-
2
-
-
84885353689
-
Early and locally advanced non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
-
23860613
-
Vansteenkiste J, De Ruysscher D, Eberhardt WE, et al. Early and locally advanced non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2013;24(Suppl 6):vi89-98.
-
(2013)
Ann Oncol.
, vol.24
, pp. vi89-vi98
-
-
Vansteenkiste, J.1
De Ruysscher, D.2
Eberhardt, W.E.3
-
3
-
-
84883013481
-
Management of non-small-cell lung cancer: Recent developments
-
1:CAS:528:DC%2BC3sXhtlClt7%2FF 23972814
-
Reck M, Heigener DF, Mok T, et al. Management of non-small-cell lung cancer: recent developments. Lancet. 2013;382(9893):709-19.
-
(2013)
Lancet.
, vol.382
, Issue.9893
, pp. 709-719
-
-
Reck, M.1
Heigener, D.F.2
Mok, T.3
-
4
-
-
84861203302
-
EGFR-mutated oncogene-addicted non-small cell lung cancer: Current trends and future prospects
-
1:CAS:528:DC%2BC38Xnt1Kltb0%3D 22119437
-
Soria JC, Mok TS, Cappuzzo F, Jänne PA. EGFR-mutated oncogene-addicted non-small cell lung cancer: current trends and future prospects. Cancer Treat Rev. 2012;38(5):416-30.
-
(2012)
Cancer Treat Rev.
, vol.38
, Issue.5
, pp. 416-430
-
-
Soria, J.C.1
Mok, T.S.2
Cappuzzo, F.3
Jänne, P.A.4
-
5
-
-
84937513065
-
Afatinib versus cisplatin-based chemotherapy for EGFR mutation-positive lung adenocarcinoma (LUX-Lung 3 and LUX-Lung 6): Analysis of overall survival data from two randomised, phase 3 trials
-
1:CAS:528:DC%2BC2MXhtVSgt7%2FP 26051236
-
Yang JC, Wu Y, Schuler M, et al. Afatinib versus cisplatin-based chemotherapy for EGFR mutation-positive lung adenocarcinoma (LUX-Lung 3 and LUX-Lung 6): analysis of overall survival data from two randomised, phase 3 trials. Lancet Oncol. 2015;16(7):830-8.
-
(2015)
Lancet Oncol.
, vol.16
, Issue.7
, pp. 830-838
-
-
Yang, J.C.1
Wu, Y.2
Schuler, M.3
-
6
-
-
84911493241
-
Metastatic non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
-
25115305
-
Reck M, Popat S, Reinmuth N, et al. Metastatic non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2014;25(Suppl 3):iii27-39.
-
(2014)
Ann Oncol.
, vol.25
, pp. iii27-iii39
-
-
Reck, M.1
Popat, S.2
Reinmuth, N.3
-
7
-
-
84862586903
-
Emerging new agents for the management of patients with non-small cell lung cancer
-
1:CAS:528:DC%2BC38Xht1WksLnK 22712796
-
Capelletto E, Novello S. Emerging new agents for the management of patients with non-small cell lung cancer. Drugs. 2012;72(Suppl 1):37-52.
-
(2012)
Drugs.
, vol.72
, pp. 37-52
-
-
Capelletto, E.1
Novello, S.2
-
8
-
-
84937729800
-
Treatment of ALK-rearranged non-small cell lung cancer: Recent progress and future directions
-
1:CAS:528:DC%2BC2MXhtVKlsrvE 26076736
-
Cameron L, Solomon B. Treatment of ALK-rearranged non-small cell lung cancer: recent progress and future directions. Drugs. 2015;75(10):1059-70.
-
(2015)
Drugs.
, vol.75
, Issue.10
, pp. 1059-1070
-
-
Cameron, L.1
Solomon, B.2
-
9
-
-
84936791837
-
Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer
-
1:CAS:528:DC%2BC2MXht12qu7%2FJ 26028407
-
Brahmer J, Reckamp KL, Baas P, et al. Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer. N Engl J Med. 2015;373(2):123-35.
-
(2015)
N Engl J Med.
, vol.373
, Issue.2
, pp. 123-135
-
-
Brahmer, J.1
Reckamp, K.L.2
Baas, P.3
-
10
-
-
84931424042
-
Phase III, randomized trial (CheckMate 057) of nivolumab (NIVO) versus docetaxel (DOC) in advanced non-squamous cell (non-SQ) non-small cell lung cancer (NSCLC)
-
Paz-Ares L, Horn L, Borghaei H, et al. Phase III, randomized trial (CheckMate 057) of nivolumab (NIVO) versus docetaxel (DOC) in advanced non-squamous cell (non-SQ) non-small cell lung cancer (NSCLC). J Clin Oncol. 2015;33(15):LBA109.
-
(2015)
J Clin Oncol
, vol.33
, Issue.15
, pp. LBA109
-
-
Paz-Ares, L.1
Horn, L.2
Borghaei, H.3
-
11
-
-
84929481480
-
Pembrolizumab for the treatment of non-small-cell lung cancer
-
25891174
-
Garon EB, Rizvi NA, Hui R, et al. Pembrolizumab for the treatment of non-small-cell lung cancer. N Engl J Med. 2015;372(21):2018-28.
-
(2015)
N Engl J Med.
, vol.372
, Issue.21
, pp. 2018-2028
-
-
Garon, E.B.1
Rizvi, N.A.2
Hui, R.3
-
12
-
-
79959945851
-
Genetic and epigenetic changes in lung carcinoma and their clinical implications
-
21423157
-
Wen J, Fu J, Zhang W, Guo M. Genetic and epigenetic changes in lung carcinoma and their clinical implications. Mod Pathol. 2011;24(7):932-43.
-
(2011)
Mod Pathol.
, vol.24
, Issue.7
, pp. 932-943
-
-
Wen, J.1
Fu, J.2
Zhang, W.3
Guo, M.4
-
13
-
-
84871673425
-
Specific biomarkers are associated with docetaxel and gemcitabine-resistant NSCLC cell lines
-
3567725 23397475
-
Pasini A, Paganelli G, Tesei, et al. Specific biomarkers are associated with docetaxel and gemcitabine-resistant NSCLC cell lines. Transl Oncol. 2012;5(6):461-8.
-
(2012)
Transl Oncol.
, vol.5
, Issue.6
, pp. 461-468
-
-
Pasini, A.1
Paganelli, G.2
Tesei3
-
14
-
-
84871282536
-
The significance of epigenetic alterations in lung carcinogenesis
-
3518808 23086271
-
Brzeziańska E, Dutkowska A, Antczak A. The significance of epigenetic alterations in lung carcinogenesis. Mol Biol Rep. 2013;40(1):309-25.
-
(2013)
Mol Biol Rep.
, vol.40
, Issue.1
, pp. 309-325
-
-
Brzeziańska, E.1
Dutkowska, A.2
Antczak, A.3
-
15
-
-
33847065486
-
The epigenomics of cancer
-
3894624 1:CAS:528:DC%2BD2sXis12ju7k%3D 17320506
-
Jones PA, Baylin SB. The epigenomics of cancer. Cell. 2007;128(4):683-92.
-
(2007)
Cell.
, vol.128
, Issue.4
, pp. 683-692
-
-
Jones, P.A.1
Baylin, S.B.2
-
16
-
-
77349111955
-
Lung cancer: From single-gene methylation to methylome profiling
-
1:CAS:528:DC%2BC3cXitVOjtL8%3D 20099008
-
Heller G, Zielinski CC, Zöchbauer-Müller S. Lung cancer: from single-gene methylation to methylome profiling. Cancer Metastasis Rev. 2010;29(1):95-107.
-
(2010)
Cancer Metastasis Rev.
, vol.29
, Issue.1
, pp. 95-107
-
-
Heller, G.1
Zielinski, C.C.2
Zöchbauer-Müller, S.3
-
18
-
-
4544250024
-
Gene-promoter hypermethylation as a biomarker in lung cancer
-
1:CAS:528:DC%2BD2cXntFCmsbY%3D 15343277
-
Belinsky SA. Gene-promoter hypermethylation as a biomarker in lung cancer. Nat Rev Cancer. 2004;4(9):707-17.
-
(2004)
Nat Rev Cancer.
, vol.4
, Issue.9
, pp. 707-717
-
-
Belinsky, S.A.1
-
19
-
-
33645521023
-
Promoter hypermethylation of multiple genes in sputum precedes lung cancer incidence in a high-risk cohort
-
1:CAS:528:DC%2BD28Xitlertb8%3D 16540689
-
Belinsky SA, Liechty KC, Gentry FD, et al. Promoter hypermethylation of multiple genes in sputum precedes lung cancer incidence in a high-risk cohort. Cancer Res. 2006;66(6):3338-44.
-
(2006)
Cancer Res.
, vol.66
, Issue.6
, pp. 3338-3344
-
-
Belinsky, S.A.1
Liechty, K.C.2
Gentry, F.D.3
-
20
-
-
84888205771
-
Epigenetic biomarkers in lung cancer
-
1:CAS:528:DC%2BC38XntlSnsLk%3D 22546286
-
Liloglou T, Bediaga NG, Brown BR, Field JK, Davies MP. Epigenetic biomarkers in lung cancer. Cancer Lett. 2014;342(2):200-12.
-
(2014)
Cancer Lett.
