Role of septin cytoskeleton in dopaminergic neurotransmission and neurodegeneration

Japanese Journal of Neuropsychopharmacology

Volumn 32, Issue 1, 2012, Pages 25-29

  Kinoshita, Makoto ^a  

^a NAGOYA UNIVERSITY   (Japan)

Author keywords

Synuclein; Dopamine transporter; Membrane skeleton; Scaffold

Indexed keywords

ACTIN; SEPTIN;

BIPOLAR DISORDER; BRACHIAL PLEXUS NEUROPATHY; CYTOSKELETON; DOPAMINERGIC TRANSMISSION; INTERMEDIATE FILAMENT; MICROTUBULE; NERVE DEGENERATION; PARKINSON DISEASE; SCHIZOPHRENIA; SHORT SURVEY;

ALPHA-SYNUCLEIN; ANIMALS; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; HUMANS; MICE; NEURODEGENERATIVE DISEASES; PARKINSON DISEASE; SEPTINS; SYNAPTIC TRANSMISSION;

EID: 84861397066     PISSN: 13402544     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Short Survey

References (27)

1. Auluck, P. K., Caraveo, G. and Lindquist, S. (2010) α-Synuclein: Membrane interactions and toxicity in Parkinson's disease. Annu Rev Cell Dev Biol, 26: 211-233.
2. Barr, A. M., Young, C. E., Sawada, K., Trimble, W. S., Phillips, A. G. and Honer, W. G. (2004) Abnormalities of presynaptic protein CDCrel-1 in striatum of rats reared in social isolation: Relevance to neural connectivity in schizophrenia. Eur J Neurosci, 20: 303-307. (Pubitemid 38932150)
3. Choi, P., Snyder, H., Petrucelli, L., Theisler, C., Chong, M., Zhang, Y., Lim, K., Chung, K. K., Kehoe, K., D'Adamio, L., Lee, J. M., Cochran, E., Bowser, R., Dawson, T. M. and Wolozin, B. (2003) SEPT5-v2 is a parkin-binding protein. Brain Res Mol Brain Res, 117: 179-189. (Pubitemid 38366031)
4. Dong, Z., Ferger, B., Paterna, J. C., Vogel, D., Furier, S., Osinde, M., Feldon, J. and Büeler, H. (2003) Dopamine-dependent neurodegeneration in rats induced by viral vector-mediated overexpression of the parkin target protein, CDCrel-1. Proc Natl Acad Sci USA, 100: 12438-12443. (Pubitemid 37271578)
5. Giasson, B. I., Duda, J. E., Quinn, S. M., Zhang, B., Trojanowski, J. Q. and Lee, V. M. (2002) Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alphasynuclein. Neuron, 34: 521-533. (Pubitemid 34628750)
6. Hu, Q., Milenkovic, L., Jin, H., Scott, M. P., Nachury, M. V., Spiliotis, E. T. and Nelson, W. J. (2010) A septin diffusion barrier at the base of the primary cilium maintains ciliary membrane protein distribution. Science, 329: 436-439.
7. Ihara, M., Tomimoto, H., Kitayama, H., Morioka, Y., Akiguchi, I., Shibasaki, H., Noda, M. and Kinoshita, M. (2003) Association of the cytoskeletal GTP-binding protein Sept4/H5 with cytoplasmic inclusions found in Parkinson's disease and other synucleinopathies. J Biol Chem, 278: 24095-25102.
8. Ihara, M., Yamasaki, N., Hagiwara, A., Tanigaki, A., Kitano, A., Hikawa, R., Tomimoto, H., Noda, M., Takanashi, M., Mori, H., Hattori, N., Miyakawa, T. and Kinoshita, M. (2007) Sept4, a component of presynaptic scaffold and Lewy bodies, is required for the suppression of alpha-synuclein neurotoxicity. Neuron, 53: 519-533. (Pubitemid 46216751)
9. Kinoshita, M. (2006) Diversity of septin scaffolds. Curr Opin Cell Biol, 18: 54-60.
10. Kinoshita, M. (2008) Insight into septin functions from mouse models. In Russell, S.E.H., Pringle, J. and Hall, P. (Eds) The Septins. John Wiley & Sons, pp319-336.
11. Kinoshita, M., Kumar, S., Mizoguchi, A., Ide, C., Kinoshita, A., Haraguchi, T., Hiraoka, Y. and Noda, M. (1997) Nedd5, a mammalian septin, is a novel cytoskeletal component interacting with actin-based structures. Genes Dev, 11: 1535-1547. (Pubitemid 27274398)
12. Kuhlenbäumer, G., Hannibal, M. C., Nelis, E., Schumacher, A., Verpoorten, N., Meuleman, J., Watts, G. D., De Vriendt, E., Young, P., Stögbauer, F., Halfter, H., Irobi, J., Goossens, D., Del-Favero, J., Betz, B. G., Hor, H., Kuriemann, G., Bird, T. D., Airaksinen, E., Mononen, T., Serradell, A. P., Prats, J. M., Van Broeckhoven, C., De Jonghe, P., Timmerman, V., Ringelstein, E. B. and Chance, P. F. (2005) Mutations in SEPT9 cause hereditary neuralgic amyotrophy. Nat Genet, 37: 1044-1046. (Pubitemid 41486655)
