Neuroinflammation and cognitive aging

Current Psychiatry Reports

Volumn 12, Issue 1, 2010, Pages 39-45

  Ownby, Raymond L ^a  

^a NOVA SOUTHEASTERN UNIVERSITY   (United States)

Author keywords

Cognition; Cognition disorders; Cognitive aging; Neuroinflammation; TNF

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CHOLINESTERASE INHIBITOR; GALANTAMINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; MEMANTINE; NONSTEROID ANTIINFLAMMATORY AGENT; OMEGA 3 FATTY ACID; TUMOR NECROSIS FACTOR ALPHA;

AGING; ALZHEIMER DISEASE; ANTIINFLAMMATORY ACTIVITY; COGNITIVE DEFECT; COGNITIVE THERAPY; CYTOKINE PRODUCTION; DEPRESSION; DIET SUPPLEMENTATION; DOPAMINERGIC SYSTEM; HUMAN; ILLNESS BEHAVIOR; INFLAMMATION; MENTAL PERFORMANCE; MENTAL STRESS; METABOLIC SYNDROME X; MILD COGNITIVE IMPAIRMENT; NEUROPROTECTION; NONHUMAN; PHYSICAL ACTIVITY; PSYCHOSOCIAL WITHDRAWAL; REVIEW; RISK FACTOR; RISK REDUCTION; SHORT TERM MEMORY; WORKING MEMORY;

AGING; BRAIN; COGNITION; COGNITION DISORDERS; HUMANS; INFLAMMATION;

EID: 77549083704     PISSN: 15233812     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11920-009-0082-1     Document Type: Review

References (63)