, vol.342
, Issue.2
, pp. 200-212
-
-
Liloglou, T.1
Bediaga, N.G.2
Brown, B.R.3
Field, J.K.4
Davies, M.P.5
-
21
-
-
4344596649
-
The relationship between aberrant methylation and survival in non-small-cell lung cancers
-
2364802 1:CAS:528:DC%2BD2cXmsVCgsbw%3D 15266335
-
Toyooka S, Suzuki M, Maruyama R, et al. The relationship between aberrant methylation and survival in non-small-cell lung cancers. Br J Cancer. 2004;91(4):771-4.
-
(2004)
Br J Cancer.
, vol.91
, Issue.4
, pp. 771-774
-
-
Toyooka, S.1
Suzuki, M.2
Maruyama, R.3
-
22
-
-
0038418287
-
Hypermethylation of RASSF1A promoter is associated with the age at starting smoking and a poor prognosis in primary non-small cell lung cancer
-
1:CAS:528:DC%2BD3sXltVGqsro%3D 12839968
-
Kim DH, Kim JS, Ji YI, et al. Hypermethylation of RASSF1A promoter is associated with the age at starting smoking and a poor prognosis in primary non-small cell lung cancer. Cancer Res. 2003;63(13):3743-6.
-
(2003)
Cancer Res.
, vol.63
, Issue.13
, pp. 3743-3746
-
-
Kim, D.H.1
Kim, J.S.2
Ji, Y.I.3
-
23
-
-
40849124009
-
DNA methylation markers and early recurrence in stage I lung cancer
-
1:CAS:528:DC%2BD1cXjt1aiurc%3D 18337602
-
Brock MV, Hooker CM, Ota-Machida E, et al. DNA methylation markers and early recurrence in stage I lung cancer. N Engl J Med. 2008;358(11):1118-28.
-
(2008)
N Engl J Med.
, vol.358
, Issue.11
, pp. 1118-1128
-
-
Brock, M.V.1
Hooker, C.M.2
Ota-Machida, E.3
-
24
-
-
34248217444
-
Methylation of human microRNA genes in normal and neoplastic cells
-
1:CAS:528:DC%2BD2sXhtVSgu73J 17457051
-
Weber B, Stresemann C, Brueckner B, Lyko F. Methylation of human microRNA genes in normal and neoplastic cells. Cell Cycle. 2007;6(9):1001-5.
-
(2007)
Cell Cycle.
, vol.6
, Issue.9
, pp. 1001-1005
-
-
Weber, B.1
Stresemann, C.2
Brueckner, B.3
Lyko, F.4
-
25
-
-
33847763576
-
Genetic unmasking of an epigenetically silenced microRNA in human cancer cells
-
1:CAS:528:DC%2BD2sXhvVWrurk%3D 17308079
-
Lujambio A, Ropero S, Ballestar E, et al. Genetic unmasking of an epigenetically silenced microRNA in human cancer cells. Cancer Res. 2007;67(4):1424-9.
-
(2007)
Cancer Res.
, vol.67
, Issue.4
, pp. 1424-1429
-
-
Lujambio, A.1
Ropero, S.2
Ballestar, E.3
-
26
-
-
0034720284
-
CpG methylation is maintained in human cancer cells lacking DNMT1
-
1:CAS:528:DC%2BD3cXjtFyntLs%3D 10801130
-
Rhee I, Jair KW, Yen RW, et al. CpG methylation is maintained in human cancer cells lacking DNMT1. Nature. 2000;404:1003-7.
-
(2000)
Nature.
, vol.404
, pp. 1003-1007
-
-
Rhee, I.1
Jair, K.W.2
Yen, R.W.3
-
27
-
-
0031860739
-
Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases
-
1:CAS:528:DyaK1cXls1Sns7w%3D 9662389
-
Okano M, Xie S, Li E. Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases. Nat Genet. 1998;19(3):219-20.
-
(1998)
Nat Genet.
, vol.19
, Issue.3
, pp. 219-220
-
-
Okano, M.1
Xie, S.2
Li, E.3
-
28
-
-
33747891190
-
Elevated mRNA levels of DNA methyltransferase-1 as an independent prognostic factor in primary nonsmall cell lung cancer
-
1:CAS:528:DC%2BD28XpvVCrtb0%3D 16888795
-
Kim H, Kwon YM, Kim JS, et al. Elevated mRNA levels of DNA methyltransferase-1 as an independent prognostic factor in primary nonsmall cell lung cancer. Cancer. 2006;107(5):1042-9.
-
(2006)
Cancer.
, vol.107
, Issue.5
, pp. 1042-1049
-
-
Kim, H.1
Kwon, Y.M.2
Kim, J.S.3
-
29
-
-
33846111256
-
Alteration of DNA methyltransferases contributes to 5'CpG methylation and poor prognosis in lung cancer
-
17140695
-
Lin RK, Hsu HS, Chang JW, et al. Alteration of DNA methyltransferases contributes to 5'CpG methylation and poor prognosis in lung cancer. Lung Cancer. 2007;55(2):205-13.
-
(2007)
Lung Cancer.
, vol.55
, Issue.2
, pp. 205-213
-
-
Lin, R.K.1
Hsu, H.S.2
Chang, J.W.3
-
30
-
-
0031837109
-
Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription
-
1:CAS:528:DyaK1cXls1Cqsbg%3D 9620779
-
Jones PL, Veenstra GJ, Wade PA, et al. Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. Nat Genet. 1998;19(2):187-91.
-
(1998)
Nat Genet.
, vol.19
, Issue.2
, pp. 187-191
-
-
Jones, P.L.1
Veenstra, G.J.2
Wade, P.A.3
-
31
-
-
0032574977
-
Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
-
Nan X, Ng HH, Johnson CA, Laherty CD, et al. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature. 1999;393(6683):386-9.
-
(1999)
Nature.
, vol.393
, Issue.6683
, pp. 386-389
-
-
Nan, X.1
Ng, H.H.2
Johnson, C.A.3
Laherty, C.D.4
-
32
-
-
0037423186
-
The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation
-
1:CAS:528:DC%2BD3sXot1yisg%3D%3D 12427740
-
Fuks F, Hurd PJ, Wolf D, Nan X, Bird AP, Kouzarides T. The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation. J Biol Chem. 2003;278(6):4035-40.
-
(2003)
J Biol Chem.
, vol.278
, Issue.6
, pp. 4035-4040
-
-
Fuks, F.1
Hurd, P.J.2
Wolf, D.3
Nan, X.4
Bird, A.P.5
Kouzarides, T.6
-
33
-
-
47849083984
-
Epigenetic interplay between histone modifications and DNA methylation in gene silencing
-
18407786
-
Vaissière T, Sawan C, Herceg Z. Epigenetic interplay between histone modifications and DNA methylation in gene silencing. Mutat Res. 2008;659(1-2):40-8.
-
(2008)
Mutat Res.
, vol.659
, Issue.1-2
, pp. 40-48
-
-
Vaissière, T.1
Sawan, C.2
Herceg, Z.3
-
34
-
-
65649142216
-
Global levels of histone modifications predict prognosis in different cancers
-
2671251 1:CAS:528:DC%2BD1MXlvVWnurk%3D 19349354
-
Seligson DB, Horvath S, McBrian MA, et al. Global levels of histone modifications predict prognosis in different cancers. Am J Pathol. 2009;174(5):1619-28.
-
(2009)
Am J Pathol.
, vol.174
, Issue.5
, pp. 1619-1628
-
-
Seligson, D.B.1
Horvath, S.2
McBrian, M.A.3
-
35
-
-
84862792039
-
Global histone modification pattern associated with recurrence and disease-free survival in non-small cell lung cancer patients
-
22360506
-
Song JS, Kim YS, Kim DK, et al. Global histone modification pattern associated with recurrence and disease-free survival in non-small cell lung cancer patients. Pathol Int. 2012;62(3):182-90.
-
(2012)
Pathol Int.
, vol.62
, Issue.3
, pp. 182-190
-
-
Song, J.S.1
Kim, Y.S.2
Kim, D.K.3
-
36
-
-
34247880441
-
Development of histone deacetylase inhibitors for cancer treatment
-
1:CAS:528:DC%2BD2sXkt1Wqsrk%3D 17428177
-
Marchion D, Münster P. Development of histone deacetylase inhibitors for cancer treatment. Expert Rev Anticancer Ther. 2007;7(4):583-98.
-
(2007)
Expert Rev Anticancer Ther.
, vol.7
, Issue.4
, pp. 583-598
-
-
Marchion, D.1
Münster, P.2
-
37
-
-
4944223370
-
Histone deacetylase 1 mRNA expression in lung cancer
-
15474665
-
Sasaki H, Moriyama S, Nakashima Y, et al. Histone deacetylase 1 mRNA expression in lung cancer. Lung Cancer. 2004;46(2):171-8.
-
(2004)
Lung Cancer.
, vol.46
, Issue.2
, pp. 171-178
-
-
Sasaki, H.1
Moriyama, S.2
Nakashima, Y.3
-
38
-
-
84859434875
-
Combining microRNA-449a/b with a HDAC inhibitor has a synergistic effect on growth arrest in lung cancer
-
22078727
-
Jeon HS, Lee SY, Lee EJ, et al. Combining microRNA-449a/b with a HDAC inhibitor has a synergistic effect on growth arrest in lung cancer. Lung Cancer. 2012;76(2):171-6.
-
(2012)
Lung Cancer.
