarese, and J.D. Richter Facilitation of dendritic mRNA transport by CPEB Genes. Dev. 17 5 2003 638 653 10.1101/gad.1053003
33. T. Hiesberger, M. Trommsdorff, B.W. Howell, A. Goffinet, M.C. Mumby, J.A. Cooper, and J. Herz Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation Neuron 24 2 1999 481 489
34. J. Herz, and Y. Chen Reelin, lipoprotein receptors and synaptic plasticity Nat. Rev. Neurosci. 7 11 2006 850 859 10.1038/nrn2009
35. S. Hauf, R.W. Cole, S. LaTerra, C. Zimmer, G. Schnapp, R. Walter, A. Heckel, J. van Meel, C.L. Rieder, and J.M. Peters The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint J. Cell. Biol. 161 2 2003 281 294 10.1083/jcb.200208092
36. S. Hehlgans, M. Haase, and N. Cordes Signalling via integrins: implications for cell survival and anticancer strategies Biochim. Biophys. Acta 1775 1 2007 163 180 10.1016/j.bbcan.2006.09.001
37. G.E. Hannigan, C. Leung-Hagesteijn, L. Fitz-Gibbon, M.G. Coppolino, G. Radeva, J. Filmus, J.C. Bell, and S. Dedhar Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase Nature 379 6560 1996 91 96 10.1038/379091a0
38. C.T. Kuo, S. Zhu, S. Younger, L.Y. Jan, and Y.N. Jan Identification of E2/E3 ubiquitinating enzymes and caspase activity regulating Drosophila sensory neuron dendrite pruning Neuron 51 3 2006 283 290 10.1016/j.neuron.2006.07.014
39. M. Kinoshita Role of septin cytoskeleton in dopaminergic neurotransmission and neurodegeneration Nihon shinkei seishin yakurigaku zasshi Jpn. J. Psychopharmacol. 32 1 2012 25 29
40. M. Kutmon, T. Kelder, P. Mandaviya, C.T. Evelo, and S.L. Coort CyTargetLinker: a cytoscape app to integrate regulatory interactions in network analysis PLoS ONE 8 12 2013 e82160 10.1371/journal.pone.0082160
41. N.B. Karkanias, and R.L. Papke Lithium modulates desensitization of the glutamate receptor subtype gluR3 in Xenopus oocytes Neurosci. Lett. 277 3 1999 153 156
42. F. Karege, N. Perroud, S. Burkhardt, R. Fernandez, E. Ballmann, R. La Harpe, and A. Malafosse Alterations in phosphatidylinositol 3-kinase activity and PTEN phosphatase in the prefrontal cortex of depressed suicide victims Neuropsychobiology 63 4 2011 224 231 10.1159/000322145
43. P.H. Lee, C. O'Dushlaine, B. Thomas, and S.M. Purcell INRICH: interval-based enrichment analysis for genome-wide association studies Bioinformatics 28 13 2012 1797 1799 10.1093/bioinformatics/bts191
44. B.R. Lubbers, A.B. Smit, S. Spijker, and M.C. van den Oever Neural ECM in addiction, schizophrenia, and mood disorder Prog. Brain Res. 214 2014 263 284 10.1016/B978-0-444-63486-3.00012-8
45. H. Le-Niculescu, D.F. Levey, M. Ayalew, L. Palmer, L.M. Gavrin, N. Jain, E. Winiger, S. Bhosrekar, G. Shankar, M. Radel, E. Bellanger, H. Duckworth, K. Olesek, J. Vergo, R. Schweitzer, M. Yard, A. Ballew, A. Shekhar, G.E. Sandusky, N.J. Schork, S.M. Kurian, D.R. Salomon, and A.B. Niculescu 3rd Discovery and validation of blood biomarkers for suicidality Mol. Psychiatry 18 12 2013 1249 1264 10.1038/mp.2013.95
46. J. Marchini, and B. Howie Genotype imputation for genome-wide association studies Nat. Rev. Genet. 11 7 2010 499 511 10.1038/nrg2796
47. L. Martucci, A.H. Wong, V. De Luca, O. Likhodi, G.W. Wong, N. King, and J.L. Kennedy N-methyl-d-aspartate receptor NR2B subunit gene GRIN2B in schizophrenia and bipolar disorder: Polymorphisms and mRNA levels Schizophr. Res. 84 2-3 2006 214 221 10.1016/j.schres.2006.02.001
