-
1
-
-
84861832244
-
Label-free quantitative LC-MS proteomics of Alzheimer’s disease and normally aged human brains
-
Andreev VP, Petyuk VA, Brewer HM, Karpievitch YV, Xie F, Clarke J, et al. 2012. Label-free quantitative LC-MS proteomics of Alzheimer’s disease and normally aged human brains. J Proteome Res 11(6):3053–3067; doi: 10.1021/pr3001546.
-
(2012)
J Proteome Res
, vol.11
, Issue.6
, pp. 3053-3067
-
-
Andreev, V.P.1
Petyuk, V.A.2
Brewer, H.M.3
Karpievitch, Y.V.4
Xie, F.5
Clarke, J.6
-
2
-
-
84872570129
-
Alzheimer’s disease and the “Valley Of Death”: Not enough guidance from human brain tissue?
-
Beach TG. 2013. Alzheimer’s disease and the “Valley Of Death”: not enough guidance from human brain tissue? J Alzheimers Dis 33(Suppl 1):S219–S1.
-
(2013)
J Alzheimers Dis
, vol.33
, pp. SSS1-S219
-
-
Beach, T.G.1
-
3
-
-
84867839464
-
Induced pluripotent stem cells: The new patient?
-
Bellin M, Marchetto MC, Gage FH, Mummery CL. 2012. Induced pluripotent stem cells: the new patient? Nat Rev Mol Cell Biol 13(11):713–726; doi: 10.1038/nrm1.
-
(2012)
Nat Rev Mol Cell Biol
, vol.13
, Issue.11
, pp. 713-726
-
-
Bellin, M.1
Marchetto, M.C.2
Gage, F.H.3
Mummery, C.L.4
-
4
-
-
84921913471
-
Engineered in vitro disease models
-
Benam KH, Dauth S, Hassell B, Herland A, Jain A, Jang KJ, et al. 2015. Engineered in vitro disease models. Annu Rev Pathol 10(1):195–262; doi: 10.1146/annurev-pathol-012414-1.
-
(2015)
Annu Rev Pathol
, vol.10
, Issue.1
, pp. 195-262
-
-
Benam, K.H.1
Dauth, S.2
Hassell, B.3
Herland, A.4
Jain, A.5
Jang, K.J.6
-
5
-
-
77956090909
-
Evolution in environmental health: Incorporating the infectious disease paradigm
-
Birnbaum LS, Jung P. 2010. Evolution in environmental health: incorporating the infectious disease paradigm. Environ Health Perspect 118(8):A327–A328; doi: 10.1289/ehp.1.
-
(2010)
Environ Health Perspect
, vol.118
, Issue.8
, pp. A327-A328
-
-
Birnbaum, L.S.1
Jung, P.2
-
6
-
-
84912064761
-
A three-dimensional human neural cell culture model of Alzheimer’s disease
-
Choi SH, Kim YH, Hebisch M, Sliwinski C, Lee S, D’Avanzo C, et al. 2014. A three-dimensional human neural cell culture model of Alzheimer’s disease. Nature 515(7526):274–1.
-
(2014)
Nature
, vol.515
, Issue.7526
, pp. 274-281
-
-
Choi, S.H.1
Kim, Y.H.2
Hebisch, M.3
Sliwinski, C.4
Lee, S.5
D’Avanzo, C.6
-
7
-
-
79960100831
-
Reengineering translational science: The time is right
-
Collins FS. 2011. Reengineering translational science: the time is right. Sci Transl Med 3(90):90cm17; doi: 10.1126/scitranslmed.1.
-
(2011)
Sci Transl Med
, vol.3
, Issue.90
-
-
Collins, F.S.1
-
8
-
-
84923762812
-
A new initiative on precision medicine
-
Collins FS, Varmus H. 2015. A new initiative on precision medicine. N Engl J Med 372(2):793–795; doi: 10.1056/NEJMp1.
