Elevation in cerebral blood flow velocity with aerobic fitness throughout healthy human ageing

Journal of Physiology

Volumn 586, Issue 16, 2008, Pages 4005-4010

  Ainslie, Philip N ^a   Cotter, James D ^a   George, Keith P ^a   Lucas, Sam ^a   Murrell, Carissa ^a   Shave, Rob ^b   Thomas, Kate N ^a   Williams, Michael J A ^c   Atkinson, Greg ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

^c BRUNEL UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AEROBIC EXERCISE; AGE; AGED; AGING; ANALYSIS OF COVARIANCE; ARTICLE; BLOOD FLOW VELOCITY; BLOOD PRESSURE; BODY MASS; BRAIN BLOOD FLOW; BRAIN OXYGEN CONSUMPTION; CEREBROVASCULAR DISEASE; CONTROLLED STUDY; DOPPLER ECHOGRAPHY; ENDURANCE; HUMAN; HUMAN EXPERIMENT; MALE; MIDDLE CEREBRAL ARTERY; NORMAL HUMAN; PRIORITY JOURNAL; RISK FACTOR; SITTING; MUSCLE TRAINING; OXYGEN CONSUMPTION;

ADOLESCENT; ADULT; AGED; AGING; BLOOD FLOW VELOCITY; CEREBROVASCULAR CIRCULATION; EXERCISE; HUMANS; MALE; MIDDLE AGED; OXYGEN; PHYSICAL FITNESS;

EID: 50049089621     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2008.158279     Document Type: Article

References (37)