48. D. Martins-de-Souza, W.F. Gattaz, A. Schmitt, G. Maccarrone, E. Hunyadi-Gulyas, M.N. Eberlin, G.H. Souza, S. Marangoni, J.C. Novello, C.W. Turck, and E. Dias-Neto Proteomic analysis of dorsolateral prefrontal cortex indicates the involvement of cytoskeleton, oligodendrocyte, energy metabolism and new potential markers in schizophrenia J. Psychiatr. Res. 43 11 2009 978 986 10.1016/j.jpsychires.2008.11.006
49. T. Marumoto, S. Honda, T. Hara, M. Nitta, T. Hirota, E. Kohmura, and H. Saya Aurora-A kinase maintains the fidelity of early and late mitotic events in HeLa cells J. Biol. Chem. 278 51 2003 51786 51795 10.1074/jbc.M306275200
50. A.M. Morimoto, M.G. Tomlinson, K. Nakatani, J.B. Bolen, R.A. Roth, and R. Herbst The MMAC1 tumor suppressor phosphatase inhibits phospholipase C and integrin-linked kinase activity Oncogene 19 2 2000 200 209 10.1038/sj.onc.1203288
51. V. Napolioni, F. Lombardi, R. Sacco, P. Curatolo, B. Manzi, R. Alessandrelli, R. Militerni, C. Bravaccio, C. Lenti, M. Saccani, C. Schneider, R. Melmed, T. Pascucci, S. Puglisi-Allegra, K.L. Reichelt, F. Rousseau, P. Lewin, and A.M. Persico Family-based association study of ITGB3 in autism spectrum disorder and its endophenotypes Eur. J. Hum. Genet. 19 3 2011 353 359 10.1038/ejhg.2010.180
52. M.A. Nieto The snail superfamily of zinc-finger transcription factors Nat. Rev. Mol. Cell. Biol. 3 3 2002 155 166 10.1038/nrm757
53. G. Ovadia, and S. Shifman The genetic variation of RELN expression in schizophrenia and bipolar disorder PLoS ONE 6 5 2011 e19955 10.1371/journal.pone.0019955
54. F. Ogawa, E.L. Malavasi, D.K. Crummie, J.E. Eykelenboom, D.C. Soares, S. Mackie, D.J. Porteous, and J.K. Millar DISC1 complexes with TRAK1 and Miro1 to modulate anterograde axonal mitochondrial trafficking Hum. Mol. Genet. 23 4 2014 906 919 10.1093/hmg/ddt485
55. K. Ogawa, Y. Tanaka, T. Uruno, X. Duan, Y. Harada, F. Sanematsu, K. Yamamura, M. Terasawa, A. Nishikimi, J.F. Cote, and Y. Fukui DOCK5 functions as a key signaling adaptor that links FcepsilonRI signals to microtubule dynamics during mast cell degranulation J. Exp. Med. 211 7 2014 1407 1419 10.1084/jem.20131926
56. B. Phipson, and G.K. Smyth Permutation P-values should never be zero: calculating exact P-values when permutations are randomly drawn Stat. Appl. Genet. Mol. Biol. 9 2010 10.2202/1544-6115.1585 Article39 (1-12)
57. S. Purcell, B. Neale, K. Todd-Brown, L. Thomas, M.A. Ferreira, D. Bender, J. Maller, P. Sklar, P.I. de Bakker, M.J. Daly, and P.C. Sham PLINK: a tool set for whole-genome association and population-based linkage analyses Am. J. Hum. Genet. 81 3 2007 559 575 10.1086/519795
58. J. Poul, and M. Fait Verification of suitability of the child shoes with open heel part (author's transl)] Acta Chir. Orthop. Traumatol. Cechoslov. 42 5 1975 479 481
59. K. Probst-Schendzielorz, C. Scholl, O. Efimkina, E. Ersfeld, R. Viviani, A. Serretti, C. Fabbri, D. Gurwitz, S. Lucae, M. Ising, A.M. Paul, M.L. Lehmann, M. Steffens, C. Crisafulli, M. Calabro, F. Holsboer, and J. Stingl CHL1, ITGB3 and SLC6A4 gene expression and antidepressant drug response: results from the Munich Antidepressant Response Signature (MARS) study Pharmacogenomics 16 7 2015 689 701 10.2217/pgs.15.31
60. S. Persad, S. Attwell, V. Gray, M. Delcommenne, A. Troussard, J. Sanghera, and S. Dedhar Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells Proc. Natl. Acad. Sci. U.S.A. 97 7 2000 3207 3212 10.1073/pnas.060579697
