Adverse Outcome Pathways: Development and Use in Toxicology

Encyclopedia of Toxicology: Third Edition

Volumn , Issue , 2014, Pages 95-99

  Willett, C ^a  

^a Humane Society of the United States   (United States)

Author keywords

Adverse outcome pathway; Integrated testing strategy; Pathway based toxicology; Systems biology; Systems toxicology; Toxicity pathway

Indexed keywords

EID: 84946069027     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-386454-3.01244-6     Document Type: Chapter

References (18)

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7. Organization of Economic Cooperation and Development (OECD) The Adverse Outcome Pathway for Skin Sensitization Initiated by Covalent Binding to Proteins, Part 1: Scientific Evidence 2012, Series on Testing and Assessment, No.168.
8. Organization for Economic Cooperation and Development (OECD) Guidance Document on Developing and Assessing Adverse Outcome Pathways 2013, Series on Testing and Assessment No. 184.
9. Schultz T.W., Diderich B., Enoch S. The OECD Adverse Outcome Pathway Approach. AXLR8-2 Workshop and Progress Report: Alternative Testing Strategies 2011, DG Research and Innovation and AXLR8 Administration, Free University of Berlin, Berlin.
10. US Environmental Protection Agency Presentation to the 39th Joint Meeting of the Chemicals Committee and the Working Party on Chemicals: Experiences Using Integrated Approaches to Fulfil Information Requirements for Testing and Assessment 2006, (accessed 30.08.12.). http://www.oecd.org/env/chemicalsafetyandbiosafety/36286164.pdf.
11. AltTox, A Comprehensive Resource for Technical and Policy Information on the Development and Use of Alternative Methods. http://alttox.org.
12. European Commission Joint Research Council's SEURAT project. http://www.seurat-1.eu.
13. Hamner Institutes, Institute for Chemical Safety Sciences Toxicity Testing for the 21st Century project. http://www.thehamner.org/institutes-centers/institute-for-chemical-safety-sciences/toxicity-testing-in-the-21st-century%20.
14. Human Toxicology Project Consortium. http://www.humantoxicologyproject.org/.
15. Johns Hopkins School for Public Health Center for Alternatives to Animal Testing. http://caat.jhsph.edu/.
16. OECD Guidance on Document on Developing and Assessing Adverse Outcome Pathways. http://search.oecd.org/officialdocuments/displaydocumentpdf/?cote%3Denv/jm/mono(2013)6%26doclanguage%3Den.
17. US EPA Tox21 program. http://epa.gov/ncct/Tox21.
18. US EPA ToxCast program. http://www.epa.gov/ncct/toxcast.