CAUSEL: An epigenome- and genome-editing pipeline for establishing function of noncoding GWAS variants

Nature Medicine

Volumn 21, Issue 11, 2015, Pages 1357-1363

  Spisák, Sándor ^a,l   Lawrenson, Kate ^b,l,n   Fu, Yanfang ^c,d,l,n   Csabai, István ^e   Cottman, Rebecca T ^c,d   Seo, Ji Heui ^a   Haiman, Christopher ^b,f   Han, Ying ^b   Lenci, Romina ^a   Li, Qiyuan ^a,g   Tisza, Viktória ^a,h   Szállási, Zoltán ^h,i,j   Herbert, Zachery T ^a   Chabot, Matthew ^a   Pomerantz, Mark ^a   Solymosi, Norbert ^k   Gayther, Simon A ^l,m   Joung, J Keith ^b,l   Freedman, Matthew L ^c,d  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e EÖTVÖS LORÁND UNIVERSITY   (Hungary)

^f UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^g XIAMEN UNIVERSITY   (China)

^h BOSTON CHILDREN S HOSPITAL   (United States)

ⁱ TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^j SEMMELWEIS UNIVERSITY   (Hungary)

^k SZENT ISTVÁN UNIVERSITY   (Hungary)

^l CEDARS SINAI MEDICAL CENTER   (United States)

^m BROAD INSTITUTE OF MIT AND HARVARD   (United States)

ⁿ BIOGEN   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION ACTIVATOR LIKE EFFECTOR NUCLEASE; DNA BINDING PROTEIN; HISTONE; HOMEODOMAIN PROTEIN; HOXB13 PROTEIN, HUMAN; MESSENGER RNA; REGULATORY FACTOR X TRANSCRIPTION FACTOR; RFX6 PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

ALLELE; ARTICLE; AUTOSOMAL RECESSIVE DISORDER; BINDING SITE; CANCER RISK; CELL ADHESION; CONTROLLED STUDY; EPIGENETICS; GENE LOCUS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOME; GENOTYPE; HOMEOBOX; HUMAN; HUMAN CELL; MALE; POSITION WEIGHT MATRIX; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATE CANCER CELL LINE; PROTEIN FUNCTION; REGULATORY MECHANISM; REGULATORY SEQUENCE; SINGLE NUCLEOTIDE POLYMORPHISM; CHROMOSOMAL MAPPING; CHROMOSOME 6; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; HISTONE CODE; METABOLISM; PROSTATE TUMOR; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL LINE;

ALLELES; CELL LINE, TUMOR; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 6; DNA-BINDING PROTEINS; EPIGENOMICS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HISTONE CODE; HISTONES; HOMEODOMAIN PROTEINS; HUMANS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROSTATIC NEOPLASMS; REGULATORY FACTOR X TRANSCRIPTION FACTORS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSCRIPTION FACTORS;

EID: 84946221310     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.3975     Document Type: Article

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