-
1
-
-
3943092621
-
Pathways towards and away from alzheimer's disease
-
Mattson MP (2004) Pathways towards and away from Alzheimer's disease. Nature 430:631-639
-
(2004)
Nature
, vol.430
, pp. 631-639
-
-
Mattson, M.P.1
-
2
-
-
2542455537
-
Small assemblies of unmodified amyloid beta-protein are the proximate neurotoxin in alzheimer's disease
-
Klein WL, Stine WB Jr, Teplow D.B. (2004) Small assemblies of unmodified amyloid beta-protein are the proximate neurotoxin in Alzheimer's disease. Neurobiol Aging 25:569-580
-
(2004)
Neurobiol Aging
, vol.25
, pp. 569-580
-
-
Klein, W.L.1
Stine Jr., W.B.2
Teplow, D.B.3
-
3
-
-
5344277556
-
Deciphering the molecular basis of memory failure in alzheimer's disease
-
Walsh DM, Selkoe D.J. (2004) Deciphering the molecular basis of memory failure in Alzheimer's disease. Neuron 44:181-193
-
(2004)
Neuron
, vol.44
, pp. 181-193
-
-
Walsh, D.M.1
Selkoe, D.J.2
-
4
-
-
12344273726
-
The blood-brain barrier: Bottleneck in brain drug development
-
Pardridge WM (2005) The blood-brain barrier: bottleneck in brain drug development. NeuroRx 2:3-14
-
(2005)
NeuroRx
, vol.2
, pp. 3-14
-
-
Pardridge, W.M.1
-
5
-
-
67650642274
-
Nanotechnological applications for the treatment of neurodegenerative disorders
-
Modi G, Pillay V, Choonara Y.E., Ndesendo VMK, du Toit LC, Naidoo D (2009) Nanotechnological applications for the treatment of neurodegenerative disorders. Progress Neurobiol 88:272-285
-
(2009)
Progress Neurobiol
, vol.88
, pp. 272-285
-
-
Modi, G.1
Pillay, V.2
Choonara, Y.E.3
Ndesendo, V.M.K.4
Du Toit, L.C.5
Naidoo, D.6
-
6
-
-
0036707316
-
Biodegradable nanoparticles for drug delivery and targeting
-
Hans ML, Lowman A.M. (2002) Biodegradable nanoparticles for drug delivery and targeting. Curr Opin Solid State Mater Sci 6:319-327
-
(2002)
Curr Opin Solid State Mater Sci
, vol.6
, pp. 319-327
-
-
Hans, M.L.1
Lowman, A.M.2
-
8
-
-
67349121612
-
Albumin nanoparticles targeted with apo E enter the CNS by transcytosis and are delivered to neurons
-
Zensi A, Begley D, Pontikis C., Legros C, Mihoreanu L, Wagner S., Büchel C, von Briesen H, Kreuter J (2009) Albumin nanoparticles targeted with Apo E enter the CNS by transcytosis and are delivered to neurons. J Control Release 137:78-86
-
(2009)
J Control Release
, vol.137
, pp. 78-86
-
-
Zensi, A.1
Begley, D.2
Pontikis, C.3
Legros, C.4
Mihoreanu, L.5
Wagner, S.6
Büchel, C.7
Von Briesen, H.8
Kreuter, J.9
-
10
-
-
75149127160
-
Chitosan nanoparticles as a new delivery system for the anti-alzheimer drug tacrine
-
Wilson B, Samanta MK, Santhi K, Kumar KPS, Ramasamy M, Suresh B. (2010) Chitosan nanoparticles as a new delivery system for the anti-Alzheimer drug tacrine. Nanomedicine 6:144-152
-
(2010)
Nanomedicine
, vol.6
, pp. 144-152
-
-
Wilson, B.1
Samanta, M.K.2
Santhi, K.3
Kumar, K.P.S.4
Ramasamy, M.5
Suresh, B.6
-
11
-
-
0034526161
-
Influence of benzyl benzoate as oil core on the physicochemical properties of spray-dried powders from polymeric nanocapsules containing indomethacin
-
Guterres SS, Weiss V, de Luca Freitas L, Pohlmann AR (2000) Influence of benzyl benzoate as oil core on the physicochemical properties of spray-dried powders from polymeric nanocapsules containing indomethacin. Drug Deliv 7:195-199
-
(2000)
Drug Deliv
, vol.7
, pp. 195-199
-
-
Guterres, S.S.1
Weiss, V.2
De Luca Freitas, L.3
Pohlmann, A.R.4
-
12
-
-
11844260830
-
Diffusion and mathematical modeling of release profiles from nanocarriers
-
Pohlmann AR, Soares LU, Cruz L, Da Silveira NP, Guterres S.S. (2004) Diffusion and mathematical modeling of release profiles from nanocarriers. Curr Drug Deliv 1:103-110
-
(2004)
Curr Drug Deliv
, vol.1
, pp. 103-110
-
-
Pohlmann, A.R.1
Soares, L.U.2
Cruz, L.3
Da Silveira, N.P.4
Guterres, S.S.5
-
13
-
-
34250805429
-
Dexamethasone-loaded nanoparticle-coated microparticles: Correlation between in vitro drug release and drug transport across caco-2 cell mono-layers
-
Beck RCR, Pohlmann AR, Hoffmeister C, Gallas M.R., Collnot E., Schaefer UF, Guterres SS, Lehr C.M. (2007) Dexamethasone-loaded nanoparticle-coated microparticles: correlation between in vitro drug release and drug transport across Caco-2 cell mono-layers. Eur J Pharm Biopharm 67:8-30