1. Aaslid R, Markwalder TM & Nornes H (1982). Noninvasive transcranial Doppler ultrasound recording of flow velocity in basal cerebral arteries. J Neurosurg 57, 769-774.
2. 2 reactivity in healthy humans: relation to endothelial function. Exp Physiol 92, 769-777.
3. Beason-Held LL, Moghekar A, Zonderman AB, Kraut MA & Resnick SM (2007). Longitudinal changes in cerebral blood flow in the older hypertensive brain. Stroke 38, 1766-1773.
4. Bland JM & Altman DG (1999). Measuring agreement in method comparison studies. Stat Meth Med Res 8, 135-160.
5. Buijs PC, Krabbe-Hartkamp MJ, Bakker CJ, de Lange EE, Ramos LM, Breteler MM & Mali WP (1998). Effect of age on cerebral blood flow: measurement with ungated two-dimensional phase-contrast MR angiography in 250 adults. Radiology 209, 667-674.
6. Carro E, Nunez A, Busiguina S & Torres-Aleman I (2000). Circulating insulin-like growth factor I mediates effects of exercise on the brain. J Neurosci 20, 2926-2933.
7. Clarkson P, Montgomery HE, Mullen MJ, Donald AE, Powe AJ, Bull T, Jubb M, World M & Deanfield JE (1999). Exercise training enhances endothelial function in young men. J Am Coll Cardiol 33, 1379-1385.
8. Colcombe SJ, Erickson KI, Raz N, Webb AG, Cohen NJ, McAuley E & Kramer AF (2003). Aerobic fitness reduces brain tissue loss in aging humans. J Gerontol A Biol Sci Med Sci 58, 176-180.
9. Colcombe SJ, Erickson KI, Scalf PE, Kim JS, Prakash R, McAuley E, Elavsky S, Marquez DX, Hu L & Kramer AF (2006). Aerobic exercise training increases brain volume in aging humans. J Gerontol A Biol Sci Med Sci 61, 1166-1170.
10. DeSouza CA, Shapiro LF, Clevenger CM, Dinenno FA, Monahan KD, Tanaka H & Seals DR (2000). Regular aerobic exercise prevents and restores age-related declines in endothelium-dependent vasodilation in healthy men. Circulation 102, 1351-1357.
11. Endres M, Gertz K, Lindauer U, Katchanov J, Schultze J, Schrock H, Nickenig G, Kuschinsky W, Dirnagl U & Laufs U (2003). Mechanisms of stroke protection by physical activity. Ann Neurol 54, 582-590.
12. Endres M, Laufs U, Liao JK & Moskowitz MA (2004). Targeting eNOS for stroke protection. Trends Neurosci 27, 283-289.
13. Field A (2005). Discovering Statistics Using SPSS, 2nd edn. Sage Publications, London.
14. Franzoni F, Galetta F, Morizzo C, Lubrano V, Palombo C, Santoro G, Ferrannini E & Quinones-Galvan A (2004). Effects of age and physical fitness on microcirculatory function. Clin Sci (Lond) 106, 329-335.
15. Gertz K, Priller J, Kronenberg G, Fink KB, Winter B, Schrock H, Ji S, Milosevic M, Harms C, Bohm M, Dirnagl U, Laufs U & Endres M (2006). Physical activity improves long-term stroke outcome via endothelial nitric oxide synthase-dependent augmentation of neovascularization and cerebral blood flow. Circ Res 99, 1132-1140.
16. Giller CA, Bowman G, Dyer H, Mootz L & Krippner W (1993). Cerebral arterial diameters during changes in blood pressure and carbon dioxide during craniotomy. Neurosurgery 32, 737-741.
17. Higashi Y, Sasaki S, Kurisu S, Yoshimizu A, Sasaki N, Matsuura H, Kajiyama G & Oshima T (1999). Regular aerobic exercise augments endothelium-dependent vascular relaxation in normotensive as well as hypertensive subjects: Role of endothelium-derived nitric oxide. Circulation 100, 1194-1202.
18. Hoth KF, Tate DF, Poppas A, Forman DE, Gunstad J, Moser DJ, Paul RH, Jefferson AL, Haley AP & Cohen RA (2007). Endothelial function and white matter hyperintensities in older adults with cardiovascular disease. Stroke 38, 308-312.
19. Kashimada A, Machida K, Honda N, Mamiya T, Takahashi T, Kamano T, Inoue Y & Osada H (1994). [Measurement of cerebral blood flow in normal subjects by phase contrast MR imaging](in Japanese). Nippon Igaku Hoshasen Gakkai Zasshi 54, 1116-1125.
20. Kirkham FJ, Padayachee TS, Parsons S, Seargeant LS, House FR & Gosling RG (1986). Transcranial measurement of blood velocities in the basal cerebral arteries using pulsed Doppler ultrasound: Velocity as an index of flow. Ultrasound Med Biol 12, 15-21.
21. Kramer AF, Hahn S, Cohen NJ, Banich MT, McAuley E, Harrison CR, Chason J, Vakil E, Bardell L, Boileau RA & Colcombe A (1999). Ageing, fitness and neurocognitive function. Nature 400, 418-419.
22. 2 vasoreactivity: Association with endothelial dysfunction. Am J Physiol Heart Circ Physiol 291, H1856-H1861.
23. Matteis M, Troisi E, Monaldo BC, Caltagirone C & Silvestrini M (1998). Age and sex differences in cerebral hemodynamics: A transcranial Doppler study. Stroke 29, 963-967.
24. Nelson E & Rennels M (1970). Innervation of intracranial arteries. Brain 93, 475-490.
25. Niehaus L, Lehmann R, Roricht S & Meyer BU (2001). Age-related reduction in visually evoked cerebral blood flow responses. Neurobiol Aging 22, 35-38.
26. Nielsen KC & Owman C (1967). Adrenergic innervation of pial arteries related to the circle of Willis in the cat. Brain Res 6, 773-776.
27. 2 reactivity to end-tidal, arterial and internal jugular vein. J Physiol 584, 347-357.
28. Rinder MR, Spina RJ & Ehsani AA (2000). Enhanced endothelium-dependent vasodilation in older endurance-trained men. J Appl Physiol 88, 761-766.
29. Scheel P, Ruge C, Petruch UR & Schoning M (2000). Color duplex measurement of cerebral blood flow volume in healthy adults. Stroke 31, 147-150.
30. Seals DR & Dinenno FA (2004). Collateral damage: Cardiovascular consequnces of chronic sympathetic activation with human aging. Am J Physiol Heart Circ Physiol 287, H1895-H1905.
31. Serrador JM, Picot PA, Rutt BK, Shoemaker JK & Bondar RL (2000). MRI measures of middle cerebral artery diameter in conscious humans during simulated orthostasis. Stroke 31, 1672-1678.
32. Shephard RJ & Balady GJ (1999). Exercise as cardiovascular therapy. Circulation 99, 963-972.
33. Stoquart-ElSankari S, Baledent O, Gondry-Jouet C, Makki M, Godefroy O & Meyer ME (2007). Aging effects on cerebral blood and cerebrospinal fluid flows. J Cereb Blood Flow Metab 27, 1563-1572.
34. Taddei S, Galetta F, Virdis A, Ghiadoni L, Salvetti G, Franzoni F, Giusti C & Salvetti A (2000). Physical activity prevents age-related impairment in nitric oxide availability in elderly athletes. Circulation 101, 2896-2901.
35. Valdueza JM, Balzer JO, Villringer A, Vogl TJ, Kutter R & Einhaupl KM (1997). Changes in blood flow velocity and diameter of the middle cerebral artery during hyperventilation: Assessment with MR and transcranial Doppler sonography. AJNR Am J Neuroradiol 18, 1929-1934.
36. Vaynman S, Ying Z & Gomez-Pinilla F (2004). Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition. Eur J Neurosci 20, 2580-2590.
37. Zar JH (1999). Biostatistical Analysis. Prentice Hall, Englewood Cliffs, NJ.