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Volumn 72, Issue C, 2010, Pages 141-179

Statistical Methods for Pathway Analysis of Genome-Wide Data for Association with Complex Genetic Traits

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; BIOLOGICAL MODEL; BOOK; GENERAL ASPECTS OF DISEASE; GENETIC ASSOCIATION; GENETICS; HUMAN;

EID: 77958486255     PISSN: 00652660     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-380862-2.00007-2     Document Type: Book
Times cited : (85)

References (109)
  • 1
    • 63449107173 scopus 로고    scopus 로고
    • A general modular framework for gene set enrichment analysis
    • Ackermann M., Strimmer K. A general modular framework for gene set enrichment analysis. BMC Bioinform. 2009, 10:47.
    • (2009) BMC Bioinform. , vol.10 , pp. 47
    • Ackermann, M.1    Strimmer, K.2
  • 2
    • 29244448340 scopus 로고    scopus 로고
    • Microarray data analysis: From disarray to consolidation and consensus
    • Allison D.B., Cui X., Page G.P., Sabripour M. Microarray data analysis: From disarray to consolidation and consensus. Nat. Rev. Genet. 2006, 7:55-65.
    • (2006) Nat. Rev. Genet. , vol.7 , pp. 55-65
    • Allison, D.B.1    Cui, X.2    Page, G.P.3    Sabripour, M.4
  • 5
    • 58849112975 scopus 로고    scopus 로고
    • Pathways-based analyses of whole-genome association study data in bipolar disorder reveal genes mediating ion channel activity and synaptic neurotransmission
    • Askland K., Read C., Moore J. Pathways-based analyses of whole-genome association study data in bipolar disorder reveal genes mediating ion channel activity and synaptic neurotransmission. Hum. Genet. 2009, 125:63-79.
    • (2009) Hum. Genet. , vol.125 , pp. 63-79
    • Askland, K.1    Read, C.2    Moore, J.3
  • 8
    • 18744389489 scopus 로고    scopus 로고
    • Significance analysis of functional categories in gene expression studies: A structured permutation approach
    • Barry W.T., Nobel A.B., Wright F.A. Significance analysis of functional categories in gene expression studies: A structured permutation approach. Bioinformatics 2005, 21:1943-1949.
    • (2005) Bioinformatics , vol.21 , pp. 1943-1949
    • Barry, W.T.1    Nobel, A.B.2    Wright, F.A.3
  • 9
    • 3142665525 scopus 로고    scopus 로고
    • GOstat: Find statistically overrepresented gene ontologies within a group of genes
    • Beissbarth T., Speed T.P. GOstat: Find statistically overrepresented gene ontologies within a group of genes. Bioinformatics 2004, 20:1464-1465.
    • (2004) Bioinformatics , vol.20 , pp. 1464-1465
    • Beissbarth, T.1    Speed, T.P.2
  • 10
    • 0001677717 scopus 로고
    • Controlling the false discovery rate: A practical an powerful approach to multiple testing
    • Benjamini Y., Hochberg Y. Controlling the false discovery rate: A practical an powerful approach to multiple testing. J. R. Stat. Soc. Series B 1995, 57:289-300.
    • (1995) J. R. Stat. Soc. Series B , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 11
    • 67651033722 scopus 로고    scopus 로고
    • The novel "genomic pathway approach" to complex diseases: A reason for (over-)optimism?
    • Breitling L.P., Steyerberg E.W., Brenner H. The novel "genomic pathway approach" to complex diseases: A reason for (over-)optimism?. Epidemiology 2009, 20:500-507.
    • (2009) Epidemiology , vol.20 , pp. 500-507
    • Breitling, L.P.1    Steyerberg, E.W.2    Brenner, H.3
  • 13
    • 1042302103 scopus 로고    scopus 로고
    • Early prediction of drug metabolism and toxicity: Systems biology approach and modeling
    • Bugrim A., Nikolskaya T., Nikolsky Y. Early prediction of drug metabolism and toxicity: Systems biology approach and modeling. Drug Discov. Today 2004, 9:127-135.
