메뉴 건너뛰기




Volumn 180, Issue 1, 1996, Pages 353-364

A gradient of Cactus protein degradation establishes dorsoventral polarity in the Drosophila embryo

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; PROTEIN; SERINE;

EID: 0030601972     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1006/dbio.1996.0308     Document Type: Article
Times cited : (102)

References (50)
  • 1
    • 0021603716 scopus 로고
    • Information for the dorsal-ventral pattern of the Drosophila embryo is stored as maternal mRNA
    • Anderson, K. V., and Nüsslein-Volhard, C. (1984). Information for the dorsal-ventral pattern of the Drosophila embryo is stored as maternal mRNA. Nature 311, 223-227.
    • (1984) Nature , vol.311 , pp. 223-227
    • Anderson, K.V.1    Nüsslein-Volhard, C.2
  • 2
    • 0003455528 scopus 로고
    • Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York
    • Ashburner, M. (1989). "Drosophila: A. Laboratory Handbook." Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
    • (1989) Drosophila: A. Laboratory Handbook
    • Ashburner, M.1
  • 3
    • 0028916254 scopus 로고
    • Cactus protein degradation mediates Drosophila dorsal-ventral signaling
    • Belvin, M. P., Jin, Y., and Anderson, K. V. (1995). Cactus protein degradation mediates Drosophila dorsal-ventral signaling. Genes Dev. 9, 783-793.
    • (1995) Genes Dev. , vol.9 , pp. 783-793
    • Belvin, M.P.1    Jin, Y.2    Anderson, K.V.3
  • 4
    • 0030294481 scopus 로고    scopus 로고
    • A gradient of cytoplasmic Cactus degradation establishes the nuclear localization gradient of the dorsal morphogen in Drosophila
    • in press
    • Bergmann, A., Stein, D., Geisler, R., Hagenmaier, S., Schmid, B., Fernandez, N., Schnell, B., and Nüsslein-Volhard, C. (1996). A gradient of cytoplasmic Cactus degradation establishes the nuclear localization gradient of the dorsal morphogen in Drosophila. Mech. Dev., in press.
    • (1996) Mech. Dev.
    • Bergmann, A.1    Stein, D.2    Geisler, R.3    Hagenmaier, S.4    Schmid, B.5    Fernandez, N.6    Schnell, B.7    Nüsslein-Volhard, C.8
  • 6
    • 0028986075 scopus 로고
    • Control of IκB-α proteolysis by site-specific, signal-induced phosphorylation
    • Brown, K., Gerstberger, S., Carlson, L., Franzoso, G., and Siebenlist, U. (1995). Control of IκB-α proteolysis by site-specific, signal-induced phosphorylation. Science 267, 1485-1488.
    • (1995) Science , vol.267 , pp. 1485-1488
    • Brown, K.1    Gerstberger, S.2    Carlson, L.3    Franzoso, G.4    Siebenlist, U.5
  • 7
    • 0029865142 scopus 로고    scopus 로고
    • Purification and molecular characterization of IRAK, an IL-1 Receptor-Associated Kinase
    • Cao, Z., Henzel, W. J., and Gao, X. (1996). Purification and molecular characterization of IRAK, an IL-1 Receptor-Associated Kinase. Science 271, 1128-1131.
    • (1996) Science , vol.271 , pp. 1128-1131
    • Cao, Z.1    Henzel, W.J.2    Gao, X.3
  • 8
    • 0030004897 scopus 로고    scopus 로고
    • Site-specific phosphorylation of IκB-α by a novel ubiquitination-dependent protein kinase activity
    • Chen, Z. J., Parent, L., and Maniatis, T. (1996). Site-specific phosphorylation of IκB-α by a novel ubiquitination-dependent protein kinase activity. Cell 84, 853-862.
