메뉴 건너뛰기




Volumn 37, Issue 11, 2015, Pages 579-589

Leishmania mexicana amastigotes inhibit p38 and JNK and activate PI3K/AKT: Role in the inhibition of apoptosis of dendritic cells

Author keywords

Amastigotes; Apoptosis; Dendritic cells; Leishmania mexicana; Mitogen activated protein kinase; PI3K

Indexed keywords

CAMPTOTHECIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE 1;

EID: 84945137881     PISSN: 01419838     EISSN: 13653024     Source Type: Journal    
DOI: 10.1111/pim.12275     Document Type: Article
Times cited : (15)

References (59)
  • 1
    • 0033991292 scopus 로고    scopus 로고
    • The host response to Leishmania infection
    • Solbach W & Laskay T. The host response to Leishmania infection. Adv Immunol 2000; 74: 275-317.
    • (2000) Adv Immunol , vol.74 , pp. 275-317
    • Solbach, W.1    Laskay, T.2
  • 2
    • 0033987177 scopus 로고    scopus 로고
    • Leishmania parasites and their ploys to disrupt macrophage activation
    • Kane MM & Mosser DM. Leishmania parasites and their ploys to disrupt macrophage activation. Curr Opin Hematol 2000; 7: 26-31.
    • (2000) Curr Opin Hematol , vol.7 , pp. 26-31
    • Kane, M.M.1    Mosser, D.M.2
  • 3
    • 0034235989 scopus 로고    scopus 로고
    • Leishmania-host-cell interaction: complexities and alternative views
    • Rittig MG & Bogdan C. Leishmania-host-cell interaction: complexities and alternative views. Parasitol Today 2000; 16: 292-297.
    • (2000) Parasitol Today , vol.16 , pp. 292-297
    • Rittig, M.G.1    Bogdan, C.2
  • 4
    • 84856136186 scopus 로고    scopus 로고
    • The critical role of JNK in the ER-mitochondrial crosstalk during apoptotic cell death
    • Verma G & Datta M. The critical role of JNK in the ER-mitochondrial crosstalk during apoptotic cell death. J Cell Physiol 2012; 227: 1791-1795.
    • (2012) J Cell Physiol , vol.227 , pp. 1791-1795
    • Verma, G.1    Datta, M.2
  • 5
    • 0033554554 scopus 로고    scopus 로고
    • Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1)
    • Hoeflich KP, Yeh WC, Yao Z, Mak TW & Woodgett JR. Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1). Oncogene 1999; 18: 5814-5820.
    • (1999) Oncogene , vol.18 , pp. 5814-5820
    • Hoeflich, K.P.1    Yeh, W.C.2    Yao, Z.3    Mak, T.W.4    Woodgett, J.R.5
  • 6
    • 0035066383 scopus 로고    scopus 로고
    • Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation
    • Kyriakis JM & Avruch J. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev 2001; 81: 807-869.
    • (2001) Physiol Rev , vol.81 , pp. 807-869
    • Kyriakis, J.M.1    Avruch, J.2
  • 8
    • 12844257688 scopus 로고    scopus 로고
    • Tumour necrosis factor-alpha- vs. growth factor deprivation-promoted cell death: distinct converging pathways
    • Macdonald NJ, Delderfield SM, Zhang W & Taglialatela G. Tumour necrosis factor-alpha- vs. growth factor deprivation-promoted cell death: distinct converging pathways. Aging Cell 2003; 2: 245-256.
    • (2003) Aging Cell , vol.2 , pp. 245-256
    • Macdonald, N.J.1    Delderfield, S.M.2    Zhang, W.3    Taglialatela, G.4
  • 10
    • 0037216749 scopus 로고    scopus 로고
    • Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets
    • Hommes DW, Peppelenbosch MP & van Deventer SJ. Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets. Gut 2003; 52: 144-151.
    • (2003) Gut , vol.52 , pp. 144-151
    • Hommes, D.W.1    Peppelenbosch, M.P.2    van Deventer, S.J.3
  • 11
    • 0032935664 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases: specific messages from ubiquitous messengers
    • Schaeffer HJ & Weber MJ. Mitogen-activated protein kinases: specific messages from ubiquitous messengers. Mol Cell Biol 1999; 19: 2435-2444.
