Interference of a novel indolylmaleimide with microtubules induces mitotic arrest and apoptosis in human progenitor and cancer cells

Biochemical Pharmacology

Volumn 85, Issue 6, 2013, Pages 763-771

  Eisenlöffel, Christian ^a   Schmöle, Anne Caroline ^a   Pews Davtyan, Anahit ^b   Brennführer, Anne ^b   Kuznetsov, Sergei A ^a   Hübner, Rayk ^a   Frech, Stefanie ^c   Schult, Catrin ^a   Junghanss, Christian ^a   Beller, Matthias ^b   Rolfs, Arndt ^a,d   Frech, Moritz J ^a  

^a UNIVERSITY OF ROSTOCK   (Germany)

^b LEIBNIZ INSTITUT FÜR KATALYSE E V AN DER UNIVERSITÄT ROSTOCK   (Germany)

^c Bionas GmbH   (Germany)

^d CENTOGENE AG   (Germany)

Author keywords

Apoptosis; Cancer; Indolylmaleimide; Microtubule; ReNcell VM

Indexed keywords

2 (2,4 DICHLOROPHENYL) 3 (1 METHYL 3 INDOLYL)MALEIMIDE; ANTINEOPLASTIC AGENT; IM 12; IM 15; INDOLE DERIVATIVE; PDA 66; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER STEM CELL; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPOLYMERIZATION; DOSE RESPONSE; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG CANCER; MICROTUBULE; MICROTUBULE ASSEMBLY; MITOSIS INHIBITION; NEUROBLASTOMA CELL; PRIORITY JOURNAL;

APOPTOSIS; HUMANS; IMMUNOHISTOCHEMISTRY; INDOLES; MALEIMIDES; MICROTUBULES; MITOSIS; NEOPLASMS; STEM CELLS; TUBULIN;

EID: 84874113181     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.12.013     Document Type: Article

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