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Volumn 94, Issue 6, 2014, Pages 674-682

Platelet-derived growth factor (PDGF)-C inhibits neuroretinal apoptosis in a murine model of focal retinal degeneration

Author keywords

age related macular degeneration; apoptosis; neuroprotection; platelet derived growth factor C; retina

Indexed keywords

PHOSPHATE BUFFERED SALINE; PLATELET DERIVED GROWTH FACTOR C; RECOMBINANT PLATELET DERIVED GROWTH FACTOR CC; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

EID: 84904189263     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2014.60     Document Type: Article
Times cited : (13)

References (61)
  • 1
    • 0033776193 scopus 로고    scopus 로고
    • PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor
    • Li X, Ponten A, Aase K, et al. PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor. Nat Cell Biol 2000;2:302-309.
    • (2000) Nat Cell Biol , vol.2 , pp. 302-309
    • Li, X.1    Ponten, A.2    Aase, K.3
  • 2
    • 0033772339 scopus 로고    scopus 로고
    • A new member of an old family
    • Kazlauskas A. A new member of an old family. Nat Cell Biol 2000;2:E78-E79.
    • (2000) Nat Cell Biol , vol.2
    • Kazlauskas, A.1
  • 3
    • 0037380709 scopus 로고    scopus 로고
    • Novel PDGF family members: PDGF-C and PDGF-D
    • Li X, Eriksson U. Novel PDGF family members: PDGF-C and PDGF-D. Cytokine Growth Factor Rev 2003;14:91-98.
    • (2003) Cytokine Growth Factor Rev , vol.14 , pp. 91-98
    • Li, X.1    Eriksson, U.2
  • 4
    • 22844439785 scopus 로고    scopus 로고
    • Structural requirements for activation of latent platelet-derived growth factor CC by tissue plasminogen activator
    • Fredriksson L, Ehnman M, Fieber C, et al. Structural requirements for activation of latent platelet-derived growth factor CC by tissue plasminogen activator. J Biol Chem 2005;280:26856-26862.
    • (2005) J Biol Chem , vol.280 , pp. 26856-26862
    • Fredriksson, L.1    Ehnman, M.2    Fieber, C.3
  • 5
    • 84881023573 scopus 로고    scopus 로고
    • PDGF-C: A new performer in the neurovascular interplay
    • Lee C, Zhang F, Tang Z, et al. PDGF-C: a new performer in the neurovascular interplay. Trends Mol Med 2013;19:474-486.
    • (2013) Trends Mol Med , vol.19 , pp. 474-486
    • Lee, C.1    Zhang, F.2    Tang, Z.3
  • 6
    • 0036793520 scopus 로고    scopus 로고
    • Angiogenesis stimulated by PDGF-CC, a novel member in the PDGF family, involves activation of PDGFRalphaalpha and -alphabeta receptors
    • Cao R, Brakenhielm E, Li X, et al. Angiogenesis stimulated by PDGF-CC, a novel member in the PDGF family, involves activation of PDGFRalphaalpha and -alphabeta receptors. FASEB J 2002;16:1575-1583.
    • (2002) FASEB J , vol.16 , pp. 1575-1583
    • Cao, R.1    Brakenhielm, E.2    Li, X.3
  • 7
    • 0035920172 scopus 로고    scopus 로고
    • Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor
    • Gilbertson DG, Duff ME, West JW, et al. Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor. J Biol Chem 2001;276:27406-27414.
    • (2001) J Biol Chem , vol.276 , pp. 27406-27414
    • Gilbertson, D.G.1    Duff, M.E.2    West, J.W.3
  • 8
    • 6944220086 scopus 로고    scopus 로고
    • A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling
    • Ding H, Wu X, Bostrom H, et al. A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling. Nat Genet 2004;36: 1111-1116.
