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Volumn 5, Issue , 2015, Pages

Bv8/prokineticin 2 is involved in Aβ-induced neurotoxicity

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); G PROTEIN COUPLED RECEPTOR; GASTROINTESTINAL HORMONE; NEUROPEPTIDE; PEPTIDE FRAGMENT; PROK2 PROTEIN, RAT;

EID: 84945218780     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep15301     Document Type: Article
Times cited : (40)

References (58)
  • 1
    • 84863337843 scopus 로고    scopus 로고
    • Alzheimer mechanisms and therapeutic strategies
    • Huang, Y., Mucke, L. Alzheimer mechanisms and therapeutic strategies. Cell 148, 1204-1222 (2012).
    • (2012) Cell , vol.148 , pp. 1204-1222
    • Huang, Y.1    Mucke, L.2
  • 2
    • 33847662852 scopus 로고    scopus 로고
    • Soluble protein oligomers in neurodegeneration: Lessons from the Alzheimer's amyloid beta-peptide
    • Haass, C., Selkoe, D. J. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat. Rev. Mol. Cell Biol. 8, 101-112 (2007).
    • (2007) Nat. Rev. Mol. Cell Biol , vol.8 , pp. 101-112
    • Haass, C.1    Selkoe, D.J.2
  • 3
    • 84872552899 scopus 로고    scopus 로고
    • Synaptotoxic amyloid-? Oligomers: A molecular basis for the cause, diagnosis, and treatment of Alzheimer's disease
    • Klein, W. L. Synaptotoxic amyloid-? oligomers: a molecular basis for the cause, diagnosis, and treatment of Alzheimer's disease. J Alzheimers Dis. 33, 49-65 (2013).
    • (2013) J Alzheimers Dis , vol.33 , pp. 49-65
    • Klein, W.L.1
  • 4
    • 0028171885 scopus 로고
    • Amyloid beta-protein precursor: New clues to the genesis of Alzheimer's disease
    • Selkoe, D. J. Amyloid beta-protein precursor: new clues to the genesis of Alzheimer's disease. Curr. Opin. Neurobiol. 4, 708-716 (1994).
    • (1994) Curr. Opin. Neurobiol , vol.4 , pp. 708-716
    • Selkoe, D.J.1
  • 5
    • 11444256801 scopus 로고    scopus 로고
    • Glia and their cytokines in progression of neurodegeneration
    • Mrak, R. E., Griffin, W. S. Glia and their cytokines in progression of neurodegeneration. Neurobiol. Aging 26, 349-354 (2005).
    • (2005) Neurobiol. Aging , vol.26 , pp. 349-354
    • Mrak, R.E.1    Griffin, W.S.2
  • 6
    • 0034612175 scopus 로고    scopus 로고
    • Inflammation and Alzheimer's disease
    • Akiyama, H. et al. Inflammation and Alzheimer's disease. Neurobiol. Aging 21, 383-421 (2000).
    • (2000) Neurobiol. Aging , vol.21 , pp. 383-421
    • Akiyama, H.1
  • 7
    • 33748471099 scopus 로고    scopus 로고
    • Inflammation in Alzheimer disease: Driving force, bystander or beneficial response
    • Wyss-Coray, T. Inflammation in Alzheimer disease: driving force, bystander or beneficial response? Nat. Med. 12, 1005-1015 (2006).
    • (2006) Nat Med , vol.12 , pp. 1005-1015
    • Wyss-Coray, T.1
  • 8
    • 33847613885 scopus 로고    scopus 로고
    • Inflammatory processes in Alzheimer's disease
    • Heneka, M. T., O'Banion, M. K. Inflammatory processes in Alzheimer's disease. J. Neuroimmunol. 184, 69-91 (2007).
    • (2007) J. Neuroimmunol , vol.184 , pp. 69-91
    • Heneka, M.T.1    O'Banion, M.K.2
  • 10
    • 0032509889 scopus 로고    scopus 로고
    • Chemokines-chemotactic cytokines that mediate inflammation
    • Luster, A. D. Chemokines-chemotactic cytokines that mediate inflammation. N. Engl. J. Med. 338, 436-445 (1998).
