Resveratrol as an adjunct therapy in cyclophosphamide-treated MCF-7 cells and breast tumor explants

Cancer Science

Volumn 102, Issue 5, 2011, Pages 1059-1067

  Singh, Neetu ^a   Nigam, Manisha ^a,b   Ranjan, Vishal ^a,b   Zaidi, Deeba ^a   Garg, Vivek Kumar ^c   Sharma, Sharad ^a   Chaturvedi, Rashmi ^c   Shankar, Rishi ^d   Kumar, Sadan ^a   Sharma, Ramesh ^a   Mitra, Kalyan ^a   Balapure, Anil K ^a   Rath, Srikanta K ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b UNIVERSITY OF ALLAHABAD   (India)

^c Lucknow Cancer Institute   (India)

^d CSIR INDIAN INSTITUTE OF TOXICOLOGY RESEARCH   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLINE; CYCLOPHOSPHAMIDE; ESTROGEN RECEPTOR; FAS LIGAND; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN BID; PROTEIN P53; REACTIVE OXYGEN METABOLITE; RESVERATROL; STRESS ACTIVATED PROTEIN KINASE;

ADJUVANT THERAPY; ADULT; ANTIGEN EXPRESSION; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER ADJUVANT THERAPY; CANCER COMBINATION CHEMOTHERAPY; CELL CYCLE PROGRESSION; CELL STRAIN MCF 7; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENTIATION; EXPLANT; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MITOCHONDRIAL MEMBRANE POTENTIAL; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; TISSUE CULTURE;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL CYCLE; CELL LINE, TUMOR; CHEMOTHERAPY, ADJUVANT; CYCLOPHOSPHAMIDE; FEMALE; HUMANS; IMMUNOPRECIPITATION; MICROSCOPY, ELECTRON, TRANSMISSION; MIDDLE AGED; OXIDATIVE STRESS; STILBENES; TUMOR CELLS, CULTURED;

EID: 79954604486     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2011.01893.x     Document Type: Article

References (30)

1. Lawenda BD, Kelly KM, Ladas EJ, Sagar SM, Vickers A, Blumberg JB. Should supplemental antioxidant administration be avoided during chemotherapy and radiation therapy? JNCI 2008; 100: 773-83.
2. Garg AK, Buchholz TA, Aggarwal BB. Chemosensitization and radiosensitization of tumors by plant polyphenols. Antioxid Redox Signal 2005; 7: 1630-47.
3. Pathak AK, Bhutani M, Guleria R et al. Chemotherapy alone vs. chemotherapy plus high dose multiple antioxidants in patients with advanced non-small cell lung cancer. J Am Coll Nutr 2005; 24 (1): 16-21.
4. Lissoni P, Barni S, Mandala M et al. Decreased toxicity and increased efficacy of cancer chemotherapy using the pineal hormone melatonin in metastatic solid tumour patients with poor clinical status. Eur J Cancer 1999; 35 (12): 1688-92.
5. Dorai T, Aggarwal BB. Role of chemopreventive agents in cancer therapy. Cancer Lett 2004; 215: 129-40.
6. Block KI, Koch AC, Mead MN, Tothy PK, Newman RA, Gyllenhaal C. Impact of antioxidant supplementation on chemotherapeutic toxicity: a systematic review of the evidence from randomized controlled trials. Int J Cancer 2008; 123 (6): 1227-39.
7. Sarkar FH, Li Y. Using chemopreventive agents to enhance the efficacy of cancer therapy. Cancer Res 2006; 66 (7): 3347-50.
8. Singh N, Nigam M, Ranjan V, Sharma R, Balapure AK, Rath SK. Caspase mediated enhanced apoptotic action of cyclophosphamide and Resveratrol treated MCF-7 cells. J Pharmacol Sci 2009; 109 (4): 473-85.
9. Yadav VK, Balaji S, Suresh PS et al. Pharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment for osteoporosis. Nat Med 2010; 16: 308-12.
10. Srivastava A, Tiwari M, Sinha RA et al. Molecular iodine induces caspase independent apoptosis in human breast carcinoma cells involving mitochondria-mediated pathway. J Biol Chem 2006; 281: 19762-71.
11. Nigam M, Ranjan V, Srivastava S, Sharma R, Balapure AK. Centchroman induces G0/G1 arrest and caspase-dependent apoptosis involving mitochondrial membrane depolarization in MCF-7 and MDA MB-231 human breast cancer cells. Life Sci 2008; 82: 577-90.
12. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with folin phenol reagent. J Biol Chem 1951; 193: 265-75.
13. Nigam M, Singh N, Ranjan V et al. Centchroman mediated apoptosis involves cross-talk between extrinsic/intrinsic pathways and oxidative regulation. Life Sci 2010; 87: 750-8.
14. McCord JM, Fridovich I. Superoxide dismutase: an enzymatic function for erythrocupein. J Biol Chem 1969; 244: 6049-55.
15. Beutler E. Catalase. In: Beutler E, ed. Red Cell Metabolism, A Manual of Biochemical Methods. New York: Academic Press, 1975; 89-90.
16. Sharma R, Srivastava S, Bajapai VK, Balapure AK. Histological and ultrastructural regulation in rabbit endometrial explants by estrogen in serum-free culture. In vitro Cell Dev Biol 2002; 38: 293-7.
17. Barthwal M, Srivastava K. Histologic studies on endometrium of menstruating monkeys wearing IUDS: comparative evaluation of drugs. Adv Contracept 1990; 6: 113-24.
18. Mobley JA, Brueggemeier RW. Estrogen receptor-mediated regulation of oxidative stress and DNA damage in breast cancer. Carcinogenesis 2004; 25: 3-9.
19. D'Autreaux B, Toledano MB. ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis. Mol Cell Biol 2007; 8: 813-24.
20. Salganik RI. The benefits and hazards of antioxidants: controlling apoptosis and other protective mechanisms in cancer patients and the human population. J Am Coll Nutr 2001; 20: 464S-72S.
21. Elmore S. Apoptosis: a review of programmed cell death. Toxicol Pathol 2007; 35 (4): 495-516.
22. Fuster JJ, Sanz-Gonzalez SM, Moll UM, Andres V. Classic and novel roles of p53: prospects for anticancer therapy. Trends Mol Med 2007; 13: 192-9.
23. Chopin V, Toillon RA, Jouy N, Le Bourhis X. P21WAF1/CIP1 is dispensable for G1arrest, but indispensable for apoptosis induced by sodium butyrate in MCF-7 breast cancer cells. Oncogene 2004; 23: 21-9.
24. Blundell RA. The biology of p21Waf1/Cip1 - review paper. Am J Biochem Biotech 2006; 2 (1): 33-40.
25. Cayrol C, Knibiehler M, Ducommun B. p21 binding to PCNA causes G1 and G2 cell cycle arrest in p53-deficient cells. Oncogene 1998; 16: 311-20.
26. Osthoff-Schulze K, Ferrari D, Los M, Wesselborg S, Peter ME. Apoptosis signaling by death receptors. Eur J Biochem 1998; 254: 439-59.
27. Filomeni G, Rotilio G, Ciriolo MR. Disulfide relays and phosphorylative cascades: partners in redox-mediated signaling pathways. Cell Death Differ 2005; 12: 1555-63.
28. Matsuzawa A, Ichijo H. Stress-responsive protein kinases in redox-regulated apoptosis signaling. Antioxid Redox Signal 2005; 7: 472-81.
29. Junttila MR, Li SP, Westermarck J. Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival. FASEB J 2008; 22 (4): 954-65.
30. 2 in cultured endothelial cells. Arch Biochem Biophys 1993; 302: 348.