, vol.76
, Issue.2
, pp. 171-176
-
-
Jeon, H.S.1
Lee, S.Y.2
Lee, E.J.3
-
39
-
-
78049509611
-
Strong expression of HDAC3 correlates with a poor prognosis in patients with adenocarcinoma of the lung
-
1:CAS:528:DC%2BC3cXht1elt7bF
-
Minamiya Y, Ono T, Saito H, et al. Strong expression of HDAC3 correlates with a poor prognosis in patients with adenocarcinoma of the lung. Tumor Biol. 2010;31(5):533-9.
-
(2010)
Tumor Biol.
, vol.31
, Issue.5
, pp. 533-539
-
-
Minamiya, Y.1
Ono, T.2
Saito, H.3
-
40
-
-
4544322261
-
Reduced expression of class II histone deacetylase genes is associated with poor prognosis in lung cancer patients
-
1:CAS:528:DC%2BD2cXnvVWls7c%3D 15305372
-
Osada H, Tatematsu Y, Saito H, et al. Reduced expression of class II histone deacetylase genes is associated with poor prognosis in lung cancer patients. Int J Cancer. 2004;112(1):26-32.
-
(2004)
Int J Cancer.
, vol.112
, Issue.1
, pp. 26-32
-
-
Osada, H.1
Tatematsu, Y.2
Saito, H.3
-
41
-
-
79955506975
-
The histone methyltransferase and putative oncoprotein MMSET is overexpressed in a large variety of human tumors
-
1:CAS:528:DC%2BC3MXlsVGgs7k%3D 21385930
-
Hudlebusch HR, Santoni-Rugiu E, Simon R, et al. The histone methyltransferase and putative oncoprotein MMSET is overexpressed in a large variety of human tumors. Clin Cancer Res. 2011;17(9):2919-33.
-
(2011)
Clin Cancer Res.
, vol.17
, Issue.9
, pp. 2919-2933
-
-
Hudlebusch, H.R.1
Santoni-Rugiu, E.2
Simon, R.3
-
42
-
-
77953978709
-
Distinctive expression of the polycomb group proteins Bmi1 polycomb ring finger oncogene and enhancer of zeste homolog 2 in nonsmall cell lung cancers and their clinical and clinicopathologic significance
-
1:CAS:528:DC%2BC3cXptlWktrc%3D 20564407
-
Kikuchi J, Kinoshita I, Shimizu Y, et al. Distinctive expression of the polycomb group proteins Bmi1 polycomb ring finger oncogene and enhancer of zeste homolog 2 in nonsmall cell lung cancers and their clinical and clinicopathologic significance. Cancer. 2010;116(12):3015-24.
-
(2010)
Cancer.
, vol.116
, Issue.12
, pp. 3015-3024
-
-
Kikuchi, J.1
Kinoshita, I.2
Shimizu, Y.3
-
43
-
-
84903155987
-
Histone lysine demethylase (KDM) subfamily 4: Structures, functions and therapeutic potential
-
3853420 24349617
-
Labbé RM, Holowatyj A, Yang ZQ. Histone lysine demethylase (KDM) subfamily 4: structures, functions and therapeutic potential. Am J Transl Res. 2013;6(1):1-15.
-
(2013)
Am J Transl Res.
, vol.6
, Issue.1
, pp. 1-15
-
-
Labbé, R.M.1
Holowatyj, A.2
Yang, Z.Q.3
-
44
-
-
32844454603
-
Histone demethylation by a family of JmjC domain-containing proteins
-
1:CAS:528:DC%2BD28XhsVSkuro%3D 16362057
-
Tsukada Y, Fang J, Erdjument-Bromage H, et al. Histone demethylation by a family of JmjC domain-containing proteins. Nature. 2006;439:811-6.
-
(2006)
Nature.
, vol.439
, pp. 811-816
-
-
Tsukada, Y.1
Fang, J.2
Erdjument-Bromage, H.3
-
45
-
-
84890060286
-
KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling
-
3859406 1:CAS:528:DC%2BC3sXhvFSqur3M 24200691
-
Wagner KW, Alam H, Dhar SS, et al. KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling. J Clin Invest. 2013;123(12):5231-46.
-
(2013)
J Clin Invest.
, vol.123
, Issue.12
, pp. 5231-5246
-
-
Wagner, K.W.1
Alam, H.2
Dhar, S.S.3
-
46
-
-
84896291131
-
Transcriptional repression of histone deacetylase 3 by the histone demethylase KDM2A is coupled to tumorigenicity of lung cancer cells
-
3953262 1:CAS:528:DC%2BC2cXktlWjtrk%3D 24482232
-
Dhar SS, Alam H, Li N, et al. Transcriptional repression of histone deacetylase 3 by the histone demethylase KDM2A is coupled to tumorigenicity of lung cancer cells. J Biol Chem. 2014;289(11):7483-96.
-
(2014)
J Biol Chem.
, vol.289
, Issue.11
, pp. 7483-7496
-
-
Dhar, S.S.1
Alam, H.2
Li, N.3
-
47
-
-
84877861510
-
KDM4/JMJD2 histone demethylases: Epigenetic regulators in cancer cells
-
3655154 1:CAS:528:DC%2BC3sXnsFejs7o%3D 23644528
-
Berry WL, Janknecht R. KDM4/JMJD2 histone demethylases: epigenetic regulators in cancer cells. Cancer Res. 2013;73(10):2936-42.
-
(2013)
Cancer Res.
, vol.73
, Issue.10
, pp. 2936-2942
-
-
Berry, W.L.1
Janknecht, R.2
-
48
-
-
84878972592
-
Deregulation of the histone demethylase JMJD2A is involved in human carcinogenesis through regulation of the G(1)/S transition
-
1:CAS:528:DC%2BC3sXnsVGmtbc%3D 23603248
-
Kogure M, Takawa M, Cho HS, et al. D eregulation of the histone demethylase JMJD2A is involved in human carcinogenesis through regulation of the G(1)/S transition. Cancer Lett. 2013;336(1):76-84.
-
(2013)
Cancer Lett.
, vol.336
, Issue.1
, pp. 76-84
-
-
Kogure, M.1
Takawa, M.2
Cho, H.S.3
-
49
-
-
79952534189
-
Regulation of chromatin by histone modifications
-
3193420 1:CAS:528:DC%2BC3MXivVCgurc%3D 21321607
-
Bannister AJ, Kouzarides T. Regulation of chromatin by histone modifications. Cell Res. 2011;21(3):381-95.
-
(2011)
Cell Res.
, vol.21
, Issue.3
, pp. 381-395
-
-
Bannister, A.J.1
Kouzarides, T.2
-
50
-
-
79959829510
-
Histone arginine methylation
-
3409563 21074527
-
Di Lorenzo A, Bedford MT. Histone arginine methylation. FEBS Lett. 2011;585(13):2024-31.
-
(2011)
FEBS Lett.
, vol.585
, Issue.13
, pp. 2024-2031
-
-
Di Lorenzo, A.1
Bedford, M.T.2
-
51
-
-
84878342895
-
Cross-talk among epigenetic modifications: Lessons from histone arginine methylation
-
1:CAS:528:DC%2BC3sXotV2qsL0%3D 23697934
-
Molina-Serrano D, Schiza V, Kirmizis A. Cross-talk among epigenetic modifications: lessons from histone arginine methylation. Biochem Soc Trans. 2013;41(3):751-9.
-
(2013)
Biochem Soc Trans.
, vol.41
, Issue.3
, pp. 751-759
-
-
Molina-Serrano, D.1
Schiza, V.2
Kirmizis, A.3
-
52
-
-
78649638594
-
Dysregulation of PRMT1 and PRMT6, type I arginine methyltransferases, is involved in various types of human cancers
-
1:CAS:528:DC%2BC3cXhsVOkt7fP 20473859
-
Yoshimatsu M, Toyokawa G, Hayami S, et al. Dysregulation of PRMT1 and PRMT6, type I arginine methyltransferases, is involved in various types of human cancers. Int J Cancer. 2011;128(3):562-73.
-
(2011)
Int J Cancer.
, vol.128
, Issue.3
, pp. 562-573
-
-
Yoshimatsu, M.1
Toyokawa, G.2
Hayami, S.3
-
53
-
-
84881477406
-
High expression of JMJD6 predicts unfavorable survival in lung adenocarcinoma
-
1:CAS:528:DC%2BC3sXhtFWjsrfJ
-
Zhang J, Ni SS, Zhao WL, Dong XC, Wang JL. High expression of JMJD6 predicts unfavorable survival in lung adenocarcinoma. Tumor Biol. 2013;34(4):2397-401.
-
(2013)
Tumor Biol.
, vol.34
, Issue.4
, pp. 2397-2401
-
-
Zhang, J.1
Ni, S.S.2
Zhao, W.L.3
Dong, X.C.4
Wang, J.L.5
-
54
-
-
84878944044
-
Readout of epigenetic modifications
-
1:CAS:528:DC%2BC3sXhtFOqsrzN 23642229
-
Patel DJ, Wang Z. Readout of epigenetic modifications. Annu Rev Biochem. 2013;82:81-118.
-
(2013)
Annu Rev Biochem.
, vol.82
, pp. 81-118
-
-
Patel, D.J.1
Wang, Z.2
-
55
-
-
84888106365
-
Efficacy of BET bromodomain inhibition in Kras-mutant non-small cell lung cancer
-
1:CAS:528:DC%2BC3sXhslyku7rF 24045185
-
Shimamura T, Chen Z, Soucheray M, et al. Efficacy of BET bromodomain inhibition in Kras-mutant non-small cell lung cancer. Clin Cancer Res. 2013;19(22):6183-92.