    • (2004) Drug Discov. Today , vol.9 , pp. 127-135
    • Bugrim, A.1    Nikolskaya, T.2    Nikolsky, Y.3
  • 14
    • 38549174065 scopus 로고    scopus 로고
    • The Mouse Genome Database (MGD): Mouse biology and model systems
    • Mouse Genome Database Group, Database issue
    • Bult C.J., Eppig J.T., Kadin J.A., Richardson J.E., Blake J.A. The Mouse Genome Database (MGD): Mouse biology and model systems. Nucleic Acids Res. 2008, 36(Database issue):D724-D728. Mouse Genome Database Group.
    • (2008) Nucleic Acids Res. , vol.36
    • Bult, C.J.1    Eppig, J.T.2    Kadin, J.A.3    Richardson, J.E.4    Blake, J.A.5
  • 16
    • 73149103718 scopus 로고    scopus 로고
    • Prioritizing GWAS results: A review of statistical methods and recommendations for their application
    • Cantor R.M., Lange K., Sinsheimer J.S. Prioritizing GWAS results: A review of statistical methods and recommendations for their application. Am. J. Hum. Genet. 2010, 86:6-22.
    • (2010) Am. J. Hum. Genet. , vol.86 , pp. 6-22
    • Cantor, R.M.1    Lange, K.2    Sinsheimer, J.S.3
  • 18
    • 77949853541 scopus 로고    scopus 로고
    • Gene, region and pathway level analyses in whole-genome studies
    • De la Cruz O., Wen X., Ke B., Song M., Nicolae D.L. Gene, region and pathway level analyses in whole-genome studies. Genet. Epidemiol. 2010, 34:222-231.
    • (2010) Genet. Epidemiol. , vol.34 , pp. 222-231
    • De la Cruz, O.1    Wen, X.2    Ke, B.3    Song, M.4    Nicolae, D.L.5
  • 20
    • 0032714352 scopus 로고    scopus 로고
    • Genomic control for association studies
    • Devlin B., Roeder K. Genomic control for association studies. Biometrics 1999, 55:997-1004.
    • (1999) Biometrics , vol.55 , pp. 997-1004
    • Devlin, B.1    Roeder, K.2
  • 24
    • 0344826563 scopus 로고    scopus 로고
    • Rank truncated product of P-values, with application to genomewide association scans
    • Dudbridge F., Koeleman B.P. Rank truncated product of P-values, with application to genomewide association scans. Genet. Epidemiol. 2003, 25:360-366.
    • (2003) Genet. Epidemiol. , vol.25 , pp. 360-366
    • Dudbridge, F.1    Koeleman, B.P.2
  • 25
    • 4143076901 scopus 로고    scopus 로고
    • Efficient computation of significance levels for multiple associations in large studies of correlated data, including genomewide association studies
    • Dudbridge F., Koeleman B.P. Efficient computation of significance levels for multiple associations in large studies of correlated data, including genomewide association studies. Am. J. Hum. Genet. 2004, 75:424-435.
    • (2004) Am. J. Hum. Genet. , vol.75 , pp. 424-435
    • Dudbridge, F.1    Koeleman, B.P.2
  • 30
    • 2642566695 scopus 로고    scopus 로고
    • A probabilistic view of gene function
    • Fraser A.G., Marcotte E.M. A probabilistic view of gene function. Nat. Genet 2004, 36:559-564.
    • (2004) Nat. Genet , vol.36 , pp. 559-564
    • Fraser, A.G.1    Marcotte, E.M.2
  • 31
    • 69849105388 scopus 로고    scopus 로고
    • Unite and conquer: Univariate and multivariate approaches for finding differentially expressed gene sets
    • Glazko G.V., Emmert-Streib F. Unite and conquer: Univariate and multivariate approaches for finding differentially expressed gene sets. Bioinformatics 2009, 25:2348-2354.
