Pathogenic role of the Wnt signaling pathway activation in laser-induced choroidal neovascularization

Investigative Ophthalmology and Visual Science

Volumn 54, Issue 1, 2013, Pages 141-154

  Hu, Yang ^a   Chen, Ying ^a   Lin, Mingkai ^a   Lee, Kyungwon ^a   Mott, Robert A ^a   Ma, Jian Xing ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ACTIN; BETA CATENIN; CYCLIN D1; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; IMMUNOGLOBULIN G; INTERCELLULAR ADHESION MOLECULE 1; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; MESSENGER RNA; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY MAB2F1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULOTROPIN; LIGAND; LOW DENSITY LIPOPROTEIN RECEPTOR; LRP6 PROTEIN, MOUSE; VERY LOW DENSITY LIPOPROTEIN RECEPTOR;

ANGIOGENESIS; ANIMAL EXPERIMENT; ARTICLE; BLOOD VESSEL PERMEABILITY; CELL CULTURE; CONTROLLED STUDY; DENSITOMETRY; EYE FUNDUS; GENE EXPRESSION; HUMAN; HUMAN CELL; LASER COAGULATION; MALE; MOUSE; NONHUMAN; ONCOGENE C MYC; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; RETINA FLUORESCEIN ANGIOGRAPHY; RETINA MACULA AGE RELATED DEGENERATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUBRETINAL NEOVASCULARIZATION; WESTERN BLOTTING; WNT SIGNALING PATHWAY; AGE; ANIMAL; ANOXIA; BROWN NORWAY RAT; C57BL MOUSE; CELL LINE; CYTOLOGY; DISEASE MODEL; DRUG ANTAGONISM; EXUDATIVE MACULAR DEGENERATION; GENETICS; IMMUNOLOGY; LASER; METABOLISM; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY; PIGMENT EPITHELIUM;

AGE FACTORS; ANIMALS; ANOXIA; ANTIBODIES, MONOCLONAL; CELL LINE; CHOROIDAL NEOVASCULARIZATION; DISEASE MODELS, ANIMAL; HUMANS; LASERS; LIGANDS; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-6; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RATS; RATS, INBRED BN; RECEPTORS, LDL; RETINAL PIGMENT EPITHELIUM; WET MACULAR DEGENERATION; WNT SIGNALING PATHWAY;

MLCS; MLOWN;

EID: 84874514724     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.12-10281     Document Type: Article

References (41)