    • (1996) Cell , vol.84 , pp. 853-862
    • Chen, Z.J.1    Parent, L.2    Maniatis, T.3
  • 9
    • 0029670083 scopus 로고    scopus 로고
    • Mapping of the inducible IκB phosphorylation sites that signal its ubiquitination and degradation
    • DiDonato, J., Mercurio, F., Rosette, C., Wu-Li, J., Suyang, H., Ghosh, S., and Karin, M. (1996). Mapping of the inducible IκB phosphorylation sites that signal its ubiquitination and degradation. Mol. Cell. Biol. 16, 1295-1304.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 1295-1304
    • DiDonato, J.1    Mercurio, F.2    Rosette, C.3    Wu-Li, J.4    Suyang, H.5    Ghosh, S.6    Karin, M.7
  • 10
    • 0025182099 scopus 로고
    • Autonomous determination of anterior structures in the early Drosophila embryo by the bicoid morphogen
    • Driever, W., Siegel, V., and Nüsslein-Volhard, C. (1990). Autonomous determination of anterior structures in the early Drosophila embryo by the bicoid morphogen. Development 109, 811-820.
    • (1990) Development , vol.109 , pp. 811-820
    • Driever, W.1    Siegel, V.2    Nüsslein-Volhard, C.3
  • 11
    • 0029840669 scopus 로고    scopus 로고
    • Origins of immunity: Relish, a compound Rel-like gene in the antibacterial defense of Drosophila
    • Dushay, M. S., Åsling, B., and Hultmark, D. (1996). Origins of immunity: Relish, a compound Rel-like gene in the antibacterial defense of Drosophila. Proc. Natl. Acad. Sci. USA 93, 10343-10347.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 10343-10347
    • Dushay, M.S.1    Åsling, B.2    Hultmark, D.3
  • 12
    • 0029360415 scopus 로고
    • The death domain: A module shared by proteins with diverse cellular functions
    • Feinstein, E., Kimichi, A., Wallach, D., Boldin, M., and Varfolomeev, E. (1995). The death domain: A module shared by proteins with diverse cellular functions. Trends Biochem. 20, 342-344.
    • (1995) Trends Biochem. , vol.20 , pp. 342-344
    • Feinstein, E.1    Kimichi, A.2    Wallach, D.3    Boldin, M.4    Varfolomeev, E.5
  • 13
    • 0029007386 scopus 로고
    • Interaction of the pelle kinase with the membrane-associated protein tube is required for transduction of the dorsoventral signal in Drosophila embryos
    • Galindo, R. L., Edwards, D. N., Gillespie, S. K. H., and Wasserman, S. A. (1995). Interaction of the pelle kinase with the membrane-associated protein tube is required for transduction of the dorsoventral signal in Drosophila embryos. Development 121, 2209-2218.
    • (1995) Development , vol.121 , pp. 2209-2218
    • Galindo, R.L.1    Edwards, D.N.2    Gillespie, S.K.H.3    Wasserman, S.A.4
  • 14
    • 0025774776 scopus 로고
    • Drosophila Toll and IL-1 receptor
    • Gay, N. J., and Keith, F. J. (1991). Drosophila Toll and IL-1 receptor [letter]. Nature 351, 355-356.
    • (1991) Nature , vol.351 , pp. 355-356
    • Gay, N.J.1    Keith, F.J.2
  • 15
    • 0026486817 scopus 로고
    • Cactus, a gene involved in dorsoventral pattern formation of Drosophila, is related to the IκB gene family of vertebrates
    • Geisler, R., Bergmann, A., Hiromi, Y., and Nüsslein-Volhard, C. (1992). cactus, a gene involved in dorsoventral pattern formation of Drosophila, is related to the IκB gene family of vertebrates. Cell 71, 613-621.