    • (2004) Nat Genet , vol.36 , pp. 1111-1116
    • Ding, H.1    Wu, X.2    Bostrom, H.3
  • 9
    • 62349094951 scopus 로고    scopus 로고
    • PDGF-C and -D and their receptors PDGFR-alpha and PDGFR-beta in atherosclerotic human arteries
    • Karvinen H, Rutanen J, Leppanen O, et al. PDGF-C and -D and their receptors PDGFR-alpha and PDGFR-beta in atherosclerotic human arteries. Eur J Clin Invest 2009;39:320-327.
    • (2009) Eur J Clin Invest , vol.39 , pp. 320-327
    • Karvinen, H.1    Rutanen, J.2    Leppanen, O.3
  • 10
    • 46749118298 scopus 로고    scopus 로고
    • Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke
    • Su EJ, Fredriksson L, Geyer M, et al. Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke. Nat Med 2008;14:731-737.
    • (2008) Nat Med , vol.14 , pp. 731-737
    • Su, E.J.1    Fredriksson, L.2    Geyer, M.3
  • 11
    • 57849106330 scopus 로고    scopus 로고
    • PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment
    • Crawford Y, Kasman I, Yu L, et al. PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment. Cancer Cell 2009;15:21-34.
    • (2009) Cancer Cell , vol.15 , pp. 21-34
    • Crawford, Y.1    Kasman, I.2    Yu, L.3
  • 12
    • 77951074818 scopus 로고    scopus 로고
    • Survival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3beta phosphorylation
    • Tang Z, Arjunan P, Lee C, et al. Survival effect of PDGF-CC rescues neurons from apoptosis in both brain and retina by regulating GSK3beta phosphorylation. J Exp Med 2010;207:867-880.
    • (2010) J Exp Med , vol.207 , pp. 867-880
    • Tang, Z.1    Arjunan, P.2    Lee, C.3
  • 13
    • 34250155972 scopus 로고    scopus 로고
    • A potential role for PDGF-C in experimental and clinical proliferative vitreoretinopathy
    • Lei H, Hovland P, Velez G, et al. A potential role for PDGF-C in experimental and clinical proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci 2007;48:2335-2342.
    • (2007) Invest Ophthalmol Vis Sci , vol.48 , pp. 2335-2342
    • Lei, H.1    Hovland, P.2    Velez, G.3
  • 14
    • 0036175903 scopus 로고    scopus 로고
    • The expression of SCDGF/PDGF-C/ fallotein and SCDGF-B/PDGF-D in the rat central nervous system
    • Hamada T, Ui-Tei K, Imaki J, et al. The expression of SCDGF/PDGF-C/ fallotein and SCDGF-B/PDGF-D in the rat central nervous system. Mech Dev 2002;112:161-164.
    • (2002) Mech Dev , vol.112 , pp. 161-164
    • Hamada, T.1    Ui-Tei, K.2    Imaki, J.3
  • 15
    • 38549103142 scopus 로고    scopus 로고
    • PDGF-C and -D induced proliferation/migration of human RPE is abolished by inflammatory cytokines
    • Li R, Maminishkis A, Wang FE, et al. PDGF-C and -D induced proliferation/migration of human RPE is abolished by inflammatory cytokines. Invest Ophthalmol Vis Sci 2007;48:5722-5732.
    • (2007) Invest Ophthalmol Vis Sci , vol.48 , pp. 5722-5732
    • Li, R.1    Maminishkis, A.2    Wang, F.E.3
  • 16
    • 85047694353 scopus 로고    scopus 로고
    • Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors
    • Li X, Tjwa M, Moons L, et al. Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors. J Clin Invest 2005;115:118-127.
    • (2005) J Clin Invest , vol.115 , pp. 118-127
    • Li, X.1    Tjwa, M.2    Moons, L.3
  • 17
    • 57649135172 scopus 로고    scopus 로고
    • A role for VEGF as a negative regulator of pericyte function and vessel maturation
    • Greenberg JI, Shields DJ, Barillas SG, et al. A role for VEGF as a negative regulator of pericyte function and vessel maturation. Nature 2008;456:809-813.