    • (2009) Bioinformatics , vol.25 , pp. 2348-2354
    • Glazko, G.V.1    Emmert-Streib, F.2
  • 32
    • 34249663294 scopus 로고    scopus 로고
    • Analyzing gene expression data in terms of gene sets: Methodological issues
    • Goeman J.J., Bühlmann P. Analyzing gene expression data in terms of gene sets: Methodological issues. Bioinformatics 2007, 23:980-987.
    • (2007) Bioinformatics , vol.23 , pp. 980-987
    • Goeman, J.J.1    Bühlmann, P.2
  • 34
    • 36448946146 scopus 로고    scopus 로고
    • Improved detection of overrepresentation of Gene-Ontology annotations with parent child analysis
    • Grossmann S., Bauer S., Robinson P.N., Vingron M. Improved detection of overrepresentation of Gene-Ontology annotations with parent child analysis. Bioinformatics 2007, 23:3024-3031.
    • (2007) Bioinformatics , vol.23 , pp. 3024-3031
    • Grossmann, S.1    Bauer, S.2    Robinson, P.N.3    Vingron, M.4
  • 37
    • 56649097558 scopus 로고    scopus 로고
    • GSEA-SNP: Applying gene set enrichment analysis to SNP data from genome-wide association studies
    • Holden M., Deng S., Wojnowski L., Kulle B. GSEA-SNP: Applying gene set enrichment analysis to SNP data from genome-wide association studies. Bioinformatics 2008, 24:2784-2785.
    • (2008) Bioinformatics , vol.24 , pp. 2784-2785
    • Holden, M.1    Deng, S.2    Wojnowski, L.3    Kulle, B.4
  • 39
    • 68949204302 scopus 로고    scopus 로고
    • Strategies and issues in the detection of pathway enrichment in genome-wide association studies
    • Hong M.G., Pawitan Y., Magnusson P.K., Prince J.A. Strategies and issues in the detection of pathway enrichment in genome-wide association studies. Hum. Genet. 2009, 126:289-301.
    • (2009) Hum. Genet. , vol.126 , pp. 289-301
    • Hong, M.G.1    Pawitan, Y.2    Magnusson, P.K.3    Prince, J.A.4
  • 41
    • 61449172037 scopus 로고    scopus 로고
    • Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
    • Huang da W., Sherman B.T., Lempicki R.A. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat. Protoc. 2009, 4:44-57.
    • (2009) Nat. Protoc. , vol.4 , pp. 44-57
    • Huang da, W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 42
    • 58549112996 scopus 로고    scopus 로고
    • Bioinformatics enrichment tools: Paths toward the comprehensive functional analysis of large gene lists
    • Huang da W., Sherman B.T., Lempicki R.A. Bioinformatics enrichment tools: Paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res. 2009, 37:1-13.
    • (2009) Nucleic Acids Res. , vol.37 , pp. 1-13
    • Huang da, W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 43
    • 37549057612 scopus 로고    scopus 로고
    • GlobalANCOVA: Exploration and assessment of gene group effects
    • Hummel M., Meister R., Mansmann U. GlobalANCOVA: Exploration and assessment of gene group effects. Bioinformatics 2008, 24:78-85.
    • (2008) Bioinformatics , vol.24 , pp. 78-85
    • Hummel, M.1    Meister, R.2    Mansmann, U.3
  • 45
    • 79959503826 scopus 로고    scopus 로고
    • The International HapMap Project
    • International HapMap Consortium
    • The International HapMap Project. Nature 2003, 426:789-796. International HapMap Consortium.
    • (2003) Nature , vol.426 , pp. 789-796
  • 46
    • 68449086236 scopus 로고    scopus 로고
    • Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
    • International Schizophrenia Consortium
    • Purcell S.M., Wray N.R., Stone J.L., Visscher P.M., O'Donovan M.C., Sullivan P.F., Sklar P. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 2009, 460:748-752. International Schizophrenia Consortium.
