Immune responses in age-related macular degeneration and a possible long-term therapeutic strategy for prevention

American Journal of Ophthalmology

Volumn 158, Issue 1, 2014, Pages

  Nussenblatt, Robert B ^a   Lee, Richard W J ^b   Chew, Emily ^a   Wei, Lai ^a   Liu, Baoying ^a   Sen, H Nida ^a   Dick, Andrew D ^b   Ferris, Frederick L ^a  

^a NATIONAL EYE INSTITUTE   (United States)

^b MOORFIELDS EYE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 17;

ADAPTIVE IMMUNITY; AGING; ENVIRONMENTAL FACTOR; EPIGENETICS; GENETIC ASSOCIATION; HOMEOSTASIS; HUMAN; IMMUNE DYSREGULATION; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOTHERAPY; LONG TERM CARE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETINA MACULA AGE RELATED DEGENERATION; REVIEW; RISK FACTOR;

ADAPTIVE IMMUNITY; AGING; GENE-ENVIRONMENT INTERACTION; HUMANS; IMMUNE SYSTEM; IMMUNITY, INNATE; IMMUNOTHERAPY; MACULAR DEGENERATION;

EID: 84902551886     PISSN: 00029394     EISSN: 18791891     Source Type: Journal    
DOI: 10.1016/j.ajo.2014.03.014     Document Type: Article

References (52)