    • (2008) Nature , vol.456 , pp. 809-813
    • Greenberg, J.I.1    Shields, D.J.2    Barillas, S.G.3
  • 18
    • 77955435616 scopus 로고    scopus 로고
    • PDGF-CC blockade inhibits pathological angiogenesis by acting on multiple cellular and molecular targets
    • Hou X, Kumar A, Lee C, et al. PDGF-CC blockade inhibits pathological angiogenesis by acting on multiple cellular and molecular targets. Proc Natl Acad Sci USA 2010;107:12216-12221.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 12216-12221
    • Hou, X.1    Kumar, A.2    Lee, C.3
  • 19
    • 56249140828 scopus 로고    scopus 로고
    • Age-related macular degeneration
    • Coleman HR, Chan CC, Ferris 3rd FL, et al. Age-related macular degeneration. Lancet 2008;372:1835-1845.
    • (2008) Lancet , vol.372 , pp. 1835-1845
    • Coleman, H.R.1    Chan, C.C.2    Ferris III, F.L.3
  • 20
    • 78651266899 scopus 로고    scopus 로고
    • Prevalence of age-related macular degeneration in the US population
    • Klein R, Chou CF, Klein BE, et al. Prevalence of age-related macular degeneration in the US population. Arch Ophthalmol 2011;129:75-80.
    • (2011) Arch Ophthalmol , vol.129 , pp. 75-80
    • Klein, R.1    Chou, C.F.2    Klein, B.E.3
  • 21
    • 84860511567 scopus 로고    scopus 로고
    • Age-related macular degeneration
    • Lim LS, Mitchell P, Seddon JM, et al. Age-related macular degeneration. Lancet 2012;379:1728-1738.
    • (2012) Lancet , vol.379 , pp. 1728-1738
    • Lim, L.S.1    Mitchell, P.2    Seddon, J.M.3
  • 22
    • 84863727273 scopus 로고    scopus 로고
    • Understanding age-related macular degeneration (AMD): Relationships between the photoreceptor/retinal pigment epithelium/Bruchs membrane/ choriocapillaris complex
    • Bhutto I, Lutty G. Understanding age-related macular degeneration (AMD): relationships between the photoreceptor/retinal pigment epithelium/Bruchs membrane/choriocapillaris complex. Mol Aspects Med 2012;33:295-317.
    • (2012) Mol Aspects Med , vol.33 , pp. 295-317
    • Bhutto, I.1    Lutty, G.2
  • 24
    • 0034956476 scopus 로고    scopus 로고
    • Photoreceptor topography in ageing and age-related maculopathy
    • Curcio CA. Photoreceptor topography in ageing and age-related maculopathy. Eye (Lond) 2001;15:376-383.
    • (2001) Eye (Lond) , vol.15 , pp. 376-383
    • Curcio, C.A.1
  • 25
    • 33749440219 scopus 로고    scopus 로고
    • Age-related macular degeneration
    • de Jong PT. Age-related macular degeneration. N Engl J Med 2006;355:1474-1485.
    • (2006) N Engl J Med , vol.355 , pp. 1474-1485
    • De Jong, P.T.1
  • 26
    • 84876919797 scopus 로고    scopus 로고
    • The impact of inflammation to the antioxidant defense parameters in AMD patients
    • Colak E, Majkic-Singh N, Zoric L, et al. The impact of inflammation to the antioxidant defense parameters in AMD patients. Aging Clin Exp Res 2012;24:588-594.
    • (2012) Aging Clin Exp Res , vol.24 , pp. 588-594
    • Colak, E.1    Majkic-Singh, N.2    Zoric, L.3
  • 28
    • 80052920397 scopus 로고    scopus 로고
    • Analysis of complement expression in light-induced retinal degeneration: Synthesis and deposition of C3 by microglia/macrophages is associated with focal photoreceptor degeneration
    • Rutar M, Natoli R, Kozulin P, et al. Analysis of complement expression in light-induced retinal degeneration: synthesis and deposition of C3 by microglia/macrophages is associated with focal photoreceptor degeneration. Invest Ophthalmol Vis Sci 2011;52:5347-5358.
