OBATOCLAX and ABT-737 induce ER stress responses in human melanoma cells that limit induction of apoptosis

PLoS ONE

Volumn 8, Issue 12, 2013, Pages

  Wroblewski, David ^a   Jiang, Chen Chen ^a   Croft, Amanda ^a   Farrelly, Margaret L ^a   Zhang, Xu Dong ^a   Hersey, Peter ^b  

^a UNIVERSITY OF NEWCASTLE   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; ACTIVATING TRANSCRIPTION FACTOR 6; BH3 PROTEIN; OBATOCLAX; PROTEIN BCL 2; PROTEIN IRE1; PROTEIN MCL 1; RECOMBINANT PROTEIN; RNA; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; X BOX BINDING PROTEIN 1;

APOPTOSIS; ARTICLE; AUTOPHAGY; CELL VIABILITY; ENDOPLASMIC RETICULUM STRESS; HUMAN; HUMAN CELL; MELANOMA CELL; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE; UNFOLDED PROTEIN RESPONSE; UPREGULATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; AUTOPHAGY; BIPHENYL COMPOUNDS; CALCIUM; CELL LINE, TUMOR; CYTOSOL; DRUG RESISTANCE, NEOPLASM; ENDOPLASMIC RETICULUM STRESS; HUMANS; MELANOMA; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; NITROPHENOLS; PIPERAZINES; PROTO-ONCOGENE PROTEINS C-BCL-2; PYRROLES; SULFONAMIDES; UNFOLDED PROTEIN RESPONSE; UP-REGULATION;

EID: 84893203144     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0084073     Document Type: Article

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