-
(2013)
Clin Cancer Res.
, vol.19
, Issue.22
, pp. 6183-6192
-
-
Shimamura, T.1
Chen, Z.2
Soucheray, M.3
-
56
-
-
79952384705
-
Cancer epigenetics reaches mainstream oncology
-
21386836
-
Rodríguez-Paredes M, Esteller M. Cancer epigenetics reaches mainstream oncology. Nat Med. 2011;17(3):330-9.
-
(2011)
Nat Med.
, vol.17
, Issue.3
, pp. 330-339
-
-
Rodríguez-Paredes, M.1
Esteller, M.2
-
57
-
-
84866327150
-
Low molecular weight amidoximes that act as potent inhibitors of lysine-specific demethylase 1
-
3482425 1:CAS:528:DC%2BC38XhtFKnsrvJ 22876979
-
Hazeldine S, Pachaiyappan B, Steinbergs N, et al. Low molecular weight amidoximes that act as potent inhibitors of lysine-specific demethylase 1. J Med Chem. 2012;55(17):7378-91.
-
(2012)
J Med Chem.
, vol.55
, Issue.17
, pp. 7378-7391
-
-
Hazeldine, S.1
Pachaiyappan, B.2
Steinbergs, N.3
-
58
-
-
84896316506
-
Chromatin remodeling by polyamines and polyamine analogues
-
1:CAS:528:DC%2BC3sXhtVOjtb%2FN 23836422
-
Pasini A, Caldarera CM, Giordano E. Chromatin remodeling by polyamines and polyamine analogues. Amino Acids. 2014;46(3):595-603.
-
(2014)
Amino Acids.
, vol.46
, Issue.3
, pp. 595-603
-
-
Pasini, A.1
Caldarera, C.M.2
Giordano, E.3
-
59
-
-
84892949766
-
Predicting response to epigenetic therapy
-
3871230 1:CAS:528:DC%2BC2cXntFejtA%3D%3D 24382389
-
Treppendahl MB, Kristensen LS, Grønbæk K. Predicting response to epigenetic therapy. J Clin Invest. 2014;124(1):47-55.
-
(2014)
J Clin Invest.
, vol.124
, Issue.1
, pp. 47-55
-
-
Treppendahl, M.B.1
Kristensen, L.S.2
Grønbæk, K.3
-
60
-
-
31344466008
-
DNA methylation and gene silencing in cancer
-
1:CAS:528:DC%2BD28Xjs1Gisg%3D%3D 16341240
-
Baylin SB. DNA methylation and gene silencing in cancer. Nat Clin Pract Oncol. 2005;2(Suppl 1):S4-11.
-
(2005)
Nat Clin Pract Oncol.
, vol.2
, pp. S4-S11
-
-
Baylin, S.B.1
-
61
-
-
84871521209
-
Histone deacetylase inhibitors: A patent review (2009-2011)
-
1:CAS:528:DC%2BC38XhvVCksrrN 23094822
-
Carafa V, Miceli M, Altucci L, Nebbioso A. Histone deacetylase inhibitors: a patent review (2009-2011). Expert Opin Ther Pat. 2013;23(1):1-17.
-
(2013)
Expert Opin Ther Pat.
, vol.23
, Issue.1
, pp. 1-17
-
-
Carafa, V.1
Miceli, M.2
Altucci, L.3
Nebbioso, A.4
-
62
-
-
84875978060
-
HDAC inhibitors induce tumor-cell-selective pro-apoptotic transcriptional responses
-
10.1038/cddis.2013.9 3734831 1:CAS:528:DC%2BC3sXhtVyksbbJ 23449455
-
Bolden JE, Shi W, Jankowski K, et al. HDAC inhibitors induce tumor-cell-selective pro-apoptotic transcriptional responses. Cell Death Dis. 2013;4:e519. doi: 10.1038/cddis.2013.9.
-
(2013)
Cell Death Dis
, vol.4
, pp. e519
-
-
Bolden, J.E.1
Shi, W.2
Jankowski, K.3
-
63
-
-
73949128107
-
Histone deacetylase inhibitors in cancer therapy
-
1:CAS:528:DC%2BD1MXhsFKkt7vE 19826124
-
Lane AA, Chabner BA. Histone deacetylase inhibitors in cancer therapy. J Clin Oncol. 2009;27(32):5459-68.
-
(2009)
J Clin Oncol.
, vol.27
, Issue.32
, pp. 5459-5468
-
-
Lane, A.A.1
Chabner, B.A.2
-
64
-
-
73949149251
-
Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma
-
2773225 1:CAS:528:DC%2BD1MXhsFKkt7vO 19826128
-
Piekarz RL, Frye R, Turner M, et al. Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma. J Clin Oncol. 2009;27(32):5410-7.
-
(2009)
J Clin Oncol.
, vol.27
, Issue.32
, pp. 5410-5417
-
-
Piekarz, R.L.1
Frye, R.2
Turner, M.3
-
65
-
-
33845996135
-
Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL)
-
1785068 1:CAS:528:DC%2BD2sXivVyrt7g%3D 16960145 (published erratum appears in Blood. 2007;109(12):5086)
-
Duvic M, Talpur R, Ni X, et al. Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL). Blood. 2007;109(1):31-9 (published erratum appears in Blood. 2007;109(12):5086).
-
(2007)
Blood.
, vol.109
, Issue.1
, pp. 31-39
-
-
Duvic, M.1
Talpur, R.2
Ni, X.3
-
66
-
-
80051788362
-
Histone deacetylase inhibitors sensitize human non-small cell lung cancer cells to ionizing radiation through acetyl p53-mediated c-myc down-regulation
-
21642861
-
Seo SK, Jin HO, Woo SH, et al. Histone deacetylase inhibitors sensitize human non-small cell lung cancer cells to ionizing radiation through acetyl p53-mediated c-myc down-regulation. J Thorac Oncol. 2011;6(8):1313-9.
-
(2011)
J Thorac Oncol.
, vol.6
, Issue.8
, pp. 1313-1319
-
-
Seo, S.K.1
Jin, H.O.2
Woo, S.H.3
-
67
-
-
33845741562
-
Histone deacetylase (HDAC) inhibitor LBH589 increases duration of gamma-H2AX foci and confines HDAC4 to the cytoplasm in irradiated non-small cell lung cancer
-
1:CAS:528:DC%2BD28Xht1KnsLzO 17145876
-
Geng L, Cuneo KC, Fu A, et al. Histone deacetylase (HDAC) inhibitor LBH589 increases duration of gamma-H2AX foci and confines HDAC4 to the cytoplasm in irradiated non-small cell lung cancer. Cancer Res. 2006;66(23):11298-304.
-
(2006)
Cancer Res.
, vol.66
, Issue.23
, pp. 11298-11304
-
-
Geng, L.1
Cuneo, K.C.2
Fu, A.3
-
68
-
-
68149170764
-
Sensitization to gamma-irradiation-induced cell cycle arrest and apoptosis by the histone deacetylase inhibitor trichostatin A in non-small cell lung cancer (NSCLC) cells
-
1:CAS:528:DC%2BD1MXovFOnsbs%3D 19270532
-
Zhang F, Zhang T, Teng ZH, et al. Sensitization to gamma-irradiation-induced cell cycle arrest and apoptosis by the histone deacetylase inhibitor trichostatin A in non-small cell lung cancer (NSCLC) cells. Cancer Biol Ther. 2009;8(9):823-31.
-
(2009)
Cancer Biol Ther.
, vol.8
, Issue.9
, pp. 823-831
-
-
Zhang, F.1
Zhang, T.2
Teng, Z.H.3
-
69
-
-
84888031752
-
The novel HDAC inhibitor NDACI054 sensitizes human cancer cells to radiotherapy
-
1:CAS:528:DC%2BC3sXhsV2ms73P 24060178
-
Hehlgans S, Storch K, Lange I, Cordes N. The novel HDAC inhibitor NDACI054 sensitizes human cancer cells to radiotherapy. Radiother Oncol. 2013;109(1):126-32.
-
(2013)
Radiother Oncol.
, vol.109
, Issue.1
, pp. 126-132
-
-
Hehlgans, S.1
Storch, K.2
Lange, I.3
Cordes, N.4
-
70
-
-
83355172959
-
Synergistic antitumor effects of novel HDAC inhibitors and paclitaxel in vitro and in vivo
-
Zuco V, DeCesare M, Cincinelli R, et al. Synergistic antitumor effects of novel HDAC inhibitors and paclitaxel in vitro and in vivo. PLoS One. 2013;6:e29085.
-
(2013)
PLoS One.
, vol.6
, pp. e29085
-
-
Zuco, V.1
DeCesare, M.2
Cincinelli, R.3
-
71
-
-
84862669889
-
Organosulfur derivatives of the HDAC inhibitor valproic acid sensitize human lung cancer cell lines to apoptosis and to cisplatin cytotoxicity
-
1:CAS:528:DC%2BC38XovVGlsr4%3D 22212895
-
Tesei A, Brigliadori G, Carloni S, et al. Organosulfur derivatives of the HDAC inhibitor valproic acid sensitize human lung cancer cell lines to apoptosis and to cisplatin cytotoxicity. J Cell Physiol. 2012;227(10):3389-96.