-
(2015)
N Engl J Med
, vol.372
, Issue.2
, pp. 793-795
-
-
Collins, F.S.1
Varmus, H.2
-
9
-
-
81355123249
-
Software for systems biology: From tools to integrated platforms
-
Ghosh S, Matsuoka Y, Asai Y, Hsin KY, Kitano H. 2011. Software for systems biology: from tools to integrated platforms. Nat Rev Genet 12(12):821–832; doi: 10.1038/nrg1.
-
(2011)
Nat Rev Genet
, vol.12
, Issue.12
, pp. 821-832
-
-
Ghosh, S.1
Matsuoka, Y.2
Asai, Y.3
Hsin, K.Y.4
Kitano, H.5
-
10
-
-
65649088259
-
Genetic and environmental pathways to complex diseases
-
Gohlke JM, Thomas R, Zhang Y, Rosenstein MC, Davis AP, Murphy C, et al. 2009. Genetic and environmental pathways to complex diseases. BMC Syst Biol 3:46; doi: 10.1186/1752-0509-3-1.
-
(2009)
BMC Syst Biol
, vol.3
, pp. 46
-
-
Gohlke, J.M.1
Thomas, R.2
Zhang, Y.3
Rosenstein, M.C.4
Davis, A.P.5
Murphy, C.6
-
11
-
-
84918582701
-
Mass spectrometry-based proteomics: From cancer biology to protein biomarkers, drug targets, and clinical applications
-
accessed 14 May 2015
-
Jimenez CR, Verheul HM. 2014. Mass spectrometry-based proteomics: from cancer biology to protein biomarkers, drug targets, and clinical applications. Am Soc Clin Oncol Educ Book:e504–e510. Available: http://meetinglibrary.asco.org/content/11400504-144 [accessed 14 May 2015].
-
(2014)
Am Soc Clin Oncol Educ Book
-
-
Jimenez, C.R.1
Verheul, H.M.2
-
12
-
-
78951480503
-
Pharmaceutical innovation in the 21st century: New drug approvals in the first decade, 2000-2009
-
Kaitin KI, DiMasi JA. 2011. Pharmaceutical innovation in the 21st century: new drug approvals in the first decade, 2000-2009. Clin Pharmacol Ther 89(2):183–188; doi: 10.1038/clpt.2010.1.
-
(2011)
Clin Pharmacol Ther
, vol.89
, Issue.2
, pp. 183-188
-
-
Kaitin, K.I.1
Dimasi, J.A.2
-
13
-
-
34249010944
-
Clinical validation of the “in silico” prediction of immunogenicity of a human recombinant therapeutic protein
-
Koren E, De Groot AS, Jawa V, Beck KD, Boone T, Rivera D, et al. 2007. Clinical validation of the “in silico” prediction of immunogenicity of a human recombinant therapeutic protein. Clin Immunol 124(1):26–1.
-
(2007)
Clin Immunol
, vol.124
, Issue.1
, pp. 26-31
-
-
Koren, E.1
De Groot, A.S.2
Jawa, V.3
Beck, K.D.4
Boone, T.5
Rivera, D.6
-
14
-
-
84906318882
-
Considering a new paradigm for Alzheimer’s disease research
-
Langley GR. 2014. Considering a new paradigm for Alzheimer’s disease research. Drug Discov Today 19(8):1114–1.
-
(2014)
Drug Discov Today
, vol.19
, Issue.8
, pp. 1114-1121
-
-
Langley, G.R.1
-
15
-
-
36949022443
-
What will whole genome searches for susceptibility genes for common complex disease offer to clinical practice?
-
Lango H, Weedon MN. 2008. What will whole genome searches for susceptibility genes for common complex disease offer to clinical practice? J Intern Med 263(1):16–1.
-
(2008)
J Intern Med
, vol.263
, Issue.1
, pp. 16-21
-
-
Lango, H.1
Weedon, M.N.2
-
16
-
-
45149116962
-
Translational research: The full cycle
-
Ledford H. 2008. Translational research: the full cycle. Nature 453:843–845; doi: 10.1038/453843a
-
(2008)
Nature
, vol.453
, pp. 843-845
-
-
Ledford, H.1
-
17
-
-
80455162391
-
Exposure science and the exposome: An opportunity for coherence in the environmental health sciences
-
Lioy PJ, Rappaport SM. 2011. Exposure science and the exposome: an opportunity for coherence in the environmental health sciences. Environ Health Perspect 119:A466–A467; doi: 10.1289/ehp.1.
