SCOPUS 정보 검색 플랫폼

Science Translational Medicine

Volumn 6, Issue 221, 2014, Pages

Drug discovery: Turning the titanic

(1) Zerhouni, Elias A a

a NATIONAL INSTITUTES OF HEALTH (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PCSK9 PROTEIN, HUMAN; SERINE PROTEINASE;

ANIMAL; CLINICAL TRIAL (TOPIC); DRUG DEVELOPMENT; DRUG INDUSTRY; ECONOMICS; EDITORIAL; GENETICS; HUMAN; METABOLISM; MOLECULARLY TARGETED THERAPY; TRANSLATIONAL RESEARCH;

ANIMALS; CLINICAL TRIALS AS TOPIC; DRUG DISCOVERY; DRUG INDUSTRY; HUMANS; MOLECULAR TARGETED THERAPY; PROPROTEIN CONVERTASES; SERINE ENDOPEPTIDASES; TRANSLATIONAL MEDICAL RESEARCH;

EID: 84897487215 PISSN: 19466234 EISSN: 19466242 Source Type: Journal
DOI: 10.1126/scitranslmed.3008294 Document Type: Review

Times cited : (15)

References (6)

1
- 84872591994
- Pharmaceutical innovation gets a little help from new friends
- B. H. Munos, Pharmaceutical innovation gets a little help from new friends. Sci. Transl. Med. 5, 168ed1 (2013).
- (2013) Sci. Transl. Med. , vol.5
- Munos, B.H.¹

2
- 0037603589
- Mutations in PCSK9 cause autosomal dominant hypercholesterolemia
- M. Abifadel, M. Varret, J. P. Rabès, D. Allard, K. Ouguerram, M. Devillers, C. Cruaud, S. Benjannet, L. Wickham, D. Erlich, A. Derré, L. Villéger, M. Farnier, I. Beucler, E. Bruckert, J. Chambaz, B. Chanu, J. M. Lecerf, G. Luc, P. Moulin, J. Weissenbach, A. Prat, M. Krempf, C. Junien, N. G. Seidah, C. Boileau, Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. Nat. Genet. 34, 154-156 (2003).
- (2003) Nat. Genet. , vol.34 , pp. 154-156
- Abifadel, M.¹ Varret, M.² Rabès, J.P.³ Allard, D.⁴ Ouguerram, K.⁵ Devillers, M.⁶ Cruaud, C.⁷ Benjannet, S.⁸ Wickham, L.⁹ Erlich, D.¹⁰ Derré, A.¹¹ Villéger, L.¹² Farnier, M.¹³ Beucler, I.¹⁴ Bruckert, E.¹⁵ Chambaz, J.¹⁶ Chanu, B.¹⁷ Lecerf, J.M.¹⁸ Luc, G.¹⁹ Moulin, P.²⁰ more..

3
- 33645103550
- Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
- J. C. Cohen, E. Boerwinkle, T. H. Mosley Jr., H. H. Hobbs, Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N. Engl. J. Med. 354, 1264-1272 (2006).
- (2006) N. Engl. J. Med. , vol.354 , pp. 1264-1272
- Cohen, J.C.¹ Boerwinkle, E.² Mosley Jr., T.H.³ Hobbs, H.H.⁴

4
- 50149101511
- Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates
- M. Frank-Kamenetsky, A. Grefhorst, N. N. Anderson, T. S. Racie, B. Bramlage, A. Akinc, D. Butler, K. Charisse, R. Dorkin, Y. Fan, C. Gamba-Vitalo, P. Hadwiger, M. Jayaraman, M. John, K. N. Jayaprakash, M. Maier, L. Nechev, K. G. Rajeev, T. Read, I. Röhl, J. Soutschek, P. Tan, J. Wong, G. Wang, T. Zimmermann, A. de Fougerolles, H. P. Vornlocher, R. Langer, D. G. Anderson, M. Manoharan, V. Koteliansky, J. D. Horton, K. Fitzgerald, Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates. Proc. Natl. Acad. Sci. U.S.A. 105, 11915-11920 (2008).
- (2008) Proc. Natl. Acad. Sci. U.S.A. , vol.105 , pp. 11915-11920
- Frank-Kamenetsky, M.¹ Grefhorst, A.² Anderson, N.N.³ Racie, T.S.⁴ Bramlage, B.⁵ Akinc, A.⁶ Butler, D.⁷ Charisse, K.⁸ Dorkin, R.⁹ Fan, Y.¹⁰ Gamba-Vitalo, C.¹¹ Hadwiger, P.¹² Jayaraman, M.¹³ John, M.¹⁴ Jayaprakash, K.N.¹⁵ Maier, M.¹⁶ Nechev, L.¹⁷ Rajeev, K.G.¹⁸ Read, T.¹⁹ Röhl, I.²⁰ more..

5
- 84925937200
- Rare mutation ignites race for cholesterol drug
- 9 July
- "Rare mutation ignites race for cholesterol drug," New York Times, 9 July 2013; www.nytimes.com/2013/07/10/health/rare-mutation-prompts- race-for-cholesterol-drug.html?pagewanted=all&-r=0.
- (2013) New York Times

6
- 84864206454
- Antibodies to PCSK9: A superior way to lower LDL cholesterol?
- K. N. Maxwell, J. L. Breslow, Antibodies to PCSK9: A superior way to lower LDL cholesterol? Circ. Res. 111, 274-277 (2012).
- (2012) Circ. Res. , vol.111 , pp. 274-277
- Maxwell, K.N.¹ Breslow, J.L.²

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.