    • (1998) N. Engl. J. Med , vol.338 , pp. 436-445
    • Luster, A.D.1
  • 11
    • 0032892888 scopus 로고    scopus 로고
    • Chemokine and chemokine receptor expression in the central nervous system
    • Hesselgesser, J., Horuk, R. Chemokine and chemokine receptor expression in the central nervous system. J. Neurovirol. 5, 13-26 (1999).
    • (1999) J. Neurovirol , vol.5 , pp. 13-26
    • Hesselgesser, J.1    Horuk, R.2
  • 12
    • 0033231896 scopus 로고    scopus 로고
    • Chemokines in the CNS: Plurifunctional mediators in diverse states
    • Asensio, V. C., Campbell, I. L. Chemokines in the CNS: plurifunctional mediators in diverse states. Trends Neurosci. 22, 504-12 (1999).
    • (1999) Trends Neurosci , vol.22 , pp. 504-512
    • Asensio, V.C.1    Campbell, I.L.2
  • 13
    • 84861078831 scopus 로고    scopus 로고
    • A review: Inflammatory process in Alzheimer's disease, role of cytokines
    • Rubio-Perez, J. M., Morillas-Ruiz, J. M. A review: inflammatory process in Alzheimer's disease, role of cytokines. Scientific World Journal 2012, 756357 (2012).
    • (2012) Scientific World Journal 2012 , pp. 756357
    • Rubio-Perez, J.M.1    Morillas-Ruiz, J.M.2
  • 14
    • 35448954048 scopus 로고    scopus 로고
    • The many roles of chemokine receptors in neurodegenerative disorders: Emerging new therapeutical strategies
    • Mines, M., Ding, Y., Fan, G. H. The many roles of chemokine receptors in neurodegenerative disorders: emerging new therapeutical strategies. Curr. Med. Chem. 14, 2456-2470 (2007).
    • (2007) Curr. Med. Chem , vol.14 , pp. 2456-2470
    • Mines, M.1    Ding, Y.2    Fan, G.H.3
  • 15
    • 0033033979 scopus 로고    scopus 로고
    • Bv8, a small protein from frog skin, and its homolog from snake venom induce hyperalgesia in rats
    • Mollay, C. et al. Bv8, a small protein from frog skin, and its homolog from snake venom induce hyperalgesia in rats. Eur. J. Pharmacol. 374, 189-196 (1999).
    • (1999) Eur. J. Pharmacol , vol.374 , pp. 189-196
    • Mollay, C.1
  • 16
    • 0038110045 scopus 로고    scopus 로고
    • The AVIT protein family. Secreted cysteine-rich vertebrate proteins with diverse functions
    • Kaser, A., Winklmayr, M., Lepperdinger, G., Kreil, G. The AVIT protein family. Secreted cysteine-rich vertebrate proteins with diverse functions. EMBO J. 4, 469-473 (2003).
    • (2003) EMBO J , vol.4 , pp. 469-473
    • Kaser, A.1    Winklmayr, M.2    Lepperdinger, G.3    Kreil, G.4
  • 17
    • 27644505416 scopus 로고    scopus 로고
    • Biological activities of Bv8 analogues
    • Negri, L. et al. Biological activities of Bv8 analogues. Br. J. Pharmacol. 146, 625-632 (2005).
    • (2005) Br. J. Pharmacol , vol.146 , pp. 625-632
    • Negri, L.1
  • 18
    • 70149094320 scopus 로고    scopus 로고
    • The chemokine Bv8/prokineticin 2 is up-regulated in inflammatory granulocytes and modulates inflammatory pain
    • Giannini, E. et al. The chemokine Bv8/prokineticin 2 is up-regulated in inflammatory granulocytes and modulates inflammatory pain. Proc Natl Acad Sci USA 106, 14646-14651 (2009).
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 14646-14651
    • Giannini, E.1
  • 19
    • 34548864108 scopus 로고    scopus 로고
    • Bv8/prokineticin proteins and their receptors
    • Negri, L., Lattanzi, R., Giannini, E., Melchiorri, P. Bv8/prokineticin proteins and their receptors. Life Sci. 81, 1103-1116 (2007).