    • (1999) Mol Cell Biol , vol.19 , pp. 2435-2444
    • Schaeffer, H.J.1    Weber, M.J.2
  • 12
    • 0034096201 scopus 로고    scopus 로고
    • Protein phosphatases and the regulation of mitogen-activated protein kinase signalling
    • Keyse SM. Protein phosphatases and the regulation of mitogen-activated protein kinase signalling. Curr Opin Cell Biol 2000; 12: 186-192.
    • (2000) Curr Opin Cell Biol , vol.12 , pp. 186-192
    • Keyse, S.M.1
  • 13
    • 84893692276 scopus 로고    scopus 로고
    • p38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents
    • Sui X, Kong N, Ye L, et al. p38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents. Cancer Lett 2014; 344: 174-179.
    • (2014) Cancer Lett , vol.344 , pp. 174-179
    • Sui, X.1    Kong, N.2    Ye, L.3
  • 14
    • 77955059513 scopus 로고    scopus 로고
    • Mechanisms and functions of p38 MAPK signalling
    • Cuadrado A & Nebreda AR. Mechanisms and functions of p38 MAPK signalling. Biochem J 2010; 429: 403-417.
    • (2010) Biochem J , vol.429 , pp. 403-417
    • Cuadrado, A.1    Nebreda, A.R.2
  • 15
    • 84857216258 scopus 로고    scopus 로고
    • Role of the JNK pathway in human diseases
    • Sabapathy K. Role of the JNK pathway in human diseases. Prog Mol Biol Transl Sci 2012; 106: 145-169.
    • (2012) Prog Mol Biol Transl Sci , vol.106 , pp. 145-169
    • Sabapathy, K.1
  • 16
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-Kinase AKT pathway in human cancer
    • Vivanco I & Sawyers CL. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2002; 2: 489-501.
    • (2002) Nat Rev Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 17
    • 0036595397 scopus 로고    scopus 로고
    • Cytotoxic T lymphocytes: all roads lead to death
    • Barry M & Bleackley RC. Cytotoxic T lymphocytes: all roads lead to death. Nat Rev Immunol 2002; 2: 401-409.
    • (2002) Nat Rev Immunol , vol.2 , pp. 401-409
    • Barry, M.1    Bleackley, R.C.2
  • 19
    • 0034234669 scopus 로고    scopus 로고
    • The modulation of host cell apoptosis by intracellular bacterial pathogens
    • Gao LY & Kwaik YA. The modulation of host cell apoptosis by intracellular bacterial pathogens. Trends Microbiol 2000; 8: 306-313.
    • (2000) Trends Microbiol , vol.8 , pp. 306-313
    • Gao, L.Y.1    Kwaik, Y.A.2
  • 21
    • 33750338625 scopus 로고    scopus 로고
    • Pro- and anti-apoptotic activities of protozoan parasites
    • Schaumburg F, Hippe D, Vutova P & Luder CG. Pro- and anti-apoptotic activities of protozoan parasites. Parasitology 2006; 132(Suppl): S69-S85.
    • (2006) Parasitology , vol.132 , Issue.SUPPL , pp. S69-S85
    • Schaumburg, F.1    Hippe, D.2    Vutova, P.3    Luder, C.G.4
  • 22
    • 3042782584 scopus 로고    scopus 로고
    • Leishmania major-mediated prevention of programmed cell death induction in infected macrophages is associated with the repression of mitochondrial release of cytochrome c
    • Akarid K, Arnoult D, Micic-Polianski J, Sif J, Estaquier J & Ameisen JC. Leishmania major-mediated prevention of programmed cell death induction in infected macrophages is associated with the repression of mitochondrial release of cytochrome c. J Leukoc Biol 2004; 76: 95-103.