    • (1992) Cell , vol.71 , pp. 613-621
    • Geisler, R.1    Bergmann, A.2    Hiromi, Y.3    Nüsslein-Volhard, C.4
  • 16
    • 0028176570 scopus 로고
    • Dorsal, a Drosophila Rel-like protein, is phosphorylated upon activation of the transmembrane protein Toll
    • Gillespie, S. K. H., and Wasserman, S. A. (1994). dorsal, a Drosophila Rel-like protein, is phosphorylated upon activation of the transmembrane protein Toll. Mol. Cell. Biol. 14, 3559-3568.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 3559-3568
    • Gillespie, S.K.H.1    Wasserman, S.A.2
  • 17
    • 0027464796 scopus 로고
    • Homeostatic balance between dorsal and cactus proteins in the Drosophila embryo
    • Govind, S., Brennan, L., and Steward, R. (1993). Homeostatic balance between dorsal and cactus proteins in the Drosophila embryo. Development 117, 135-148.
    • (1993) Development , vol.117 , pp. 135-148
    • Govind, S.1    Brennan, L.2    Steward, R.3
  • 18
    • 0028075756 scopus 로고
    • Activation of the kinase Pelle by Tube in the dorsoventral signal transduction pathway of Drosophila embryo
    • Großhans, J. A., Bergman, A., Haffter, P., and Nüsslein-Volhard, C. (1994). Activation of the kinase Pelle by Tube in the dorsoventral signal transduction pathway of Drosophila embryo. Nature 372, 563-566.
    • (1994) Nature , vol.372 , pp. 563-566
    • Großhans, J.A.1    Bergman, A.2    Haffter, P.3    Nüsslein-Volhard, C.4
  • 19
    • 0024508141 scopus 로고
    • Synergistic activation and repression of transcription by Drosophila homeobox proteins
    • Han, K., Levine, M. S., and Manley, J. L. (1989). Synergistic activation and repression of transcription by Drosophila homeobox proteins. Cell 56, 573-583.
    • (1989) Cell , vol.56 , pp. 573-583
    • Han, K.1    Levine, M.S.2    Manley, J.L.3
  • 20
    • 0003448569 scopus 로고
    • Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York
    • Harlow, E., and Lane, D. (1988). "Antibodies: A Laboratory Manual." Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
    • (1988) Antibodies: A Laboratory Manual
    • Harlow, E.1    Lane, D.2
  • 21
    • 0027441761 scopus 로고
    • Genetic characterization of tube and pelle, genes required for signaling between Toll and dorsal in specification of the dorsal-ventral pattern of the Drosophila embryo
    • Hecht, P. M., and Anderson, K. V. (1993). Genetic characterization of tube and pelle, genes required for signaling between Toll and dorsal in specification of the dorsal-ventral pattern of the Drosophila embryo. Genetics 135, 405-417.
    • (1993) Genetics , vol.135 , pp. 405-417
    • Hecht, P.M.1    Anderson, K.V.2
  • 22
    • 0026722283 scopus 로고
    • Dorsal-twist interactions establish snail expression in the presumptive mesoderm of the Drosophila embryo
    • Ip, Y. T., Park, R. E., Kosman, D., Yazdanbakhsh, K., and Levine, M. (1992). dorsal-twist interactions establish snail expression in the presumptive mesoderm of the Drosophila embryo. Genes Dev. 6, 1518-1530.
    • (1992) Genes Dev. , vol.6 , pp. 1518-1530
    • Ip, Y.T.1    Park, R.E.2    Kosman, D.3    Yazdanbakhsh, K.4    Levine, M.5
  • 24
    • 0026491071 scopus 로고
    • Characterization of the Drosophila cactus locus and analysis of interactions between cactus and dorsal proteins
    • Kidd, S. (1992). Characterization of the Drosophila cactus locus and analysis of interactions between cactus and dorsal proteins. Cell 71, 623-635.
    • (1992) Cell , vol.71 , pp. 623-635
    • Kidd, S.1
  • 25
    • 0027432438 scopus 로고
    • Relocalization of Drosophila dorsal protein can be induced by a rise in cytoplasmic calcium concentration and the expression of constitutively active but not wild-type Toll receptors
    • Kubota, K., Keith, F. J., and Gay, N. J. (1993). Relocalization of Drosophila dorsal protein can be induced by a rise in cytoplasmic calcium concentration and the expression of constitutively active but not wild-type Toll receptors. Biochem. J. 296, 497-503.
