Pigment epithelium-derived factor reduces apoptosis and pro-inflammatory cytokine gene expression in a murine model of focal retinal degeneration

ASN Neuro

Volumn 5, Issue 5, 2013, Pages 309-319

  Wang, Yujuan ^a,b   Subramanian, Preeti ^a   Shen, Defen ^a   Tuo, Jingsheng ^a   Becerra, S Patricia ^a   Chan, Chi Chao ^a  

^a NATIONAL EYE INSTITUTE   (United States)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

Age related macular degeneration; Apoptosis; Inflammation; Neuroprotection; Pigment epithelium derived factor; Retina

Indexed keywords

[2,6 DIMETHYL 8 (2,6,6 TRIMETHYL 1 CYCLOHEXEN 1 YL)OCTATETRA ENYL] 1 (2 HYDROXYETHYL) 4 [4 METHYL 6(2,6,6 TRIMETHYL 1 CYCLOHEXEN 1 YL)HEXATRIENYL]PYRIDINIUM; LIPOFUSCIN; PIGMENT EPITHELIUM DERIVED FACTOR; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; A2E COMPOUND; ANTIINFLAMMATORY AGENT; CCL2 PROTEIN, MOUSE; CHEMOKINE RECEPTOR; CRB1 PROTEIN, MOUSE; CX3CR1 PROTEIN, MOUSE; CYTOKINE; EYE PROTEIN; MONOCYTE CHEMOTACTIC PROTEIN 1; NERVE GROWTH FACTOR; NERVE PROTEIN; PIGMENT EPITHELIUM-DERIVED FACTOR; PYRIDINIUM DERIVATIVE; RETINOID; SERINE PROTEINASE INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; GENE EXPRESSION; HISTOPATHOLOGY; INFLAMMATION; MOUSE; NEUROPROTECTION; NONHUMAN; OPHTHALMOSCOPY; PATHOGENESIS; PIGMENT EPITHELIUM; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; RETINA MACULA AGE RELATED DEGENERATION; RETINA NERVE CELL; WILD TYPE; ANIMAL; C57BL MOUSE; CELL CULTURE; CYTOLOGY; DISEASE MODEL; DRUG EFFECT; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; MUTATION; PATHOLOGY; RETINA; RETINA DEGENERATION; TRANSGENIC MOUSE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; APOPTOSIS; CELLS, CULTURED; CHEMOKINE CCL2; CYTOKINES; DISEASE MODELS, ANIMAL; EPITHELIAL CELLS; EYE PROTEINS; GENE EXPRESSION REGULATION; HUMANS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; NERVE GROWTH FACTORS; NERVE TISSUE PROTEINS; PYRIDINIUM COMPOUNDS; RECEPTORS, CHEMOKINE; RETINA; RETINAL DEGENERATION; RETINOIDS; SERPINS;

EID: 84888879158     PISSN: 17590914     EISSN: None     Source Type: Journal    
DOI: 10.1042/AN20130028     Document Type: Article

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