Positive association between GRIN2B gene and bipolar disorder in the Chinese Han Population

Psychiatry Research

Volumn 185, Issue 1-2, 2011, Pages 290-292

  Zhao, Qian ^a   Che, Ronglin ^a   Zhang, Zhao ^a   Wang, Peng ^c   Li, Jun ^a   Li, You ^a   Huang, Ke ^a   Tang, Wei ^a   Feng, Guoyin ^d   Lindpaintner, Klaus ^f   He, Lin ^a,b,e   Shi, Yongyong ^a,b  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b Chinese Academy of Sciences   (China)

^c Wuhu No 4 People's Hospital   (China)

^d SHANGHAI MENTAL HEALTH CENTER   (China)

^e FUDAN UNIVERSITY   (China)

^f Roche China Ltd   (China)

Author keywords

Bipolar disorder; Genetic association; GRIN2B

Indexed keywords

N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B;

ADULT; ALLELIC SPECIFIC MULTIPLEX LIGATION DETECTION REACTION TECHNOLOGY; ARTICLE; BIPOLAR DISORDER; CASE CONTROL STUDY; CHINESE; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENE FUNCTION; GENE TECHNOLOGY; GENETIC ASSOCIATION; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; BIPOLAR DISORDER; CHI-SQUARE DISTRIBUTION; CHINA; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PSYCHIATRIC STATUS RATING SCALES; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 78650194942     PISSN: 01651781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.psychres.2009.11.026     Document Type: Article

References (10)

1. Abi-Saab W.M., D'Souza D.C., Moghaddam B., Krystal J.H. The NMDA antagonist model for schizophrenia: promise and pitfalls. Pharmacopsychiatry 1998, 31(Suppl 2):104-109.
2. Avramopoulos D., Lasseter V.K., Fallin M.D., Wolyniec P.S., McGrath J.A., Nestadt G., Valle D., Pulver A.E. Stage II follow-up on a linkage scan for bipolar disorder in the Ashkenazim provides suggestive evidence for chromosome 12p and the GRIN2B gene. Genetics in Medicine 2007, 9:745-751.
3. Fallin M.D., Lasseter V.K., Avramopoulos D., Nicodemus K.K., Wolyniec P.S., McGrath J.A., Steel G., Nestadt G., Liang K.Y., Huganir R.L., Valle D., Pulver A.E. Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios. American Journal of Human Genetics 2005, 77:918-936.
4. Hess S.D., Daggett L.P., Crona J., Deal C., Lu C.C., Urrutia A., Chavez-Noriega L., Ellis S.B., Johnson E.C., Velicelebi G. Cloning and functional characterization of human heteromeric N-methyl-D-aspartate receptors. The Journal of Pharmacology and Experimental Therapeutics 1996, 278:808-816.
5. Martucci L., Wong A.H., De Luca V., Likhodi O., Wong G.W., King N., Kennedy J.L. N-methyl-D-aspartate receptor NR2B subunit gene GRIN2B in schizophrenia and bipolar disorder: polymorphisms and mRNA levels. Schizophrenia Research 2006, 84:214-221.
6. Purcell S., Neale B., Todd-Brown K., Thomas L., Ferreira M.A., Bender D., Maller J., Sklar P., de Bakker P.I., Daly M.J., Sham P.C. PLINK: a tool set for whole-genome association and population-based linkage analyses. The American Journal of Human Genetics 2007, 81:559-575.
7. Schito A.M., Pizzuti A., Di Maria E., Schenone A., Ratti A., Defferrari R., Bellone E., Mancardi G.L., Ajmar F., Mandich P. mRNA distribution in adult human brain of GRIN2B, a N-methyl-D-aspartate (NMDA) receptor subunit. Neuroscience Letters 1997, 239:49-53.
8. Serretti A., Mandelli L. The genetics of bipolar disorder: genome 'hot regions', genes, new potential candidates and future directions. Mol Psychiatry 2008, 13:742-771.
9. Shi Y.Y., He L. SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci. Cell Research 2005, 15:97-98.
10. Szczepankiewicz A., Skibinska M., Rybakowski J., Leszczynska-Rodziewicz A., Tomaszewska M., Twarowska-Hauser J. Lack of association of three GRIN2B polymorphisms with bipolar disorder. World Journal of Biological Psychiatry 2008, 1-5.