-
(2012)
J Cell Physiol.
, vol.227
, Issue.10
, pp. 3389-3396
-
-
Tesei, A.1
Brigliadori, G.2
Carloni, S.3
-
72
-
-
73449144466
-
Vorinostat increases carboplatin and paclitaxel activity in non-small-cell lung cancer cells
-
2795066 1:CAS:528:DC%2BD1MXhsFGjs7bO 19621389
-
Owonikoko TK, Ramalingam SS, Kanterewicz B, et al. Vorinostat increases carboplatin and paclitaxel activity in non-small-cell lung cancer cells. Int J Cancer. 2010;126(3):743-55.
-
(2010)
Int J Cancer.
, vol.126
, Issue.3
, pp. 743-755
-
-
Owonikoko, T.K.1
Ramalingam, S.S.2
Kanterewicz, B.3
-
73
-
-
84908092488
-
Histone deacetylase inhibition synergistically enhances pemetrexed cytotoxicity through induction of apoptosis and autophagy in non-small cell lung cancer
-
4198757 25301686
-
Del Bufalo D, Desideri M, De Luca T, et al. Histone deacetylase inhibition synergistically enhances pemetrexed cytotoxicity through induction of apoptosis and autophagy in non-small cell lung cancer. Mol Cancer. 2014;13:230.
-
(2014)
Mol Cancer.
, vol.13
, pp. 230
-
-
Del Bufalo, D.1
Desideri, M.2
De Luca, T.3
-
74
-
-
77950809059
-
A chromatin-mediated reversible drug tolerant state in cancer cell subpopulations
-
2851638 1:CAS:528:DC%2BC3cXlsVSgtb8%3D 20371346
-
Sharma SV, Lee DY, Li B, et al. A chromatin-mediated reversible drug tolerant state in cancer cell subpopulations. Cell. 2010;141:69-80.
-
(2010)
Cell.
, vol.141
, pp. 69-80
-
-
Sharma, S.V.1
Lee, D.Y.2
Li, B.3
-
75
-
-
84924875404
-
The combination of irreversible EGFR TKIs and SAHA induces apoptosis and autophagy-mediated cell death to overcome acquired resistance in EGFR T790M-mutated lung cancer
-
1:CAS:528:DC%2BC2cXhvF2jsLfF 25382705
-
Lee TG, Jeong EH, Kim SY, Kim HR, Kim CH. The combination of irreversible EGFR TKIs and SAHA induces apoptosis and autophagy-mediated cell death to overcome acquired resistance in EGFR T790M-mutated lung cancer. Int J Cancer. 2015;136(11):2717-29.
-
(2015)
Int J Cancer.
, vol.136
, Issue.11
, pp. 2717-2729
-
-
Lee, T.G.1
Jeong, E.H.2
Kim, S.Y.3
Kim, H.R.4
Kim, C.H.5
-
76
-
-
65649134414
-
Histone deacetylase inhibitor romidepsin enhances anti-tumor effect of erlotinib in non-small cell lung cancer (NSCLC) cell lines
-
2758160 19179890
-
Zhang W, Peyton M, Xie Y, et al. Histone deacetylase inhibitor romidepsin enhances anti-tumor effect of erlotinib in non-small cell lung cancer (NSCLC) cell lines. J Thorac Oncol. 2009;4(2):161-6.
-
(2009)
J Thorac Oncol.
, vol.4
, Issue.2
, pp. 161-166
-
-
Zhang, W.1
Peyton, M.2
Xie, Y.3
-
77
-
-
78751512281
-
Combination therapy with Vidaza and entinostat suppresses tumor growth and reprograms the epigenome in an orthotopic lung cancer model
-
3075424 1:CAS:528:DC%2BC3MXlsFKmug%3D%3D 21224363
-
Belinsky SA, Grimes MJ, Picchi MA, et al. Combination therapy with Vidaza and entinostat suppresses tumor growth and reprograms the epigenome in an orthotopic lung cancer model. Cancer Res. 2011;71:454-62.
-
(2011)
Cancer Res.
, vol.71
, pp. 454-462
-
-
Belinsky, S.A.1
Grimes, M.J.2
Picchi, M.A.3
-
78
-
-
0035866353
-
DNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors
-
1:CAS:528:DC%2BD3MXhvVelsbc%3D 11245429
-
Zhu WG, Lakshmanan RR, Beal MD, Otterson GA. DNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors. Cancer Res. 2001;61:1327-33.
-
(2001)
Cancer Res.
, vol.61
, pp. 1327-1333
-
-
Zhu, W.G.1
Lakshmanan, R.R.2
Beal, M.D.3
Otterson, G.A.4
-
79
-
-
84876231994
-
Blockade of DNA methylation enhances the therapeutic effect of gefitinib in non-small cell lung cancer cells
-
1:CAS:528:DC%2BC3sXntlGmu7s%3D 23440266
-
Li XY, Wu JZ, Cao HX, et al. Blockade of DNA methylation enhances the therapeutic effect of gefitinib in non-small cell lung cancer cells. Oncol Rep. 2013;29(5):1975-82.
-
(2013)
Oncol Rep.
, vol.29
, Issue.5
, pp. 1975-1982
-
-
Li, X.Y.1
Wu, J.Z.2
Cao, H.X.3
-
80
-
-
84872029247
-
Inhibition of class I histone deacetylases in non-small cell lung cancer by honokiol leads to suppression of cancer cell growth and induction of cell death in vitro and in vivo
-
3549881 1:CAS:528:DC%2BC3sXjt1Crt7s%3D 23221619
-
Singh T, Prasad R, Katiyar SK. Inhibition of class I histone deacetylases in non-small cell lung cancer by honokiol leads to suppression of cancer cell growth and induction of cell death in vitro and in vivo. Epigenetics. 2013;8:54-65.
-
(2013)
Epigenetics
, vol.8
, pp. 54-65
-
-
Singh, T.1
Prasad, R.2
Katiyar, S.K.3
-
81
-
-
77958572898
-
A novel histone deacetylase inhibitor exhibits antitumor activity via apoptosis induction, F-actin disruption and gene acetylation in lung cancer
-
Tang YA, Wen WL, Chang JW, et al. A novel histone deacetylase inhibitor exhibits antitumor activity via apoptosis induction, F-actin disruption and gene acetylation in lung cancer. PLoS One. 2010;14:e12417.
-
(2010)
PLoS One.
, vol.14
, pp. e12417
-
-
Tang, Y.A.1
Wen, W.L.2
Chang, J.W.3
-
82
-
-
84876401638
-
Silibinin synergizes with histone deacetylase and DNA methyltransferase inhibitors in upregulating E-cadherin expression together with inhibition of migration and invasion of human non-small cell lung cancer cells
-
3629797 1:CAS:528:DC%2BC3sXntVCgsLY%3D 23461975
-
Mateen S, Raina K, Agarwal C, et al. Silibinin synergizes with histone deacetylase and DNA methyltransferase inhibitors in upregulating E-cadherin expression together with inhibition of migration and invasion of human non-small cell lung cancer cells. J Pharmacol Exp Ther. 2013;345(2):206-14.
-
(2013)
J Pharmacol Exp Ther.
, vol.345
, Issue.2
, pp. 206-214
-
-
Mateen, S.1
Raina, K.2
Agarwal, C.3
-
83
-
-
84867401194
-
Epigenetic therapy with 3-deazaneplanocin A, an inhibitor of the histone methyltransferase EZH2, inhibits growth of non-small cell lung cancer cells
-
3472089 22925699
-
Kikuchi J, Takashina T, Kinoshita I, et al. Epigenetic therapy with 3-deazaneplanocin A, an inhibitor of the histone methyltransferase EZH2, inhibits growth of non-small cell lung cancer cells. Lung Cancer. 2012;78(2):138-43.
-
(2012)
Lung Cancer.
, vol.78
, Issue.2
, pp. 138-143
-
-
Kikuchi, J.1
Takashina, T.2
Kinoshita, I.3
-
84
-
-
84883297274
-
DZNep, inhibitor of S-adenosylhomocysteine hydrolase, down-regulates expression of SETDB1 H3K9me3 HMTase in human lung cancer cells
-
1:CAS:528:DC%2BC3sXhtlCnsbnM 23933322
-
Lee JK, Kim KC. DZNep, inhibitor of S-adenosylhomocysteine hydrolase, down-regulates expression of SETDB1 H3K9me3 HMTase in human lung cancer cells. Biochem Biophys Res Commun. 2013;438(4):647-52.
-
(2013)
Biochem Biophys Res Commun.
, vol.438
, Issue.4
, pp. 647-652
-
-
Lee, J.K.1
Kim, K.C.2
-
85
-
-
79958822224
-
Inhibition of histone lysine methylation enhances cancer-testis antigen expression in lung cancer cells: Implications for adoptive immunotherapy of cancer
-
3116976 1:CAS:528:DC%2BC3MXnsFKhsbg%3D 21546573
-
Rao M, Chinnasamy N, Hong JA, et al. Inhibition of histone lysine methylation enhances cancer-testis antigen expression in lung cancer cells: implications for adoptive immunotherapy of cancer. Cancer Res. 2011;71(12):4192-204.
-
(2011)
Cancer Res.