    • (2011) Invest Ophthalmol Vis Sci , vol.52 , pp. 5347-5358
    • Rutar, M.1    Natoli, R.2    Kozulin, P.3
  • 29
    • 84865369140 scopus 로고    scopus 로고
    • Oxidative stress activates NLRP3 inflammasomes in ARPE-19 cells-implications for age-related macular degeneration (AMD)
    • Kauppinen A, Niskanen H, Suuronen T, et al. Oxidative stress activates NLRP3 inflammasomes in ARPE-19 cells-implications for age-related macular degeneration (AMD). Immunol Lett 2012;147:29-33.
    • (2012) Immunol Lett , vol.147 , pp. 29-33
    • Kauppinen, A.1    Niskanen, H.2    Suuronen, T.3
  • 30
    • 79951561948 scopus 로고    scopus 로고
    • The role of anti-inflammatory agents in age-related macular degeneration (AMD) treatment
    • Wang Y, Wang VM, Chan CC. The role of anti-inflammatory agents in age-related macular degeneration (AMD) treatment. Eye 2011;25: 127-139.
    • (2011) Eye , vol.25 , pp. 127-139
    • Wang, Y.1    Wang, V.M.2    Chan, C.C.3
  • 31
    • 84860883878 scopus 로고    scopus 로고
    • DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88
    • Tarallo V, Hirano Y, Gelfand BD, et al. DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88. Cell 2012;149:847-859.
    • (2012) Cell , vol.149 , pp. 847-859
    • Tarallo, V.1    Hirano, Y.2    Gelfand, B.D.3
  • 32
    • 84863845318 scopus 로고    scopus 로고
    • Mechanisms of age-related macular degeneration
    • Ambati J, Fowler BJ. Mechanisms of age-related macular degeneration. Neuron 2012;75:26-39.
    • (2012) Neuron , vol.75 , pp. 26-39
    • Ambati, J.1    Fowler, B.J.2
  • 33
    • 84887402319 scopus 로고    scopus 로고
    • Aging is not a disease: Distinguishing age-related macular degeneration from aging
    • Ardeljan D, Chan CC. Aging is not a disease: Distinguishing age-related macular degeneration from aging. Prog Retin Eye Res 2013;37: 68-89.
    • (2013) Prog Retin Eye Res , vol.37 , pp. 68-89
    • Ardeljan, D.1    Chan, C.C.2
  • 34
    • 0036875316 scopus 로고    scopus 로고
    • The role of apoptosis in age-related macular degeneration
    • Dunaief JL, Dentchev T, Ying GS, et al. The role of apoptosis in age-related macular degeneration. Arch Ophthalmol 2002;120: 1435-1442.
    • (2002) Arch Ophthalmol , vol.120 , pp. 1435-1442
    • Dunaief, J.L.1    Dentchev, T.2    Ying, G.S.3
  • 36
    • 84877696645 scopus 로고    scopus 로고
    • Controversial view of a genetically altered mouse model of focal retinal degeneration
    • Chu XK, Wang Y, Ardeljan D, et al. Controversial view of a genetically altered mouse model of focal retinal degeneration. Bioengineered 2012;4:130-135.
    • (2012) Bioengineered , vol.4 , pp. 130-135
    • Chu, X.K.1    Wang, Y.2    Ardeljan, D.3
  • 37
    • 77951254301 scopus 로고    scopus 로고
    • Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD)
    • Ramkumar HL, Zhang J, Chan CC. Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD). Prog Retin Eye Res 2010;29:169-190.
    • (2010) Prog Retin Eye Res , vol.29 , pp. 169-190
    • Ramkumar, H.L.1    Zhang, J.2    Chan, C.C.3
  • 38
    • 34648846532 scopus 로고    scopus 로고
    • Murine ccl2/cx3cr1 deficiency results in retinal lesions mimicking human age-related macular degeneration
    • Tuo J, Bojanowski CM, Zhou M, et al. Murine ccl2/cx3cr1 deficiency results in retinal lesions mimicking human age-related macular degeneration. Invest Ophthalmol Vis Sci 2007;48:3827-3836.