-
(2007)
Eur J Pharm Biopharm
, vol.67
, pp. 8-30
-
-
Beck, R.C.R.1
Pohlmann, A.R.2
Hoffmeister, C.3
Gallas, M.R.4
Collnot, E.5
Schaefer, U.F.6
Guterres, S.S.7
Lehr, C.M.8
-
14
-
-
44749087128
-
Determining the simultaneous presence of drug nanocrystals in drug-loaded polymeric nanocapsule aqueous suspensions: A relation between light scattering and drug content
-
Pohlmann AR, Mezzalira G, Venturini C., Cruz L, Bernardi A, Jäger E, Battastini AMO, Silveira NP, Guterres SS (2008) Determining the simultaneous presence of drug nanocrystals in drug-loaded polymeric nanocapsule aqueous suspensions: a relation between light scattering and drug content. Int J Pharmac 359:288-293
-
(2008)
Int J Pharmac
, vol.359
, pp. 288-293
-
-
Pohlmann, A.R.1
Mezzalira, G.2
Venturini, C.3
Cruz, L.4
Bernardi, A.5
Jäger, E.6
Battastini, A.M.O.7
Silveira, N.P.8
Guterres, S.S.9
-
15
-
-
67349188238
-
Indomethacin-loaded nanocapsules treatment reduces in vivo glioblastoma growth in a rat glioma model
-
Bernardi A, Braganhol E, Jäger E, Figueiró F, Edelweiss MI, Pohlmann AR, Guterres SS, Battastini AMO (2009) Indomethacin-loaded nanocapsules treatment reduces in vivo glioblastoma growth in a rat glioma model. Cancer Lett 281:53-63
-
(2009)
Cancer Lett
, vol.281
, pp. 53-63
-
-
Bernardi, A.1
Braganhol, E.2
Jäger, E.3
Figueiró, F.4
Edelweiss, M.I.5
Pohlmann, A.R.6
Guterres, S.S.7
Battastini, A.M.O.8
-
16
-
-
79953020260
-
Characterization of trans-resveratrol-loaded lipid-core nanocapsules and tissue distribution studies in rats
-
Frozza RL, Bernardi A, Paese K., Hoppe JB, da Silva T, Battastini AMO, Pohlmann AR, Guterres SS, Salbego C (2010) Characterization of trans-resveratrol-loaded lipid-core nanocapsules and tissue distribution studies in rats. J Biomed Nanotechnol 6:694-703
-
(2010)
J Biomed Nanotechnol
, vol.6
, pp. 694-703
-
-
Frozza, R.L.1
Bernardi, A.2
Paese, K.3
Hoppe, J.B.4
Da Silva, T.5
Battastini, A.M.O.6
Pohlmann, A.R.7
Guterres, S.S.8
Salbego, C.9
-
17
-
-
84870351750
-
Indomethacin-loaded lipid-core nanocapsules reduce the damage triggered by Aβ1-42 in alzheimer's disease models
-
Bernardi A, Frozza RL, Meneghetti A, Hoppe J.B., Battastini AM, Pohlmann AR, Guterres SS, Salbego C.G. (2012) Indomethacin-loaded lipid-core nanocapsules reduce the damage triggered by Aβ1-42 in Alzheimer's disease models. Int J Nanomedicine 7:4927-4942
-
(2012)
Int J Nanomedicine
, vol.7
, pp. 4927-4942
-
-
Bernardi, A.1
Frozza, R.L.2
Meneghetti, A.3
Hoppe, J.B.4
Battastini, A.M.5
Pohlmann, A.R.6
Guterres, S.S.7
Salbego, C.G.8
-
18
-
-
0030977937
-
Wine consumption and dementia in the elderly: A prospective community study in the bordeaux area
-
Orgogozo JM, Dartigues JF, Lafont S, Letenneur L., Commenges D, Salomon R, Renaud S., Breteler M.B. (1997) Wine consumption and dementia in the elderly: a prospective community study in the Bordeaux area. Rev Neurol 153:185-192
-
(1997)
Rev Neurol
, vol.153
, pp. 185-192
-
-
Orgogozo, J.M.1
Dartigues, J.F.2
Lafont, S.3
Letenneur, L.4
Commenges, D.5
Salomon, R.6
Renaud, S.7
Breteler, M.B.8
-
19
-
-
0036725818
-
Risk factors for alzheimer's disease: A prospective analysis from the canadian study of health and aging
-
Lindsay J, Laurin D, Verreault R., Hébert R, Helliwell B., Hill GB, McDowell I (2002) Risk factors for Alzheimer's disease: a prospective analysis from the Canadian Study of Health and Aging. Am J Epidemiol 156:445-453
-
(2002)
Am J Epidemiol
, vol.156
, pp. 445-453
-
-
Lindsay, J.1
Laurin, D.2
Verreault, R.3
Hébert, R.4
Helliwell, B.5
Hill, G.B.6
McDowell, I.7
-
20
-
-
57449120637
-
Therapeutic potential of resveratrol in alzheimer's disease
-
Review
-
Vingtdeux V, Dreses-Werringloer U, Zhao H., Davies P, Marambaud P. (2008) Therapeutic potential of resveratrol in Alzheimer's disease. BMC Neurosci 9 (Suppl 2):S6, Review
-
(2008)
BMC Neurosci
, vol.9
, Issue.SUPPL. 2
-
-
Vingtdeux, V.1
Dreses-Werringloer, U.2
Zhao, H.3
Davies, P.4
Marambaud, P.5
-
21
-
-
33747886389
-
Resveratrol - A boon for treating alzheimer's disease?
