Acetylshikonin induces apoptosis of hepatitis B virus X protein-expressing human hepatocellular carcinoma cells via endoplasmic reticulum stress

European Journal of Pharmacology

Volumn 735, Issue 1, 2014, Pages 132-140

  Moon, Jeong ^a   Koh, Sang Seok ^b   Malilas, Waraporn ^a   Cho, Il Rae ^a   Kaewpiboon, Chutima ^c   Kaowinn, Sirichat ^a   Lee, Keesook ^d   Jhun, Byung Hak ^a   Choi, Young Whan ^a   Chung, Young Hwa ^a  

^a Pusan National University   (South Korea)

^b Dong A University   (South Korea)

^c CHULALONGKORN UNIVERSITY   (Thailand)

^d Chonnam National University   (South Korea)

Author keywords

Acetylshikonin; ER stress; JNK; Nur77; Reactive oxygen species

Indexed keywords

ACETYLCYSTEINE; ACETYLSHIKONIN; CASPASE 3; CASPASE 8; CASPASE 9; CYCLOHEXIMIDE; GLUCOSE REGULATED PROTEIN 78; HEPATITIS B VIRUS X PROTEIN; NUCLEAR RECEPTOR NUR77; REACTIVE OXYGEN METABOLITE; SALUBRINAL; SHIKONIN DERIVATIVE; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; ANTHRAQUINONE DERIVATIVE; ANTINEOPLASTIC AGENT; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; NR4A1 PROTEIN, HUMAN; TRANSACTIVATOR PROTEIN;

ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL PROTECTION; CELL STRESS; CELLULAR DISTRIBUTION; CELLULAR STRESS RESPONSE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOPLASM; DRUG PROTEIN BINDING; DRUG TARGETING; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LIVER CANCER CELL LINE; LIVER CELL CARCINOMA; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; UBIQUITINATION; UPREGULATION; CARCINOMA, HEPATOCELLULAR; CELL SURVIVAL; DRUG EFFECTS; GENETICS; LIVER NEOPLASMS; METABOLISM; TUMOR CELL LINE;

ANTHRAQUINONES; ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL SURVIVAL; ENDOPLASMIC RETICULUM STRESS; HUMANS; LIVER NEOPLASMS; MAP KINASE KINASE 4; NUCLEAR RECEPTOR SUBFAMILY 4, GROUP A, MEMBER 1; RNA, SMALL INTERFERING; TRANS-ACTIVATORS; UP-REGULATION;

EID: 84899775493     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2014.04.021     Document Type: Article

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