    • (2007) Invest Ophthalmol Vis Sci , vol.48 , pp. 3827-3836
    • Tuo, J.1    Bojanowski, C.M.2    Zhou, M.3
  • 39
    • 42449086469 scopus 로고    scopus 로고
    • Ccl2/Cx3cr1-deficient mice: An animal model for age-related macular degeneration
    • Chan CC, Ross RJ, Shen D, et al. Ccl2/Cx3cr1-deficient mice: an animal model for age-related macular degeneration. Ophthalmic Res 2008;40: 124-128.
    • (2008) Ophthalmic Res , vol.40 , pp. 124-128
    • Chan, C.C.1    Ross, R.J.2    Shen, D.3
  • 40
    • 84863723643 scopus 로고    scopus 로고
    • The Rd8 mutation of the Crb1 gene is present in vendor lines of C57BL/6N mice and embryonic stem cells, and confounds ocular induced mutant phenotypes
    • Mattapallil MJ, Wawrousek EF, Chan CC, et al. The Rd8 mutation of the Crb1 gene is present in vendor lines of C57BL/6N mice and embryonic stem cells, and confounds ocular induced mutant phenotypes. Invest Ophthalmol Vis Sci 2012;53:2921-2927.
    • (2012) Invest Ophthalmol Vis Sci , vol.53 , pp. 2921-2927
    • Mattapallil, M.J.1    Wawrousek, E.F.2    Chan, C.C.3
  • 41
    • 84876339803 scopus 로고    scopus 로고
    • Age- and light-dependent development of localised retinal atrophy in CCL2(-/-)CX3CR1(GFP/GFP) mice
    • Chen M, Hombrebueno JR, Luo C, et al. Age- and light-dependent development of localised retinal atrophy in CCL2(-/-)CX3CR1(GFP/GFP) mice. PLoS One 2013;8:e61381.
    • (2013) PLoS One , vol.8
    • Chen, M.1    Hombrebueno, J.R.2    Luo, C.3
  • 42
    • 0030010569 scopus 로고    scopus 로고
    • Differential utilization of Janus kinasesignal transducer activator of transcription signaling pathways in the stimulation of human natural killer cells by IL-2, IL-12, and IFN-alpha
    • Yu CR, Lin JX, Fink DW, et al. Differential utilization of Janus kinasesignal transducer activator of transcription signaling pathways in the stimulation of human natural killer cells by IL-2, IL-12, and IFN-alpha. J Immunol 1996;157:126-137.
    • (1996) J Immunol , vol.157 , pp. 126-137
    • Yu, C.R.1    Lin, J.X.2    Fink, D.W.3
  • 43
    • 82755194865 scopus 로고    scopus 로고
    • AAV5-mediated sFLT01 gene therapy arrests retinal lesions in Ccl2(-/-)/Cx3cr1(-/-) mice
    • Tuo J, Pang JJ, Cao X, et al. AAV5-mediated sFLT01 gene therapy arrests retinal lesions in Ccl2(-/-)/Cx3cr1(-/-) mice. Neurobiol Aging 2012;33:433e431-410.
    • (2012) Neurobiol Aging , vol.33
    • Tuo, J.1    Pang, J.J.2    Cao, X.3
  • 44
    • 84862804838 scopus 로고    scopus 로고
    • Anti-inflammatory recombinant TSG-6 stabilizes the progression of focal retinal degeneration in a murine model
    • Tuo J, Cao X, Shen D, et al. Anti-inflammatory recombinant TSG-6 stabilizes the progression of focal retinal degeneration in a murine model. J Neuroinflammation 2012;9:59.
    • (2012) J Neuroinflammation , vol.9 , pp. 59
    • Tuo, J.1    Cao, X.2    Shen, D.3
  • 45
    • 54049101650 scopus 로고    scopus 로고
    • Direct labeling and visualization of blood vessels with lipophilic carbocyanine dye DiI
    • Li Y, Song Y, Zhao L, et al. Direct labeling and visualization of blood vessels with lipophilic carbocyanine dye DiI. Nat Protoc 2008;3: 1703-1708.