-
Anekonda TS (2006) Resveratrol-A boon for treating Alzheimer's disease? Brain Res Rev 52:316-326
-
(2006)
Brain Res Rev
, vol.52
, pp. 316-326
-
-
Anekonda, T.S.1
-
22
-
-
43549088782
-
Resveratrol A multi-targeted agent for age-associated chronic diseases
-
Harikumar KB, Aggarwal B.B. (2008) Resveratrol A multi-targeted agent for age-associated chronic diseases. Cell Cycle 8:1020-1035
-
(2008)
Cell Cycle
, vol.8
, pp. 1020-1035
-
-
Harikumar, K.B.1
Aggarwal, B.B.2
-
23
-
-
33745962138
-
Therapeutic potential of resveratrol: The in vivo evidence
-
Baur JA, Sinclair D.A. (2006) Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov 5:493-506
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 493-506
-
-
Baur, J.A.1
Sinclair, D.A.2
-
24
-
-
27844497059
-
Resveratrol promotes clearance of alzheimer's disease amyloid-beta peptides
-
Marambaud P, Zhao H, Davies P. (2005) Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides. J Biol Chem 280:37377-37382
-
(2005)
J Biol Chem
, vol.280
, pp. 37377-37382
-
-
Marambaud, P.1
Zhao, H.2
Davies, P.3
-
25
-
-
60249098801
-
Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of alzheimer's disease
-
Karuppagounder SS, Pinto JT, Xu H, Chen H.L., Beal MF, Gibson G.E. (2009) Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease. Neurochem Int 54:111-118
-
(2009)
Neurochem Int
, vol.54
, pp. 111-118
-
-
Karuppagounder, S.S.1
Pinto, J.T.2
Xu, H.3
Chen, H.L.4
Beal, M.F.5
Gibson, G.E.6
-
26
-
-
77950575506
-
AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism
-
Vingtdeux V, Giliberto L, Zhao H., Chandakkar P, Wu Q, Simon J.E., Janle EM, Lobo J, Ferruzzi MG, Davies P, Marambaud P (2010) AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism. J Biol Chem 285:9100-9113
-
(2010)
J Biol Chem
, vol.285
, pp. 9100-9113
-
-
Vingtdeux, V.1
Giliberto, L.2
Zhao, H.3
Chandakkar, P.4
Wu, Q.5
Simon, J.E.6
Janle, E.M.7
Lobo, J.8
Ferruzzi, M.G.9
Davies, P.10
Marambaud, P.11
-
27
-
-
51349132313
-
Cancer chemopreventive and therapeutic potential of resveratrol: Mechanistic perspectives
-
Kundu JK, Surh Y-J (2008) Cancer chemopreventive and therapeutic potential of resveratrol: mechanistic perspectives. Cancer Lett 296:243-261
-
(2008)
Cancer Lett
, vol.296
, pp. 243-261
-
-
Kundu, J.K.1
Surh, Y.-J.2
-
28
-
-
52649144195
-
Resveratrol and novel potent activators of SIRT1: Effects on aging and age-related diseases
-
Knutson MD, Leeuwenburgh C. (2008) Resveratrol and novel potent activators of SIRT1: effects on aging and age-related diseases. Nutr Rev 66:591-596
-
(2008)
Nutr Rev
, vol.66
, pp. 591-596
-
-
Knutson, M.D.1
Leeuwenburgh, C.2
-
29
-
-
75149192820
-
Sirtuins as novel targets for alzheimer's disease and other neurodegenerative disorders: Experimental and genetic evidence
-
Albani D, Polito L, Forloni G. (2010) Sirtuins as novel targets for Alzheimer's disease and other neurodegenerative disorders: experimental and genetic evidence. J Alzheimers Dis 19:11-26
-
(2010)
J Alzheimers Dis
, vol.19
, pp. 11-26
-
-
Albani, D.1
Polito, L.2
Forloni, G.3
-
30
-
-
33751072349
-
Resveratrol improves health and survival of mice on a high-calorie diet
-
Baur JA, Pearson KJ, Price N.L., Jamieson HA, Lerin C, Kalra A, Prabhu V.V., Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy S, Fishbein KW, Spencer RG, Lakatta EG, Le Couteur D, Shaw RJ, Navas P, Puigserver P, Ingram DK, de Cabo R, Sinclair DA (2006) Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444:337-342
-
(2006)
Nature
, vol.444
, pp. 337-342
-
-
Baur, J.A.1
Pearson, K.J.2
Price, N.L.3
Jamieson, H.A.4
Lerin, C.5
Kalra, A.6
Prabhu, V.V.7
Allard, J.S.8
Lopez-Lluch, G.9
Lewis, K.10
Pistell, P.J.11
Poosala, S.12
Becker, K.G.13
Boss, O.14
Gwinn, D.15
Wang, M.16
Ramaswamy, S.17
Fishbein, K.W.18
Spencer, R.G.19
Lakatta, E.G.20
Le Couteur, D.21
Shaw, R.J.22
Navas, P.23
Puigserver, P.24
Ingram, D.K.25
De Cabo, R.26
Sinclair, D.A.27
more..