, vol.71
, Issue.12
, pp. 4192-4204
-
-
Rao, M.1
Chinnasamy, N.2
Hong, J.A.3
-
86
-
-
84927547043
-
EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors
-
4393352 1:CAS:528:DC%2BC2MXhslehs7o%3D 25629630
-
Fillmore CM, Xu C, Desai PT, et al. EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors. Nature. 2015;520(7546):239-42.
-
(2015)
Nature.
, vol.520
, Issue.7546
, pp. 239-242
-
-
Fillmore, C.M.1
Xu, C.2
Desai, P.T.3
-
87
-
-
84859480637
-
Over-expression of LSD1 promotes proliferation, migration and invasion in non-small cell lung cancer
-
3320866 1:CAS:528:DC%2BC38XlvV2jsr4%3D 22493729
-
Lv T, Yuan D, Miao X, et al. Over-expression of LSD1 promotes proliferation, migration and invasion in non-small cell lung cancer. PLoS One. 2012;7(4):e35065.
-
(2012)
PLoS One.
, vol.7
, Issue.4
, pp. e35065
-
-
Lv, T.1
Yuan, D.2
Miao, X.3
-
88
-
-
84889595831
-
A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth
-
3724450 23792809
-
Wang L, Chang J, Varghese D, et al. A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth. Nat Commun. 2013;4:2035.
-
(2013)
Nat Commun.
, vol.4
, pp. 2035
-
-
Wang, L.1
Chang, J.2
Varghese, D.3
-
89
-
-
84869753078
-
Sensitivity of human lung adenocarcinoma cell lines to targeted inhibition of BET epigenetic signaling proteins
-
3511085 1:CAS:528:DC%2BC38XhvValsrzN 23129625
-
Lockwood WW, Zejnullahu K, Bradner JE, Varmus H. Sensitivity of human lung adenocarcinoma cell lines to targeted inhibition of BET epigenetic signaling proteins. Proc Natl Acad Sci USA. 2012;109(47):19408-13.
-
(2012)
Proc Natl Acad Sci USA.
, vol.109
, Issue.47
, pp. 19408-19413
-
-
Lockwood, W.W.1
Zejnullahu, K.2
Bradner, J.E.3
Varmus, H.4
-
90
-
-
0030974771
-
Pilot phase I-II study on 5-aza- 20-deoxycytidine (decitabine) in patients with metastatic lung cancer
-
1:CAS:528:DyaK2sXjsVyktbg%3D 9180389
-
Momparler RL, Bouffard DY, Momparler LF, et al. Pilot phase I-II study on 5-aza- 20-deoxycytidine (decitabine) in patients with metastatic lung cancer. Anticancer Drugs. 1997;8:358-68.
-
(1997)
Anticancer Drugs.
, vol.8
, pp. 358-368
-
-
Momparler, R.L.1
Bouffard, D.Y.2
Momparler, L.F.3
-
91
-
-
33750326078
-
Phase I study of decitabine-mediated gene expression in patients with cancers involving the lung, esophagus, or pleura
-
1:CAS:528:DC%2BD28XhtVartbvF 17020984
-
Schrump DS, Fischette MR, Nguyen DM, et al. Phase I study of decitabine-mediated gene expression in patients with cancers involving the lung, esophagus, or pleura. Clin Cancer Res. 2006;12:5777-85.
-
(2006)
Clin Cancer Res.
, vol.12
, pp. 5777-5785
-
-
Schrump, D.S.1
Fischette, M.R.2
Nguyen, D.M.3
-
92
-
-
3843151628
-
Phase II trial of the histone deacetylase inhibitor pivaloyloxymethyl butyrate (Pivanex, AN-9) in advanced non-small cell lung cancer
-
15301879
-
Reid T, Valone F, Lipera W, et al. Phase II trial of the histone deacetylase inhibitor pivaloyloxymethyl butyrate (Pivanex, AN-9) in advanced non-small cell lung cancer. Lung Cancer. 2004;45(3):381-6.
-
(2004)
Lung Cancer.
, vol.45
, Issue.3
, pp. 381-386
-
-
Reid, T.1
Valone, F.2
Lipera, W.3
-
93
-
-
40749101544
-
Clinical and molecular responses in lung cancer patients receiving Romidepsin
-
1:CAS:528:DC%2BD1cXoslGg 18172270
-
Schrump DS, Fischette MR, Nguyen DM, et al. Clinical and molecular responses in lung cancer patients receiving Romidepsin. Clin Cancer Res. 2008;14(1):188-98.
-
(2008)
Clin Cancer Res.
, vol.14
, Issue.1
, pp. 188-198
-
-
Schrump, D.S.1
Fischette, M.R.2
Nguyen, D.M.3
-
94
-
-
67649399669
-
Vorinostat (NSC#701852) in patients with relapsed non-small cell lung cancer: A Wisconsin Oncology Network phase II study
-
3050710 19347984
-
Traynor AM, Dubey S, Eickhoff JC, et al. Vorinostat (NSC#701852) in patients with relapsed non-small cell lung cancer: a Wisconsin Oncology Network phase II study. J Thorac Oncol. 2009;4:522-6.
-
(2009)
J Thorac Oncol.
, vol.4
, pp. 522-526
-
-
Traynor, A.M.1
Dubey, S.2
Eickhoff, J.C.3
-
95
-
-
21244458052
-
Phase I and pharmacokinetic study of MS-275, a histone deacetylase inhibitor, in patients with advanced and refractory solid tumors or lymphoma
-
1:CAS:528:DC%2BD2MXmtVahtL8%3D 15851766
-
Ryan QC, Headlee D, Acharya M, et al. Phase I and pharmacokinetic study of MS-275, a histone deacetylase inhibitor, in patients with advanced and refractory solid tumors or lymphoma. J Clin Oncol. 2005;23:3912-22.
-
(2005)
J Clin Oncol.
, vol.23
, pp. 3912-3922
-
-
Ryan, Q.C.1
Headlee, D.2
Acharya, M.3
-
96
-
-
50249095068
-
Early phase II trial of oral vorinostat in relapsed or refractory breast, colorectal, or non-small cell lung cancer
-
1:CAS:528:DC%2BD1cXhtVSku7fM 18425418
-
Vansteenkiste J, VanCutsem E, Dumez H, et al. Early phase II trial of oral vorinostat in relapsed or refractory breast, colorectal, or non-small cell lung cancer. Invest New Drugs. 2008;26:483-8.
-
(2008)
Invest New Drugs
, vol.26
, pp. 483-488
-
-
Vansteenkiste, J.1
VanCutsem, E.2
Dumez, H.3
-
97
-
-
84864349146
-
A phase I study of oral panobinostat (LBH589) in Japanese patients with advanced solid tumors
-
1:CAS:528:DC%2BC38XmvFalsr4%3D 21484248
-
Fukutomi A, Hatake K, Matsui K, et al. A phase I study of oral panobinostat (LBH589) in Japanese patients with advanced solid tumors. Invest New Drugs. 2012;30(3):1096-106.
-
(2012)
Invest New Drugs.
, vol.30
, Issue.3
, pp. 1096-1106
-
-
Fukutomi, A.1
Hatake, K.2
Matsui, K.3
-
98
-
-
84877574817
-
The future of epigenetic therapy in solid tumors: Lessons from the past
-
3730253 1:CAS:528:DC%2BC3sXmvFOrsr0%3D 23546521
-
Azad N, Zahnow CA, Rudin CM, Baylin SB. The future of epigenetic therapy in solid tumors: lessons from the past. Nat Rev Clin Oncol. 2013;10(5):256-66.
-
(2013)
Nat Rev Clin Oncol.
, vol.10
, Issue.5
, pp. 256-266
-
-
Azad, N.1
Zahnow, C.A.2
Rudin, C.M.3
Baylin, S.B.4
-
99
-
-
84863337757
-
Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells
-
3312044 1:CAS:528:DC%2BC38Xkt1ygt7o%3D 22439938
-
Tsai HC, Li H, Van Neste L, et al. Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells. Cancer Cell. 2012;21(3):430-46.
-
(2012)
Cancer Cell.
, vol.21
, Issue.3
, pp. 430-446
-
-
Tsai, H.C.1
Li, H.2
Van Neste, L.3
-
100
-
-
84899751803
-
New strategies in lung cancer: Epigenetic therapy for non-small cell lung cancer
-
4325981 1:CAS:528:DC%2BC2cXnsFWitrw%3D 24644000
-
Forde PM, Brahmer JR, Kelly RJ. New strategies in lung cancer: epigenetic therapy for non-small cell lung cancer. Clin Cancer Res. 2014;20(9):2244-8.
-
(2014)
Clin Cancer Res.
, vol.20
, Issue.9
, pp. 2244-2248
-
-
Forde, P.M.1
Brahmer, J.R.2
Kelly, R.J.3
-
101
-
-
84865760040
-
Inhaled chemotherapy in lung cancer: Future concept of nanomedicine
-
3356182 1:CAS:528:DC%2BC38XlsFyrsLk%3D 22619512
-
Zarogoulidis P, Chatzaki E, Porpodis K, et al. Inhaled chemotherapy in lung cancer: future concept of nanomedicine. Int J Nanomedicine. 2012;7:1551-15572.
-
(2012)
Int J Nanomedicine.
, vol.7
, pp. 1551-15572
-
-
Zarogoulidis, P.1
Chatzaki, E.2
Porpodis, K.3
-
102
-
-
84862935227
-
Polyamine-based small molecule epigenetic modulators
-
3535317 1:CAS:528:DC%2BC38XktFGgsw%3D%3D 23293738
-
Sharma SK, Hazeldine S, Crowley ML, et al. Polyamine-based small molecule epigenetic modulators. Medchemcomm. 2012;3(1):14-21.