    • (2004) J Leukoc Biol , vol.76 , pp. 95-103
    • Akarid, K.1    Arnoult, D.2    Micic-Polianski, J.3    Sif, J.4    Estaquier, J.5    Ameisen, J.C.6
  • 23
    • 0028294578 scopus 로고
    • Intracellular infection by Leishmania donovani inhibits macrophage apoptosis
    • Moore KJ & Matlashewski G. Intracellular infection by Leishmania donovani inhibits macrophage apoptosis. J Immunol 1994; 152: 2930-2937.
    • (1994) J Immunol , vol.152 , pp. 2930-2937
    • Moore, K.J.1    Matlashewski, G.2
  • 24
    • 0028049413 scopus 로고
    • Leishmania donovani infection enhances macrophage viability in the absence of exogenous growth factor
    • Moore KJ, Turco SJ & Matlashewski G. Leishmania donovani infection enhances macrophage viability in the absence of exogenous growth factor. J Leukoc Biol 1994; 55: 91-98.
    • (1994) J Leukoc Biol , vol.55 , pp. 91-98
    • Moore, K.J.1    Turco, S.J.2    Matlashewski, G.3
  • 25
    • 27744545566 scopus 로고    scopus 로고
    • Infection with Leishmania infantum Inhibits actinomycin D-induced apoptosis of human monocytic cell line U-937
    • Lisi S, Sisto M, Acquafredda A, et al. Infection with Leishmania infantum Inhibits actinomycin D-induced apoptosis of human monocytic cell line U-937. J Eukaryot Microbiol 2005; 52: 211-217.
    • (2005) J Eukaryot Microbiol , vol.52 , pp. 211-217
    • Lisi, S.1    Sisto, M.2    Acquafredda, A.3
  • 26
    • 0037100438 scopus 로고    scopus 로고
    • Inhibition of the spontaneous apoptosis of neutrophil granulocytes by the intracellular parasite Leishmania major
    • Aga E, Katschinski DM, van Zandbergen G, et al. Inhibition of the spontaneous apoptosis of neutrophil granulocytes by the intracellular parasite Leishmania major. J Immunol 2002; 169: 898-905.
    • (2002) J Immunol , vol.169 , pp. 898-905
    • Aga, E.1    Katschinski, D.M.2    van Zandbergen, G.3
  • 27
    • 59849096757 scopus 로고    scopus 로고
    • Leishmania mexicana: inhibition of camptothecin-induced apoptosis of monocyte-derived dendritic cells
    • Valdes-Reyes L, Argueta J, Moran J, et al. Leishmania mexicana: inhibition of camptothecin-induced apoptosis of monocyte-derived dendritic cells. Exp Parasitol 2009; 121: 199-207.
    • (2009) Exp Parasitol , vol.121 , pp. 199-207
    • Valdes-Reyes, L.1    Argueta, J.2    Moran, J.3
  • 28
    • 84876406300 scopus 로고    scopus 로고
    • Inhibition of dendritic cell apoptosis by Leishmania mexicana amastigotes
    • Gutierrez-Kobeh L, de Oyarzabal E, Argueta J, et al. Inhibition of dendritic cell apoptosis by Leishmania mexicana amastigotes. Parasitol Res 2013; 112: 1755-1762.
    • (2013) Parasitol Res , vol.112 , pp. 1755-1762
    • Gutierrez-Kobeh, L.1    de Oyarzabal, E.2    Argueta, J.3
  • 29
    • 33845447657 scopus 로고    scopus 로고
    • Leishmania promastigotes activate PI3K/Akt signalling to confer host cell resistance to apoptosis
    • Ruhland A, Leal N & Kima PE. Leishmania promastigotes activate PI3K/Akt signalling to confer host cell resistance to apoptosis. Cell Microbiol 2007; 9: 84-96.
    • (2007) Cell Microbiol , vol.9 , pp. 84-96
    • Ruhland, A.1    Leal, N.2    Kima, P.E.3
  • 30
    • 84873407183 scopus 로고    scopus 로고
    • Infection of neutrophil granulocytes with Leishmania major activates ERK 1/2 and modulates multiple apoptotic pathways to inhibit apoptosis
    • Sarkar A, Aga E, Bussmeyer U, et al. Infection of neutrophil granulocytes with Leishmania major activates ERK 1/2 and modulates multiple apoptotic pathways to inhibit apoptosis. Med Microbiol Immunol 2013; 202: 25-35.