1. Park DC: The basic mechanisms accounting for age-related decline in cognitive function. In Cognitive Aging: A Primer. Edited by Park D, Schwarz N. Philadelphia: Taylor & Francis; 2000:3-21.
2. RB Cattell 1963 Theory of fluid and crystallized intelligence: a critical experiment J Educ Psychol 54 1 22 10.1037/h0046743
3. CL Grady 2008 Cognitive neuroscience of aging Ann N Y Acad Sci 1124 127 144 10.1196/annals.1440.009 18400928 Grady provides an excellent review of the current status of research on cognitive aging
4. TA Salthouse JE Pink 2008 Why is working memory related to fluid intelligence? Psychon Bull Rev 15 364 371 10.3758/PBR.15.2.364 18488653
5. U Lindenberger P Ghisletta 2009 Cognitive and sensory declines in old age: gauging the evidence for a common cause Psychol Aging 24 1 16 10.1037/a0014986 19290733 This article provides a useful review of current thinking about possible links between changes in both mental and sensory status with increasing age
6. DA Drachman 2006 Aging of the brain, entropy, and Alzheimer disease Neurology 67 1340 1352 10.1212/01.wnl.0000240127.89601.83 1:CAS:528: DC%2BD28XhtVKrt7vJ 17060558 (Pubitemid 44632055)
7. R Yirmiya Y Pollak M Morag, et al. 2000 Illness, cytokines, and depression Ann N Y Acad Sci 917 478 487 1:CAS:528:DC%2BD3cXovFymsbs%3D 11268375
8. KS Krabbe A Reichenberg R Yirmiya, et al. 2005 Low-dose endotoxemia and human neuropsychological functions Brain Behav Immun 19 453 460 10.1016/j.bbi.2005.04.010 1:CAS:528:DC%2BD2MXntVGjurY%3D 15963684 (Pubitemid 41074784)
9. L Capuron A Ravaud AH Miller R Dantzer 2004 Baseline mood and psychosocial characteristics of patients developing depressive symptoms during interleukin-2 and/or interferon-alpha cancer therapy Brain Behav Immun 18 205 213 10.1016/j.bbi.2003.11.004 1:CAS:528:DC%2BD2cXis1Whs7c%3D 15050647 (Pubitemid 38429760)
10. A Reichenberg R Yirmiya A Schuld, et al. 2001 Cytokine-associated emotional and cognitive disturbances in humans Arch Gen Psychiatry 58 445 452 10.1001/archpsyc.58.5.445 1:STN:280:DC%2BD3M3ltlCrtA%3D%3D 11343523
11. DC Lau B Dhillon H Yan, et al. 2005 Adipokines: molecular links between obesity and atherosclerosis Am J Physiol Heart Circ Physiol 288 H2031 H2041 10.1152/ajpheart.01058.2004 1:CAS:528:DC%2BD2MXktlShsbo%3D 15653761 (Pubitemid 40604084)
12. CR Gomez ED Boehmer EJ Kovacs 2005 The aging innate immune system Curr Opin Immunol 17 457 462 10.1016/j.coi.2005.07.013 1:CAS:528:DC%2BD2MXpslyiu78%3D 16084711 (Pubitemid 41207946)
13. LC Hawkley JT Cacioppo 2004 Stress and the aging immune system Brain Behav Immun 18 114 119 10.1016/j.bbi.2003.09.005 1:CAS:528: DC%2BD2cXps1Olsg%3D%3D 14986706 (Pubitemid 38169155)
14. T Arimoto DY Choi X Lu, et al. 2007 Interleukin-10 protects against inflammation-mediated degeneration of dopaminergic neurons in substantia nigra Neurobiol Aging 28 894 906 10.1016/j.neurobiolaging.2006.04.011 1:CAS:528:DC%2BD2sXksFWnt70%3D (Pubitemid 46589742)
15. HK Kuo CJ Yen CH Chang, et al. 2005 Relation of C-reactive protein to stroke, cognitive disorders, and depression in the general population: systematic review and meta-analysis Lancet Neurol 4 371 380 10.1016/S1474- 4422(05)70099-5 1:CAS:528:DC%2BD2MXls1eisL4%3D 15907742 (Pubitemid 40720034)
16. D Gimeno M Kivimaki EJ Brunner, et al. 2009 Associations of C-reactive protein and interleukin-6 with cognitive symptoms of depression: 12-year follow-up of the Whitehall II study Psychol Med 39 413 423 10.1017/ S0033291708003723 1:STN:280:DC%2BD1M7jt12qsw%3D%3D 18533059 This article definitively links CRP and IL-6 with depression in a well-known longitudinal study