-
31
-
-
20344364428
-
Metabolism and bioavailability of trans-resveratrol
-
Wenzel E, Somoza V. (2005) Metabolism and bioavailability of trans-resveratrol. Mol Nutr Food Res 49:472-481
-
(2005)
Mol Nutr Food Res
, vol.49
, pp. 472-481
-
-
Wenzel, E.1
Somoza, V.2
-
32
-
-
84858709095
-
Administration of resveratrol: What formulation solutions to bioavailability limitations?
-
Amri A, Chaumeil JC, Sfar S, Charrueau C. (2012) Administration of resveratrol: what formulation solutions to bioavailability limitations? J Control Release 158:182-193
-
(2012)
J Control Release
, vol.158
, pp. 182-193
-
-
Amri, A.1
Chaumeil, J.C.2
Sfar, S.3
Charrueau, C.4
-
33
-
-
67649802306
-
Sustained release from lipid-core nanocapsules by varying the core viscosity and the particle surface area
-
Jäger E., Venturini CG, Poletto F.S., Colomé LM, Pohlmann JPU, Bernardi A, Battastini AMO, Guterres SS, Pohlmann AR (2009) Sustained release from lipid-core nanocapsules by varying the core viscosity and the particle surface area. J Biomed Nanotechnol 5:130-140
-
(2009)
J Biomed Nanotechnol
, vol.5
, pp. 130-140
-
-
Jäger, E.1
Venturini, C.G.2
Poletto, F.S.3
Colomé, L.M.4
Pohlmann, J.P.U.5
Bernardi, A.6
Battastini, A.M.O.7
Guterres, S.S.8
Pohlmann, A.R.9
-
35
-
-
4744367412
-
The value of spontaneous alternation behavior (SAB) as a test of retention in pharmacological investigations of memory
-
Huges RN (2004) The value of spontaneous alternation behavior (SAB) as a test of retention in pharmacological investigations of memory. Neurosci Biobehav Rev 28:497-505
-
(2004)
Neurosci Biobehav Rev
, vol.28
, pp. 497-505
-
-
Huges, R.N.1
-
36
-
-
34347215149
-
Object recognition in rats and mice: A one-trial non-matching-to-sample learning task to study 'recognition memory'
-
Bevins RA, Besheer J. (2006) Object recognition in rats and mice: a one-trial non-matching-to-sample learning task to study 'recognition memory'. Nat Protocols 1:1306-1311
-
(2006)
Nat Protocols
, vol.1
, pp. 1306-1311
-
-
Bevins, R.A.1
Besheer, J.2
-
37
-
-
0023691166
-
A new one-trial test for neurobio-logical studies of memory in rats. 1. Behavioral data
-
Ennaceur A, Delacour J. (1988) A new one-trial test for neurobio-logical studies of memory in rats. 1. Behavioral data. Behav Brain Res 31:47-59
-
(1988)
Behav Brain Res
, vol.31
, pp. 47-59
-
-
Ennaceur, A.1
Delacour, J.2
-
38
-
-
0018619593
-
Review of the folin-phenol protein quantification method of lowry, rosebrough, farr and randall
-
Peterson GL (1979) Review of the Folin-phenol protein quantification method of Lowry, Rosebrough, Farr and Randall. Anal Biochem 100:201-220
-
(1979)
Anal Biochem
, vol.100
, pp. 201-220
-
-
Peterson, G.L.1
-
39
-
-
33748762484
-
Protective effect of resveratrol against oxygen-glucose deprivation in organotypic hippocampal slice cultures: Involvement of PI3-K pathway
-
Zamin LL, Dillenburg-Pilla P, Argenta-Comiran R, Horn AP, Simão F, Nassif M., Gerhardt D, Frozza RL, Salbego C (2006) Protective effect of resveratrol against oxygen-glucose deprivation in organotypic hippocampal slice cultures: involvement of PI3-K pathway. Neurobiol Dis 24:170-182
-
(2006)
Neurobiol Dis
, vol.24
, pp. 170-182
-
-
Zamin, L.L.1
Dillenburg-Pilla, P.2
Argenta-Comiran, R.3
Horn, A.P.4
Simão, F.5
Nassif, M.6
Gerhardt, D.7
Frozza, R.L.8
Salbego, C.9
-
40
-
-
0036884291
-
Protein kinase C inhibits amyloid β-peptide neurotoxicity by acting on members of the wnt pathway
-
Garrido JL, Godoy J, Alvarez A., Bronfman M, InestrosaNC (2002) Protein kinase C inhibits amyloid β-peptide neurotoxicity by acting on members of the Wnt pathway. FASEB J 14:1982-1984
-
(2002)
FASEB J
, vol.14
, pp. 1982-1984
-
-
Garrido, J.L.1
Godoy, J.2
Alvarez, A.3
Bronfman, M.4
Inestrosa, N.C.5
-
41
-
-
0037220599
-
Activation of wnt signaling rescues neurodegeneration and behavioral impairments induced by β-amyloid fibrils
-