    • (1993) Biochem. J. , vol.296 , pp. 497-503
    • Kubota, K.1    Keith, F.J.2    Gay, N.J.3
  • 26
    • 0028877993 scopus 로고
    • Functional analysis and regulation of nuclear import of dorsal during the immune response in Drosophila
    • Lemaitre, B., Meister, M., Govind, S., Georgel, P., Steward, R., Reichhart, J. M., and Hoffmann, J. A. (1995). Functional analysis and regulation of nuclear import of dorsal during the immune response in Drosophila. EMBO J. 14, 536-545.
    • (1995) EMBO J. , vol.14 , pp. 536-545
    • Lemaitre, B.1    Meister, M.2    Govind, S.3    Georgel, P.4    Steward, R.5    Reichhart, J.M.6    Hoffmann, J.A.7
  • 27
    • 0026030444 scopus 로고
    • Genetic and molecular characterization of tube, a Drosophila gene maternally required for embryonic dorsoventral polarity
    • Letsou, A., Alexander, S., Orth, K., and Wasserman, S. A. (1991). Genetic and molecular characterization of tube, a Drosophila gene maternally required for embryonic dorsoventral polarity. Proc. Natl. Acad. Sci. USA 88, 810-814.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 810-814
    • Letsou, A.1    Alexander, S.2    Orth, K.3    Wasserman, S.A.4
  • 28
    • 0027266027 scopus 로고
    • Domain mapping of tube, a protein essential for dorsoventral patterning of the Drosophila embryo
    • Letsou, A., Alexander, S., and Wasserman, S. A. (1993). Domain mapping of tube, a protein essential for dorsoventral patterning of the Drosophila embryo. EMBO J. 12, 3449-3458.
    • (1993) EMBO J. , vol.12 , pp. 3449-3458
    • Letsou, A.1    Alexander, S.2    Wasserman, S.A.3
  • 31
    • 0028167111 scopus 로고
    • The spätzle gene encodes a component of the extracellular signaling pathway establishing the dorsal-ventral pattern of the Drosophila embryo
    • Morisato, D., and Anderson, K. V. (1994). The spätzle gene encodes a component of the extracellular signaling pathway establishing the dorsal-ventral pattern of the Drosophila embryo. Cell 76, 677-688.
    • (1994) Cell , vol.76 , pp. 677-688
    • Morisato, D.1    Anderson, K.V.2
  • 32
    • 0029591416 scopus 로고
    • Signaling pathways that establish the dorsal-ventral pattern of the Drosophila embryo
    • Morisato, D., and Anderson, K. V. (1995). Signaling pathways that establish the dorsal-ventral pattern of the Drosophila embryo. Annu. Rev. Genet. 29, 371-399.
    • (1995) Annu. Rev. Genet. , vol.29 , pp. 371-399
    • Morisato, D.1    Anderson, K.V.2
  • 33
    • 0026784680 scopus 로고
    • Selective nuclear transport of the Drosophila morphogen dorsal can be established by a signaling pathway involving the transmembrane protein Toll and protein kinase A
    • Norris, J. L., and Manley, J. L. (1992). Selective nuclear transport of the Drosophila morphogen dorsal can be established by a signaling pathway involving the transmembrane protein Toll and protein kinase A. Genes Dev. 6, 1654-1667.
    • (1992) Genes Dev. , vol.6 , pp. 1654-1667
    • Norris, J.L.1    Manley, J.L.2
  • 34
    • 0028907904 scopus 로고
    • Regulation of dorsal in cultured cells by Toll and tube: Tube function involves a novel mechanism
    • Norris, J. L., and Manley, J. L. (1995). Regulation of dorsal in cultured cells by Toll and tube: Tube function involves a novel mechanism. Genes Dev. 9, 358-369.