17. MJ Stampfer 2006 Cardiovascular disease and Alzheimer's disease: Common links J Intern Med 260 211 223 10.1111/j.1365-2796.2006.01687.x 1:CAS:528:DC%2BD28XhtVOgur3N 16918818 (Pubitemid 44253634)
18. EP Helzner JA Luchsinger N Scarmeas, et al. 2009 Contribution of vascular risk factors to the progression in Alzheimer disease Arch Neurol 66 343 348 10.1001/archneur.66.3.343 19273753
19. G Li MM Cherrier DW Tsuang, et al. 2006 Salivary cortisol and memory function in human aging Neurobiol Aging 27 1705 1714 10.1016/j.neurobiolaging. 2005.09.031 1:CAS:528:DC%2BD28Xps1Oisro%3D 16274857 (Pubitemid 44363109)
20. SJ Lupien M Lepage 2001 Stress, memory, and the hippocampus: can't live with it, can't live without it Behav Brain Res 127 137 158 10.1016/S0166- 4328(01)00361-8 1:STN:280:DC%2BD3MnntlSgsQ%3D%3D 11718889 (Pubitemid 33062407)
21. I Goshen R Yirmiya 2009 Interleukin-1 (IL-1): a central regulator of stress responses Front Neuroendocrinol 30 30 45 10.1016/j.yfrne.2008.10.001 1:CAS:528:DC%2BD1MXhsVKnug%3D%3D 19017533
22. LP Fried CM Tangen J Walston, et al. 2001 Frailty in older adults: evidence for a phenotype J Gerontol A Biol Sci Med Sci 56 M146 M156 1:STN:280:DC%2BD3M7osFejuw%3D%3D 11253156
23. H Bergman L Ferrucci J Guralnik, et al. 2007 Frailty: an emerging research and clinical paradigm issues and controversies J Gerontol A Biol Sci Med Sci 62 731 737 17634320
24. JI Barzilay C Blaum T Moore, et al. 2007 Insulin resistance and inflammation as precursors of frailty: the Cardiovascular Health Study Arch Intern Med 167 635 641 10.1001/archinte.167.7.635 17420420 (Pubitemid 46598454)
25. AS Buchman JA Schneider S Leurgans DA Bennett 2008 Physical frailty in older persons is associated with Alzheimer disease pathology Neurology 71 499 504 10.1212/01.wnl.0000324864.81179.6a 18695161
26. RL Hunter B Cheng DY Choi, et al. 2009 Intrastriatal lipopolysaccharide injection induces parkinsonism in C57/B6 mice J Neurosci Res 87 1913 1921 10.1002/jnr.22012 1:CAS:528:DC%2BD1MXlsVWnurY%3D 19224579
27. Long-Smith CM, Sullivan AM, Nolan YM: The influence of microglia on the pathogenesis of Parkinson's disease. Prog Neurobiol 2009 Aug 15 (Epub ahead of print).
28. L Backman L Nyberg U Lindenberger, et al. 2006 The correlative triad among aging, dopamine, and cognition: current status and future prospects Neurosci Biobehav Rev 30 791 807 10.1016/j.neubiorev.2006.06.005 16901542 (Pubitemid 44389711)
29. MA Beydoun HA Beydoun Y Wang 2008 Obesity and central obesity as risk factors for incident dementia and its subtypes: a systematic review and meta-analysis Obes Rev 9 204 218 10.1111/j.1467-789X.2008.00473.x 1:STN:280:DC%2BD1c3lvVCgtg%3D%3D 18331422 (Pubitemid 351550691)
30. V Sweat V Starr H Bruehl, et al. 2008 C-reactive protein is linked to lower cognitive performance in overweight and obese women Inflammation 31 198 207 10.1007/s10753-008-9065-3 1:CAS:528:DC%2BD1cXlsFCitr4%3D 18347963
31. BW Penninx BJ Nicklas AB Newman, et al. 2009 Metabolic syndrome and physical decline in older persons: results from the Health, Aging and Body Composition Study J Gerontol A Biol Sci Med Sci 64 96 102 19164274
32. N Vogelzangs AT Beekman MG Dik, et al. 2009 Late-life depression, cortisol, and the metabolic syndrome Am J Geriatr Psychiatry 17 716 721 10.1097/JGP.0b013e3181aad5d7 19625789
33. K Yaffe AL Weston T Blackwell KA Krueger 2009 The metabolic syndrome and development of cognitive impairment among older women Arch Neurol 66 324 328 10.1001/archneurol.2008.566 19273750