61. S. Qiu, and E.J. Weeber Reelin signaling facilitates maturation of CA1 glutamatergic synapses J. Neurophysiol. 97 3 2007 2312 2321 10.1152/jn.00869.2006
62. R.C. Roberts, L. Xu, J.K. Roche, and B. Kirkpatrick Ultrastructural localization of reelin in the cortex in post-mortem human brain J. Comp. Neurol. 482 3 2005 294 308 10.1002/cne.20408
63. P.F. Sullivan, M.J. Daly, and M. O'Donovan Genetic architectures of psychiatric disorders: the emerging picture and its implications Nat. Rev. Genet. 13 8 2012 537 551 10.1038/nrg3240
64. A.V. Segre, D. Consortium, M. investigators, L. Groop, V.K. Mootha, M.J. Daly, and D. Altshuler Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits PLoS Genet. 6 8 2010 10.1371/journal.pgen.1001058
65. S. Suzuki, M. Mizutani, K. Suzuki, M. Yamada, M. Kojima, H. Hatanaka, and S. Koizumi Brain-derived neurotrophic factor promotes interaction of the Nck2 adaptor protein with the TrkB tyrosine kinase receptor Biochem. Biophys. Res. Commun. 294 5 2002 1087 1092 10.1016/S0006-291X(02)00606-X
66. J. Satoh, N. Kawana, and Y. Yamamoto Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases Gene Regul. Syst. Biol. 7 2013 139 152 10.4137/GRSB.S13204
67. A. Szczepankiewicz, M. Skibinska, A. Suwalska, J. Hauser, and J.K. Rybakowski No association of three GRIN2B polymorphisms with lithium response in bipolar patients Pharmacol. Rep. 61 3 2009 448 452
68. A.M. Thiess Observation on health hazards and poisonings by o-phthalodinitril zen- fur Arbeitsmedizin und Arbeitsschutz 18 10 1968 303 312
69. M. Tatsuka, H. Katayama, T. Ota, T. Tanaka, S. Odashima, F. Suzuki, and Y. Terada Multinuclearity and increased ploidy caused by overexpression of the aurora- and Ipl1-like midbody-associated protein mitotic kinase in human cancer cells Cancer Res. 58 21 1998 4811 4816
70. A. Ventruti, T.M. Kazdoba, S. Niu, and G. D'Arcangelo Reelin deficiency causes specific defects in the molecular composition of the synapses in the adult brain Neuroscience 189 2011 32 42 10.1016/j.neuroscience.2011.05.050
71. H. Wurdak, S. Zhu, K.H. Min, L. Aimone, L.L. Lairson, J. Watson, G. Chopiuk, J. Demas, B. Charette, R. Halder, E. Weerapana, B.F. Cravatt, H.T. Cline, E.C. Peters, J. Zhang, J.R. Walker, C. Wu, J. Chang, T. Tuntland, C.Y. Cho, and P.G. Schultz A small molecule accelerates neuronal differentiation in the adult rat Proc. Natl. Acad. Sci. U.S.A. 107 38 2010 16542 16547 10.1073/pnas.1010300107
72. L.A. Weiss, G. Kosova, R.J. Delahanty, L. Jiang, E.H. Cook, C. Ober, and J.S. Sutcliffe Variation in ITGB3 is associated with whole-blood serotonin level and autism susceptibility Eur. J. Hum. Genet. 14 8 2006 923 931 10.1038/sj.ejhg.5201644
73. Y.T. Yang, C.L. Wang, and L. Van Aelst DOCK7 interacts with TACC3 to regulate interkinetic nuclear migration and cortical neurogenesis Nat. Neurosci. 15 9 2012 1201 1210 10.1038/nn.3171
74. X. Yan, L. Cao, Q. Li, Y. Wu, H. Zhang, H. Saiyin, X. Liu, X. Zhang, Q. Shi, and L. Yu Aurora C is directly associated with Survivin and required for cytokinesis Genes Cells: Devoted Mol. Cell Mech. 10 6 2005 617 626 10.1111/j.1365-2443.2005.00863.x
75. Q. Zhao, R. Che, Z. Zhang, P. Wang, J. Li, Y. Li, K. Huang, W. Tang, G. Feng, K. Lindpaintner, L. He, and Y. Shi Positive association between GRIN2B gene and bipolar disorder in the Chinese Han Population Psychiatry Res. 185 1-2 2011 290 292 10.1016/j.psychres.2009.11.026