    • (2009) Nature , vol.460 , pp. 748-752
    • Purcell, S.M.1    Wray, N.R.2    Stone, J.L.3    Visscher, P.M.4    O'Donovan, M.C.5    Sullivan, P.F.6    Sklar, P.7
  • 47
    • 33847324900 scopus 로고    scopus 로고
    • Extensions to gene set enrichment
    • Jiang Z., Gentleman R. Extensions to gene set enrichment. Bioinformatics 2007, 23:306-313.
    • (2007) Bioinformatics , vol.23 , pp. 306-313
    • Jiang, Z.1    Gentleman, R.2
  • 48
    • 0033982936 scopus 로고    scopus 로고
    • KEGG: Kyoto encyclopedia of genes and genomes
    • Kanehisa M., Goto S. KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 2000, 28(1):27-30.
    • (2000) Nucleic Acids Res. , vol.28 , Issue.1 , pp. 27-30
    • Kanehisa, M.1    Goto, S.2
  • 49
    • 75549090213 scopus 로고    scopus 로고
    • KEGG for representation and analysis of molecular networks involving diseases and drugs
    • Database issue
    • Kanehisa M., Goto S., Furumichi M., Tanabe M., Hirakawa M. KEGG for representation and analysis of molecular networks involving diseases and drugs. Nucleic Acids Res. 2010, 38(Database issue):D355-D360.
    • (2010) Nucleic Acids Res. , vol.38
    • Kanehisa, M.1    Goto, S.2    Furumichi, M.3    Tanabe, M.4    Hirakawa, M.5
  • 50
    • 24644470505 scopus 로고    scopus 로고
    • Ontological analysis of gene expression data: Current tools, limitations, and open problems
    • Khatri P., Drǎghici S. Ontological analysis of gene expression data: Current tools, limitations, and open problems. Bioinformatics 2005, 21:3587-3595.
    • (2005) Bioinformatics , vol.21 , pp. 3587-3595
    • Khatri, P.1    Drǎghici, S.2
  • 51
    • 0037767293 scopus 로고    scopus 로고
    • Roth FP (2003) Predicting gene function from patterns of annotation
    • King O.D., Foulger R.E., Dwight S.S., White J.V. Roth FP (2003) Predicting gene function from patterns of annotation. Genome Res. 2003, 13(5):896-904.
    • (2003) Genome Res. , vol.13 , Issue.5 , pp. 896-904
    • King, O.D.1    Foulger, R.E.2    Dwight, S.S.3    White, J.V.4
  • 52
    • 12744269194 scopus 로고    scopus 로고
    • Identifying interacting SNPs using Monte Carlo logic regression
    • Kooperberg C., Ruczinski I. Identifying interacting SNPs using Monte Carlo logic regression. Genet. Epidemiol. 2005, 28:157-170.
    • (2005) Genet. Epidemiol. , vol.28 , pp. 157-170
    • Kooperberg, C.1    Ruczinski, I.2
  • 53
    • 67651052308 scopus 로고    scopus 로고
    • Complex diseases, complex genes. Keeping pathways on the right track
    • Kraft P., Raychaudhuri S. Complex diseases, complex genes. Keeping pathways on the right track. Epidemiology 2009, 20:508-510.
    • (2009) Epidemiology , vol.20 , pp. 508-510
    • Kraft, P.1    Raychaudhuri, S.2
  • 56
    • 67649891830 scopus 로고    scopus 로고
    • Text-based over-representation analysis of microarray gene lists with annotation bias
    • Leong H.S., Kipling D. Text-based over-representation analysis of microarray gene lists with annotation bias. Nucleic Acids Res. 2009, 37:e79.
    • (2009) Nucleic Acids Res. , vol.37
    • Leong, H.S.1    Kipling, D.2
  • 58
    • 25144474547 scopus 로고    scopus 로고
    • Hotelling's T2 multivariate profiling for detecting differential expression in microarrays
    • Lu Y., Liu P.Y., Xiao P., Deng H.W. Hotelling's T2 multivariate profiling for detecting differential expression in microarrays. Bioinformatics 2005, 21:3105-3113.