-
(2012)
Medchemcomm.
, vol.3
, Issue.1
, pp. 14-21
-
-
Sharma, S.K.1
Hazeldine, S.2
Crowley, M.L.3
-
103
-
-
84866032751
-
Depletion of HDAC6 enhances cisplatin-induced DNA damage and apoptosis in non-small cell lung cancer cells
-
3434198 1:CAS:528:DC%2BC38XhtlCisLjF 22957056
-
Wang L, Xiang S, Williams KA, et al. Depletion of HDAC6 enhances cisplatin-induced DNA damage and apoptosis in non-small cell lung cancer cells. PLoS One. 2012;7(9):e44265.
-
(2012)
PLoS One.
, vol.7
, Issue.9
, pp. e44265
-
-
Wang, L.1
Xiang, S.2
Williams, K.A.3
-
104
-
-
0242442588
-
Inhibition of DNA methylation and histone deacetylation prevents murine lung cancer
-
1:CAS:528:DC%2BD3sXovVGlsLk%3D 14612500
-
Belinsky SA, Klinge DM, Stidley CA, et al. Inhibition of DNA methylation and histone deacetylation prevents murine lung cancer. Cancer Res. 2003;63:7089-93.
-
(2003)
Cancer Res.
, vol.63
, pp. 7089-7093
-
-
Belinsky, S.A.1
Klinge, D.M.2
Stidley, C.A.3
-
105
-
-
84872316231
-
Phase I study of 5-aza-2′-deoxycytidine in combination with valproic acid in non-small cell lung cancer
-
1:CAS:528:DC%2BC3sXktFCgsQ%3D%3D 23053268
-
Chu BF, Karpenko MJ, Liu Z, et al. Phase I study of 5-aza-2′-deoxycytidine in combination with valproic acid in non-small cell lung cancer. Cancer Chemother Pharmacol. 2013;71:115-21.
-
(2013)
Cancer Chemother Pharmacol.
, vol.71
, pp. 115-121
-
-
Chu, B.F.1
Karpenko, M.J.2
Liu, Z.3
-
106
-
-
34548395116
-
A phase II study of epigenetic therapy with hydralazine and magnesium valproate to overcome chemotherapy resistance in refractory solid tumors
-
1:STN:280:DC%2BD2srhtFaqug%3D%3D 17761710
-
Candelaria M, Gallardo-Rincón D, Arce C, et al. A phase II study of epigenetic therapy with hydralazine and magnesium valproate to overcome chemotherapy resistance in refractory solid tumors. Ann Oncol. 2007;18(9):1529-38.
-
(2007)
Ann Oncol.
, vol.18
, Issue.9
, pp. 1529-1538
-
-
Candelaria, M.1
Gallardo-Rincón, D.2
Arce, C.3
-
107
-
-
70349665197
-
A phase I dose-finding study of 5-azacytidine in combination with sodium phenylbutyrate in patients with refractory solid tumors
-
2845396 1:CAS:528:DC%2BD1MXhtF2lurjO 19789320
-
Lin J, Gilbert J, Rudek MA, et al. A phase I dose-finding study of 5-azacytidine in combination with sodium phenylbutyrate in patients with refractory solid tumors. Clin Cancer Res. 2009;15(19):6241-9.
-
(2009)
Clin Cancer Res.
, vol.15
, Issue.19
, pp. 6241-6249
-
-
Lin, J.1
Gilbert, J.2
Rudek, M.A.3
-
108
-
-
79952710830
-
Phase I study of decitabine in combination with vorinostat in patients with advanced solid tumors and non-Hodgkin's lymphomas
-
1:CAS:528:DC%2BC3MXjtFChtrs%3D 21278245
-
Stathis A, Hotte SJ, Chen EX, et al. Phase I study of decitabine in combination with vorinostat in patients with advanced solid tumors and non-Hodgkin's lymphomas. Clin Cancer Res. 2011;17(6):1582-90.
-
(2011)
Clin Cancer Res.
, vol.17
, Issue.6
, pp. 1582-1590
-
-
Stathis, A.1
Hotte, S.J.2
Chen, E.X.3
-
109
-
-
84655163371
-
Combination epigenetic therapy has efficacy in patients with refractory advanced non-small cell lung cancer
-
3353724 1:CAS:528:DC%2BC3MXhs1agt7rK 22586682
-
Juergens RA, Wrangle J, Vendetti FP, et al. Combination epigenetic therapy has efficacy in patients with refractory advanced non-small cell lung cancer. Cancer Discov. 2011;1(7):598-607.
-
(2011)
Cancer Discov.
, vol.1
, Issue.7
, pp. 598-607
-
-
Juergens, R.A.1
Wrangle, J.2
Vendetti, F.P.3
-
110
-
-
84894069675
-
Histone deacetylases inhibitors: Conjugation to other anti-tumor pharmacophores provides novel tools for cancer treatment
-
1:CAS:528:DC%2BC2cXitFymu78%3D 24205827
-
Papavassiliou KA, Papavassiliou AG. Histone deacetylases inhibitors: conjugation to other anti-tumor pharmacophores provides novel tools for cancer treatment. Expert Opin Investig Drugs. 2014;23(3):291-4.
-
(2014)
Expert Opin Investig Drugs.
, vol.23
, Issue.3
, pp. 291-294
-
-
Papavassiliou, K.A.1
Papavassiliou, A.G.2
-
111
-
-
84879641705
-
The design and synthesis of a new class of RTK/HDAC dual-targeted inhibitors
-
1:CAS:528:DC%2BC3sXpvFWmt7g%3D 23736786
-
Zhang X, Su M, Chen Y, et al. The design and synthesis of a new class of RTK/HDAC dual-targeted inhibitors. Molecules. 2013;18(6):6491-503.
-
(2013)
Molecules.
, vol.18
, Issue.6
, pp. 6491-6503
-
-
Zhang, X.1
Su, M.2
Chen, Y.3
-
112
-
-
73949140461
-
Carboplatin and paclitaxel in combination with either vorinostat or placebo for first line therapy of advanced non-small cell lung cancer
-
2799233 1:CAS:528:DC%2BC3cXhtF2ku7c%3D 19933908
-
Ramalingam SS, Maitland ML, Frankel P, et al. Carboplatin and paclitaxel in combination with either vorinostat or placebo for first line therapy of advanced non-small cell lung cancer. J Clin Oncol. 2010;28:56-62.
-
(2010)
J Clin Oncol.
, vol.28
, pp. 56-62
-
-
Ramalingam, S.S.1
Maitland, M.L.2
Frankel, P.3
-
113
-
-
77956225157
-
Randomised, double-blind phase II-III study of first line paclitaxel (P) plus carboplatin (C) in combination with vorinostat or placebo in patients with advanced non-small-cell lung cancer (NSCLC) [abstract no. 0-9007]
-
Belani C, Ramalingam S, Kalemkerian G, et al. Randomised, double-blind phase II-III study of first line paclitaxel (P) plus carboplatin (C) in combination with vorinostat or placebo in patients with advanced non-small-cell lung cancer (NSCLC) [abstract no. 0-9007]. Eur J Cancer Suppl. 2009;7(2):507.
-
(2009)
Eur J Cancer Suppl
, vol.7
, Issue.2
, pp. 507
-
-
Belani, C.1
Ramalingam, S.2
Kalemkerian, G.3
-
114
-
-
85027954125
-
DNA methylation profiling in the clinic: Applications and challenges
-
1:CAS:528:DC%2BC38Xht12jsbjK 22945394
-
Heyn H, Esteller M. DNA methylation profiling in the clinic: applications and challenges. Nat Rev Genet. 2012;13:679-92.
-
(2012)
Nat Rev Genet.
, vol.13
, pp. 679-692
-
-
Heyn, H.1
Esteller, M.2
-
115
-
-
84866434919
-
Genomic landscape of non-small cell lung cancer in smokers and never-smokers
-
3656590 1:CAS:528:DC%2BC38XhtlKrtr7I 22980976
-
Govindan R, Ding L, Griffith M, et al. Genomic landscape of non-small cell lung cancer in smokers and never-smokers. Cell. 2012;150:1121-34.
-
(2012)
Cell.
, vol.150
, pp. 1121-1134
-
-
Govindan, R.1
Ding, L.2
Griffith, M.3
-
116
-
-
84885924300
-
PARAMOUNT: Final overall survival results of the phase III study of maintenance pemetrexed versus placebo immediately after induction treatment with pemetrexed plus cisplatin for advanced nonsquamous non-small-cell lung cancer
-
1:CAS:528:DC%2BC3sXhsV2gu7vO 23835707
-
Paz-Ares LG, de Marinis F, Dediu M, et al. PARAMOUNT: final overall survival results of the phase III study of maintenance pemetrexed versus placebo immediately after induction treatment with pemetrexed plus cisplatin for advanced nonsquamous non-small-cell lung cancer. J Clin Oncol. 2013;31(23):2895-902.
-
(2013)
J Clin Oncol.