1. United Nations. World Population Prospects: the 2000 Review. 2001. Available at http://www.un.org/esa/population/publications/wpp2000/highlights. pdf. Published February 28, 2001. Accessed September 26, 2013.
2. World Health Organization Prevention of Blindness and Visual Impairment. Priority Eye Diseases 2012 Available at http://www.who.int/blindness/causes/ priority/en/index8.html Accessed September 26, 2013
3. N. Congdon, B. O'Colmain, and C.C. Klaver et al. Causes and prevalence of visual impairment among adults in the United States Arch Ophthalmol 122 4 2004 477 485 (Pubitemid 38456282)
4. D.S. Friedman, B.J. O'Colmain, and B. Munoz et al. Prevalence of age-related macular degeneration in the United States Arch Ophthalmol 122 4 2004 564 572 (Pubitemid 38456293)
5. P.L. Penfold, M.C. Killingsworth, and S.H. Sarks Senile macular degeneration: the involvement of immunocompetent cells Graefes Arch Clin Exp Ophthalmol 223 1985 69 76 (Pubitemid 15051681)
6. F. Parmeggiani, M.R. Romano, and C. Costagliola et al. Mechanism of inflammation in age-related macular degeneration Mediators Inflamm 2012 2012 546786
7. Chew EY, Clemons TE, Agrón E, et al, for the Age-Related Eye Disease Study Research Group. Ten-year follow-up of age-related macular degeneration in the Age-Related Eye Disease Study. AREDS Report No. 36. JAMA Ophthalmol 2014;132(3):272-277.
8. Age-Related Eye Disease Study Research Group The Age-Related Eye Disease Study system for classifying age-related macular degeneration from stereoscopic color fundus photographs: The Age-Related Eye Disease Study Report Number 6 Am J Ophthalmol 132 2001 668 681
9. M.S. Gottfredsdottir, T. Sverrisson, D.C. Musch, and E. Stefansson Age related macular degeneration in monozygotic twins and their spouses in Iceland Acta Ophthalmol Scand 77 4 1999 422 425 (Pubitemid 29368859)
10. J. Tuo, R.J. Ross, and A.A. Herzlich et al. A high omega-3 fatty acid diet reduces retinal lesions in a murine model of macular degeneration Am J Pathol 175 2 2009 799 807
11. M.C. Kenney, M. Chwa, and S.R. Atilano et al. Mitochondrial DNA variants mediate energy production and expression levels for CFH, C3 and EFEMP1 genes: implications for age-related macular degeneration PloS One 8 1 2013 e54339
12. O.A. Anderson, A. Finkelstein, and D.T. Shima A2E induces IL-1ss production in retinal pigment epithelial cells via the NLRP3 inflammasome PloS One 8 6 2013 e67263
13. R. Medzhitov Origin and physiological roles of inflammation Nature 454 7203 2008 428 435
14. H. Xu, M. Chen, and J.V. Forrester Para-inflammation in the aging retina Prog Retin Eye Res 28 5 2009 348 368
15. M. Schwartz, and R. Shechter Systemic inflammatory cells fight off neurodegenerative disease Nat Rev Neurol 6 7 2010 405 410
16. D.C. Ferrara, J.E. Merriam, and K.B. Freund et al. Analysis of major alleles associated with age-related macular degeneration in patients with multifocal choroiditis: strong association with complement factor H Arch Ophthalmol 126 11 2008 1562 1566
17. I.A. Thompson, B. Liu, and H.N. Sen et al. Association of complement factor H tyrosine 402 histidine genotype with posterior involvement in sarcoid-related uveitis Am j Ophthalmol 155 6 2013 1068 1074.e1061
18. D.H. Anderson, M.J. Radeke, and N.B. Gallo et al. The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited Prog Retin Eye Res 29 2 2010 95 112
19. M.J. Mattapallil, E.F. Wawrousek, and C.C. Chan et al. The Rd8 mutation of the Crb1 gene is present in vendor lines of C57BL/6N mice and embryonic stem cells, and confounds ocular induced mutant phenotypes Invest Ophthalmol Vis Sci 53 6 2012 2921 2927
20. M. Chen, J.V. Forrester, and H. Xu Dysregulation in retinal para-inflammation and age-related retinal degeneration in CCL2 or CCR2 deficient mice PloS One 6 8 2011 e22818
21. M. Chen, J.R. Hombrebueno, and C. Luo et al. Age- and light-dependent development of localised retinal atrophy in CCL2(-/-)CX3CR1(GFP/GFP) mice PloS One 8 4 2013 e61381
22. F. Cruz-Guilloty, A.M. Saeed, and J.J. Echegaray et al. Infiltration of proinflammatory m1 macrophages into the outer retina precedes damage in a mouse model of age-related macular degeneration Int J Inflam 2013 2013 503725
23. J.G. Hollyfield, V.L. Bonilha, and M.E. Rayborn et al. Oxidative damage-induced inflammation initiates age-related macular degeneration Nat Med 14 2 2008 194 198 (Pubitemid 351214555)
24. W. Ma, L. Zhao, and W.T. Wong Microglia in the outer retina and their relevance to pathogenesis of age-related macular degeneration Adv Exp Med Biol 723 2012 37 42
25. J.B. Fordham, J. Hua, and S.R. Morwood et al. Environmental conditioning in the control of macrophage thrombospondin-1 production Sci Rep 2 2012 512
