The novel HDAC inhibitor NDACI054 sensitizes human cancer cells to radiotherapy

Radiotherapy and Oncology

Volumn 109, Issue 1, 2013, Pages 126-132

  Hehlgans, Stephanie ^a,b   Storch, Katja ^a   Lange, Inga ^a   Cordes, Nils ^a,c  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b GOETHE UNIVERSITY   (Germany)

^c DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

3D cell culture; Cancer cell lines; Dna repair; Hdac inhibitor; Ionizing radiation

Indexed keywords

CASPASE 3; DNA DEPENDENT PROTEIN KINASE; HISTONE DEACETYLASE INHIBITOR; HISTONE H2AX; HISTONE H3; NDACI 054; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; NOVARTIS DEACETYLASE INHIBITOR 054; PROTEIN P53; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; ATAXIA TELANGIECTASIA; CANCER CELL; CANCER RADIOTHERAPY; CANCER SURVIVAL; CELL ASSAY; CELL SURVIVAL; CLONOGENESIS; COLORECTAL CARCINOMA; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DNA REPAIR; ENZYME ACTIVITY; ENZYME INHIBITION; EXTRACELLULAR MATRIX; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HISTONE ACETYLATION; HUMAN; HUMAN CELL; LUNG CARCINOMA; PANCREAS CARCINOMA; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN PHOSPHORYLATION; RADIOSENSITIZATION;

3D CELL CULTURE; CANCER CELL LINES; DNA REPAIR; HDAC INHIBITOR; IONIZING RADIATION;

ACETYLATION; CELL LINE, TUMOR; CELL SURVIVAL; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; HISTONE DEACETYLASE INHIBITORS; HISTONES; HUMANS; NEOPLASMS; PHOSPHORYLATION; RADIATION-SENSITIZING AGENTS;

EID: 84888031752     PISSN: 01678140     EISSN: 18790887     Source Type: Journal    
DOI: 10.1016/j.radonc.2013.08.023     Document Type: Article

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