De Ferrari G.V., Chacón MA, Barría MI, Garrido J.L., Godoy JA, Olivares G, Reyes AE, Alvarez A, Bronfman M, Inestrosa NC (2003) Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by β-amyloid fibrils. Mol Psychiatry 8:195-208
-
(2003)
Mol Psychiatry
, vol.8
, pp. 195-208
-
-
De Ferrari, G.V.1
Chacón, M.A.2
Barría, M.I.3
Garrido, J.L.4
Godoy, J.A.5
Olivares, G.6
Reyes, A.E.7
Alvarez, A.8
Bronfman, M.9
Inestrosa, N.C.10
-
42
-
-
80051772933
-
WNT5A signaling contributes to Aβ-induced neuroinflammation and neurotoxicity
-
Li B, Zhong L, Yang X., Andersson T, Huang M, Tang S-J (2011) WNT5A signaling contributes to Aβ-induced neuroinflammation and neurotoxicity. PlosOne 6:1-10
-
(2011)
PlosOne
, vol.6
, pp. 1-10
-
-
Li, B.1
Zhong, L.2
Yang, X.3
Andersson, T.4
Huang, M.5
Tang, S.-J.6
-
43
-
-
58149380025
-
Animal models of alzheimer's disease: Therapeutic implications
-
Woodruff-Pak DS (2008) Animal models of Alzheimer's disease: therapeutic implications. J Alzheimers Dis 15:507-521
-
(2008)
J Alzheimers Dis
, vol.15
, pp. 507-521
-
-
Woodruff-Pak, D.S.1
-
44
-
-
34248547813
-
Soluble protein oligomers as emerging toxins in alzheimer's and others amyloid diseases
-
Ferreira ST, Vieira MN, De Felice FG (2007) Soluble protein oligomers as emerging toxins in Alzheimer's and others amyloid diseases. IUBMB Life 59:332-345
-
(2007)
IUBMB Life
, vol.59
, pp. 332-345
-
-
Ferreira, S.T.1
Vieira, M.N.2
De Felice, F.G.3
-
45
-
-
50349083093
-
Dendritic spine loss and synaptic alterations in alzheimer's disease
-
Knobloch M, Mansuy I.M. (2008) Dendritic spine loss and synaptic alterations in Alzheimer's disease. Mol Neurobiol 37:73-82
-
(2008)
Mol Neurobiol
, vol.37
, pp. 73-82
-
-
Knobloch, M.1
Mansuy, I.M.2
-
47
-
-
33747760358
-
Hippocampal synaptic loss in early alzheimer's disease and mild cognitive impairment
-
Scheff SW, Price DA, Schmitt F.A., Mufson E.J. (2006) Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment. Neurobiol Aging 27:1372-1384
-
(2006)
Neurobiol Aging
, vol.27
, pp. 1372-1384
-
-
Scheff, S.W.1
Price, D.A.2
Schmitt, F.A.3
Mufson, E.J.4
-
48
-
-
34249027009
-
Connecting TNF-α signaling pathways to iNOS expression in a mouse model of alzheimer's disease: Relevance for the behavioral and synaptic deficits induced by amyloid β protein
-
Medeiros R, Prediger RDS, Passos GF, Pandolfo P, Duarte F.S., Franco JL, Dafre AL, Di Giunta G, Figueiredo CP, Takahashi RN, Campos MM, Calixto JB (2007) Connecting TNF-α signaling pathways to iNOS expression in a mouse model of Alzheimer's disease: relevance for the behavioral and synaptic deficits induced by amyloid β protein. J Neurosci 27:5394-5404
-
(2007)
J Neurosci
, vol.27
, pp. 5394-5404
-
-
Medeiros, R.1
Prediger, R.D.S.2
Passos, G.F.3
Pandolfo, P.4
Duarte, F.S.5
Franco, J.L.6
Dafre, A.L.7
Di Giunta, G.8
Figueiredo, C.P.9
Takahashi, R.N.10
Campos, M.M.11
Calixto, J.B.12
-
49
-
-
72449208698
-
2A receptor blockade prevents synaptotoxicity and memory dysfunction caused by β-amyloid peptides via p38 mitogen-activated protein kinase pathway
-
2A receptor blockade prevents synaptotoxicity and memory dysfunction caused by β-amyloid peptides via p38 mitogen-activated protein kinase pathway. J Neurosci 29:14741-14751
-
(2009)
J Neurosci
, vol.29
, pp. 14741-14751
-
-
Canas, P.M.1
Porciúncula, L.O.2
Cunha, G.M.A.3
Silva, C.G.4
Machado, N.J.5
Oliveira, J.M.A.6
Oliveira, C.R.7
Cunha, R.A.8
-
50
-
-
73549087659
-
Role of the macrophage inflammatory protein-1α/CC chemokine receptor 5 signaling pathway in the neuroinflammatory response and cognitive deficits induced by β-amyloid peptide
-
Passos GF, Figueiredo CP, Prediger RDS, Pandolfo P, Duarte F.S., Medeiros R., Calixto J.B. (2009) Role of the macrophage inflammatory protein-1α/CC chemokine receptor 5 signaling pathway in the neuroinflammatory response and cognitive deficits induced by β-amyloid peptide. Am J Pathol 175:1586-1597
-
(2009)
Am J Pathol
, vol.175
, pp. 1586-1597
-
-
Passos, G.F.1
