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note
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Acknowledgments: I thank numerous colleagues for helpful comments on this essay, including C. Austin, T. Fauci, J. Goldstein, K. Hudson, E. Lander, S. Paul, L. Tabak, and H. Varmus. I also thank R. Ranganathan and C. Woods for the analysis included in Table 1 and R. Ranganathan and R. Kolberg for assistance in manuscript preparation.
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