, vol.31
, Issue.23
, pp. 2895-2902
-
-
Paz-Ares, L.G.1
De Marinis, F.2
Dediu, M.3
-
117
-
-
84895456119
-
Discovery and development of DNA methylation-based biomarkers for lung cancer
-
1:CAS:528:DC%2BC2cXnslClurw%3D 24579947
-
Walter K, Holcomb T, Januario T, et al. Discovery and development of DNA methylation-based biomarkers for lung cancer. Epigenomics. 2014;6(1):59-72.
-
(2014)
Epigenomics.
, vol.6
, Issue.1
, pp. 59-72
-
-
Walter, K.1
Holcomb, T.2
Januario, T.3
-
118
-
-
84891801684
-
A prognostic DNA methylation signature for stage I non-small-cell lung cancer
-
24081945
-
Sandoval J, Mendez-Gonzalez J, Nadal E, et al. A prognostic DNA methylation signature for stage I non-small-cell lung cancer. J Clin Oncol. 2013;31(32):4140-7.
-
(2013)
J Clin Oncol.
, vol.31
, Issue.32
, pp. 4140-4147
-
-
Sandoval, J.1
Mendez-Gonzalez, J.2
Nadal, E.3
-
119
-
-
84890130945
-
Alterations of immune response of non-small cell lung cancer with Azacytidine
-
3875770 24162015
-
Wrangle J, Wang W, Koch A, et al. Alterations of immune response of non-small cell lung cancer with Azacytidine. Oncotarget. 2013;4(11):2067-79.
-
(2013)
Oncotarget.
, vol.4
, Issue.11
, pp. 2067-2079
-
-
Wrangle, J.1
Wang, W.2
Koch, A.3
-
120
-
-
10844248177
-
Trial with CI-994 paclitaxel and/or carboplatin
-
1:CAS:528:DC%2BD2cXhtVentrbL 15641487
-
Pauer LR, Olivares J, Cunningham C, et al. Trial with CI-994 paclitaxel and/or carboplatin. Cancer Invest. 2004;22(6):886-96.
-
(2004)
Cancer Invest.
, vol.22
, Issue.6
, pp. 886-896
-
-
Pauer, L.R.1
Olivares, J.2
Cunningham, C.3
-
121
-
-
84856557385
-
Phase I study of vorinostat (suberoylanilide hydroxamic acid, NSC 701852) in combination with docetaxel in patients with advanced and relapsed solid malignancies
-
1:CAS:528:DC%2BC38XotVWjtA%3D%3D 20686817
-
Schneider BJ, Kalemkerian GP, Bradley D, et al. Phase I study of vorinostat (suberoylanilide hydroxamic acid, NSC 701852) in combination with docetaxel in patients with advanced and relapsed solid malignancies. Invest New Drugs. 2012;30(1):249-57.
-
(2012)
Invest New Drugs.
, vol.30
, Issue.1
, pp. 249-257
-
-
Schneider, B.J.1
Kalemkerian, G.P.2
Bradley, D.3
-
122
-
-
84864004796
-
Randomized phase II trial of erlotinib with and without entinostat in patients with advanced non-small-cell lung cancer who progressed on prior chemotherapy
-
1:CAS:528:DC%2BC38XhtFCjtrbO 22508830
-
Witta SE, Jotte RM, Konduri K, et al. Randomized phase II trial of erlotinib with and without entinostat in patients with advanced non-small-cell lung cancer who progressed on prior chemotherapy. J Clin Oncol. 2012;30(18):2248-55.
-
(2012)
J Clin Oncol.
, vol.30
, Issue.18
, pp. 2248-2255
-
-
Witta, S.E.1
Jotte, R.M.2
Konduri, K.3
-
123
-
-
84899471596
-
Phase I/II trial of vorinostat (SAHA) and erlotinib for non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations after erlotinib progression
-
24636848
-
Reguart N, Rosell R, Cardenal F, et al. Phase I/II trial of vorinostat (SAHA) and erlotinib for non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations after erlotinib progression. Lung Cancer. 2014;84(2):161-7.
-
(2014)
Lung Cancer.
, vol.84
, Issue.2
, pp. 161-167
-
-
Reguart, N.1
Rosell, R.2
Cardenal, F.3
-
124
-
-
84873097735
-
A phase I study of sorafenib and vorinostat in patients with advanced solid tumors with expanded cohorts in renal cell carcinoma and non-small cell lung cancer
-
1:CAS:528:DC%2BC3sXhs1Ohtbk%3D 22415798
-
Dasari A, Gore L, Messersmith WA, et al. A phase I study of sorafenib and vorinostat in patients with advanced solid tumors with expanded cohorts in renal cell carcinoma and non-small cell lung cancer. Invest New Drugs. 2013;31(1):115-25.
-
(2013)
Invest New Drugs.
, vol.31
, Issue.1
, pp. 115-125
-
-
Dasari, A.1
Gore, L.2
Messersmith, W.A.3
-
125
-
-
84896502954
-
A Phase i, pharmacokinetic, and pharmacodynamic study of panobinostat, an HDAC inhibitor, combined with erlotinib in patients with advanced aerodigestive tract tumors
-
4051132 1:CAS:528:DC%2BC2cXks1Ojt7c%3D 24429877
-
Gray JE, Haura E, Chiappori A, et al. A Phase i, pharmacokinetic, and pharmacodynamic study of panobinostat, an HDAC inhibitor, combined with erlotinib in patients with advanced aerodigestive tract tumors. Clin Cancer Res. 2014;20(6):1644-55.
-
(2014)
Clin Cancer Res.
, vol.20
, Issue.6
, pp. 1644-1655
-
-
Gray, J.E.1
Haura, E.2
Chiappori, A.3
-
126
-
-
84867899520
-
Phase I trial of induction histone deacetylase and proteasome inhibition followed by surgery in non-small cell lung cancer
-
3473142 1:CAS:528:DC%2BC38XhsFSgt73P 23059775
-
Jones DR, Moskaluk CA, Gillenwater HH, et al. Phase I trial of induction histone deacetylase and proteasome inhibition followed by surgery in non-small cell lung cancer. J Thorac Oncol. 2012;7:1683-90.
-
(2012)
J Thorac Oncol.
, vol.7
, pp. 1683-1690
-
-
Jones, D.R.1
Moskaluk, C.A.2
Gillenwater, H.H.3
-
127
-
-
84888607613
-
A phase I study of vorinostat in combination with bortezomib in patients with advanced malignancies
-
3901262 1:CAS:528:DC%2BC3sXhslCmtLbE 24114121
-
Schelman WR, Traynor AM, Holen KD, et al. A phase I study of vorinostat in combination with bortezomib in patients with advanced malignancies. Invest New Drugs. 2013;31(6):1539-46.
-
(2013)
Invest New Drugs.
, vol.31
, Issue.6
, pp. 1539-1546
-
-
Schelman, W.R.1
Traynor, A.M.2
Holen, K.D.3
-
128
-
-
84899061436
-
Vorinostat and bortezomib as third-line therapy in patients with advanced non-small cell lung cancer: A Wisconsin Oncology Network Phase II study
-
4310688 1:CAS:528:DC%2BC2cXitFylu70%3D 23728919
-
Hoang T, Campbell TC, Zhang C, et al. Vorinostat and bortezomib as third-line therapy in patients with advanced non-small cell lung cancer: a Wisconsin Oncology Network Phase II study. Invest New Drugs. 2014;32(1):195-9.
-
(2014)
Invest New Drugs.
, vol.32
, Issue.1
, pp. 195-199
-
-
Hoang, T.1
Campbell, T.C.2
Zhang, C.3
-
129
-
-
84871407100
-
Phase 1 clinical trial of the novel proteasome inhibitor marizomib with the histone deacetylase inhibitor vorinostat in patients with melanoma, pancreatic and lung cancer based on in vitro assessments of the combination
-
1:CAS:528:DC%2BC38Xhs1Sht7fM 22080430
-
Millward M, Price T, Townsend A, et al. Phase 1 clinical trial of the novel proteasome inhibitor marizomib with the histone deacetylase inhibitor vorinostat in patients with melanoma, pancreatic and lung cancer based on in vitro assessments of the combination. Invest New Drugs. 2012;30(6):2303-17.
-
(2012)
Invest New Drugs.
, vol.30
, Issue.6
, pp. 2303-2317
-
-
Millward, M.1
Price, T.2
Townsend, A.3
-
130
-
-
84926430579
-
Identification of coexistence of DNA methylation and H3K27me3 specifically in cancer cells as a promising target for epigenetic therapy
-
25477340
-
Takeshima H, Wakabayashi M, Hattori N, et al. Identification of coexistence of DNA methylation and H3K27me3 specifically in cancer cells as a promising target for epigenetic therapy. Carcinogenesis. 2015;36(2):192-201.
-
(2015)
Carcinogenesis.
, vol.36
, Issue.2
, pp. 192-201
-
-
Takeshima, H.1
Wakabayashi, M.2
Hattori, N.3
-
131
-
-
85050578395
-
Inhibitors of emerging epigenetic targets for cancer therapy: A patent review (2010-2014)
-
1:CAS:528:DC%2BC2MXhtFKhtr7I 26174566
-
Tanaka M, Roberts JM, Qi J, Bradner JE. Inhibitors of emerging epigenetic targets for cancer therapy: a patent review (2010-2014). Pharm Pat Anal. 2015;4(4):261-84.
-
(2015)
Pharm Pat Anal.
, vol.4
, Issue.4
, pp. 261-284
-
-
Tanaka, M.1
Roberts, J.M.2
Qi, J.3
Bradner, J.E.4
|