Figueiredo, C.P.2
Prediger, R.D.S.3
Pandolfo, P.4
Duarte, F.S.5
Medeiros, R.6
Calixto, J.B.7
-
51
-
-
70350126316
-
Effects of indomethacin-loaded nanocapsules in experimental model of inflammation in rats
-
Bernardi A, Zilberstein AC, Jäger E, Campos M.M., Morrone FB, Calixto JB, Pohlmann AR, Guterres S.S., Battastini AMO (2009) Effects of indomethacin-loaded nanocapsules in experimental model of inflammation in rats. Br J Pharmacol 158:1104-1111
-
(2009)
Br J Pharmacol
, vol.158
, pp. 1104-1111
-
-
Bernardi, A.1
Zilberstein, A.C.2
Jäger, E.3
Campos, M.M.4
Morrone, F.B.5
Calixto, J.B.6
Pohlmann, A.R.7
Guterres, S.S.8
Battastini, A.M.O.9
-
52
-
-
77957021083
-
Protective effects of indomethacin-loaded nanocapsules against oxygen-glucose deprivation in organotypic hippocampal slice cultures: Involvement of neuroinflammation
-
Bernardi A, Frozza RL, Horn A.P., Campos MM, Calixto JB, Salbego C, Pohlmann A.R., Guterres SS, Battastini AMO (2010) Protective effects of indomethacin-loaded nanocapsules against oxygen-glucose deprivation in organotypic hippocampal slice cultures: involvement of neuroinflammation. Neurochem Int 57:629-636
-
(2010)
Neurochem Int
, vol.57
, pp. 629-636
-
-
Bernardi, A.1
Frozza, R.L.2
Horn, A.P.3
Campos, M.M.4
Calixto, J.B.5
Salbego, C.6
Pohlmann, A.R.7
Guterres, S.S.8
Battastini, A.M.O.9
-
53
-
-
77954701127
-
Pleiotropic mechanisms facilitated by resveratrol and its metabolites
-
Calamini B, Ratia K, Malkowski M.G., Cuendet M., Pezzuto JM, Santarsiero BD, Mesecar A.D. (2010) Pleiotropic mechanisms facilitated by resveratrol and its metabolites. Biochem J 429(2):273-282
-
(2010)
Biochem J
, vol.429
, Issue.2
, pp. 273-282
-
-
Calamini, B.1
Ratia, K.2
Malkowski, M.G.3
Cuendet, M.4
Pezzuto, J.M.5
Santarsiero, B.D.6
Mesecar, A.D.7
-
54
-
-
77954331919
-
Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites
-
Hoshino J, Park EJ, Kondratyuk T.P., Marler L., Pezzuto JM, van Breemen RB, Mo S, Li Y, Cushman M (2010) Selective synthesis and biological evaluation of sulfate-conjugated resveratrol metabolites. J Med Chem 53(13):5033-5043
-
(2010)
J Med Chem
, vol.53
, Issue.13
, pp. 5033-5043
-
-
Hoshino, J.1
Park, E.J.2
Kondratyuk, T.P.3
Marler, L.4
Pezzuto, J.M.5
Van Breemen, R.B.6
Mo, S.7
Li, Y.8
Cushman, M.9
-
55
-
-
70350764804
-
Antitumor activity of resveratrol and its sulfated metabolites against human breast cancer cells
-
Miksits M, Wlcek K, Svoboda M., Kunert O, Haslinger E, Thalhammer T., Szekeres T, Jäger W (2009) Antitumor activity of resveratrol and its sulfated metabolites against human breast cancer cells. Planta Med 75(11):1227-1230
-
(2009)
Planta Med
, vol.75
, Issue.11
, pp. 1227-1230
-
-
Miksits, M.1
Wlcek, K.2
Svoboda, M.3
Kunert, O.4
Haslinger, E.5
Thalhammer, T.6
Szekeres, T.7
Jäger, W.8
-
56
-
-
78851469101
-
Biovailability of resveratrol
-
Walle T (2011) Biovailability of resveratrol. Ann NY Acad Sci 1215:9-15
-
(2011)
Ann NY Acad Sci
, vol.1215
, pp. 9-15
-
-
Walle, T.1
-
57
-
-
0028911362
-
Passage of peptides through the blood-brain barrier with colloidal polymer particles (nanoparticles)
-
Kreuter J, Alyautdin RN, Kharkevich D.A., Ivanov A.A. (1995) Passage of peptides through the blood-brain barrier with colloidal polymer particles (nanoparticles). Brain Res 674:171-174
-
(1995)
Brain Res
, vol.674
, pp. 171-174
-
-
Kreuter, J.1
Alyautdin, R.N.2
Kharkevich, D.A.3
Ivanov, A.A.4
-
58
-
-
0030993566
-
Delivery of loperamide across the blood-brain barrier with polysorbate 80-coated poly(butylcyanoacrylate) nano-particles
-
Alyautdin RN, Petrov VE, Langer K, Berthold A., Kharkevich DA, Kreuter J. (1997) Delivery of loperamide across the blood-brain barrier with polysorbate 80-coated poly(butylcyanoacrylate) nano-particles. Pharm Res 14:325-328
-
(1997)
Pharm Res
, vol.14
, pp. 325-328
-
-
Alyautdin, R.N.1
Petrov, V.E.2
Langer, K.3
Berthold, A.4
Kharkevich, D.A.5
Kreuter, J.6
-
59
-
-
0032712180