26. R. Macaulay, A.N. Akbar, and S.M. Henson The role of the T cell in age-related inflammation Age (Dordr) 35 3 2013 563 572
27. J.P. Chou, and R.B. Effros T cell replicative senescence in human aging Curr Pharm Des 19 9 2013 1680 1698
28. M. Malaguarnera, E. Cristaldi, G. Romano, and L. Malaguarnera Autoimmunity in the elderly: implications for cancer J Cancer Res Ther 8 4 2012 520 527
29. V. Schmitt, L. Rink, and P. Uciechowski The Th17/Treg balance is disturbed during aging Exp Gerontol 48 12 2013 1379 1386
30. X. Cao, D. Shen, and M.M. Patel et al. Macrophage polarization in the maculae of age-related macular degeneration: a pilot study Path Int 61 9 2011 528 535
31. G. Pawelec, A. Akbar, C. Caruso, R. Solana, B. Grubeck-Loebenstein, and A. Wikby Human immunosenescence: is it infectious? Immunol Rev 205 2005 257 268 (Pubitemid 40780191)
32. J.V. Forrester Bowman lecture on the role of inflammation in degenerative disease of the eye Eye 27 3 2013 340 352
33. S.M. Whitcup, A. Sodhi, and J.P. Atkinson et al. The role of the immune response in age-related macular degeneration Int J Inflam 2013 2013 348092
34. B. Liu, L. Wei, and C. Meyerle et al. Complement component C5a promotes expression of IL-22 and IL-17 from human T cells and its implication in age-related macular degeneration J Trans Med 9 2011 1 12
35. L. Wei, B. Liu, and J. Tuo et al. Hypomethylation of the IL17RC promoter associates with age-related macular degeneration Cell Rep 2 5 2012 1151 1158
36. K. Morohoshi, N. Patel, and M. Ohbayashi et al. Serum autoantibody biomarkers for age-related macular degeneration and possible regulators of neovascularization Exp Mol Pathol 92 1 2012 64 73
37. A. Fauci Glucocorticoid effects on circulating human mononuclear cells J Reticuloendothel Soc 26 suppl 1979 727 738 (Pubitemid 10171966)
38. E.A. Felinski, A.E. Cox, B.E. Phillips, and D.A. Antonetti Glucocorticoids induce transactivation of tight junction genes occludin and claudin-5 in retinal endothelial cells via a novel cis-element Exp Eye Res 86 6 2008 867 878
39. A. Geltzer, A. Turalba, and S.S. Vedula Surgical implantation of steroids with antiangiogenic characteristics for treating neovascular age-related macular degeneration Cochrane Database Syst Rev 1 2013 CD005022
40. L. McKinley, J.F. Alcorn, and A. Peterson et al. TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice J Immunol 181 6 2008 4089 4097
41. R.W. Lee, T.J. Creed, and L.P. Schewitz et al. CD4+CD25(int) T cells in inflammatory diseases refractory to treatment with glucocorticoids J Immunol 179 11 2007 7941 7948
42. R.W. Lee, L.P. Schewitz, L.B. Nicholson, C.M. Dayan, and A.D. Dick Steroid refractory CD4+ T cells in patients with sight-threatening uveitis Invest Ophthalmol Vis Sci 50 9 2009 4273 4278
43. R.B. Nussenblatt, G. Byrnes, and H.N. Sen et al. A randomized pilot study of systemic immunosuppression in the treatment of age-related macular degeneration with choroidal neovascularization Retina 30 10 2010 1579 1587
44. H. Kaneko, S. Dridi, and V. Tarallo et al. DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration Nature 471 7338 2011 325 330
45. J.L. Riley, C.H. June, and B.R. Blazar Human T regulatory cell therapy: take a billion or so and call me in the morning Immunity 30 5 2009 656 665
46. H.L. Weiner, A.P. da Cunha, F. Quintana, and H. Wu Oral tolerance Immunol Rev 241 1 2011 241 259
47. A.L. Kau, P.P. Ahern, N.W. Griffin, A.L. Goodman, and J.I. Gordon Human nutrition, the gut microbiome and the immune system Nature 474 7351 2011 327 336
48. A.M. Faria, and H.L. Weiner Oral tolerance Immunol Rev 206 2005 232 259 (Pubitemid 41105174)
49. R.B. Nussenblatt, I. Gery, and H.L. Weiner et al. Treatment of uveitis by oral administration of retinal antigens: results of a phase I/II randomized masked trial Am J Ophthalmol 123 5 1997 583 592 (Pubitemid 27203278)
50. E.C. Koffeman, M. Genovese, and D. Amox et al. Epitope-specific immunotherapy of rheumatoid arthritis: clinical responsiveness occurs with immune deviation and relies on the expression of a cluster of molecules associated with T cell tolerance in a double-blind, placebo-controlled, pilot phase II trial Arthritis Rheum 60 11 2009 3207 3216
51. A.E. Postlethwaite, W.K. Wong, and P. Clements et al. A multicenter, randomized, double-blind, placebo-controlled trial of oral type I collagen treatment in patients with diffuse cutaneous systemic sclerosis: I. oral type I collagen does not improve skin in all patients, but may improve skin in late-phase disease Arthritis Rheum 58 6 2008 1810 1822 (Pubitemid 351847536)
52. K. Kapp, J. Maul, and A. Hostmann et al. Modulation of systemic antigen-specific immune responses by oral antigen in humans Eur J Immunol 40 11 2010 3128 3137