Engineering of the cofactor specificities and isoform-specific inhibition of malic enzyme

Journal of Biological Chemistry

Volumn 284, Issue 7, 2009, Pages 4536-4544

  Hsieh, Ju Yi ^a   Hung, Hui Chih ^a  

^a NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING AFFINITIES; COFACTOR; COFACTOR SPECIFICITY; CYTOSOLIC; FUMARATE; ISOFORM; ISOFORMS; KINETIC ANALYSIS; MALIC ENZYMES; MAMMALIAN ENZYMES; OXIDATIVE DECARBOXYLATION; PYRUVATE; SIMULTANEOUS REDUCTION; TRIPLE MUTANTS;

BINDING ENERGY; CARBOXYLATION; CATALYSTS; COMPOSITE MICROMECHANICS; ENZYMES; MAMMALS;

ENZYME INHIBITION;

ADENOSINE TRIPHOSPHATE; ISOENZYME; LYSINE; MALATE DEHYDROGENASE (DECARBOXYLATING); NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RECOMBINANT ENZYME; MALATE DEHYDROGENASE; MITOCHONDRIAL PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE;

ARTICLE; BINDING AFFINITY; CATALYSIS; CONTROLLED STUDY; ENZYME ANALYSIS; ENZYME ENGINEERING; ENZYME INHIBITION; ENZYME KINETICS; ENZYME PURIFICATION; ENZYME SPECIFICITY; ENZYME STRUCTURE; HUMAN; KINETICS; MUTANT; MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SITE DIRECTED MUTAGENESIS; AMINO ACID SUBSTITUTION; ANIMAL; DECARBOXYLATION; GENETICS; METABOLISM; MISSENSE MUTATION; OXIDATION REDUCTION REACTION; PHYSIOLOGY; PROTEIN BINDING; PROTEIN QUATERNARY STRUCTURE;

MAMMALIA;

AMINO ACID SUBSTITUTION; ANIMALS; DECARBOXYLATION; HUMANS; ISOENZYMES; MALATE DEHYDROGENASE; MITOCHONDRIAL PROTEINS; MUTATION, MISSENSE; NAD; NADP; OXIDATION-REDUCTION; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY;

EID: 63249093924     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M807008200     Document Type: Article

References (39)

1. Hsu, R. Y. (1982) Mol. Cell. Biochem. 43, 3-26
2. Teller, J. K., and Fahien, L. A. (1990) Protein Expression Purif. 1, 151-154
3. Loeber, G., Infante, A. A., Maurer-Fogy, I., Krystek, E., and Dworkin, M. B. (1991) J. Biol. Chem. 266, 3016-3021
4. Cleland, W. W. (2000) Protein Pept. Lett. 7, 305-312
5. Xu, Y., Bhargava, G., Wu, H., Loeber, G., and Tong, L. (1999) Structure (Lond.) 7, 877-889
6. Yang, Z., Floyd, D. L., Loeber, G., and Tong, L. (2000) Nat. Struct. Biol. 7, 251-257
7. Yang, Z., Zhang, H., Hung, H. C., Kuo, C. C., Tsai, L. C., Yuan, H. S., Chou, W. Y., Chang, G. G., and Tong, L. (2002) Protein Sci. 11, 332-341
8. Coleman, D. E., Rao, G. S., Goldsmith, E. J., Cook, P. F., and Harris, B. G. (2002) Biochemistry 41, 6928-6938
9. Chang, G. G., and Tong, L. (2003) Biochemistry 42, 12721-12733
10. Loeber, G., Dworkin, M. B., Infante, A., and Ahorn, H. (1994) FEBS Lett. 344, 181-186
11. Chang, G. G., Wang, J. K., Huang, T. M., Lee, H. J., Chou, W. Y., and Meng, C. L. (1991) Eur. J. Biochem. 202, 681-688
12. Loeber, G., Maurer-Fogy, I., and Schwendenwein, R. (1994) Biochem. J. 304, 687-692
13. Mandella, R. D., and Sauer, L. A. T. (1975) J. Biol. Chem. 250, 5877-5884
14. Sauer, L. A., Dauchy, R. T., Nagel, W. O., and Morris, H. P. (1980) J. Biol. Chem. 255, 3844-3848
15. Baggetto, L. G. (1992) Biochimie (Paris) 74, 959-974
16. Sanz, N., Diez-Fernandez, D., Valverde, A. M., Lorenzo, M., Benito, M., and Cascales, M. (1997) Br. J. Cancer 75, 487-492
17. Moreadith, R. W., and Lehninger, A. L. (1984) J. Biol. Chem. 259, 6215-6221
18. Moreadith, R. W., and Lehninger, A. L. (1984) J. Biol. Chem. 259, 6222-6227
19. Fahien, L. A., and Teller, J. K. (1992) J. Biol. Chem. 267, 10411-10422
20. Mckeehan, W. L. (1982) Cell Biol. Int. Rep. 6, 635-650
21. Yang, Z., Lanks, C. W., and Tong, L. (2002) Structure (Lond.) 10, 951-960
22. Sauer, L. A. (1973) Biochem. Biophys. Res. Commun. 50, 52
23. Landsperger, W. J., and Harris, B. G. (1976) J. Biol. Chem. 251, 3599-3602
24. Hung, H. C., Kuo, M. W., Chang, G. G., and Liu, G. Y. (2005) Biochem. J. 392, 39-45
25. Teller, J. K., Fahien, L. A., and Davis, J. W. (1992) J. Biol. Chem. 267, 10423-10432
26. Zdnierowicz, S., Swierczynski, J., and Selewski, L. (1988) Biochem. Med. Metab. Biol. 39, 208-216
27. Lai, C. J., Harris, B. G., and Cook, P. F. (1992) Arch. Biochem. Biophys. 299, 214-219
28. Karsten, W. E., Pais, J. E., Rao, G. S., Harris, B. G., and Cook, P. F. (2003) Biochemistry 42, 9712-9721
29. Hsu, W. C., Hung, H. C., Tong, L., and Chang, G. G. (2004) Biochemistry 43, 7382-7390
30. Hung, H. C., Chien, Y. C., Hsieh, J. Y., Chang, G. G., and Liu, G. Y. (2005) Biochemistry 44, 12737-12745
31. Kuo, C. C., Tsai, L. C., Chin, T. Y., Chang, G. G., and Chou, W. Y. (2000) Biochem. Biophys. Res. Commun. 270, 821-825
32. Hsieh, J. Y., Liu, G. Y., Chang, G. G., and Hung, H. C. (2006) J. Biol. Chem. 281, 23237-23245
33. Aktas, D. F., and Cook, P. F. (2008) Biochemistry, 47, 2539-2546
34. Aktas, D. F., and Cook, P. F. (2008) BBA-Proteins Proteom. 1784, 2059-2064
35. Hsieh, J. Y., Liu, G. Y., and Hung, H. C. (2008) FEBS J. 275, 5383-5392
36. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254
37. Altschul, S. F., Boguski, M. S., Gish, W., and Wootton, J. C. (1994) Nat. Genet. 6, 119-129
38. Higgins, D., Thompson, J., Gibson, T., Thompson, J. D., Higgins, D. G., and Gibson, T. J. (1994) Nucleic Acids Res. 22, 4673-4680
39. Hall, T. A. (1999) Nucleic Acids Symp. Ser. 41, 95-98