Metabolic connection of inflammatory pain: Pivotal role of a pyruvate dehydrogenase kinase-pyruvate dehydrogenase-lactic acid axis

Journal of Neuroscience

Volumn 35, Issue 42, 2015, Pages 14353-14369

  Jha, Mithilesh Kumar ^a   Song, Gyun Jee ^a   Lee, Maan Gee ^a   Jeoung, Nam Ho ^b   Go, Younghoon ^a   Harris, Robert A ^c   Park, Dong Ho ^a   Kook, Hyun ^d   Lee, In Kyu ^a   Suk, Kyoungho ^a  

^a Kyungpook National University School of Medicine   (South Korea)

^b Catholic University of Daegu   (South Korea)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Chonnam National University Medical School   (South Korea)

Author keywords

Chronic inflammatory pain; Inflammation; Macrophages; Metabolism; Pain; PDK PDH lactic acid axis

Indexed keywords

INTERLEUKIN 1BETA; INTERLEUKIN 6; LACTIC ACID; NITRITE; PYRUVATE DEHYDROGENASE; PYRUVATE DEHYDROGENASE KINASE; PYRUVATE DEHYDROGENASE KINASE 2; PYRUVATE DEHYDROGENASE KINASE 4; TUMOR NECROSIS FACTOR ALPHA; PROTEIN SERINE THREONINE KINASE; PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING) KINASE; PYRUVATE DEHYDROGENASE COMPLEX;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; CONTROLLED STUDY; GENOTYPE; GLIA; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INFLAMMATORY PAIN; MACROPHAGE; METABOLISM; MOTOR NERVE CONDUCTION; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; PAW EDEMA; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; CELL CULTURE; COMPLICATION; DEFICIENCY; DISEASE MODEL; EDEMA; GENE EXPRESSION REGULATION; GENETICS; HYPERALGESIA; KNOCKOUT MOUSE; MALE; NERVE CONDUCTION; PAIN; PAIN MEASUREMENT; PAIN THRESHOLD; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; TIME;

ANIMALS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; EDEMA; GENE EXPRESSION REGULATION; HYPERALGESIA; INFLAMMATION; LACTIC ACID; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEURAL CONDUCTION; PAIN; PAIN MEASUREMENT; PAIN THRESHOLD; PROTEIN-SERINE-THREONINE KINASES; PYRUVATE DEHYDROGENASE COMPLEX; TIME FACTORS;

EID: 84944909818     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1910-15.2015     Document Type: Article

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