-
(2011)
Environ Health Perspect
, vol.119
, pp. A466-A467
-
-
Lioy, P.J.1
Rappaport, S.M.2
-
18
-
-
78149488365
-
A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells
-
Marchetto MC, Carromeu C, Acab A, Yu D, Yeo GW, Mu Y, et al. 2010. A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells. Cell 143(4):527–1.
-
(2010)
Cell
, vol.143
, Issue.4
, pp. 527-531
-
-
Marchetto, M.C.1
Carromeu, C.2
Acab, A.3
Yu, D.4
Yeo, G.W.5
Mu, Y.6
-
19
-
-
80052225992
-
Downregulation of VAPB expression in motor neurons derived from induced pluripotent stem cells of ALS8 patients
-
Mitne-Neto M, Machado-Costa M, Marchetto MC, Bengtson MH, Joazeiro CA, Tsuda H, et al. 2011. Downregulation of VAPB expression in motor neurons derived from induced pluripotent stem cells of ALS8 patients. Hum Mol Genet 20:3642–3652; doi: 10.1093/hmg/ddr284.
-
(2011)
Hum Mol Genet
, vol.20
, pp. 3642-3652
-
-
Mitne-Neto, M.1
Machado-Costa, M.2
Marchetto, M.C.3
Bengtson, M.H.4
Joazeiro, C.A.5
Tsuda, H.6
-
20
-
-
84961120508
-
The human model: Changing focus on autism research
-
Muotri AR. 2015. The human model: changing focus on autism research. Biol Psychiatry; doi: 10.1016/j.biopsych.2015.03.012.
-
(2015)
Biol Psychiatry
-
-
Muotri, A.R.1
-
21
-
-
84923362619
-
Roadmap Epigenomics Consortium. 2015. Integrative analysis of 111 reference human epigenomes
-
NIH (National Institutes of Health)
-
NIH (National Institutes of Health) Roadmap Epigenomics Consortium. 2015. Integrative analysis of 111 reference human epigenomes. Nature 518(7539):317–330; doi: 10.1038/nature14248.
-
Nature
, vol.518
, Issue.7539
, pp. 317-330
-
-
-
22
-
-
85052722223
-
-
NRC (National Research Council), Washington, DC:National Academies Press, accessed 14 May 2015
-
NRC (National Research Council). 2007. Toxicity Testing in the 21st Century: A Vision and a Strategy. Washington, DC:National Academies Press. Available: http://dels.nas.edu/Report/Toxicity-Testing-Twenty-first/11970 [accessed 14 May 2015].
-
(2007)
Toxicity Testing in the 21St Century: A Vision and A Strategy
-
-
-
23
-
-
84894281260
-
-
OECD (Organisation for Economic Co-operation and Development), OECD Series on Testing and Assessment No. 168. Part 1: Scientific Evidence. ENV/JM/MONO(2012)10/PART1. Paris:OECD, accessed 14 May 2015
-
OECD (Organisation for Economic Co-operation and Development). 2012. The adverse outcome pathway for skin sensitisation initiated by covalent binding to proteins. OECD Series on Testing and Assessment No. 168. Part 1: Scientific Evidence. ENV/JM/MONO(2012)10/PART1. Paris:OECD. Available: www.oecd.org/officialdocuments/displaydocumentpdf/?cote=env/jm/mono(2012)10/part1&doclanguage=en [accessed 14 May 2015].
-
(2012)
The Adverse Outcome Pathway for Skin Sensitisation Initiated by Covalent Binding to Proteins
-
-
-
25
-
-
84901706695
-
Is animal research sufficiently evidence based to be a cornerstone of biomedical research?