1. Munoz B, Klein R, Rodriguez J, Snyder R, West SK. Prevalence of age-related macular degeneration in a population-based sample of Hispanic people in Arizona: Proyecto VER. Arch Ophthalmol. 2005;123:1575-1580.
2. Edwards AO, Ritter R III, Abel KJ, Manning A, Panhuysen C, Farrer LA. Complement factor H polymorphism and agerelated macular degeneration. Science. 2005;308:421-424.
3. Orsulic S, Peifer M. Cell-cell signalling: wingless lands at last. Curr Biol. 1996;6:1363-1367.
4. Tamai K, Zeng X, Liu C, et al. A mechanism for Wnt coreceptor activation. Mol Cell. 2004;13:149-156.
5. Miller JR. The Wnts. Genome Biol. 2002;3:REVIEWS3001.
6. Dale TC. Signal transduction by the Wnt family of ligands. Biochem J. 1998;329(part 2:209-223).
7. Bilic J, Huang YL, Davidson G, et al. Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation. Science. 2007;316:1619-1622.
8. Liu G, Bafico A, Harris VK, Aaronson SA. A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor. Mol Cell Biol. 2003;23:5825-5835.
9. Piao S, Lee SH, Kim H, et al. Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/betacatenin signaling. PLoS One. 2008;3:e4046.
10. Wu G, Huang H, Garcia Abreu J, He X. Inhibition of GSK3 phosphorylation of beta-catenin via phosphorylated PPPSPXS motifs of Wnt coreceptor LRP6. PLoS One. 2009;4:e4926.
11. Beagle B, Johnson GV. Differential modulation of TCF/LEF-1 activity by the soluble LRP6-ICD. PLoS One. 2010;5:e11821.
12. Ojesina AI. The role of beta-catenin in regulating angiogenesis in Wilms tumor. J Pediatr Surg. 2004;39:1446-1447; author reply 1447.
13. Tachikawa K, Schroder O, Frey G, Briggs SP, Sera T. Regulation of the endogenous VEGF-A gene by exogenous designed regulatory proteins. Proc Natl Acad Sci U S A. 2004;101: 15225-15230.
14. Easwaran V, Lee SH, Inge L, et al. beta-Catenin regulates vascular endothelial growth factor expression in colon cancer. Cancer Res. 2003;63:3145-3153.
15. Lichtlen PD, Lam T, Nork M, Streit T, Urech DM. Relative contribution of VEGF and TNF-alpha in the cynomolgus laserinduced CNV model: comparing efficacy of bevacizumab, adalimumab and ESBA105. Invest Ophthalmol Vis Sci. 2010; 51:4738-4745.
16. Lu M, Adamis AP. Molecular biology of choroidal neovascularization. Ophthalmol Clin North Am. 2006;19:323-334.
17. Miller H, Miller B, Ishibashi T, Ryan SJ. Pathogenesis of laserinduced choroidal subretinal neovascularization. Invest Ophthalmol Vis Sci. 1990;31:899-908.
18. Toma HS, Barnett JM, Penn JS, Kim SJ. Improved assessment of laser-induced choroidal neovascularization. Microvasc Res. 2010;80:295-302.
19. Sheets KG, Zhou Y, Ertel MK, et al. Neuroprotectin D1 attenuates laser-induced choroidal neovascularization in mouse. Mol Vis. 2010;16:320-329.
20. Takehana Y, Kurokawa T, Kitamura T, et al. Suppression of laser-induced choroidal neovascularization by oral tranilast in the rat. Invest Ophthalmol Vis Sci. 1999;40:459-466.
21. Chen Y, Hu Y, Lu K, Flannery JG, Ma JX. Very low density lipoprotein receptor, a negative regulator of the wnt signaling pathway and choroidal neovascularization. J Biol Chem. 2007; 282:34420-34428.
22. Zhou T, He X, Cheng R, et al. Implication of dysregulation of the canonical wingless-type MMTV integration site (WNT) pathway in diabetic nephropathy. Diabetologia. 2012;55:255-266.
23. Chen Y, Hu Y, Moiseyev G, Zhou KK, Chen D, Ma JX. Photoreceptor degeneration and retinal inflammation induced by very low-density lipoprotein receptor deficiency. Microvasc Res. 2009;78:119-127.
24. Zhou T, Hu Y, Chen Y, et al. The pathogenic role of the canonical Wnt pathway in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2010;51:4371-4379.
25. Zhou T, Zhou KK, Lee K, et al. The role of lipid peroxidation products and oxidative stress in activation of the canonical wingless-type MMTV integration site (WNT) pathway in a rat model of diabetic retinopathy. Diabetologia. 2011;54:459-468.
26. Zhang XZ, Jiang JB, Luo XQ, et al. Effect of vascular endothelial growth factor small interfering RNA (siRNA) on retinal microvascular endothelial cells under hypoxia condition in vitro [in Chinese]. Zhonghua Er Ke Za Zhi. 2009;47:457-461.
27. Falkenstein IA, Cheng L, Wong-Staal F, et al. Toxicity and intraocular properties of a novel long-acting anti-proliferative and anti-angiogenic compound IMS2186. Curr Eye Res. 2008; 33:599-609.
28. Muther PS, Semkova I, Schmidt K, et al. Conditions of retinal glial and inflammatory cell activation after irradiation in a GFPchimeric mouse model. Invest Ophthalmol Vis Sci. 2010;51: 4831-4839.
29. Tsubota K. Oxidative stress and inflammation: hypothesis for the mechanism of aging [in Japanese]. Nihon Ganka Gakkai Zasshi. 2007;111:193-205; discussion 206.
30. Zhuang P, Shen Y, Lin BQ, Zhang WY, Chiou GC. Effect of quercetin on formation of choroidal neovascularization (CNV) in age-related macular degeneration(AMD). Yan Ke Xue Bao. 2011;26:23-29.
31. Shi X, Semkova I, Muther PS, Dell S, Kociok N, Joussen AM. Inhibition of TNF-alpha reduces laser-induced choroidal neovascularization. Exp Eye Res. 2006;83:1325-1334.
32. Chen Y, Hu Y, Zhou T, et al. Activation of the Wnt pathway plays a pathogenic role in diabetic retinopathy in humans and animal models. Am J Pathol. 2009;175:2676-2685.
33. Jasielska M, Semkova I, Shi X, et al. Differential role of tumor necrosis factor (TNF)-{alpha} receptors in the development of choroidal neovascularization. Invest Ophthalmol Vis Sci. 2010;51:3874-3883.
34. Mi K, Johnson GV. Role of the intracellular domains of LRP5 and LRP6 in activating the Wnt canonical pathway. J Cell Biochem. 2005;95:328-338.
35. Gong Y, Bourhis E, Chiu C, et al. Wnt isoform-specific interactions with coreceptor specify inhibition or potentiation of signaling by LRP6 antibodies. PLoS One. 2010;5:e12682.
36. Glinka A, Wu W, Delius H, Monaghan AP, Blumenstock C, Niehrs C. Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature. 1998;391: 357-362.
37. Sakane H, Yamamoto H, Kikuchi A. LRP6 is internalized by Dkk1 to suppress its phosphorylation in the lipid raft and is recycled for reuse. J Cell Sci. 2010;123:360-368.
38. Bafico A, Liu G, Yaniv A, Gazit A, Aaronson SA. Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow. Nat Cell Biol. 2001;3:683-686.
39. Ettenberg SA, Charlat O, Daley MP, et al. Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies. Proc Natl Acad Sci U S A. 2010;107:15473-15478.
40. Lee K, Hu Y, Ding L, et al. Therapeutic potential of a monoclonal antibody blocking the wnt pathway in diabetic retinopathy. Diabetes. 2012;61:2948-2957.
41. Berger C, Madshus IH, Stang E. Cetuximab in combination with anti-human IgG antibodies efficiently down-regulates the EGF receptor by macropinocytosis. Exp Cell Res. 2012;318: 2578-2591.