    • (2007) Life Sci , vol.81 , pp. 1103-1116
    • Negri, L.1    Lattanzi, R.2    Giannini, E.3    Melchiorri, P.4
  • 20
    • 33748329419 scopus 로고    scopus 로고
    • Expression of prokineticins and their receptors in the adult mouse brain
    • Cheng, M. Y., Leslie, F. M., Zhou, Q. Y. Expression of prokineticins and their receptors in the adult mouse brain. J. Comp. Neurol. 498, 796-809 (2006).
    • (2006) J. Comp. Neurol , vol.498 , pp. 796-809
    • Cheng, M.Y.1    Leslie, F.M.2    Zhou, Q.Y.3
  • 21
    • 80053551883 scopus 로고    scopus 로고
    • Bv8-prokineticins and their receptors: Modulators of pain
    • Negri, L., Lattanzi, R. Bv8-prokineticins and their receptors: modulators of pain. Curr. Pharm. Biotechnol. 12, 1720-1727 (2011).
    • (2011) Curr. Pharm. Biotechnol , vol.12 , pp. 1720-1727
    • Negri, L.1    Lattanzi, R.2
  • 22
    • 84915792618 scopus 로고    scopus 로고
    • Controlling the activation of the Bv8/prokineticin system reduces neuroinflammation and abolishes thermal and tactile hyperalgesia in neuropathic animals
    • Maftei, D. et al. Controlling the activation of the Bv8/prokineticin system reduces neuroinflammation and abolishes thermal and tactile hyperalgesia in neuropathic animals. Br. J. Pharmacol. 171, 4850-4865 (2014).
    • (2014) Br. J. Pharmacol , vol.171 , pp. 4850-4865
    • Maftei, D.1
  • 23
    • 10044275221 scopus 로고    scopus 로고
    • Bv8 and endocrine gland-derived vascular endothelial growth factor stimulate hematopoiesis and hematopoietic cell mobilization
    • LeCouter, J., Zlot, C., Tejada, M., Peale, F., Ferrara, N. Bv8 and endocrine gland-derived vascular endothelial growth factor stimulate hematopoiesis and hematopoietic cell mobilization. Proc Natl Acad Sci USA 101, 16813-8 (2004).
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 16813-16818
    • LeCouter, J.1    Zlot, C.2    Tejada, M.3    Peale, F.4    Ferrara, N.5
  • 24
    • 23044438635 scopus 로고    scopus 로고
    • PK1/EG-VEGF induces monocyte differentiation and activation
    • Dorsch, M. et al. PK1/EG-VEGF induces monocyte differentiation and activation. J. Leukoc. Biol. 78, 426-434 (2005).
    • (2005) J. Leukoc. Biol , vol.78 , pp. 426-434
    • Dorsch, M.1
  • 25
    • 84945195103 scopus 로고    scopus 로고
    • Critical role for prokineticin 2 in CNS autoimmunity
    • Abou-Hamdan, M. et al. Critical role for prokineticin 2 in CNS autoimmunity. Neurol. Neuroimmunol. Neuroinflamm. 2, e95 (2015).
    • (2015) Neurol. Neuroimmunol. Neuroinflamm , vol.2 , pp. e95
    • Abou-Hamdan, M.1
  • 26
    • 84859471538 scopus 로고    scopus 로고
    • Prokineticin 2 is an endangering mediator of cerebral ischemic injury
    • Cheng, M. Y. et al. Prokineticin 2 is an endangering mediator of cerebral ischemic injury. Proc Natl Acad. Sci USA 109, 5475-80 (2012).
    • (2012) Proc Natl Acad. Sci USA , vol.109 , pp. 5475-5480
    • Cheng, M.Y.1
  • 27
    • 84921326727 scopus 로고    scopus 로고
    • Prokineticin 2 upregulation in the peripheral nervous system has a major role in triggering and maintaining[ neuropathic pain in the chronic constriction injury model
    • press
    • Lattanzi, R. et al. Prokineticin 2 upregulation in the peripheral nervous system has a major role in triggering and maintaining[ neuropathic pain in the chronic constriction injury model. Biomed. Res. Int. in press, doi: 10.1155/2014/301292 (2014b).