-
Pound P, Bracken MB. 2014. Is animal research sufficiently evidence based to be a cornerstone of biomedical research? BMJ 348:g3387; doi: 10.1136/bmj.g1.
-
(2014)
BMJ
, pp. 348
-
-
Pound, P.1
Bracken, M.B.2
-
28
-
-
84892678119
-
-
SCHER (Scientific Committee on Health and Environmental Risks), SCENIHR (Scientific Committee on Emerging and Newly Identified Health Risks), SCCS (Scientific Committee on Consumer Safety), March, Brussels:European Commission, accessed 14 May 2015
-
SCHER (Scientific Committee on Health and Environmental Risks), SCENIHR (Scientific Committee on Emerging and Newly Identified Health Risks), SCCS (Scientific Committee on Consumer Safety). 2013. Addressing the New Challenges for Risk Assessment, March 2013. Brussels:European Commission. Available: http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_131.pdf [accessed 14 May 2015].
-
(2013)
Addressing the New Challenges for Risk Assessment
-
-
-
29
-
-
84874457770
-
Genomic responses in mouse models poorly mimic human inflammatory diseases
-
Seok J, Warren HS, Cuenca AG, Mindrinos MN, Baker HV, Xu W, et al. 2013. Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc Natl Acad Sci USA 110:3507–3512; doi: 10.1073/pnas.1.
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 3507-3512
-
-
Seok, J.1
Warren, H.S.2
Cuenca, A.G.3
Mindrinos, M.N.4
Baker, H.V.5
Xu, W.6
-
30
-
-
84908165234
-
Epigenomic programming: A future way to health?
-
Shenderov BA, Midtvedt T. 2014. Epigenomic programming: a future way to health? Microb Ecol Health Dis 8:25; doi: 10.3402/mehd.v25.1.
-
(2014)
Microb Ecol Health Dis
, vol.8
, pp. 25
-
-
Shenderov, B.A.1
Midtvedt, T.2
-
31
-
-
79954604486
-
Resveratrol as an adjunct therapy in cyclophosphamide-treated MCF-7 cells and breast tumor explants
-
Singh N, Nigam M, Ranjan V, Zaidi D, Garg VK, Sharma S, et al. 2011. Resveratrol as an adjunct therapy in cyclophosphamide-treated MCF-7 cells and breast tumor explants. Cancer Sci 102(5):1059–1067; doi: 10.1111/j.1349-7006.2011.01893.x.
-
(2011)
Cancer Sci
, vol.102
, Issue.5
, pp. 1059-1067
-
-
Singh, N.1
Nigam, M.2
Ranjan, V.3
Zaidi, D.4
Garg, V.K.5
Sharma, S.6
-
32
-
-
84878628395
-
Dynamically regulated miRNA-mRNA networks revealed by exercise
-
Tonevitsky AG, Maltseva DV, Abbasi A, Samatov TR, Sakharov DA, Shkurnikov MU, et al. 2013. Dynamically regulated miRNA-mRNA networks revealed by exercise. BMC Physiol 13:9; doi: 10.1186/1472-6793-13-1.
-
(2013)
BMC Physiol
, vol.13
, pp. 9
-
-
Tonevitsky, A.G.1
Maltseva, D.V.2
Abbasi, A.3
Samatov, T.R.4
Sakharov, D.A.5
Shkurnikov, M.U.6
-
33
-
-
79251644774
-
Whole transcriptome sequencing reveals gene expression and splicing differences in brain regions affected by Alzheimer’s disease
-
Twine NA, Janitz K, Wilkins MR, Janitz M. 2011. Whole transcriptome sequencing reveals gene expression and splicing differences in brain regions affected by Alzheimer’s disease. PLoS One 21:6; doi: 10.1371/journal.pone.0016266
-
(2011)
Plos One
, vol.21
, pp. 6
-
-
Twine, N.A.1
Janitz, K.2
Wilkins, M.R.3
Janitz, M.4
-
34
-
-
84882278959
-
Workshop meeting report organs-on-chips: Human disease models
-
van de Stolpe A, den Toonder J. 2013. Workshop meeting report organs-on-chips: human disease models. Lab Chip 13(18):3449–3470.