    • (2005) Bioinformatics , vol.21 , pp. 3105-3113
    • Lu, Y.1    Liu, P.Y.2    Xiao, P.3    Deng, H.W.4
  • 59
    • 55549147191 scopus 로고    scopus 로고
    • Personal genomes: The case of the missing heritability
    • Maher B. Personal genomes: The case of the missing heritability. Nature 2008, 456:18-21.
    • (2008) Nature , vol.456 , pp. 18-21
    • Maher, B.1
  • 60
    • 0037304758 scopus 로고    scopus 로고
    • Weighted inverse chi-square method for correlated significance tests
    • Makambi K.H. Weighted inverse chi-square method for correlated significance tests. J. Appl. Stat. 2003, 30:225-234.
    • (2003) J. Appl. Stat. , vol.30 , pp. 225-234
    • Makambi, K.H.1
  • 61
    • 43049146524 scopus 로고    scopus 로고
    • A HapMap harvest of insights into the genetics of common disease
    • Manolio T.A., Brooks L.D., Collins F.S. A HapMap harvest of insights into the genetics of common disease. J. Clin. Invest. 2008, 118:1590-1605.
    • (2008) J. Clin. Invest. , vol.118 , pp. 1590-1605
    • Manolio, T.A.1    Brooks, L.D.2    Collins, F.S.3
  • 62
    • 34347344976 scopus 로고    scopus 로고
    • A new multipoint method for genome-wide association studies by imputation of genotypes
    • Marchini J., Howie B., Myers S., McVean G., Donnelly P. A new multipoint method for genome-wide association studies by imputation of genotypes. Nat. Genet. 2007, 39(7):906-913.
    • (2007) Nat. Genet. , vol.39 , Issue.7 , pp. 906-913
    • Marchini, J.1    Howie, B.2    Myers, S.3    McVean, G.4    Donnelly, P.5
  • 63
    • 75549084894 scopus 로고    scopus 로고
    • PANTHER version 7: improved phylogenetic trees, orthologs and collaboration with the Gene Ontology Consortium
    • Mi H., Dong Q., Muruganujan A., Gaudet P., Lewis S., Thomas P.D. PANTHER version 7: improved phylogenetic trees, orthologs and collaboration with the Gene Ontology Consortium. Nucl. Acids. Res. 2010, 38:D204-D210.
    • (2010) Nucl. Acids. Res. , vol.38
    • Mi, H.1    Dong, Q.2    Muruganujan, A.3    Gaudet, P.4    Lewis, S.5    Thomas, P.D.6
  • 68
    • 60549085927 scopus 로고    scopus 로고
    • Gene-wide analyses of genome-wide association data sets: Evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk
    • Wellcome Trust Case Control Consortium
    • Moskvina V., Craddock N., Holmans P., Nikolov I., Pahwa J.S., Green E., Owen M.J., O'Donovan M.C. Gene-wide analyses of genome-wide association data sets: Evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk. Mol. Psychiatry 2009, 14:252-260. Wellcome Trust Case Control Consortium.
    • (2009) Mol. Psychiatry , vol.14 , pp. 252-260
    • Moskvina, V.1    Craddock, N.2    Holmans, P.3    Nikolov, I.4    Pahwa, J.S.5    Green, E.6    Owen, M.J.7    O'Donovan, M.C.8
  • 69
    • 26844482093 scopus 로고    scopus 로고
    • A fine-scale map of recombination rates and hotspots across the human genome
    • Myers S., Bottolo L., Freeman C., McVean G., Donnelly P. A fine-scale map of recombination rates and hotspots across the human genome. Science 2005, 310:321-324.
    • (2005) Science , vol.310 , pp. 321-324
    • Myers, S.1    Bottolo, L.2    Freeman, C.3    McVean, G.4    Donnelly, P.5
  • 70
    • 34250305651 scopus 로고    scopus 로고
    • Random-set methods identify distinct aspects of the enrichment signal in gene-set analysis
    • Newton M.A., Quintana F.A., Den Boon J.A., Sengupta S., Ahlquist P. Random-set methods identify distinct aspects of the enrichment signal in gene-set analysis. Ann. Appl. Stat. 2007, 1:85-106.