-
Significant transport of doxorubicin into the brain with polysorbate 80-coated nanoparticles
-
Gulyaev AE, Gelperina SE, Skidan I.N., Antropov AS, Kivman GY, Kreuter J. (1999) Significant transport of doxorubicin into the brain with polysorbate 80-coated nanoparticles. Pharm Res 16:1564-1569
-
(1999)
Pharm Res
, vol.16
, pp. 1564-1569
-
-
Gulyaev, A.E.1
Gelperina, S.E.2
Skidan, I.N.3
Antropov, A.S.4
Kivman, G.Y.5
Kreuter, J.6
-
60
-
-
77955091162
-
Microglia activation and anti-inflammatory regulation in alzheimer's disease
-
Lue L-F, Kuo Y-M, Beach T, Walker D.G. (2010) Microglia activation and anti-inflammatory regulation in Alzheimer's disease. Mol Neurobiol 41:115-128
-
(2010)
Mol Neurobiol
, vol.41
, pp. 115-128
-
-
Lue, L.-F.1
Kuo, Y.-M.2
Beach, T.3
Walker, D.G.4
-
61
-
-
77954977618
-
Neuroinflammation in alzheimer's disease: Mechanisms, pathologic consequences, and potential for therapeutic manipulation
-
Hensley K (2010) Neuroinflammation in Alzheimer's disease: mechanisms, pathologic consequences, and potential for therapeutic manipulation. J Alzheimers Dis 21:1-14
-
(2010)
J Alzheimers Dis
, vol.21
, pp. 1-14
-
-
Hensley, K.1
-
62
-
-
79959945013
-
Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture
-
Garwood CJ, Pooler AM, Atherton J, Hanger D.P., Noble W. (2011) Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture. Cell Death Dis 2:1-9
-
(2011)
Cell Death Dis
, vol.2
, pp. 1-9
-
-
Garwood, C.J.1
Pooler, A.M.2
Atherton, J.3
Hanger, D.P.4
Noble, W.5
-
63
-
-
84855686976
-
Resveratrol mitigates lipopolysaccharide- and Aβ-mediated microglial inflammation by inhibiting the TLR4/NF-κB/STAT signaling cascade
-
Capiralla H, Vingtdeux V, Zhao H., Sankowski R, Al-Abed Y, Davies P, Marambaud P. (2011) Resveratrol mitigates lipopolysaccharide- and Aβ-mediated microglial inflammation by inhibiting the TLR4/NF-κB/STAT signaling cascade. J Neurochem 120:461-472
-
(2011)
J Neurochem
, vol.120
, pp. 461-472
-
-
Capiralla, H.1
Vingtdeux, V.2
Zhao, H.3
Sankowski, R.4
Al-Abed, Y.5
Davies, P.6
Marambaud, P.7
-
64
-
-
79955856733
-
JNK: A stress-activated protein kinase therapeutic strategies and involvement in alzheimer's and various neurodegenerative abnormalities
-
Mehan S, Meena H, Sharma D., Sankhla R. (2011) JNK: a stress-activated protein kinase therapeutic strategies and involvement in Alzheimer's and various neurodegenerative abnormalities. J Mol Neurosci 43:376-390
-
(2011)
J Mol Neurosci
, vol.43
, pp. 376-390
-
-
Mehan, S.1
Meena, H.2
Sharma, D.3
Sankhla, R.4
-
65
-
-
2342469986
-
Neurodegenerative and physiological actions of c-jun N-terminal kinases in the mammalian brain
-
Waetzig V, Herdegen T. (2004) Neurodegenerative and physiological actions of c-Jun N-terminal kinases in the mammalian brain. Neurosci Lett 361:64-67
-
(2004)
Neurosci Lett
, vol.361
, pp. 64-67
-
-
Waetzig, V.1
Herdegen, T.2
-
66
-
-
80052811773
-
JNK plays a key role in tau hyperphosphorylation in alzheimer's disease models
-
Ploia C, Antoniou X, Sclip A., Grande V, Cardinetti D, Colombo A., Canu N, Benussi L, Ghidoni R, Forloni G, Borsello T (2011) JNK plays a key role in tau hyperphosphorylation in Alzheimer's disease models. J Alzheimers Dis 26:315-329
-
(2011)
J Alzheimers Dis
, vol.26
, pp. 315-329
-
-
Ploia, C.1
Antoniou, X.2
Sclip, A.3
Grande, V.4
Cardinetti, D.5
Colombo, A.6
Canu, N.7
Benussi, L.8
Ghidoni, R.9
Forloni, G.10
Borsello, T.11
-
67
-
-
33745301487
-
Glycogen synthase kinase 3β and alzheimer's disease: Pathophys-iological and therapeutic significance
-
Balaraman Y, Limaye AR, Levey A.I., Srinivasan S. (2006) Glycogen synthase kinase 3β and Alzheimer's disease: pathophys-iological and therapeutic significance. Cell Mol Life Sci 63:1226-1235
-
(2006)
Cell Mol Life Sci
, vol.63
, pp. 1226-1235
-
-
Balaraman, Y.1
Limaye, A.R.2
Levey, A.I.3
Srinivasan, S.4
-
68
-
-
0034598921
-
Axonal remodeling and synaptic differentiation in the cerebellum is regulated by wnt-7a signaling