    • (1995) Genes Dev. , vol.9 , pp. 358-369
    • Norris, J.L.1    Manley, J.L.2
  • 35
    • 0029925960 scopus 로고    scopus 로고
    • Functional interactions between the pelle kinase, Toll receptor, and tube suggest a mechanism for activation of dorsal
    • Norris, J. L., and Manley, J. L. (1996). Functional interactions between the pelle kinase, Toll receptor, and tube suggest a mechanism for activation of dorsal. Genes Dev. 10, 862-872.
    • (1996) Genes Dev. , vol.10 , pp. 862-872
    • Norris, J.L.1    Manley, J.L.2
  • 36
    • 0025774201 scopus 로고
    • Cactus, a maternal gene required for proper formation of the dorsoventral morphogen gradient in Drosophila embryos
    • Roth, S., Hiromi, Y., Godt, D., and Nüsslein-Volhard, C. (1991). cactus, a maternal gene required for proper formation of the dorsoventral morphogen gradient in Drosophila embryos. Development 112, 371-388.
    • (1991) Development , vol.112 , pp. 371-388
    • Roth, S.1    Hiromi, Y.2    Godt, D.3    Nüsslein-Volhard, C.4
  • 37
    • 0024834128 scopus 로고
    • A gradient of nuclear localization of the dorsal protein determines dorsoventral pattern in the Drosophila embryo
    • Roth, S., Stein, D., and Nüsslein-Volhard, C. (1989). A gradient of nuclear localization of the dorsal protein determines dorsoventral pattern in the Drosophila embryo. Cell 59, 1189-1202.
    • (1989) Cell , vol.59 , pp. 1189-1202
    • Roth, S.1    Stein, D.2    Nüsslein-Volhard, C.3
  • 38
    • 0024839859 scopus 로고
    • The graded distribution of the dorsal morphogen is initiated by selective nuclear transport in Drosophila
    • Rushlow, C. A., Han, K., Manley, J. L., and Levine, M. (1989). The graded distribution of the dorsal morphogen is initiated by selective nuclear transport in Drosophila. Cell 59, 1165-1177.
    • (1989) Cell , vol.59 , pp. 1165-1177
    • Rushlow, C.A.1    Han, K.2    Manley, J.L.3    Levine, M.4
  • 39
    • 0025804653 scopus 로고
    • Dominant and recessive mutations define functional domains of Toll, a transmembrane protein required for dorsal-ventral polarity in the Drosophila embryo
    • Schneider, D. S., Hudson, K. L., Lin, T. Y., and Anderson, K. V. (1991). Dominant and recessive mutations define functional domains of Toll, a transmembrane protein required for dorsal-ventral polarity in the Drosophila embryo. Genes Dev. 5, 797-807.
    • (1991) Genes Dev. , vol.5 , pp. 797-807
    • Schneider, D.S.1    Hudson, K.L.2    Lin, T.Y.3    Anderson, K.V.4
  • 40
    • 0028182623 scopus 로고
    • A processed form of the spätzle protein defines dorsal-ventral polarity in the Drosophila embryo
    • Schneider, D. S., Jin, Y., Morisato, D., and Anderson, K. V. (1994). A processed form of the spätzle protein defines dorsal-ventral polarity in the Drosophila embryo. Development 120, 1243-1250.
    • (1994) Development , vol.120 , pp. 1243-1250
    • Schneider, D.S.1    Jin, Y.2    Morisato, D.3    Anderson, K.V.4
  • 41
    • 0024525693 scopus 로고
    • Female sterile mutations on the second chromosome of Drosophila melanogaster. I. Maternal effect mutations
    • Schüpbach, T., and Wieschaus, E. (1989). Female sterile mutations on the second chromosome of Drosophila melanogaster. I. Maternal effect mutations. Genetics 121, 101-117.