    • (2007) Ann. Appl. Stat. , vol.1 , pp. 85-106
    • Newton, M.A.1    Quintana, F.A.2    Den Boon, J.A.3    Sengupta, S.4    Ahlquist, P.5
  • 71
    • 77951439152 scopus 로고    scopus 로고
    • Trait-associated SNPs are more likely to be eQTLs: Annotation to enhance discovery from GWAS
    • Nicolae D.L., Gamazon E., Zhang W., Duan S., Dolan M.E., Cox N.J. Trait-associated SNPs are more likely to be eQTLs: Annotation to enhance discovery from GWAS. PLoS Genet. 2010, 6:e1000888.
    • (2010) PLoS Genet. , vol.6
    • Nicolae, D.L.1    Gamazon, E.2    Zhang, W.3    Duan, S.4    Dolan, M.E.5    Cox, N.J.6
  • 72
    • 79951813475 scopus 로고    scopus 로고
    • Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility
    • The International Schizophrenia Consortium, (2010 Feb 16. [Epub ahead of print])
    • O'Dushlaine C., Kenny E., Heron E., Donohoe G., Gill M., Morris D., Corvin A. Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility. Mol. Psychiatry 2010, The International Schizophrenia Consortium, (2010 Feb 16. [Epub ahead of print]).
    • (2010) Mol. Psychiatry
    • O'Dushlaine, C.1    Kenny, E.2    Heron, E.3    Donohoe, G.4    Gill, M.5    Morris, D.6    Corvin, A.7
  • 76
    • 33746512512 scopus 로고    scopus 로고
    • Principal components analysis corrects for stratification in genome-wide association studies
    • Price A.L., Patterson N.J., Plenge R.M., Weinblatt M.E., Shadick N.A., Reich D. Principal components analysis corrects for stratification in genome-wide association studies. Nat. Genet. 2006, 38:904-909.
    • (2006) Nat. Genet. , vol.38 , pp. 904-909
    • Price, A.L.1    Patterson, N.J.2    Plenge, R.M.3    Weinblatt, M.E.4    Shadick, N.A.5    Reich, D.6
  • 77
    • 58049194158 scopus 로고    scopus 로고
    • A framework for interpreting genome-wide association studies of psychiatric disorders
    • Psychiatric GWAS Consortium Steering Committee
    • A framework for interpreting genome-wide association studies of psychiatric disorders. Mol. Psychiatry 2009, 14:10-17. Psychiatric GWAS Consortium Steering Committee.
    • (2009) Mol. Psychiatry , vol.14 , pp. 10-17
  • 79
    • 67651205715 scopus 로고    scopus 로고
    • Identifying relationships among genomic disease regions: Predicting genes at pathogenic SNP associations and rare deletions
    • International Schizophrenia Consortium
    • Raychaudhuri S., Plenge R.M., Rossin E.J., Ng A.C., Purcell S.M., Sklar P., Scolnick E.M., Xavier R.J., Altshuler D., et al. Identifying relationships among genomic disease regions: Predicting genes at pathogenic SNP associations and rare deletions. PLoS Genet. 2009, 5:e1000534. International Schizophrenia Consortium.
    • (2009) PLoS Genet. , vol.5
    • Raychaudhuri, S.1    Plenge, R.M.2    Rossin, E.J.3    Ng, A.C.4    Purcell, S.M.5    Sklar, P.6    Scolnick, E.M.7    Xavier, R.J.8    Altshuler, D.9
  • 82
    • 0034973569 scopus 로고    scopus 로고
    • Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer
    • Ritchie M.D., Hahn L.W., Roodi N., Bailey L.R., Dupont W.D., Parl F.F., Moore J.H. Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer. Am. J. Hum. Genet. 2001, 69:138-147.
    • (2001) Am. J. Hum. Genet. , vol.69 , pp. 138-147
    • Ritchie, M.D.1    Hahn, L.W.2    Roodi, N.3    Bailey, L.R.4    Dupont, W.D.5    Parl, F.F.6    Moore, J.H.7
  • 84
    • 70249134919 scopus 로고    scopus 로고
    • Molecular networks as sensors and drivers of common human diseases
    • (Review)
    • Schadt E.E. Molecular networks as sensors and drivers of common human diseases. Nature 2009, 461:218-223. (Review).