    • (2014) Biomed. Res. Int
    • Lattanzi, R.1
  • 28
    • 79959222583 scopus 로고    scopus 로고
    • The-secretase modulator CHF5074 restores memory and hippocampal synaptic plasticity in plaque-free Tg2576 mice
    • Balducci, C. et al. The -secretase modulator CHF5074 restores memory and hippocampal synaptic plasticity in plaque-free Tg2576 mice. J Alzheimers Dis. 24, 799-816 (2011).
    • (2011) J Alzheimers Dis , vol.24 , pp. 799-816
    • Balducci, C.1
  • 29
    • 33645520634 scopus 로고    scopus 로고
    • Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease
    • Jacobsen, J. S. et al. Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 103, 5161-5166 (2006).
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 5161-5166
    • Jacobsen, J.S.1
  • 30
    • 16644379264 scopus 로고    scopus 로고
    • Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function
    • Cleary, J. P. et al. Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function. Nat Neurosci. 8, 79-84 (2005).
    • (2005) Nat Neurosci , vol.8 , pp. 79-84
    • Cleary, J.P.1
  • 31
    • 77953892400 scopus 로고    scopus 로고
    • Molecular mechanisms of neurodegeneration in Alzheimer's disease
    • Crews, L., Masliah, E. Molecular mechanisms of neurodegeneration in Alzheimer's disease. Hum. Mol. Genet. 19, R12-20 (2010).
    • (2010) Hum. Mol. Genet , vol.19 , pp. R12-20
    • Crews, L.1    Masliah, E.2
  • 32
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • Hardy, J., Selkoe, D. J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297, 353-356 (2002).
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 35
    • 34147096369 scopus 로고    scopus 로고
    • Systemic inflammation, infection, ApoE alleles, and Alzheimer disease: A position paper
    • Finch, C. E., Morgan, T. E. Systemic inflammation, infection, ApoE alleles, and Alzheimer disease: a position paper. Curr. Alzheimer Res. 4, 185-189 (2007).
    • (2007) Curr. Alzheimer Res , vol.4 , pp. 185-189
    • Finch, C.E.1    Morgan, T.E.2
  • 36
    • 0033839006 scopus 로고    scopus 로고
    • Focal inflammation in the brain: Role in Alzheimer's disease
    • Cooper, N. R., Bradt, B. M., O'Barr, S., Yu, J. X. Focal inflammation in the brain: role in Alzheimer's disease. Immunol. Res. 21, 159-65 (2000).
    • (2000) Immunol. Res , vol.21 , pp. 159-165
    • Cooper, N.R.1    Bradt, B.M.2    O'Barr, S.3    Yu, J.X.4
  • 37
    • 0035690720 scopus 로고    scopus 로고
    • Glial activation in Alzheimer's disease: The role of Abeta and its associated proteins
    • Meda, L., Baron, P., Scarlato, G. Glial activation in Alzheimer's disease: the role of Abeta and its associated proteins. Neurobiol. Aging. 22, 885-893 (2001).
    • (2001) Neurobiol. Aging , vol.22 , pp. 885-893
    • Meda, L.1    Baron, P.2    Scarlato, G.3
  • 38
    • 0032891616 scopus 로고    scopus 로고
    • A central role for astrocytes in the inflammatory response to beta-amyloid; Chemokines, cytokines and reactive oxygen species are produced
    • Johnstone, M., Gearing, A. J., Miller, K. M. A central role for astrocytes in the inflammatory response to beta-amyloid; chemokines, cytokines and reactive oxygen species are produced. J Neuroimmunol. 93, 182-193 (1999).
    • (1999) J Neuroimmunol , vol.93 , pp. 182-193
    • Johnstone, M.1    Gearing, A.J.2    Miller, K.M.3
  • 39
    • 0036277146 scopus 로고    scopus 로고
    • Amyloid-beta-induced chemokine production in primary human macrophages and astrocytes
    • Smits, H. A. et al. Amyloid-beta-induced chemokine production in primary human macrophages and astrocytes. J. Neuroimmunol. 127, 160-8 (2002).
