Wnt signaling in age-related macular degeneration: Human macular tissue and mouse model

Journal of Translational Medicine

Volumn 13, Issue 1, 2015, Pages

  Tuo, Jingsheng ^a   Wang, Yujuan ^a   Cheng, Rui ^b   Li, Yichao ^a   Chen, Mei ^c   Qiu, Fangfang ^b   Qian, Haohua ^a   Shen, Defen ^a   Penalva, Rosana ^c   Xu, Heping ^c   Ma, Jian Xing ^b   Chan, Chi Chao ^a  

^a NATIONAL EYE INSTITUTE   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^c QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

Cx3cr1; rd8 mouse; ; Antibody against Wnt receptor LRP6; Ccl2; gfp gfp; mouse; Mouse model; Retinal lesion; Serum kallistatin; Wnt signaling

Indexed keywords

BETA CATENIN; CHEMOKINE RECEPTOR CX3CR1; INTERCELLULAR ADHESION MOLECULE 1; KALLISTATIN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6 MONOCLONAL ANTIBODY; MEMBRANE PROTEIN; MESSENGER RNA; MONOCLONAL ANTIBODY; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CCL2 PROTEIN, HUMAN; CCL2 PROTEIN, MOUSE; CHEMOKINE RECEPTOR; CX3CR1 PROTEIN, HUMAN; CX3CR1 PROTEIN, MOUSE; LRP6 PROTEIN, HUMAN; LRP6 PROTEIN, MOUSE; SERINE PROTEINASE INHIBITOR; WNT PROTEIN;

ADULT; AGE RELATED MACULAR DEGENERATION; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTRORETINOGRAPHY; FEMALE; GENE TARGETING; GENETIC TRANSCRIPTION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MOUSE; MOUSE MODEL; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN BLOOD LEVEL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITION; RETINA; RETINA DEGENERATION; WILD TYPE; WNT SIGNALING PATHWAY; AGING; ANIMAL; BLOOD; DISEASE MODEL; GENE EXPRESSION REGULATION; GENETICS; INTRAVITREAL DRUG ADMINISTRATION; KNOCKOUT MOUSE; MACULAR DEGENERATION; METABOLISM; MIDDLE AGED; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

AGED; AGING; ANIMALS; CHEMOKINE CCL2; DISEASE MODELS, ANIMAL; ELECTRORETINOGRAPHY; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INTRAVITREAL INJECTIONS; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-6; MACULAR DEGENERATION; MALE; MICE; MICE, KNOCKOUT; MIDDLE AGED; PHOSPHORYLATION; RECEPTORS, CHEMOKINE; RETINA; RETINAL DEGENERATION; SERPINS; SIGNAL TRANSDUCTION; WNT PROTEINS;

EID: 84945206786     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/s12967-015-0683-x     Document Type: Article

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