-
(2013)
Lab Chip
, vol.13
, Issue.18
, pp. 3449-3470
-
-
Van De Stolpe, A.1
Den Toonder, J.2
-
35
-
-
84923242876
-
Innovative human-specific investigational approaches to autoimmune disease
-
van de Stolpe A, Kauffmann RH. 2015. Innovative human-specific investigational approaches to autoimmune disease. RSC Adv 5:18451-18463; doi: 10.1039/c4ra15794j.
-
(2015)
RSC Adv
, vol.5
, pp. 18451-18463
-
-
Van De Stolpe, A.1
Kauffmann, R.H.2
-
36
-
-
84908346679
-
Systems genetics: From GWAS to disease pathways
-
van der Sijde MR, Ng A, Fu J. 2014. Systems genetics: from GWAS to disease pathways. Biochim Biophys Acta 1842(10):1903–1.
-
(2014)
Biochim Biophys Acta
, vol.1842
, Issue.10
, pp. 1903-1911
-
-
Van Der Sijde, M.R.1
Ng, A.2
Fu, J.3
-
37
-
-
84884178912
-
Development of an adverse outcome pathway from drug-mediated bile salt export pump inhibition to cholestatic liver injury
-
Vinken M, Landesmann B, Goumenou M, Vinken S, Shah I, Jaeschke H, et al. 2013. Development of an adverse outcome pathway from drug-mediated bile salt export pump inhibition to cholestatic liver injury. Toxicol Sci 136(1):97–1.
-
(2013)
Toxicol Sci
, vol.136
, Issue.1
, pp. 97-101
-
-
Vinken, M.1
Landesmann, B.2
Goumenou, M.3
Vinken, S.4
Shah, I.5
Jaeschke, H.6
-
38
-
-
84873340340
-
In situ detection of individual mRNA molecules and protein complexes or post-translational modifications using padlock probes combined with the in situ proximity ligation assay
-
Weibrecht I, Lundin E, Kiflemariam S, Mignardi M, Grundberg I, Larsson C, et al. 2013. In situ detection of individual mRNA molecules and protein complexes or post-translational modifications using padlock probes combined with the in situ proximity ligation assay. Nat Protoc 8(2):355–1.
-
(2013)
Nat Protoc
, vol.8
, Issue.2
, pp. 355-361
-
-
Weibrecht, I.1
Lundin, E.2
Kiflemariam, S.3
Mignardi, M.4
Grundberg, I.5
Larsson, C.6
-
39
-
-
84946069027
-
Adverse outcome pathways: Development and use in toxicology
-
Wexler P, ed). 3rd ed. Waltham, Massachusetts:Academic Press
-
Willett C. 2014. Adverse outcome pathways: Development and use in toxicology. In: Encyclopedia of Toxicology, Vol. 1 (Wexler P, ed). 3rd ed. Waltham, Massachusetts:Academic Press, 95–1.
-
(2014)
Encyclopedia of Toxicology
, vol.1
, pp. 95-101
-
-
Willett, C.1
-
40
-
-
84890794015
-
Modeling heart disease in a dish: From somatic cells to disease- relevant cardiomyocytes
-
Zanella F, Lyon RC, Sheikh F. 2014. Modeling heart disease in a dish: from somatic cells to disease- relevant cardiomyocytes. Trends Cardiovasc Med 24(1):32–1.
-
(2014)
Trends Cardiovasc Med
, vol.24
, Issue.1
, pp. 32-41
-
-
Zanella, F.1
Lyon, R.C.2
Sheikh, F.3
-
41
-
-
84897487215
-
Turning the Titanic
-
Zerhouni EA. 2014. Turning the Titanic. Sci Transl Med 6(221):221ed2; doi: 10.1126/scitranslmed.3008294.
-
(2014)
Sci Transl Med
, vol.6
, Issue.221
-
-
Zerhouni, E.A.1
|