    • (2013) Med Microbiol Immunol , vol.202 , pp. 25-35
    • Sarkar, A.1    Aga, E.2    Bussmeyer, U.3
  • 31
    • 84902173719 scopus 로고    scopus 로고
    • Toll-like receptor 4 promotes control of Leishmania infantum infection through inducement of leishmanicidal activity in host macrophages: role of mitogen activated kinases
    • Agallou M, Dotsika E, Frydas S & Karagouni E. Toll-like receptor 4 promotes control of Leishmania infantum infection through inducement of leishmanicidal activity in host macrophages: role of mitogen activated kinases. J Biol Regul Homeost Agents 2014; 28: 41-52.
    • (2014) J Biol Regul Homeost Agents , vol.28 , pp. 41-52
    • Agallou, M.1    Dotsika, E.2    Frydas, S.3    Karagouni, E.4
  • 32
    • 84899486727 scopus 로고    scopus 로고
    • Targeted extracellular signal-regulated kinase activation mediated by Leishmania amazonensis requires MP1 scaffold
    • Boggiatto PM, Martinez PA, Pullikuth A, et al. Targeted extracellular signal-regulated kinase activation mediated by Leishmania amazonensis requires MP1 scaffold. Microb Infect 2014; 16: 328-336.
    • (2014) Microb Infect , vol.16 , pp. 328-336
    • Boggiatto, P.M.1    Martinez, P.A.2    Pullikuth, A.3
  • 33
    • 64449084586 scopus 로고    scopus 로고
    • Activation of PI3K/Akt signaling has a dominant negative effect on IL-12 production by macrophages infected with Leishmania amazonensis promastigotes
    • Ruhland A & Kima PE. Activation of PI3K/Akt signaling has a dominant negative effect on IL-12 production by macrophages infected with Leishmania amazonensis promastigotes. Exp Parasitol 2009; 122: 28-36.
    • (2009) Exp Parasitol , vol.122 , pp. 28-36
    • Ruhland, A.1    Kima, P.E.2
  • 34
    • 19444384370 scopus 로고    scopus 로고
    • JNK activation limits dendritic cell maturation in response to reactive oxygen species by the induction of apoptosis
    • Handley ME, Thakker M, Pollara G, Chain BM & Katz DR. JNK activation limits dendritic cell maturation in response to reactive oxygen species by the induction of apoptosis. Free Radic Biol Med 2005; 38: 1637-1652.
    • (2005) Free Radic Biol Med , vol.38 , pp. 1637-1652
    • Handley, M.E.1    Thakker, M.2    Pollara, G.3    Chain, B.M.4    Katz, D.R.5
  • 35
    • 17844375379 scopus 로고    scopus 로고
    • Critical roles of Raf/MEK/ERK and PI3K/AKT signaling and inactivation of p38 MAP kinase in the differentiation and survival of monocyte-derived immature dendritic cells
    • Xie J, Qian J, Yang J, Wang S, Freeman ME 3rd & Yi Q. Critical roles of Raf/MEK/ERK and PI3K/AKT signaling and inactivation of p38 MAP kinase in the differentiation and survival of monocyte-derived immature dendritic cells. Exp Hematol 2005; 33: 564-572.
    • (2005) Exp Hematol , vol.33 , pp. 564-572
    • Xie, J.1    Qian, J.2    Yang, J.3    Wang, S.4    Freeman 3rd, M.E.5    Yi, Q.6
  • 36
    • 3242696726 scopus 로고    scopus 로고
    • p38 Mitogen-Activated protein kinase mediates dual role of ultraviolet B radiation in induction of maturation and apoptosis of monocyte-derived dendritic cells
    • Nakagawa S, Ohtani T, Mizuashi M, et al. p38 Mitogen-Activated protein kinase mediates dual role of ultraviolet B radiation in induction of maturation and apoptosis of monocyte-derived dendritic cells. J Invest Dermatol 2004; 123: 361-370.