    • (2002) J. Neuroimmunol , vol.127 , pp. 160-168
    • Smits, H.A.1
  • 40
    • 84889606928 scopus 로고    scopus 로고
    • Bindarit inhibitor of CCL2 synthesis protects neurons against Amyloid--induced toxicity
    • Severini, C. et al. Bindarit, inhibitor of CCL2 synthesis, protects neurons against Amyloid--induced toxicity. J. Alzheimers Dis. 38, 281-293 (2013).
    • (2013) J. Alzheimers Dis , vol.38 , pp. 281-293
    • Severini, C.1
  • 41
    • 57349149440 scopus 로고    scopus 로고
    • Triazine compounds as antagonists at Bv8-prokineticin receptors
    • Balboni, G. et al. Triazine compounds as antagonists at Bv8-prokineticin receptors. J. Med. Chem. 51, 7635-7639 (2008).
    • (2008) J. Med. Chem , vol.51 , pp. 7635-7639
    • Balboni, G.1
  • 42
    • 85053564530 scopus 로고    scopus 로고
    • Halogenated triazinediones behave as antagonists of PKR1: In vitro and in vivo pharmacological characterization
    • Lattanzi, R. et al. Halogenated triazinediones behave as antagonists of PKR1: in vitro and in vivo pharmacological characterization. IJPRS 5, 5064-5072 (2014a).
    • (2014) IJPRS , vol.5 , pp. 5064-5072
    • Lattanzi, R.1
  • 43
    • 84901253812 scopus 로고    scopus 로고
    • A new convenient synthetic method and preliminary pharmacological characterization of triazinediones as prokineticin receptor antagonists
    • Congiu, C. et al. A new convenient synthetic method and preliminary pharmacological characterization of triazinediones as prokineticin receptor antagonists. Eur. J. Med. Chem. 81, 334-340 (2014).
    • (2014) Eur. J. Med. Chem , vol.81 , pp. 334-340
    • Congiu, C.1
  • 44
    • 17744392200 scopus 로고    scopus 로고
    • The mammalian homologue of the novel peptide Bv8 is expressed in the central nervous system and supports neuronal survival by activating the MAP kinase/PI-3-kinase pathways
    • Melchiorri, D. et al. The mammalian homologue of the novel peptide Bv8 is expressed in the central nervous system and supports neuronal survival by activating the MAP kinase/PI-3-kinase pathways. Eur. J. Neurosci. 13, 1694-702 (2001).
    • (2001) Eur. J. Neurosci , vol.13 , pp. 1694-1702
    • Melchiorri, D.1
  • 45
    • 42149109739 scopus 로고    scopus 로고
    • Prokineticin receptor-1 induces neovascularization and epicardial-derived progenitor cell differentiation
    • Urayama, K. et al. Prokineticin receptor-1 induces neovascularization and epicardial-derived progenitor cell differentiation. Arterioscler. Thromb. Vasc. Biol. 28, 841-849 (2008).
    • (2008) Arterioscler. Thromb. Vasc. Biol. , vol.28 , pp. 841-849
    • Urayama, K.1
  • 46
    • 0037069743 scopus 로고    scopus 로고
    • Molecular cloning and characterization of prokineticin receptors
    • Soga, T. et al. Molecular cloning and characterization of prokineticin receptors. Biochim. Biophys. Acta. 1579, 173-179 (2002).
    • (2002) Biochim. Biophys. Acta , vol.1579 , pp. 173-179
    • Soga, T.1
  • 47
    • 0036954610 scopus 로고    scopus 로고
    • Nociceptive sensitization by the secretory protein Bv8
    • Negri, L. et al. Nociceptive sensitization by the secretory protein Bv8. Br. J. Pharmacol. 137, 1147-1154 (2002).
    • (2002) Br. J. Pharmacol , vol.137 , pp. 1147-1154
    • Negri, L.1
  • 49
    • 44149083565 scopus 로고    scopus 로고
    • Neuroprotective and neurotoxic properties of glial cells in the pathogenesis of Alzheimer's disease
    • Farfara, D., Lifshitz, V., Frenkel, D. Neuroprotective and neurotoxic properties of glial cells in the pathogenesis of Alzheimer's disease. J. Cell. Mol. Med. 12, 762-780. 2008.