    • (2009) Nature , vol.461 , pp. 218-223
    • Schadt, E.E.1
  • 86
    • 13844262641 scopus 로고    scopus 로고
    • Rapid simulation of P values for product methods and multiple-testing adjustment in association studies
    • Seaman S.R., Müller-Myhsok B. Rapid simulation of P values for product methods and multiple-testing adjustment in association studies. Am. J. Hum. Genet. 2005, 76:399-408.
    • (2005) Am. J. Hum. Genet. , vol.76 , pp. 399-408
    • Seaman, S.R.1    Müller-Myhsok, B.2
  • 87
    • 6944244084 scopus 로고    scopus 로고
    • A module map showing conditional activity of expression modules in cancer
    • Segal E., Friedman N., Koller D., Regev A. A module map showing conditional activity of expression modules in cancer. Nat. Genet. 2004, 36:1090-1098.
    • (2004) Nat. Genet. , vol.36 , pp. 1090-1098
    • Segal, E.1    Friedman, N.2    Koller, D.3    Regev, A.4
  • 88
    • 84856043672 scopus 로고
    • A mathematical theory of communication
    • Shannon C.E. A mathematical theory of communication. Bell Syst. Tech. J. 1948, 27:623-656.
    • (1948) Bell Syst. Tech. J. , vol.27 , pp. 623-656
    • Shannon, C.E.1
  • 89
    • 38049148026 scopus 로고    scopus 로고
    • DAVID Knowledgebase: A gene-centered database integrating heterogeneous gene annotation resources to facilitate high-throughput gene functional analysis
    • Sherman B.T., Huang da W., Tan Q., Guo Y., Bour S., Liu D., Stephens R., Baseler M.W., Lane H.C., Lempicki R.A. DAVID Knowledgebase: A gene-centered database integrating heterogeneous gene annotation resources to facilitate high-throughput gene functional analysis. BMC Bioinform. 2007, 8:426.
    • (2007) BMC Bioinform. , vol.8 , pp. 426
    • Sherman, B.T.1    Huang da, W.2    Tan, Q.3    Guo, Y.4    Bour, S.5    Liu, D.6    Stephens, R.7    Baseler, M.W.8    Lane, H.C.9    Lempicki, R.A.10
  • 90
    • 67649345185 scopus 로고
    • An improved Bonferroni procedure for multiple tests of significance
    • Simes R.J. An improved Bonferroni procedure for multiple tests of significance. Biometrika 1986, 73:751-754.
    • (1986) Biometrika , vol.73 , pp. 751-754
    • Simes, R.J.1
  • 91
    • 31744435871 scopus 로고    scopus 로고
    • Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies
    • Skol A.D., Scott L.J., Abecasis G.R., Boehnke M. Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies. Nat. Genet. 2006, 38:209-213.
    • (2006) Nat. Genet. , vol.38 , pp. 209-213
    • Skol, A.D.1    Scott, L.J.2    Abecasis, G.R.3    Boehnke, M.4
  • 92
    • 0038745614 scopus 로고    scopus 로고
    • Integrating biological databases
    • Stein L.D. Integrating biological databases. Nat. Rev. Genet. 2003, 4:337-345.
    • (2003) Nat. Rev. Genet. , vol.4 , pp. 337-345
    • Stein, L.D.1
  • 96
    • 53649098737 scopus 로고    scopus 로고
    • Pathway analysis of seven common diseases assessed by genome-wide association
    • Torkamani A., Topol E.J., Schork N.J. Pathway analysis of seven common diseases assessed by genome-wide association. Genomics 2008, 92:265-272.