    • (2004) J Invest Dermatol , vol.123 , pp. 361-370
    • Nakagawa, S.1    Ohtani, T.2    Mizuashi, M.3
  • 37
    • 0028285230 scopus 로고
    • Proliferating dendritic cell progenitors in human blood
    • Romani N, Gruner S, Brang D, et al. Proliferating dendritic cell progenitors in human blood. J Exp Med 1994; 180: 83-93.
    • (1994) J Exp Med , vol.180 , pp. 83-93
    • Romani, N.1    Gruner, S.2    Brang, D.3
  • 38
    • 0028289244 scopus 로고
    • Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha
    • Sallusto F & Lanzavecchia A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J Exp Med 1994; 179: 1109-1118.
    • (1994) J Exp Med , vol.179 , pp. 1109-1118
    • Sallusto, F.1    Lanzavecchia, A.2
  • 39
    • 67949092695 scopus 로고    scopus 로고
    • Leishmania infection inhibits cycloheximide-induced macrophage apoptosis in a strain-dependent manner
    • Donovan MJ, Maciuba BZ, Mahan CE & McDowell MA. Leishmania infection inhibits cycloheximide-induced macrophage apoptosis in a strain-dependent manner. Exp Parasitol 2009; 123: 58-64.
    • (2009) Exp Parasitol , vol.123 , pp. 58-64
    • Donovan, M.J.1    Maciuba, B.Z.2    Mahan, C.E.3    McDowell, M.A.4
  • 40
    • 0019518610 scopus 로고
    • A quick, simple method for purifying Leishmania mexicana amastigotes in large numbers
    • Hart DT, Vickerman K & Coombs GH. A quick, simple method for purifying Leishmania mexicana amastigotes in large numbers. Parasitology 1981; 82: 345-355.
    • (1981) Parasitology , vol.82 , pp. 345-355
    • Hart, D.T.1    Vickerman, K.2    Coombs, G.H.3
  • 41
    • 0022413168 scopus 로고
    • The mouse macrophage receptor for C3bi (CR3) is a major mechanism in the phagocytosis of Leishmania promastigotes
    • Mosser DM & Edelson PJ. The mouse macrophage receptor for C3bi (CR3) is a major mechanism in the phagocytosis of Leishmania promastigotes. J Immunol 1985; 135: 2785-2789.
    • (1985) J Immunol , vol.135 , pp. 2785-2789
    • Mosser, D.M.1    Edelson, P.J.2
  • 42
    • 33846203839 scopus 로고    scopus 로고
    • Activation of the MAPK, ERK, following Leishmania amazonensis infection of macrophages
    • Yang Z, Mosser DM & Zhang X. Activation of the MAPK, ERK, following Leishmania amazonensis infection of macrophages. J Immunol 2007; 178: 1077-1085.
    • (2007) J Immunol , vol.178 , pp. 1077-1085
    • Yang, Z.1    Mosser, D.M.2    Zhang, X.3
  • 43
    • 0026674542 scopus 로고
    • Axenic cultivation and characterization of Leishmania mexicana amastigote-like forms
    • Bates PA, Robertson CD, Tetley L & Coombs GH. Axenic cultivation and characterization of Leishmania mexicana amastigote-like forms. Parasitology 1992; 105(Pt 2): 193-202.
    • (1992) Parasitology , vol.105 , pp. 193-202
    • Bates, P.A.1    Robertson, C.D.2    Tetley, L.3    Coombs, G.H.4
  • 45
    • 0027473217 scopus 로고
    • Parasitism of epidermal Langerhans cells in experimental cutaneous leishmaniasis with Leishmania major
    • Blank C, Fuchs H, Rappersberger K, Rollinghoff M & Moll H. Parasitism of epidermal Langerhans cells in experimental cutaneous leishmaniasis with Leishmania major. J Infect Dis 1993; 167: 418-425.