    • (2008) Nat Protoc , vol.3 , pp. 1703-1708
    • Li, Y.1    Song, Y.2    Zhao, L.3
  • 46
    • 0035907470 scopus 로고    scopus 로고
    • Fluorescent pigments of the retinal pigment epithelium and age-related macular degeneration
    • Ben-Shabat S, Parish CA, Hashimoto M, et al. Fluorescent pigments of the retinal pigment epithelium and age-related macular degeneration. Bio-org Med Chem Lett 2001;11:1533-1540.
    • (2001) Bio-org Med Chem Lett , vol.11 , pp. 1533-1540
    • Ben-Shabat, S.1    Parish, C.A.2    Hashimoto, M.3
  • 47
    • 20144374260 scopus 로고    scopus 로고
    • Lipofuscin accumulation, abnormal electrophysiology, and photoreceptor degeneration in mutant ELOVL4 transgenic mice: A model for macular degeneration
    • Karan G, Lillo C, Yang Z, et al. Lipofuscin accumulation, abnormal electrophysiology, and photoreceptor degeneration in mutant ELOVL4 transgenic mice: a model for macular degeneration. Proc Natl Acad Sci USA 2005;102:4164-4169.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 4164-4169
    • Karan, G.1    Lillo, C.2    Yang, Z.3
  • 48
    • 0032438193 scopus 로고    scopus 로고
    • Isolation and one-step preparation of A2E and iso-A2E, fluorophores from human retinal pigment epithelium
    • Parish CA, Hashimoto M, Nakanishi K, et al. Isolation and one-step preparation of A2E and iso-A2E, fluorophores from human retinal pigment epithelium. Proc Natl Acad Sci USA 1998;95:14609-14613.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 14609-14613
    • Parish, C.A.1    Hashimoto, M.2    Nakanishi, K.3
  • 49
    • 0034940622 scopus 로고    scopus 로고
    • Age-related accumulation and spatial distribution of lipofuscin in RPE of normal subjects
    • Delori FC, Goger DG, Dorey CK. Age-related accumulation and spatial distribution of lipofuscin in RPE of normal subjects. Invest Ophthalmol Vis Sci 2001;42:1855-1866.
    • (2001) Invest Ophthalmol Vis Sci , vol.42 , pp. 1855-1866
    • Delori, F.C.1    Goger, D.G.2    Dorey, C.K.3
  • 50
    • 0141919699 scopus 로고    scopus 로고
    • Lipofuscin and macular degeneration
    • Wolf G. Lipofuscin and macular degeneration. Nutr Rev 2003; 61:342-346.
    • (2003) Nutr Rev , vol.61 , pp. 342-346
    • Wolf, G.1
  • 51
    • 70349581640 scopus 로고    scopus 로고
    • Enhanced HtrA2/Omi expression in oxidative injury to retinal pigment epithelial cells and murine models of neurodegeneration
    • Ding X, Patel M, Shen D, et al. Enhanced HtrA2/Omi expression in oxidative injury to retinal pigment epithelial cells and murine models of neurodegeneration. Invest Ophthalmol Vis Sci 2009;50: 4957-4966.
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , pp. 4957-4966
    • Ding, X.1    Patel, M.2    Shen, D.3
  • 52
    • 84868136294 scopus 로고    scopus 로고
    • Enhanced apoptosis in retinal pigment epithelium under inflammatory stimuli and oxidative stress
    • Wang Y, Shen D, Wang VM, et al. Enhanced apoptosis in retinal pigment epithelium under inflammatory stimuli and oxidative stress. Apoptosis 2012;17:1144-1155.
    • (2012) Apoptosis , vol.17 , pp. 1144-1155
    • Wang, Y.1    Shen, D.2    Wang, V.M.3
  • 53
    • 77953356981 scopus 로고    scopus 로고
    • The effects of quercetin in cultured human RPE cells under oxidative stress and in Ccl2/Cx3cr1 double deficient mice
    • Cao X, Liu M, Tuo J, et al. The effects of quercetin in cultured human RPE cells under oxidative stress and in Ccl2/Cx3cr1 double deficient mice. Exp Eye Res 2010;91:15-25.
