Does lithium treatment still work?: Evidence of stable responses over three decades

Archives of General Psychiatry

Volumn 57, Issue 2, 2000, Pages 187-190

  Baldessarini, Ross J ^a,b,d   Tondo, Leonardo ^a,b,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c UNIVERSITY OF CAGLIARI   (Italy)

^d MCLEAN HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LITHIUM;

CLINICAL TRIAL; DEPRESSION; DRUG EFFICACY; HUMAN; MANIA; MANIC DEPRESSIVE PSYCHOSIS; MORBIDITY; MORTALITY; RECURRENT DISEASE; SHORT SURVEY;

EID: 0033956384     PISSN: 0003990X     EISSN: None     Source Type: Journal    
DOI: 10.1001/archpsyc.57.2.187     Document Type: Short Survey

References (50)

1. Dickson WE, Kendell RE. Does maintenance lithium therapy prevent recurrences of mania under ordinary clinical conditions? Psychol Med. 1986; 16:521-530.
2. Markar HR, Mander AJ. Efficacy of lithium prophylaxis in clinical practice. Br J Psychiatry. 1989; 155:496-500.
3. Harrow M, Goldberg JF, Grossman LS. Meltzer HY. Outcome in manic disorders: a naturalistic followup study. Arch Gen Psychiatry. 1990;47:665-671.
4. Guscott R, Taylor L. Lithium prophylaxis in recurrent affective illness: efficacy, effectiveness and efficiency, Br J Psychiatry. 1994;164;741-746.
5. Hopkins HS, Gelenberg AJ. Treatment of bipolar disorder: how far have we come? Psychopharmacol Bull. 1994;30:27-37.
6. Sachs GS, Lafer B, Truman CJ, Noeth M, Thibault AB. Lithium monotherapy: miracle, myth and misunderstanding. Psychiatr Ann. 1994;24:299-306.
7. Moncrieff J. Lithium revisited: a re-examination of the placebo-controlled trials of lithium prophylaxis in manic-depressive disorder. Br J Psychiatry. 1995;167:569-573.
8. Gershon S, Soares JC. Current therapeutic profile of lithium. Arch Gen Psychiatry. 1997;54:16-20.
9. Silverstone T, McPherson H, Hunt N, Romans S. How effective is lithium in the prevention of relapse in bipolar disorder? a prospective naturalistic follow-up study. Aust N Z J Psychiatry. 1998; 32:61-66.
10. Baldessarini RJ. A plea for integrity of the bipolar disorder concept. Bipolar Disord. In press.
11. Hegarty JD, Baldessarini RJ, Tohen M, Waternaux C, Oepen G. One hundred years of schizophrenia: a meta-analysis of the outcome literature. Am J Psychiatry. 1994;151:1409-1416.
12. Hegarty JD, Baldessarini RJ, Tohen T, Oepen G. Schizophrenia: a 100-year retrospective: factors influencing the recent downturn in long-term outcome in schizophrenia. Am J Psychiatry. 1995; 152:1694-1695.
13. Baldessarini RJ. Drugs and the treatment of psychiatric disorders: antimanic and antidepressant agents. In: Hardman JG, Limbird LE, Molinoff PB, Ruddon RW, Gilman AG, eds. Goodman and Gilman's the Pharmacological Basis of Therapeutics. 9th ed. New York, NY: McGraw-Hill Book Co; 1996:431-459.
14. Baldessarini RJ, Tondo L, Suppes T, Faedda GL, Tohen M, Pharmacological treatment of bipolar disorder throughout the life-cycle. In: Shulman KI, Tohen M, Kutcher S, eds. Bipolar Disorder Through the Life-Cycle. New York, NY: John Wiley & Sons; 1996:299-338.
15. Baastrup PC, Poulsen JC, Schou M, Thomson K. Prophylactic lithium: double-blind discontinuation in manic-depressive and recurrent depressive disorders. Lancet. 1970;2:326-330.
16. Melia PI. Prophylactic lithium: a double-blind trial in recurrent affective disorders. Br J Psychiatry. 1970;116:621-624.
17. Coppen A, Noguera R, Bailey J, Burns BH, Swani MS, Hare EH, Gardner R. Prophylactic lithium in affective disorders. Lancet. 1971;2:275-279.
18. Small JG, Small IF, Moore DF. Experimental withdrawal of lithium in recovered manic-depressive patients: a report of five cases. Am J Psychiatry. 1971;127:1555-1558.
19. Cundall RL, Brooks PW, Murray LG. A controlled evaluation of lithium prophylaxis in affective disorders. Psychol Med. 1972;2:308-311.
20. Hullin RP, McDonald R, Allsopp MN. Prophylactic lithium in recurrent affective disorders. Lancet. 1972;1:1044-1046.
21. Fyrö B, Petterson U. A double-blind study of the prophylactic effect of lithium in manicdepressive disease. Acta Psychiatr Scand. 1977; 262:17-22.
22. Klein HE, Broucek B, Greil W. Lithium withdrawal triggers psychotic states. Br J Psychiatry. 1981;139:255-264.
23. Margo A, McMahon P. Lithium withdrawal triggers psychosis. Br J Psychiatry. 1982;141:407-410.
24. Mendlewicz J. Lithium discontinuation in bipolar illness: a double-blind prospective controlled study. In: Corsini GB, ed. Current Trends in Lithium and Rubidium Therapy. Cambridge, Mass: MTP Press; 1984:135-141.