    • (1993) J Infect Dis , vol.167 , pp. 418-425
    • Blank, C.1    Fuchs, H.2    Rappersberger, K.3    Rollinghoff, M.4    Moll, H.5
  • 46
    • 0029738086 scopus 로고    scopus 로고
    • Induction of neuronal apoptosis by camptothecin, an inhibitor of DNA topoisomerase-I: evidence for cell cycle-independent toxicity
    • Morris EJ & Geller HM. Induction of neuronal apoptosis by camptothecin, an inhibitor of DNA topoisomerase-I: evidence for cell cycle-independent toxicity. J Cell Biol 1996; 134: 757-770.
    • (1996) J Cell Biol , vol.134 , pp. 757-770
    • Morris, E.J.1    Geller, H.M.2
  • 47
    • 0027269557 scopus 로고
    • Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays
    • Gorczyca W, Gong J & Darzynkiewicz Z. Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays. Cancer Res 1993; 53: 1945-1951.
    • (1993) Cancer Res , vol.53 , pp. 1945-1951
    • Gorczyca, W.1    Gong, J.2    Darzynkiewicz, Z.3
  • 48
    • 0029951889 scopus 로고    scopus 로고
    • Ultrastructural identification of apoptotic nuclei using the TUNEL technique
    • Sanders EJ & Wride MA. Ultrastructural identification of apoptotic nuclei using the TUNEL technique. Histochem J 1996; 28: 275-281.
    • (1996) Histochem J , vol.28 , pp. 275-281
    • Sanders, E.J.1    Wride, M.A.2
  • 49
    • 0036717724 scopus 로고    scopus 로고
    • Activation of p38 mitogen-activated protein kinase attenuates Leishmania donovani infection in macrophages
    • Junghae M & Raynes JG. Activation of p38 mitogen-activated protein kinase attenuates Leishmania donovani infection in macrophages. Infect Immun 2002; 70: 5026-5035.
    • (2002) Infect Immun , vol.70 , pp. 5026-5035
    • Junghae, M.1    Raynes, J.G.2
  • 50
    • 0037460059 scopus 로고    scopus 로고
    • CD40 signaling is impaired in L. major-infected macrophages and is rescued by a p38MAPK activator establishing a host-protective memory T cell response
    • Awasthi A, Mathur R, Khan A, et al. CD40 signaling is impaired in L. major-infected macrophages and is rescued by a p38MAPK activator establishing a host-protective memory T cell response. J Exp Med 2003; 197: 1037-1043.
    • (2003) J Exp Med , vol.197 , pp. 1037-1043
    • Awasthi, A.1    Mathur, R.2    Khan, A.3
  • 51
    • 2442635429 scopus 로고    scopus 로고
    • Reciprocal CD40 signals through p38MAPK and ERK-1/2 induce counteracting immune responses
    • Mathur RK, Awasthi A, Wadhone P, Ramanamurthy B & Saha B. Reciprocal CD40 signals through p38MAPK and ERK-1/2 induce counteracting immune responses. Nat Med 2004; 10: 540-544.
    • (2004) Nat Med , vol.10 , pp. 540-544
    • Mathur, R.K.1    Awasthi, A.2    Wadhone, P.3    Ramanamurthy, B.4    Saha, B.5
  • 52
    • 0033847256 scopus 로고    scopus 로고
    • Leishmania donovani promastigotes evade the activation of mitogen-activated protein kinases p38, c-Jun N-terminal kinase, and extracellular signal-regulated kinase-1/2 during infection of naive macrophages
    • Prive C & Descoteaux A. Leishmania donovani promastigotes evade the activation of mitogen-activated protein kinases p38, c-Jun N-terminal kinase, and extracellular signal-regulated kinase-1/2 during infection of naive macrophages. Eur J Immunol 2000; 30: 2235-2244.
    • (2000) Eur J Immunol , vol.30 , pp. 2235-2244
    • Prive, C.1    Descoteaux, A.2
  • 53
    • 0036893697 scopus 로고    scopus 로고
    • Leishmania donovani suppresses activated protein 1 and NF-kappaB activation in host macrophages via ceramide generation: involvement of extracellular signal-regulated kinase
    • Ghosh S, Bhattacharyya S, Sirkar M, et al. Leishmania donovani suppresses activated protein 1 and NF-kappaB activation in host macrophages via ceramide generation: involvement of extracellular signal-regulated kinase. Infect Immun 2002; 70: 6828-6838.