13. Kusumi, A., Nakada, C., Ritchie, K., Murase, K., Suzuki, K., Murakoshi, H., Kasai, R. S., Kondo, J. and Fujiwara, T. (2005) Paradigm shift of the plasma membrane concept from the two-dimensional continuum fluid to the partitioned fluid: High-speed single-molecule tracking of membrane molecules. Annu Rev Biophys Biomol Struct, 34, 351-378. (Pubitemid 40847729)
14. Miller, R. M., Kiser, G. L., Kaysser-Kranich, T., Casaceli, C., Colla, E., Lee, M. K., Palaniappan, C. and Federoff, H. J. (2007) Wild-type and mutant alpha-synuclein induce a multi-component gene expression profile consistent with shared pathophysiology in different transgenic mouse models of PD. Exp Neurol, 204: 421-432. (Pubitemid 46343728)
15. Moran, L. B., Croisier, E., Duke, D. C., Kalaitzakis, M. E., Roncaroli, F., Deprez, M., Dexter, D. T., Pearce, R. K. and Graeber, M. B. (2007) Analysis of alpha-synuclein, dopamine and parkin pathways in neuropathologically confirmed parkinsonian nigra. Acta Neuropathol, 113: 253-263. (Pubitemid 46443561)
16. Mostowy, S., Bonazzi, M., Hamon, M. A., Tham, T. N., Mallet, A., Lelek, M., Gouin, E., Demangel, C., Brosch, R., Zimmer, C., Sartori, A., Kinoshita, M., Lecuit, M. and Cossart, P. (2010) Entrapment of intracytosolic bacteria by septin cage-like structures. Cell Host Microbe, 8: 433-444.
17. Okamoto, K., Bosch, M. and Hayashi, Y. (2009) The roles of CaMKII and F-actin in the structural plasticity of dendritic spines: A potential molecular identity of a synaptic tag? Physiology, 24: 357-366.
18. Pennington, K., Beasley, C. L., Dicker, P., Fagan, A., English, J., Pariante, C. M., Wait, R., Dunn, M. J. and Cotter, D. R. (2008) Prominent synaptic and metabolic abnormalities revealed by proteomic analysis of the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder. Mol Psychiatry, 13: 1102-1117.
19. Powell, S. B., Zhou, X. and Geyer, M. A. (2009) Prepulse inhibition and genetic mouse models of schizophrenia. Behav Brain Res, 204: 282-294.
20. Shehadeh, L., Mitsi, G., Adi, N., Bishopric, N. and Papapetropoulos, S. (2009) Expression of Lewy body protein septin 4 in postmortem brain of Parkinson's disease and control subjects. Mov Disord, 24: 204-210.
21. Shinoda, T., Ito, H., Sudo, K., Iwamoto, I., Morishita, R. and Nagata, K. (2010) Septin 14 is involved in cortical neuronal migration via interaction with Septin 4. Mol Biol Cell, 21: 1324-1334.
22. Son, J. H., Kawamata, H., Yoo, M. S., Kim, D. J., Lee, Y. K., Kim, S., Dawson, T. M., Zhang, H., Sulzer, D., Yang, L., Beal, M. F., Degiorgio, L. A., Chun, H. S., Baker, H. and Peng, C. (2005) Neurotoxicity and behavioral deficits associated with Septin 5 accumulation in dopaminergic neurons. J Neurochem, 94: 1040-1053. (Pubitemid 41170591)
23. Tanaka-Takiguchi, Y., Kinoshita, M. and Takiguchi, K. (2009) Septin-mediated uniform bracing of phospholipid membranes. Curr Biol, 19: 140-145.
24. Tooley, A. J., Gilden, J., Jacobelli, J., Beemiller, P., Trimble, W. S., Kinoshita, M. and Krummel, M. F. (2009). Amoeboid T lymphocytes require the septin cytoskeleton for cortical integrity and persistent motility. Nat Cell Biol, 11: 17-26.
25. Weirich, C. S., Erzberger, J. P. and Barrai, Y. (2008) The septin family of GTPases: Architecture and dynamics. Nat Rev Mol Cell Biol, 9: 478-489. (Pubitemid 351733401)
26. Woods, W. S., Boettcher, J. M., Zhou, D. H., Kloepper, K. D., Hartman, K. L., Ladror, D. T., Qi, Z., Rienstra, C. M. and George, J. M. (2007) Conformation-specific binding of alpha-synuclein to novel protein partners detected by phage display and NMR spectroscopy. J Biol Chem, 282: 34555-34567. (Pubitemid 350159446)
27. Zhang, Y., Gao, J., Chung, K. K., Huang, H., Dawson, V. L. and Dawson, T. M. (2000) Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1. Proc Natl Acad Sci USA, 97: 13354-13359.