34. S Craft 2009 The role of metabolic disorders in Alzheimer disease and vascular dementia: two roads converged Arch Neurol 66 300 305 10.1001/archneurol.2009.27 19273747
35. S Roriz-Filho TM Sa-Roriz I Rosset, et al. 2009 (Pre)diabetes, brain aging, and cognition Biochim Biophys Acta 1792 432 443 1:CAS:528: DC%2BD1MXkvVSktrc%3D
36. MG Dik C Jonker HC Comijs, et al. 2007 Contribution of metabolic syndrome components to cognition in older individuals Diabetes Care 30 2655 2660 10.2337/dc06-1190 17563341 (Pubitemid 47547816)
37. B Segura MA Jurado N Freixenet, et al. 2009 Mental slowness and executive dysfunctions in patients with metabolic syndrome Neurosci Lett 462 49 53 10.1016/j.neulet.2009.06.071 1:CAS:528:DC%2BD1MXoslegs70%3D 19560512
38. L Capuron S Su AH Miller, et al. 2008 Depressive symptoms and metabolic syndrome: is inflammation the underlying link? Biol Psychiatry 64 896 900 10.1016/j.biopsych.2008.05.019 1:CAS:528:DC%2BD1cXht12gu7jL 18597739
39. KH Ladwig B Marten-Mittag H Lowel, et al. 2005 C-reactive protein, depressed mood, and the prediction of coronary heart disease in initially healthy men: results from the MONICA-KORA Augsburg Cohort Study 1984-1998 Eur Heart J 26 2537 2542 10.1093/eurheartj/ehi456 1:CAS:528:DC%2BD28XktVyjtw%3D%3D 16126719 (Pubitemid 41677304)
40. K Martinowich H Manji B Lu 2007 New insights into BDNF function in depression and anxiety Nat Neurosci 10 1089 1093 10.1038/nn1971 1:CAS:528:DC%2BD2sXps1Sgu7g%3D 17726474 (Pubitemid 47339961)
41. A Arentoft V Sweat V Starr, et al. 2009 Plasma BDNF is reduced among middle-aged and elderly women with impaired insulin function: evidence of a compensatory mechanism Brain Cogn 71 147 152 10.1016/j.bandc.2009.04.009 19481324
42. G Li ER Peskind SP Millard, et al. 2009 Cerebrospinal fluid concentration of brain-derived neurotrophic factor and cognitive function in non-demented subjects PLoS One 4 e5424 10.1371/journal.pone.0005424 19412541
43. F Gomez-Pinilla S Vaynman Z Ying 2008 Brain-derived neurotrophic factor functions as a metabotrophin to mediate the effects of exercise on cognition Eur J Neurosci 28 2278 2287 10.1111/j.1460-9568.2008.06524.x 19046371
44. A Venneri R Lane 2009 Effects of cholinesterase inhibition on brain white matter volume in Alzheimer's disease Neuroreport 20 285 288 10.1097/WNR.0b013e3283207d21 1:CAS:528:DC%2BD1MXhslyhsb4%3D 19444953
45. KJ Tracey 2007 Physiology and immunology of the cholinergic antiinflammatory pathway J Clin Invest 117 289 296 10.1172/JCI30555 1:CAS:528:DC%2BD2sXhs1OqsLg%3D 17273548 (Pubitemid 46203953)
46. ADAPT Research Group 2007 Naproxen and celecoxib do not prevent AD in early results from a randomized controlled trial Neurology 68 1800 1808 10.1212/01.wnl.0000260269.93245.d2 1:STN:280:DC%2BD2szgtlKkuw%3D%3D 17460158 (Pubitemid 46791392)
47. SC Vlad DR Miller NW Kowall DT Felson 2008 Protective effects of NSAIDs on the development of Alzheimer disease Neurology 70 1672 1677 10.1212/01.wnl.0000311269.57716.63 1:CAS:528:DC%2BD1cXnsFGgtr8%3D 18458226 (Pubitemid 351644133)
48. CA Szekely JC Breitner AL Fitzpatrick, et al. 2008 NSAID use and dementia risk in the Cardiovascular Health Study: role of APOE and NSAID type Neurology 70 17 24 10.1212/01.wnl.0000284596.95156.48 1:CAS:528:DC%2BD2sXhsVGgtbfN 18003940
49. PM Kris-Etherton WS Harris LJ Appel 2003 Nutrition Committee: Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease Arterioscler Thromb Vasc Biol 23 e20 e30 10.1161/01.ATV.0000038493.65177.94 1:CAS:528:DC%2BD3sXptF2jtg%3D%3D 12588785 Published erratum appears in Arterioscler Thromb Vasc Biol 2003, 23:e31