    • (2008) J. Cell. Mol. Med , vol.12 , pp. 762-762
    • Farfara, D.1    Lifshitz, V.2    Frenkel, D.3
  • 50
    • 77956231165 scopus 로고    scopus 로고
    • Glia: The many ways to modulate synaptic plasticity
    • Ben Achour, S., Pascual, O. Glia: the many ways to modulate synaptic plasticity. Neurochem Int. 57, 440-445 (2010).
    • (2010) Neurochem Int , vol.57 , pp. 440-445
    • Ben Achour, S.1    Pascual, O.2
  • 51
    • 84884150739 scopus 로고    scopus 로고
    • Suppression of central chemokine fractalkine receptor signaling alleviates amyloid-induced memory deficiency
    • Wu, J., et al. Suppression of central chemokine fractalkine receptor signaling alleviates amyloid-induced memory deficiency. Neurobiol. Aging. 34, 2843-2852 (2013).
    • (2013) Neurobiol. Aging , vol.34 , pp. 2843-2852
    • Wu, J.1
  • 52
    • 77958099640 scopus 로고    scopus 로고
    • Prokineticin 2 suppresses GABA-activated current in rat primary sensory neurons
    • Xiong, Y. C. et al. Prokineticin 2 suppresses GABA-activated current in rat primary sensory neurons. Neuropharmacology 59, 589-594 (2010).
    • (2010) Neuropharmacology , vol.59 , pp. 589-594
    • Xiong, Y.C.1
  • 53
    • 79958131573 scopus 로고    scopus 로고
    • Prokineticin 2 regulates theelectrical activity of rat suprachiasmatic nuclei neurons
    • Ren, P. et al. Prokineticin 2 regulates theelectrical activity of rat suprachiasmatic nuclei neurons. PLoS One. 6(6) e20263 (2011).
    • (2011) PLoS One , vol.6 , Issue.6 , pp. e20263
    • Ren, P.1
  • 54
    • 77749343716 scopus 로고    scopus 로고
    • Prokineticin 2 modulates the excitability of area postrema neurons in vitro in the rat
    • Ingves, M. V., Ferguson, A. V. Prokineticin 2 modulates the excitability of area postrema neurons in vitro in the rat. Am J Physiol Regul Integr Comp Physiol. 298, 617-626 (2010).
    • (2010) Am J Physiol Regul Integr Comp Physiol , vol.298 , pp. 617-626
    • Ingves, M.V.1    Ferguson, A.V.2
  • 55
    • 84887293638 scopus 로고    scopus 로고
    • Neuroprotective effects of resveratrol against A administration in rats are improved by lipid-core nanocapsules
    • Frozza, R. L. et al. Neuroprotective effects of resveratrol against A administration in rats are improved by lipid-core nanocapsules. Mol. Neurobiol. 47, 1066-1080 (2013).
    • (2013) Mol. Neurobiol , vol.47 , pp. 1066-1080
    • Frozza, R.L.1
  • 56
    • 84891888722 scopus 로고    scopus 로고
    • Systemic administration of substance P recovers beta amyloid-induced cognitive deficits in rat: Involvement of Kv potassium channels
    • Campolongo, P. et al. Systemic administration of substance P recovers beta amyloid-induced cognitive deficits in rat: involvement of Kv potassium channels. PLoS One. 8, e78036 (2013).
    • (2013) PLoS One , vol.8 , pp. e78036
    • Campolongo, P.1
  • 57
    • 71549130405 scopus 로고    scopus 로고
    • SP protects cerebellar granule cells against beta-amyloid-induced apoptosis by down-regulation and reduced activity of Kv4 potassium channels
    • Pieri, M. et al. SP protects cerebellar granule cells against beta-amyloid-induced apoptosis by down-regulation and reduced activity of Kv4 potassium channels. Neuropharmacology. 58, 268-76 (2010).
    • (2010) Neuropharmacology , vol.58 , pp. 268-276
    • Pieri, M.1
  • 58
    • 84872796543 scopus 로고    scopus 로고
    • Inflammation subverts hippocampal synaptic plasticity in experimental multiple sclerosis
    • Nistico, R. et al. Inflammation subverts hippocampal synaptic plasticity in experimental multiple sclerosis. PLoS One 8, e54666 (2013).
    • (2013) PLoS One , vol.8 , pp. e54666
    • Nistico, R.1


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