    • (2010) Exp Eye Res , vol.91 , pp. 15-25
    • Cao, X.1    Liu, M.2    Tuo, J.3
  • 54
    • 0031593748 scopus 로고    scopus 로고
    • The relationship between BcI2 Bax and p53: Consequences for cell cycle progression and cell death
    • Basu A, Haldar S. The relationship between BcI2, Bax and p53: consequences for cell cycle progression and cell death. Mol Hum Reprod 1998;4:1099-1109.
    • (1998) Mol Hum Reprod , vol.4 , pp. 1099-1109
    • Basu, A.1    Haldar, S.2
  • 55
    • 0035947596 scopus 로고    scopus 로고
    • Bcl-2 prevents Bax oligomerization in the mitochondrial outer membrane
    • Mikhailov V, Mikhailova M, Pulkrabek DJ, et al. Bcl-2 prevents Bax oligomerization in the mitochondrial outer membrane. J Biol Chem 2001;276:18361-18374.
    • (2001) J Biol Chem , vol.276 , pp. 18361-18374
    • Mikhailov, V.1    Mikhailova, M.2    Pulkrabek, D.J.3
  • 56
    • 79954419930 scopus 로고    scopus 로고
    • Evidence that inhibition of BAX activation by BCL-2 involves its tight and preferential interaction with the BH3 domain of BAX
    • Ku B, Liang C, Jung JU, et al. Evidence that inhibition of BAX activation by BCL-2 involves its tight and preferential interaction with the BH3 domain of BAX. Cell Res 2011;21:627-641.
    • (2011) Cell Res , vol.21 , pp. 627-641
    • Ku, B.1    Liang, C.2    Jung, J.U.3
  • 57
    • 33947519417 scopus 로고    scopus 로고
    • Regulation and function of glycogen synthase kinase-3 isoforms in neuronal survival
    • Liang MH, Chuang DM. Regulation and function of glycogen synthase kinase-3 isoforms in neuronal survival. J Biol Chem 2007;282: 3904-3917.
    • (2007) J Biol Chem , vol.282 , pp. 3904-3917
    • Liang, M.H.1    Chuang, D.M.2
  • 58
    • 27644557532 scopus 로고    scopus 로고
    • The role of pericytes in blood-vessel formation and maintenance
    • Bergers G, Song S. The role of pericytes in blood-vessel formation and maintenance. Neuro Oncol 2005;7:452-464.
    • (2005) Neuro Oncol , vol.7 , pp. 452-464
    • Bergers, G.1    Song, S.2
  • 59
    • 0035160994 scopus 로고    scopus 로고
    • Contractile proteins in pericytes at the blood-brain and blood-retinal barriers
    • Bandopadhyay R, Orte C, Lawrenson JG, et al. Contractile proteins in pericytes at the blood-brain and blood-retinal barriers. J Neurocytol 2001;30:35-44.
    • (2001) J Neurocytol , vol.30 , pp. 35-44
    • Bandopadhyay, R.1    Orte, C.2    Lawrenson, J.G.3
  • 60
    • 79959327789 scopus 로고    scopus 로고
    • VEGF-independent angiogenic pathways induced by PDGF-C
    • Li X, Kumar A, Zhang F, et al. VEGF-independent angiogenic pathways induced by PDGF-C. Oncotarget 2010;1:309-314.
    • (2010) Oncotarget , vol.1 , pp. 309-314
    • Li, X.1    Kumar, A.2    Zhang, F.3
  • 61
    • 65249183165 scopus 로고    scopus 로고
    • PDGF-C induces maturation of blood vessels in a model of glioblastoma and attenuates the response to anti-VEGF treatment
    • di Tomaso E, London N, Fuja D, et al. PDGF-C induces maturation of blood vessels in a model of glioblastoma and attenuates the response to anti-VEGF treatment. PLoS ONE 2009;4:e5123.
    • (2009) PLoS ONE , vol.4
    • Di Tomaso, E.1    London, N.2    Fuja, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.