A new convenient synthetic method and preliminary pharmacological characterization of triazinediones as prokineticin receptor antagonists

European Journal of Medicinal Chemistry

Volumn 81, Issue , 2014, Pages 334-340

  Congiu, Cenzo ^a   Onnis, Valentina ^a   Deplano, Alessandro ^a   Salvadori, Severo ^b   Marconi, Veronica ^c   Maftei, Daniela ^c   Negri, Lucia ^c   Lattanzi, Roberta ^c   Balboni, Gianfranco ^a  

^a UNIVERSITY OF CAGLIARI   (Italy)

^b UNIVERSITY OF FERRARA   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Analgesic activity; Prokineticin antagonists; Triazinediones

Indexed keywords

1 [(4 BROMOBENZYL)AMINOCARBONYL] 3 (ETHOXYCARBONYL)THIOUREA; 1 [(4 FLUOROBENZYL)AMINOCARBONYL] 3 (ETHOXYCARBONYL)THIOUREA; 1 [[4 (TRIFLUOROMETHYL)BENZYL]AMINOCARBONYL] 3 (ETHOXYCARBONYL)THIOUREA; 2 [5 [4 FLUOROBENZYL) 1 (4 METHOXYBENZYL) 1,4,5,6 TETRAHYDRO 4,6 DIOXO 1,3,5 TRIAZIN 2 YLAMINO]ETHYL]GUANIDINE; 3 (4 BROMOBENZYL) 1 (4 METHOXYBENZYL) 6 (METHYLTHIO) 1,3,5 TRIAZINE 2,4(1H,3H) DIONE; 3 (4 BROMOBENZYL) 6 THIOXO 1,3,5 TRIAZINE 2,4 DIONE; 3 (4 FLUOROBENZYL) 1 (4 METHOXYBENZYL) 6 (METHYLTHIO) 1,3,5 TRIAZINE 2,4(1H,3H) DIONE; 3 (4 FLUOROBENZYL) 6 (METHYLTHIO) 1,3,5 TRIAZINE 2,4(1H,3H) DIONE; 3 (4 FLUOROBENZYL) 6 THIOXO 1,3,5 TRIAZINE 2,4 DIONE; 3 [4 (TRIFLUOROMETHYL)BENZYL] 1 (4 METHOXYBENZYL) 6 (METHYLTHIO) 1,3,5 TRIAZINE 2,4(1H,3H) DIONE; 3 [4 (TRIFLUOROMETHYL)BENZYL] 6 (METHYLTHIO) 1,3,5 TRIAZINE 2,4(1H,3H) DIONE; 3 [4 (TRIFLUOROMETHYL)BENZYL] 6 THIOXO 1,3,5 TRIAZINE 2,4 DIONE; 6 (2 AMINOETHYLAMINO) 3 (4 BROMOBENZYL) 1 (4 METHOXYBENZYL) 1,3,5 TRIAZINE 2,4(1H,3H) DIONE; 6 (2 AMINOETHYLAMINO) 3 (4 FLUOROBENZYL) 1 (4 METHOXYBENZYL) 1,3,5 TRIAZINE 2,4(1H,3H) DIONE; 6 (2 AMINOETHYLAMINO) 3 [4 (TRIFLUOROMETHYL)BENZYL] 1 (4 METHYLBENZYL) 1,3,5 TRIAZINE 2,4(1H,3H) DIONE; ANALGESIC AGENT; UNCLASSIFIED DRUG; VASCULOTROPIN INHIBITOR; [2 [5 (4 BROMOBENZYL) 1 (4 METHOXYBENZYL) 1,4,5,6 TETRAHYDRO 4,6 DIOXO 1,3,5 TRIAZIN 2 YLAMINO]ETHYL]GUANIDINE; [2 [5 (4 FLUOROBENZYL) 1 (4 METHOXYBENZYL) 1,4,5,6 TETRAHYDRO 4,6 DIOXO 1,3,5 TRIAZIN 2 YLAMINO]ETHYL]GUANIDINE; [2 [5 [4 (TRIFLUOROMETHYL)BENZYL]]] 1 [[(4 METHYLBENZYL) 1,4,5,6 TETRAHYDRO 4,6 DIOXO 1,3,5 TRIAZIN 2 YLAMINO]ETHYL]GUANIDINE; G PROTEIN COUPLED RECEPTOR; PKR1 PROTEIN, MOUSE; PKR2 PROTEIN, MOUSE; TRIAZINE DERIVATIVE;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ARTICLE; CROSS COUPLING REACTION; CYCLIZATION; DRUG PURITY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; IN VITRO STUDY; IN VIVO STUDY; INTRAPLANTAR DRUG ADMINISTRATION; MALE; METHYLATION; MITSUNOBU REACTION; MOUSE; NOCICEPTION; NONHUMAN; PAIN RECEPTOR; PAIN THRESHOLD; REDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CHEMICAL STRUCTURE; DEFICIENCY; DOSE RESPONSE; GENETICS; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MICE; MICE, INBRED C57BL; MOLECULAR STRUCTURE; RECEPTORS, G-PROTEIN-COUPLED; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZINES;

EID: 84901253812     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.05.030     Document Type: Article

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