    • (1989) Genetics , vol.121 , pp. 101-117
    • Schüpbach, T.1    Wieschaus, E.2
  • 42
    • 0027499132 scopus 로고
    • Pelle encodes a protein kinase required to establish dorsoventral polarity in the Drosophila embryo
    • Shelton, C. A., and Wasserman, S. A. (1993). pelle encodes a protein kinase required to establish dorsoventral polarity in the Drosophila embryo. Cell 72, 515-525.
    • (1993) Cell , vol.72 , pp. 515-525
    • Shelton, C.A.1    Wasserman, S.A.2
  • 43
    • 0025803877 scopus 로고
    • The polarity of the dorsoventral axis in the Drosophila embryo is defined by an extracellular signal
    • Stein, D., Roth, S., Vogelsang, E., and Nüsslein-Volhard, C. (1991). The polarity of the dorsoventral axis in the Drosophila embryo is defined by an extracellular signal. Cell 65, 725-735.
    • (1991) Cell , vol.65 , pp. 725-735
    • Stein, D.1    Roth, S.2    Vogelsang, E.3    Nüsslein-Volhard, C.4
  • 44
    • 85029462284 scopus 로고
    • Multiple extracellular activities are required for establishment of embryonic dorsalventral polarity
    • Stein, D., and Nüsslein-Volhard, C. (1992). Multiple extracellular activities are required for establishment of embryonic dorsalventral polarity. Cell 65, 725-735.
    • (1992) Cell , vol.65 , pp. 725-735
    • Stein, D.1    Nüsslein-Volhard, C.2
  • 45
    • 0024814230 scopus 로고
    • Relocalization of the dorsal protein from the cytoplasm to the nucleus correlates with its function
    • Steward, R. (1989). Relocalization of the dorsal protein from the cytoplasm to the nucleus correlates with its function. Cell 59, 1179-1188.
    • (1989) Cell , vol.59 , pp. 1179-1188
    • Steward, R.1
  • 46
    • 0026537051 scopus 로고
    • The origin of pattern and polarity in the Drosophila embryo
    • St. Johnston, D., and Nüsslein-Volhard, C. (1992). The origin of pattern and polarity in the Drosophila embryo. Cell 68, 201-219.
    • (1992) Cell , vol.68 , pp. 201-219
    • St. Johnston, D.1    Nüsslein-Volhard, C.2
  • 47
    • 0028978032 scopus 로고
    • Phosphorylation of human IκB-α on serines 32 and 36 controls IκB-α proteolysis and NF-κB activation in response to diverse stimuli
    • Traenckner, E. B., Pahl, H. L., Henkel, T., Schmidt, K. N., Wilk, S., and Baeuerle, P.A. (1995). Phosphorylation of human IκB-α on serines 32 and 36 controls IκB-α proteolysis and NF-κB activation in response to diverse stimuli. EMBO J. 14, 2876-2883.
    • (1995) EMBO J. , vol.14 , pp. 2876-2883
    • Traenckner, E.B.1    Pahl, H.L.2    Henkel, T.3    Schmidt, K.N.4    Wilk, S.5    Baeuerle, P.A.6
  • 49
    • 0027244187 scopus 로고
    • A conserved signal transduction pathway regulating the activity of the rel-like proteins dorsal and NF-κB
    • Wasserman, S. A. (1993). A conserved signal transduction pathway regulating the activity of the rel-like proteins dorsal and NF-κB. Mol. Biol. Cell. 4, 767-771.
    • (1993) Mol. Biol. Cell. , vol.4 , pp. 767-771
    • Wasserman, S.A.1
  • 50
    • 0027361974 scopus 로고
    • Dissociation of the dorsal-cactus complex and phosphorylation of the dorsal protein correlate with the nuclear localization of dorsal
    • Whalen, A. M., and Steward, R. (1993). Dissociation of the dorsal-cactus complex and phosphorylation of the dorsal protein correlate with the nuclear localization of dorsal. J. Cell Biol. 123, 523-534.
    • (1993) J. Cell Biol. , vol.123 , pp. 523-534
    • Whalen, A.M.1    Steward, R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.