    • (2008) Genomics , vol.92 , pp. 265-272
    • Torkamani, A.1    Topol, E.J.2    Schork, N.J.3
  • 97
    • 49649129873 scopus 로고    scopus 로고
    • Public databases and software for the pathway analysis of cancer genomes
    • Tsui I.F., Chari R., Lam W.L., Buys T.P. Public databases and software for the pathway analysis of cancer genomes. Cancer Inform. 2007, 3:379-397.
    • (2007) Cancer Inform. , vol.3 , pp. 379-397
    • Tsui, I.F.1    Chari, R.2    Lam, W.L.3    Buys, T.P.4
  • 99
    • 36249029788 scopus 로고    scopus 로고
    • Pathway-based approaches for analysis of genomewide association studies
    • Wang K., Li M., Bucan M. Pathway-based approaches for analysis of genomewide association studies. Am. J. Hum. Genet. 2007, 81:1278-1283.
    • (2007) Am. J. Hum. Genet. , vol.81 , pp. 1278-1283
    • Wang, K.1    Li, M.2    Bucan, M.3
  • 102
    • 0036137130 scopus 로고    scopus 로고
    • Linkage disequilibrium and the mapping of complex human traits
    • Weiss K.M., Clark A.G. Linkage disequilibrium and the mapping of complex human traits. Trends Genet. 2002, 18:19-24.
    • (2002) Trends Genet. , vol.18 , pp. 19-24
    • Weiss, K.M.1    Clark, A.G.2
  • 103
    • 84969213492 scopus 로고    scopus 로고
    • Genome-wide association study of 14,000 cases of seven common diseases and 3000 shared controls
    • Wellcome Trust Case Control Consortium
    • Wellcome Trust Case Control Consortium Genome-wide association study of 14,000 cases of seven common diseases and 3000 shared controls. Nature 2007, 447:661-678.
    • (2007) Nature , vol.447 , pp. 661-678
  • 104
    • 15244358503 scopus 로고    scopus 로고
    • Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals
    • Xie X., Lu J., Kulbokas E.J., Golub T.R., Mootha V., Lindblad-Toh K., Lander E.S., Kellis M. Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals. Nature 2005, 434:338-345.
    • (2005) Nature , vol.434 , pp. 338-345
    • Xie, X.1    Lu, J.2    Kulbokas, E.J.3    Golub, T.R.4    Mootha, V.5    Lindblad-Toh, K.6    Lander, E.S.7    Kellis, M.8
  • 106
    • 0036284203 scopus 로고    scopus 로고
    • Testing association of statistically inferred haplotypes with discrete and continuous traits in samples of unrelated individuals
    • Zaykin D.V., Westfall P.H., Young S.S., Karnoub M.A., Wagner M.J., Ehm M.G. Testing association of statistically inferred haplotypes with discrete and continuous traits in samples of unrelated individuals. Hum. Hered. 2002, 53(2):79-91.
    • (2002) Hum. Hered. , vol.53 , Issue.2 , pp. 79-91
    • Zaykin, D.V.1    Westfall, P.H.2    Young, S.S.3    Karnoub, M.A.4    Wagner, M.J.5    Ehm, M.G.6
  • 107
    • 23944458138 scopus 로고    scopus 로고
    • A general framework for weighted gene co-expression network analysis
    • (Article 17)
    • Zhang B., Horvath S. A general framework for weighted gene co-expression network analysis. Stat. Appl. Genet. Mol. Biol. 2005, 4. (Article 17).
    • (2005) Stat. Appl. Genet. Mol. Biol. , vol.4
    • Zhang, B.1    Horvath, S.2
  • 108
    • 77950339092 scopus 로고    scopus 로고
    • Integrating pathway analysis and genetics of gene expression for genome-wide association studies
    • Zhong H., Yang X., Kaplan L.M., Molony C., Schadt E.E. Integrating pathway analysis and genetics of gene expression for genome-wide association studies. Am. J. Hum. Genet. 2010, 86:581-591.
    • (2010) Am. J. Hum. Genet. , vol.86 , pp. 581-591
    • Zhong, H.1    Yang, X.2    Kaplan, L.M.3    Molony, C.4    Schadt, E.E.5
  • 109


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