    • (2002) Infect Immun , vol.70 , pp. 6828-6838
    • Ghosh, S.1    Bhattacharyya, S.2    Sirkar, M.3
  • 54
    • 53349153579 scopus 로고    scopus 로고
    • Leishmania donovani infection down-regulates TLR2-stimulated IL-12p40 and activates IL-10 in cells of macrophage/monocytic lineage by modulating MAPK pathways through a contact-dependent mechanism
    • Chandra D & Naik S. Leishmania donovani infection down-regulates TLR2-stimulated IL-12p40 and activates IL-10 in cells of macrophage/monocytic lineage by modulating MAPK pathways through a contact-dependent mechanism. Clin Exp Immunol 2008; 154: 224-234.
    • (2008) Clin Exp Immunol , vol.154 , pp. 224-234
    • Chandra, D.1    Naik, S.2
  • 55
    • 33646456171 scopus 로고    scopus 로고
    • Sodium antimony gluconate induces generation of reactive oxygen species and nitric oxide via phosphoinositide 3-kinase and mitogen-activated protein kinase activation in Leishmania donovani-infected macrophages
    • Mookerjee Basu J, Mookerjee A, Sen P, et al. Sodium antimony gluconate induces generation of reactive oxygen species and nitric oxide via phosphoinositide 3-kinase and mitogen-activated protein kinase activation in Leishmania donovani-infected macrophages. Antimicrob Agents Chemother 2006; 50: 1788-1797.
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 1788-1797
    • Mookerjee Basu, J.1    Mookerjee, A.2    Sen, P.3
  • 56
    • 79953674515 scopus 로고    scopus 로고
    • Berberine chloride mediates its anti-leishmanial activity via differential regulation of the mitogen activated protein kinase pathway in macrophages
    • Saha P, Bhattacharjee S, Sarkar A, Manna A, Majumder S & Chatterjee M. Berberine chloride mediates its anti-leishmanial activity via differential regulation of the mitogen activated protein kinase pathway in macrophages. PLoS ONE 2011; 6: e18467.
    • (2011) PLoS ONE , vol.6 , pp. e18467
    • Saha, P.1    Bhattacharjee, S.2    Sarkar, A.3    Manna, A.4    Majumder, S.5    Chatterjee, M.6
  • 57
    • 80051943703 scopus 로고    scopus 로고
    • Leishmania mexicana promastigotes inhibit macrophage IL-12 production via TLR-4 dependent COX-2, iNOS and arginase-1 expression
    • Shweash M, Adrienne McGachy H, Schroeder J, et al. Leishmania mexicana promastigotes inhibit macrophage IL-12 production via TLR-4 dependent COX-2, iNOS and arginase-1 expression. Mol Immunol 2011; 48: 1800-1808.
    • (2011) Mol Immunol , vol.48 , pp. 1800-1808
    • Shweash, M.1    Adrienne McGachy, H.2    Schroeder, J.3
  • 58
    • 0034164455 scopus 로고    scopus 로고
    • The c-Jun N-terminal kinase pathway and apoptotic signaling (review)
    • Chen YR & Tan TH. The c-Jun N-terminal kinase pathway and apoptotic signaling (review). Int J Oncol 2000; 16: 651-662.
    • (2000) Int J Oncol , vol.16 , pp. 651-662
    • Chen, Y.R.1    Tan, T.H.2
  • 59
    • 65749089265 scopus 로고    scopus 로고
    • STI571 sensitizes breast cancer cells to 5-fluorouracil, cisplatin and camptothecin in a cell type-specific manner
    • Sims JT, Ganguly S, Fiore LS, Holler CJ, Park ES & Plattner R. STI571 sensitizes breast cancer cells to 5-fluorouracil, cisplatin and camptothecin in a cell type-specific manner. Biochem Pharmacol 2009; 78: 249-260.
    • (2009) Biochem Pharmacol , vol.78 , pp. 249-260
    • Sims, J.T.1    Ganguly, S.2    Fiore, L.S.3    Holler, C.J.4    Park, E.S.5    Plattner, R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.