-
Hall AC, Lucas FR, Salinas P.C. (2000) Axonal remodeling and synaptic differentiation in the cerebellum is regulated by Wnt-7a signaling. Cell 100:525-535
-
(2000)
Cell
, vol.100
, pp. 525-535
-
-
Hall, A.C.1
Lucas, F.R.2
Salinas, P.C.3
-
69
-
-
0031456158
-
Wnt signaling: A common theme in animal development
-
Cadigan KM, Nusse R. (1997) Wnt signaling: a common theme in animal development. Genes Dev 11:3286-3305
-
(1997)
Genes Dev
, vol.11
, pp. 3286-3305
-
-
Cadigan, K.M.1
Nusse, R.2
-
70
-
-
0033966405
-
A local wnt-3a signal is required for development of the mammalian hippocampus
-
Lee SM, Tole S, Grove E., McMahon A.P. (2000) A local Wnt-3a signal is required for development of the mammalian hippocampus. Development 127:457-467
-
(2000)
Development
, vol.127
, pp. 457-467
-
-
Lee, S.M.1
Tole, S.2
Grove, E.3
McMahon, A.P.4
-
71
-
-
0033950382
-
Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1
-
Galceran J, Miyashita-Lin EM, Devaney E., Rubenstein JL, Grosschedl R. (2000) Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1. Development 127:469-482
-
(2000)
Development
, vol.127
, pp. 469-482
-
-
Galceran, J.1
Miyashita-Lin, E.M.2
Devaney, E.3
Rubenstein, J.L.4
Grosschedl, R.5
-
72
-
-
0037155691
-
Control of β-catenin phosphorylation/degradation by a dual-kinase mechanism
-
Liu C, Li Y, Semenov M., Han C, Baeg C, Tan Y., Zhang Z, Lin X, He X (2002) Control of β-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell 108:837-847
-
(2002)
Cell
, vol.108
, pp. 837-847
-
-
Liu, C.1
Li, Y.2
Semenov, M.3
Han, C.4
Baeg, C.5
Tan, Y.6
Zhang, Z.7
Lin, X.8
He, X.9
-
73
-
-
34248570158
-
Synaptotoxicity in alzheimer's disease: The wnt signaling pathway as a molecular target
-
Inestrosa NC, Varela-Nallar L, Grabowski C.P., Colombres M. (2007) Synaptotoxicity in Alzheimer's disease: the Wnt signaling pathway as a molecular target. IUBMB Life 59:316-321
-
(2007)
IUBMB Life
, vol.59
, pp. 316-321
-
-
Inestrosa, N.C.1
Varela-Nallar, L.2
Grabowski, C.P.3
Colombres, M.4
-
74
-
-
77249109792
-
Activation of wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe/PSEN1DeltaE9 mouse model of alzheimer's disease
-
Toledo EM, Inestrosa N.C. (2009) Activation of Wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe/PSEN1DeltaE9 mouse model of Alzheimer's disease. Mol Psychiatry 15:272-285
-
(2009)
Mol Psychiatry
, vol.15
, pp. 272-285
-
-
Toledo, E.M.1
Inestrosa, N.C.2
-
75
-
-
84870057502
-
The binding of resveratrol to monomer and fibril amyloid beta
-
Ge J-F, Qiao J-P, Qi C-C, Wang C-W, Zhou J-N (2012) The binding of resveratrol to monomer and fibril amyloid beta. Neurochem Int 61:1192-1201
-
(2012)
Neurochem Int
, vol.61
, pp. 1192-1201
-
-
Ge, J.-F.1
Qiao, J.-P.2
Qi, C.-C.3
Wang, C.-W.4
Zhou, J.-N.5
-
76
-
-
77954907699
-
Resveratrol selectively remodels soluble oligomers and fibrils of amyloid Aβ into off-pathway conformers
-
Ladiwala ARA, Lin JC, Bale S.S., Marcelino-Cruz AM, Bhattacharya M, Dordick J.S., Tessier P.M. (2010) Resveratrol selectively remodels soluble oligomers and fibrils of amyloid Aβ into off-pathway conformers. J Biol Chem 285:24228-24237
-
(2010)
J Biol Chem
, vol.285
, pp. 24228-24237
-
-
Ladiwala, A.R.A.1
Lin, J.C.2
Bale, S.S.3
Marcelino-Cruz, A.M.4
Bhattacharya, M.5
Dordick, J.S.6
Tessier, P.M.7
-
77
-
-
80052501210
-
Resolving controversies on the path to alzheimer's therapeutics
-
Selkoe DJ (2011) Resolving controversies on the path to Alzheimer's therapeutics. Nat Med 17(9):1060-1065
-
(2011)
Nat Med
, vol.17
, Issue.9
, pp. 1060-1065
-
-
Selkoe, D.J.1
-
78
-
-
84880759156
-
Neurotoxicity of amyloid β-protein: Synaptic and network dysfunction
-
Mucke L, Selkoe D.J. (2012) Neurotoxicity of amyloid β-protein: synaptic and network dysfunction. Cold Spring Harb Perspect Med 2(7):a006338
-
(2012)
Cold Spring Harb Perspect Med
, vol.2
, Issue.7
-
-
Mucke, L.1
Selkoe, D.J.2
|