25. Mander AJ, Loudon JB. Rapid recurrence of mania following abrupt discontinuation of lithium. Lancet. 1988;2:15-17.
26. Grot P, Cakuls P, Dostal T. Lithium drop-outs: a follow-up study of patients who discontinued prophylactic lithium in recurrent affective disorders. Int Pharmacopsychiatry. 1970;5:162-169.
27. Schou M, Thomsen K, Baastrup PC. Studies on the course of recurrent endogenous affective disorders. Int Pharmacopsychiatry. 1970;5:100-106.
28. Lapierre YD, Gagnon A, Kokkinidis L. Rapid recurrence of mania following lithium withdrawal. Biol Psychiatry. 1980;15:859-864.
29. Christodoulou GN, Lykouras EP. Abrupt lithium discontinuation in manic-depressive patients. Acta Psychiatr Scand. 1982;65:310-314.
30. King JR, Hullin RP. Withdrawal symptoms from lithium. Br J Psychiatry. 1983;143:30-35.
31. Sashidaran SP, McGuire RJ. Recurrence of affective illness after withdrawal of long-term lithium treatment. Acta Psychiatr Scand. 1983;68:126-133.
32. Bouman TK, Niemantsverdriet-van Kampen JG, Ormel J, Slooff CJ. The effectiveness of lithium prophylaxis in bipolar and unipolar depressions and schizo-affective disorders. J Affect Disord. 1986;11:275-280.
33. Molnar G, Pristach C, Feeney GM, Fava G. A pilot study of managed lithium discontinuation. Psychopharmacol Bull. 1988;24:217-219.
34. Strober M, Morrell W, Lampert C. Burroughs J. Relapse following discontinuation of lithium maintenance therapy in adolescents with bipolar I illness: a naturalistic study. Am J Psychiatry. 1990; 147:457-461.
35. Tondo L, Rudas N. Discontinuation of chronic treatment with lithium salts [in Italian]. Minerva Psichiatr. 1991;32:245-249.
36. Maj M, Pirozzi R, Magliano L. Nonresponse to reinstituted lithium prophylaxis in previously responsive bipolar patients: prevalence and predictors. Am J Psychiatry. 1995;152:1810-1811.
37. Koukopoulos A, Reginaldi D, Minnai G, Serra G, Pani L, Johnson NF. The long term prophylaxis of affective disorders. In: Gessa G, Fratta W, Pani L, Serra G, eds. Depression and Mania: From Neurobiology to Treatment. New York, NY: Raven Press: 1996:127-147.
38. Baldessarini RJ, Tondo L, Faedda GL, Suppes TR, Floris G, Rudas N. Effects of the rate of discontinuing lithium maintenance treatment in bipolar disorders. J Clin Psychiatry. 1996;57:441-448.
39. Baldessarini RJ, Tondo L, Viguera AC. Discontinuing lithium maintenance treatment in bipolar disorders: risks and implications. Bipolar Disord. 1999;1:17-24.
40. Tondo L, Baldessarini RJ, Hennen J, Floris G. Lithium maintenance treatment: depression and mania in bipolar I and II disorders. Am J Psychiatry. 1998;155:638-645.
41. Tondo L, Baldessarini RJ, Hennen J, Floris G, Silvetti F, Tohen M. Lithium treatment and risk of suicidal behavior in bipolar disorder patients. J Clin Psychiatry. 1998;58:405-414.
42. Zarate CA Jr, Tohen M, Baraibar G, Zarate SB, Baldessarini RJ. Shifts in hospital diagnostic frequencies: bipolar disorder subtypes, 19811993. J Affect Disord. 1997;43:79-84.
43. Wehr TA, Goodwin FK. Rapid cycling in manicdepressives induced by tricyclic antidepressants. Arch Gen Psychiatry. 1979;36:555-559.
44. Kukopulos A, Caliari B, Tundo A, Minnai G, Floris G, Reginaldi D, Tondo L. Rapid cyclers, temperament, and antidepressants. Compr Psychiatry. 1983;24:249-258.
45. Bauer MS, Calabrese J, Dunner DL, Post R, Whybrow PC, Gyulai L, Tay LK, Younkin SR, Bynum D, Lavori P, Price A. Multisite data reanalysis of the validity of rapid cycling as a course modifier for bipolar disorder in DSM-IV. Am J Psychiatry. 1994;151:506-515.
46. Post RM, Denicoff KD, Leverich GS, Frye MA. Drug-induced switching in bipolar disorder: epidemiology and therapeutic implications. CNS Drugs. 1997;8:352-365.
47. Maj M, Starace F, Nolfe G, Kemali D. Minimum plasma lithium levels required for effective prophylaxis in DSM-III bipolar disorder: a prospective study. Pharmacopsychiatry. 1986;19:420-423.
48. Coppen A, Standish-Barry J, Bailey J, Houston G, Silcocks P, Hermon C. Does lithium reduce the mortality of recurrent mood disorders? J Affect Disord. 1991;23:1-7.
49. Greil W, Ludwig-Mayerhofer W, Erazo N, Schochlin C, Schmidt S, Engel RR, Czernik A, Giedke H, Müller-Oerlinghausen B, Osterheider M, Rudolf GA, Sauer H, Tegeler J, Wetterling T. Lithium versus carbamazepine in the maintenance treatment of bipolar disorders: a randomized study. J Affect Disord. 1997;43:151-161.
50. Tondo L, Jamison KR, Baldessarini RJ. Effect of lithium on suicide risk in bipolar disorder patients. Ann N Y Acad Sci. 1997;836:339-351.