50. MC Morris DA Evans JL Bienias, et al. 2003 Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease Arch Neurol 60 940 946 10.1001/archneur.60.7.940 12873849 (Pubitemid 36858352)
51. M Fotuhi P Mohassel K Yaffe 2009 Fish consumption, long-chain omega-3 fatty acids and risk of cognitive decline or Alzheimer disease: a complex association Nat Clin Pract Neurol 5 140 152 10.1038/ncpneuro1044 1:CAS:528:DC%2BD1MXis1ejs7w%3D 19262590
52. Y Freund-Levi M Eriksdotter-Jonhagen T Cederholm, et al. 2006 Omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD Study: a randomized double-blind trial Arch Neurol 63 1402 1408 10.1001/archneur.63.10.1402 17030655 (Pubitemid 44547551)
53. B Wolozin SW Wang NC Li, et al. 2007 Simvastatin is associated with a reduced incidence of dementia and Parkinson's disease BMC Med 5 20 10.1186/1741-7015-5-20 17640385 (Pubitemid 47337253)
54. G Li EB Larson JA Sonnen, et al. 2007 Statin therapy is associated with reduced neuropathologic changes of Alzheimer disease Neurology 69 878 885 10.1212/01.wnl.0000277657.95487.1c 1:CAS:528:DC%2BD2sXptl2js78%3D 17724290 (Pubitemid 47329587)
55. A Solomon I Kareholt T Ngandu, et al. 2009 Serum total cholesterol, statins and cognition in non-demented elderly Neurobiol Aging 30 1006 1009 10.1016/j.neurobiolaging.2007.09.012 1:CAS:528:DC%2BD1MXltVGjtb4%3D 18022292
56. AM Petersen BK Pedersen 2005 The anti-inflammatory effect of exercise J Appl Physiol 98 1154 1162 10.1152/japplphysiol.00164.2004 1:CAS:528: DC%2BD2MXjt1Wgsr8%3D 15772055 (Pubitemid 40396484)
57. Ownby RL, Loewenstein DA, Kumar M: Anti-inflammatory effects mediate the relation between physical activity and mood in older adults. Paper presented at the Annual Meeting of the International Society of Psychoneuroendocrinology. San Francisco, CA; August 2009.
58. CW Cotman NC Berchtold LA Christie 2007 Exercise builds brain health: key roles of growth factor cascades and inflammation Trends Neurosci 30 464 472 10.1016/j.tins.2007.06.011 1:CAS:528:DC%2BD2sXhtVClsrrK 17765329 This is an excellent review of the possible links between exercise and cognitive function by way of inflammatory processes (Pubitemid 47374831)
59. S Colcombe AF Kramer 2003 Fitness effects on the cognitive function of older adults: a meta-analytic study Psychol Sci 14 125 130 10.1111/1467-9280. t01-1-01430 12661673 (Pubitemid 37283096)
60. SL Willis SL Tennstedt M Marsiske, et al. 2006 Long-term effects of cognitive training on everyday functional outcomes in older adults JAMA 296 2805 2814 10.1001/jama.296.23.2805 1:CAS:528:DC%2BD28XhtlCqtL3O 17179457 (Pubitemid 44969180)
61. SM Jaeggi M Buschkuehl J Jonides WJ Perrig 2008 Improving fluid intelligence with training on working memory Proc Natl Acad Sci U S A 105 6829 6833 10.1073/pnas.0801268105 1:CAS:528:DC%2BD1cXmt1Gis7g%3D 18443283 This article reports the exciting finding that training in one cognitive domain may have positive effects in another (Pubitemid 351754490)
62. F McNab A Varrone L Farde, et al. 2009 Changes in cortical dopamine D1 receptor binding associated with cognitive training Science 323 800 802 10.1126/science.1166102 1:CAS:528:DC%2BD1MXhtlertrw%3D 19197069 This study shows that working memory training may have effects on D1-receptor density in areas relevant to working memory function, providing a possible mechanism for the observation by Jaeggi et al. [61••] that working memory training may improve other aspects of cognitive function
63. M Buschkuehl SM Jaeggi S Hutchison, et al. 2008 Impact of working memory training on memory performance in old-old adults Psychol Aging 23 743 753 10.1037/a0014342 19140646